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Fighting Infection with Phages
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- Опубликовано: 18 авг 2024
- Around the world, harmful bacteria are gaining resistance to our most common antibiotics. However, a type of viruses called bacteriophages may provide a solution. In this video, NIAID experts Shayla Hesse, M.D., a Clinical Infectious Diseases Fellow at NIAID, and Randall Kincaid, Ph.D., a Senior Scientific Officer in the Concept Acceleration Program of NIAID's Division of Microbiology and Infectious Diseases, explain how these "phages" function, and how NIAID is supporting new phage research.
![EST Gee - NEVER NEED (Feat. Selfpaid Savage) [Official Video]](http://i.ytimg.com/vi/f2cRtr52HXI/mqdefault.jpg)
Bacteria: I am inevitable
Phage: *and I am, phage*
Toilet Paper How bacteria spells phage: M Y D O O M
Hello Inevitable, I'm Phage
human cell skin:
no.
A long time ago bacteria were our phages.
@@moonlightgaming3067 there not bacteria, there bacteria *killers.*
Highfive to those microscopic heroes.
Hell yea.
I have to corect you they are not heroes.
They are Chad heroes.
I think using bacteriophages to eradicate antibiotic-resistant bacteria is a very good idea. Hopefully more time and money will go towards the research involved in making this a reality.
Yes
From what I learned, in order for bacteria to gain resistance to bacteriophages, they have to trade away their immunity to antibiotics. So combining the two could trap them in a catch 22.
it was abandoned in the US in the 1940's s because the Soviet Union was the leader in Phage research at the time. ..So it was at least partly, an ideological decision that emerged out of American cold war politics ...Also drugs were seen as easier to monetize for profit, at least they were back then because of patent laws. It wasnt clear how they could patent an organism that evolved a billion years before capitalism. Now its understood, they patent the research and various procedures.
Thanks, little dudes.
:D
❤
🙂
They are the 1st on the deadliest killers on the planet and we are 2nd
@@gamingmoran9597 actually its the opposite
It all seems so mechanical as if they are advance nanobots. Inside our bodies.
And that's exactly what they are, ancient nanobots
@@cecilitaH Probably alien. Those bodies, scream created.
@@BelleRiverHeating I agree, panspermia, you have meteorites with bacteria, dna, and amino acids being found everywhere.
My theory is that there might have been an age where an intelligent multicellular prokaryote organism was the dominant species on Earth, think humans but made up of prokaryote (bacterial) cells instead of eukaryote cells. These large bacterial animals were made up of billions of bacteria each (just like we are made up of billions of our cells). They were as intelligent or more intelligent than humans, and one day they decided to augment themselves by inventing a nanobot that could enter their cells and insert any genes they wanted to have, could be anything from super strength to resistance against cancer. These nanobots could also use the bacterial ribosomes to self-replicate within their cells after modifying them with the desired gene, but they would stop replicating after a certain amount of bots were made and they would exit the cell without harming it, going on to augment other cells and eventually doing so to every cell in their bodies. Unfortunately for them, one of these nanobots mutated and started to multiply beyond it’s normal limit, until the cell became so full of them that it burst open, releasing thousands of those mutated bots. Soon, that species’ whole population was killed due to those mutated nanobots, which we nowadays call bacteriophages. The phages became so widespread that multicellular bacterial life became impossible because the phages would tear through a macroscopic bacterial organism in minutes due to the cells all being clumped together. After the phage apocalypse, the only bacteria left were the unicellular, microscopic bacteria we’re familiar with today, which still managed to proliferate despite phages still killing a large portion of their population everyday even until today.
@@sportsfails4998 impossible we would have at least a trace of intelligence on their dna
Highly Resistant Bacteria: you cant defeat me
Antibiotics: I know, but he can
Bacteriophage:
Highly resistant bacteria: i will evolve
Phages: lol
Bacteria have one way to counter Phages, BY REMOVING THERE DRUG RESISTENCE LOLOLOLOL
@@BlitzkriegTechno are you from kurzgesagt gang
@@dhanushchandranakkalakunta151 yes but I also got more information from outside sources
@@BlitzkriegTechno and then we can use the antibiotics LMAO hhahahahahya
Who’s here from Kersegzat only me okay
Kurzgesagt you mean? Oh then me too
Canadian _Oreo4 no I am here too
Lol hope the 21 likes satisfied your ego
Same
Me
Those things literally look terrifying
Lol
Let’s hope they are to rogue harmful cells! You can make a brilliant phage therapy for yourself, look up and research Gc-MAF
so in the end, there will always be a parasite that will feast on you.. let this be a lesson kids
Yeah, it’s called the Democratic Party, AMIRITE?
