I believe that developments that will occur in this area will change psychiatry forever as it gives us the chance to manipulate spesific regions of the brain instead using drugs that change the chemistry all over the brain. If only we had better neuroimagining techniques to identify personal pathologies of patients with psychiatric disorders, and also better tms devices that will enable more sensitive stimulation.
I have this done on me fortnightly to test action potential of r hand. However I have ALS and my weak side is the left. Does targeting the motor cortex while enervatingthe r hand influence action potential of the l side?
The two motor cortices, left and right, are strongly connected. There are studies that show positive effects on the "weak" side even when targeting the "strong" side. Of course, I do not know the exact protocol and set that is used in your case, so I can't fully judge.
How does the secundary electrical field cause a change in the membran potential of the axon? Which ions are exactyl moving ? If anyone could answer this question this would help me a lot, because I have an important presentation in 2 weeks.
I am familiar with the mechanisms of the depolarization of a nerve, but I don´t really understand how the membran potential is changed trough the electric pulse in the first place.
The change in membrane potential is very transient. The secondary electric field that follows the same direction of the axon will for open calcium gated ion channels, allowing for a very rapid and transient influx of sodium, which will generate an action potential. That is the mechanism in a nutshell, but of course one can talk about it in much more detail, for which the comment section is not an ideal place I am afraid. So I would encourage you to read the first chapters of the Oxford handbook of Transcranial Stimulation, and the following article: V. E. Amassian and P. J. Maccabee, "Transcranial Magnetic Stimulation," 2006 International Conference of the IEEE Engineering in Medicine and Biology Society, 2006, pp. 1620-1623, doi: 10.1109/IEMBS.2006.259398. I hope that helps!
if TMS activates neurons why would stimulating the area for arithmetic decrease performance rather than increase it? you said TMS stimulates neurons but then say it stops the neuron activity in the arithmetic area. that doesn't make sense
Because of interference. Your brain itself is activated for arithmetic performance. Then all of a suden you add even more activation, while the brain is doing its thing. So you add noise to the system. More activation is not always better. If you overactivate a region it will have the opposite effect and interfere with ongoing processing.
I am sorry to hear that. This video is a more mechanistic description of TMS, not so much TMS therapy. The therapeutic protocols of TMS certainly can help people, but unfortunately not everyone. This is why we need personalization of protocols, to use the right stimulation for each person
This concept is kicking my ass in uni and youve just made it so much easier so god bless you
That is great! Wonderful to hear! Good luck with your studies!
Thank you, your videos have been very helpful while studying for my exam!
We are happy that the videos were useful! :)
I believe that developments that will occur in this area will change psychiatry forever as it gives us the chance to manipulate spesific regions of the brain instead using drugs that change the chemistry all over the brain. If only we had better neuroimagining techniques to identify personal pathologies of patients with psychiatric disorders, and also better tms devices that will enable more sensitive stimulation.
Would TMS treatment help to reduce numbness in hand caused by stroke? Please advise
Wonderful work 👏
I appreciate your effort
You helped me to understand it
Thanks
May Allah bless you
Go On
Thank you for the kind words!
I have this done on me fortnightly to test action potential of r hand. However I have ALS and my weak side is the left. Does targeting the motor cortex while enervatingthe r hand influence action potential of the l side?
The two motor cortices, left and right, are strongly connected. There are studies that show positive effects on the "weak" side even when targeting the "strong" side. Of course, I do not know the exact protocol and set that is used in your case, so I can't fully judge.
How does the secundary electrical field cause a change in the membran potential of the axon? Which ions are exactyl moving ? If anyone could answer this question this would help me a lot, because I have an important presentation in 2 weeks.
I am familiar with the mechanisms of the depolarization of a nerve, but I don´t really understand how the membran potential is changed trough the electric pulse in the first place.
The change in membrane potential is very transient. The secondary electric field that follows the same direction of the axon will for open calcium gated ion channels, allowing for a very rapid and transient influx of sodium, which will generate an action potential.
That is the mechanism in a nutshell, but of course one can talk about it in much more detail, for which the comment section is not an ideal place I am afraid. So I would encourage you to read the first chapters of the Oxford handbook of Transcranial Stimulation, and the following article:
V. E. Amassian and P. J. Maccabee, "Transcranial Magnetic Stimulation," 2006 International Conference of the IEEE Engineering in Medicine and Biology Society, 2006, pp. 1620-1623, doi: 10.1109/IEMBS.2006.259398.
I hope that helps!
Can the tms machine show brain activity ?
It interferes with the brain, but it does not directly show brain activity. For that you need to combine it with other measures like EEG, EMG, or FMRI
if TMS activates neurons why would stimulating the area for arithmetic decrease performance rather than increase it? you said TMS stimulates neurons but then say it stops the neuron activity in the arithmetic area. that doesn't make sense
Because of interference. Your brain itself is activated for arithmetic performance. Then all of a suden you add even more activation, while the brain is doing its thing. So you add noise to the system.
More activation is not always better. If you overactivate a region it will have the opposite effect and interfere with ongoing processing.
can tms cure anxiety
Can tms treat emotional numbness because i have emotional numbness
TMS can be used to treat depression. If emotional numbness is a feature of depression, then it may be helpful.
good
0:34 and 0:38 what the refrancess of them?
Rossi et al. 2021
I did 46 treatments of TMS and it did absolutely nothing
I am sorry to hear that. This video is a more mechanistic description of TMS, not so much TMS therapy. The therapeutic protocols of TMS certainly can help people, but unfortunately not everyone. This is why we need personalization of protocols, to use the right stimulation for each person