Bacteria has left the chat
They're so cuuute
bacteria: you cant defeat us imune system: OH YEA? SAY HELLO TO MY TINY FRIEND
Haha! Youre very corny
The lytic cycle is so repulsive. Like watching a spider egg hatch.
Or like watching a brown recluse spider inject its prey to consume it. 🤮
That was the end of that experiment years ago after I was almost bitten buy it… so I captured it, took it in as an experiment (to watch how it attacked another bug firsthand) and then disposed of it.
Bacteria: Haha am stronk. No antibiotic can defeat me.
Bacteriophage: Omae wa, mou shindieru
Bacteria: who are you?
My name is Phage. BacterioPhage.
The coolest micro-creatures I have seen - bacteriophages...!!!
1:42 possible Jeopardy material, "Who is Felix D'herelle?"
How do you ensure the right phage is selected to infect the right bacterium? What are the components in the screening process? What happens if it is done wrong?
Bacteriophage only attacks specific type of bacteria there are hundreds of different types of phages and each only attacks a specific type of bacteria only also phages are harmless to human cells
Well some phages kills bacteria that are related from others
You may find answer to you question if you contact Eliava Institute of Bacteriophages in Georgia who have been doing extensive research in phages for more than half a century and who have been using them to treat people. They have been doing research and using them to treat people in Poland and Russia. There is also lots of information on internet.
Everybody gangsta until phage enters the chat
#Phages are the best
I've been struggling with cronic Osteomyelitis in my L5S1 of my spine antibiotics our not working I would love to gave this tried on me I have 2 little kids who need me thanks Robert Sharpe.
@@SimpLich trying to live especially right now is hard to stay safe!!
Yeah could use help with it forsure message me!!
This is your cure pubmed.ncbi.nlm.nih.gov/36959360/
I am a little late, but if anyone can answer this I would appreciate it. Could phages be responsible for curing or causing the remission of diseases in situations where alternative or homeopathic cures are thought to be responsible? From what I understand, the phages used to cure various diseases are found in nature, identified, and selectively reproduced in a lab setting in order to make enough of that particular phage for theraputic purposes. Does this mean if somebody with a particular disease comes across the a phage that kills that bacteria in the wild it would have no observable effect? At what threshold does a phage stand a chance of killing the bacteria? From everything I have been able to find, it seems like even a few phages could use a host bacteria to reproduce on a massive scale because they take over the bacteria and force it to produce more phages until the bacteria bursts.
Thank you for your inquiry. Patients with bacterial infections have been found with natural phages that have the potential to cure the infections. What has yet to be documented are cases where the observed natural bacteriophages have cured the infections. For example, rice water stool (a form of diarrhea) is a common occurrence in patients suffering from cholera, and bacteriophages which will attack the bacteria causing cholera are often found in this stool. For more information on this finding, please see the following paper: www.ncbi.nlm.nih.gov/pubmed/21304168
There are still many aspects of phage science which require further research, such as how many phages would be needed to treat different kinds of bacterial infections under different circumstances. We hope this information will be useful to you.
@@niaid Thank you so much for taking the time to respond to me.. It is difficult to this type of information and believe me I have tried.. there is a lot of research to be done it seems! Thank you for the article I will be reading it ASAP.
Is consideration being given to the fact that these living organisms could have negative side effects? Once they are done with the bacteria cells, is it possible that they would mutate and start feeding on other cell types? Is it possible that they might release substances that could cause a detrimental effect on the very organism they are meant to save?
Phages only specialise in one bacteria, which mean, hypothetically, if you have 2 infection, you would need 2 types of phages to kill them, because phages dont care for anything but its one and only bacteria
Human cell is too different, it would take a whole new course of evolution for phages to target human, the chance is like, "what if your lungs became selfware and attack your own body?"
In fact, there are about 1 million billion of them inside your intestines right now
Aucun problème
Les phages n'attaquent que les bactéries
Russia has been researching phages since the soviet union was still standing - one step ahead
Needs to be funded more across the world
Bacteria: i will end you
Phage: yes
phages are cool and everyone can agree
Those phages are like ninjas that kill e coli.
When I was studying microbiology, I was speaking to my professor about this very application. The problem we discussed was that this sort of treatment is usually only valid for the first treatment. You could never use the phage a second time if the patient becomes reinfected because the body would develop an immune response to the phage, as it is a foreign invader. Is this still an issue, and if so, how do you combat it??
Is gentically modifying the Phage possible?
@@kogan6025 kurguzugt
Phages are still viruses....meaning they can evolve also against bacteria
You and your professor clearly only think in global concepts. There is a limit to how fast your body will remove the phage. So if you overload the system with a high concentration, immunity to phage is a non-issue.
Possibly different types of phages?
Their like flood carriers and infection forms
I wish there was an immune cell that would produce these guys.
Thats not possible cells cant produce viruses
@@macdoworkerventi3986 yeah because the phages only go for bacteria, they don't go to human cells
Who knows, one day, with the advancement of technology and genetic coding, we will add one ourselves :)
these are absolutely horrifying
They keep you alive so I think you should thank them.
in what ways
They are kind tho
@@xistl4278 by killing bacterias ya know
@@xistl4278 since they are actively living in you body since birth. Bacteria are humanity's enemy and phages kill bad bacteria with ease. Very good for us. Plus antibiotics are starting to suck and also kill good bacteria too. Not worth it.
Finally natural is different and better
Dear Niaid thanks for the great video! I was wondering if you could grant me permission to use this video or another animation you may have showing the infection cycle.. We are a new startup company and we will attend an exhibition event in September so sth like that could be great to communicate what are phages actually able to do. Thanks in advance.
This footage, along with all of our videos, are in the public domain and can be freely used. We ask that you please credit the footage to NIAID. For more NIAID b-roll, visit our Flickr account at Flickr.com/photos/niaid/
Phages: Prepare for trouble!
Antibiotics: And make it double!
Talked about this in grad school in the 70s.
One question! Do Phages kill good bacteria like Lactobassilus?
They kill bacteria soooooo
@@rolebub2955 :O
@@imsogood77 but they only go to bacteria that there genes kill so maybe
Phage used to treat bacterial infections will be selected (or in some cases engineered) to attack only the specific bacteria they will combat. It is extremely unlikely that therapeutic phages will evolve to recognize and attack other types of bacteria or human cells. Phages are highly specific, and only make copies of themselves in the presence of the bacteria they target.
@@liam_dory Oh...so I think we might use phages to fight infections in the future! :)
Bacteria! Hey, how did a daddy long legs get in here?
Phage: Asta La Vista baby
Drug resistant bacteria: the body shall die lmao
Phage: no u
The scary part is that they're are also viral pages too...
Covid 19 if there were virophage: wait WHAT?!
The Soviet Union was doing this in the 70's. They already were using 2 tons a day.
Bacteria: HAHA!!!! I WILL KILL YA
Phage: not today... 💉
immunity:nice battle im gonna sleep
Awesome explain
I can't believe from what I see that nature made those things....
Those exist from longer then we do
I somehow have a hunch that this will go wrong somehow. Just a tiny, tiny hunch.
What exactly is Womezon Remedy? How does this thing really work? I see lots of people keep on speaking about this bacterial vaginosis remedy.
May i ask what happens to theoraticly, perfectly designed phages that are injected to destroy Bacteria XY after all Bacteria XY have been "destroyed"/"blown up"? Does the phage virus remain in the body or does it die together with the declining Bacteria XY population in the body ?
Since antibiotics act like a bomb for bacteria ( from my amateur understanding ) meaning they also destroy good bacteria, would it be plausable to assume that phages that remain in the body will start to nourish on other bacteria that is not wanted ?
Thanks for the great video!
Green Green here is the thing phages are always demanding more bacteria they will die if they do not find any bacteria in like five minutes also not to mention there are different types of phages all of them will only eat a certain type of bacteria this means that not all phages are going to attack the intended target also phages don’t attack human cells/good bacteria this happens because human cells and phages are to different
thanks!
For more information about phages you can watch this video ruclips.net/video/YI3tsmFsrOg/видео.html
Thank you for your inquiry. Phage used to treat bacterial infections will be selected (or in some cases engineered) to attack only the specific bacteria they will combat. It is extremely unlikely that therapeutic phages will evolve to recognize and attack other types of bacteria or human cells. Phages are highly specific, and only make copies of themselves in the presence of the bacteria they target. Once phages have treated the infection and none of these bacteria remain, the human body’s natural processes will clear the remaining phage. We hope this information will be helpful to you.
NIAID Thank you very much!
The way microorganisms like bacteria and amoeba get it the worst in a way. Amoebas eat certain giant viruses and become infected, and phages latch on to bacteria and inject their genetics, but in both cases it's like they're pregnant with viruses until they explode
As above so below. The animal kingdom and the bug world do similar things that microorganisms do. Life is strange
Please let me know that how these phages identify into good microbial flora, and bad bacteria in human body?
They don't know the difference between "bad" and "good," certain types of phages attack certain types of bacteria
Cancer: i am in danger
So do the viruses stay with you? Is the cure worse than a disease?
Does Womezon Remedy really work? I see lots of people keep on speaking about Womezon Remedy. But Im not sure if it's good enough to cure your bacterial vaginosis issue inherently .
Do you have phage against bacteroides fragilis ?
It will be good.
Not only mrsa, e coli, pseudomonas and so on.
The enemy of my enemy is my friend
Wait thwy helping to kill bacteria?! Oml i tough they are bad 😥
Is it possible to change phage dna so they target a certain virus?
I'll bet that your Idea is certainly on the table, as it were! Remember that the little Phage itself is a Virum. Obviously, it's not a Roto-Virum such as HIV or Covid.
they target bacteria, not viruses.
Thank you for this great video but my question is could phages treat intracellular infections like mycobacteria given that phages can't go inside human cells which don't have receptors for these viruses
Thank you for your inquiry. Researchers have explored several possibilities for delivering phages to harmful mycobacteria bacteria inside human cells in phage therapy. Some potential techniques include creating liposomes (tiny spherical structures which are sometimes used to deliver nutrients or drugs inside living cells) that contain phages, or harnessing a harmless “carrier” mycobacterium. By infecting the “carrier” bacterium with phages, then allowing it to enter infected human cells, researchers could deliver phages to the harmful mycobacteria. However, a significant amount of research is still needed on this subject.
@@niaid thank you so much for your response, I'm doing some research about phage therapy in college ,and this going to be a valuable extra piece of information to make some research about.
Another question is it common to phages to transport harmful genes such as toxins genes from bacterial cell to another, and if it was can scientists avoid such incidents when applying phage therapy?
Great idea! Let's develop a Trojan horse to get foreign matter into human cells! What could possibly go wrong?
This are 100% hero's
Hey, thanks spidery things
How would people even get this, oh god.
And why are these guys non-living?
Those things are one of the weirdest things I've ever seen
Are Backteriophage helping humans?
Yes
Wait. Can it kill the other viruses like somekindof poisened?
Thank you for your inquiry. Bacteriophages are viruses which attack specific kinds of bacteria. However, they do not attack other viruses or human cells. Thus, they are unlikely to be an effective treatment for viral infections. We hope this information is useful to you.
@@niaid
So what do you do if a virus becomes immune to antibiotics?
@@ansh6370 Thank you for your inquiry. Antibiotics are designed to work against bacteria or other simple living organisms that can cause disease. These drugs are not effective against viruses. Some viral infections can be treated with antiviral drugs, and many viral diseases can be prevented with vaccines. We hope this information is useful to you.
@@ansh6370 that question is wrong
I wish phases could just kill COVID-19
@Nicholas Negron
Oh
But not COVID-19 right?
@Nicholas Negron like what kind of virus. Last time I checked viruses couldn't kill other viruses
I am a bit confused 🤔.means are this phage are bacteria 🦠 or anti-bodies ?
A virus that attacks bacteria.
They are virus, a natural virus that specifically killed bacteria.
Guided missiles that multiply
Antibiotics: I used to help the world
I like phages
Mkay am I the only one who feels like phages created by someone or something they just seem too smart they even look like a result of intelligent design like little robots
Mother Nature
WE NEED THESE NOW PLEASE I BEG YOU
I think you are mistaken. They are talking about bacteriophages. Bacteriophages only attack bacteria, not viruses. So they would have no effect on other viruses such as corona
There is a virus type called virophage though. They work differently than bacteriophages and infect other giant viruses to infect a host cell together flighting for the recourses. This can help the host cell by not letting it fill with the giant cell but it is not as helpful.
Is everything alright?
How bacteriophage inject it's DNA in to the host as it is non living out side of host cell
I just realized,this virus seems familiar to a cartoon.....maybe Steven universe...
YOLEX GAMING
Can’t believe Mother Nature copied Steven universe smh
The injector machine?
Ye xD
Jimmy neutron
Lol ye jokes
How can I get these in my body soon?
They are naturally in your body
@@jevvesseyer bet
@@sleepingmelons8420 they are everywhere. They only attack bacteria.
Theres a couple of institutes, but you could do it yourself
Phages are kinda cute but i want one in me now thx cuties
You need phage?
There's millions in your body right now
Nice!
its like a nano bot mechanicaly produced in your body
Bacteria:I am the strongest
Phage:I am about to end this whole mans career
Covid-19:You aint gonna slepp cause of me
Why dont we try to use the phages against the coronavirus
because they only kill bacteia
There is always a bigger fish, but in this case it's a smaller fish
That bacteria blowing up looked like the flood from halo
Who else like the hardbass in the backround???
That is good ideas
Covid: I am unstoppable!
Bacteriophage: Idiot.
They not attack the virus the Bacteriophage they attack bad bacteria not good bacteria
Then little guys are lit 🔥
I want to become part of it
For God so loved the world, that he gave his only begotten Son, that whosoever believeth in him should not perish, but have everlasting life. John 3:16, Ephesians 2:8-9, Romans 4:5, Jesus Christ is the only way, KJV
Can Phages kill other viruses?
Ever notice that they kinda look like the Tholians from Star Trek?
Bacteria:NO ONE CAN DEFY ME
Phages omae wa mon shinderu
BaCTRRIA:NANI
PHaGES:EEEEEEEEEEEEE
Bacteria:ded
Phages:yum yum
kurzgesagt is great
Man they are basically a organic nanonot
This reminds me of Neon in the Matrix
How she doesn’t say the letters in MRSA irritates me on another level
Are you an imbecile? That's what everyone calls it, you stupid idiot
Like a nano robot
Where are these phages?
Thank you for your inquiry. You may be interested to know that bacteriophages can be found almost everywhere on the planet. Researchers often look for beneficial bacteriophages in freshwater ponds and lakes, sewage, and dirt or soil.
You have in the body
Use it against COVID-19
AirborneFCA bacteriophages only kill bacteria
Most effective killer of covid19....... Drumroll please!.......
Radio mag frequency.
Call it a hunch.
Why else would there be an international race to get it up. Especially if everyone knew a storm was coming.
Always consider the theoretical flip side. Love your neighbors and believe the best ❤️. Overcome fear with faith. Our time is short under the most optimal conditions. The roaring lion can't get through the door unless we let him in. Abide in the fortress of the most high.
Silver Nanoparticles help against Covid19 also.
Covid: hey
covid and phages are homies unfortunately 👁👄👁
oh, yeah I see it you say it already
We have a virus problem right now
@Bring this Emote back! Yes and I have the cold now amazing
No they attack bad bacteria bonus they not attack good bacteria
@@liannep7 yep i know
Can phages be used against the corona virus.?
Most likely but we cant design phages on the size of corona, only the aliens have this capabillity so we should ask them very kindly
No as it is not a bacteria
nope corona virus arent bacteria