The Chinese Genetic Experiments That Shocked The World | Answers With Joe
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- Опубликовано: 9 сен 2024
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Last year, a RUclips video announced the birth of the first genetically engineered babies from a secret lab in China, and the event set off a firestorm of controversy in the medical field.
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LINKS LINKS LINKS:
Birth announcement video:
• About Lulu and Nana: T...
The call for a moratorium on genetic editing:
www.nature.com...
www.theverge.c...
Natural resistance to HIV:
www.nature.com...
www.newscienti...
www.newscienti...
www.npr.org/se...
I attended a talk by one of the women who helped develop CRISPR (Jennifer Doudna) and she broke down what this scientist did a little bit more.
Apparently when you use CRISPR to ‘snip’ the dna it’s really good at cutting at the correct location, but not very good yet at putting what you want inside that location.
Apparently the doctor actually modified the dna in both twins differently, so they both don’t actually have the same artificial mutation.
He also ‘missed’ the gene they were targeting by a couple base pairs.
The desired outcome may still work, but it also may not.
Summary is: CRISPR is great at cutting the dna at the correct location, but as it operates now you almost kinda get ‘random’ DNA placed back in between those cuts and controlling what exactly goes into the area that’s cut is significantly difficult and one of the challenges these scientists face going forward.
Thanks for that extra info!
sech1243
You miss 100% of the shots that you don't take?
In regard to the last paragraph it really depends on what you want to do. You fundamentally have two options if you use the conventional CRISPR/Cas9 system (there are a lot of adaptations as well): You can introduce random mutations at a certain point in the genome or you can exchange certain parts (for instance a mutated gene for a "healthy" gene). These outcomes depend on two mechanisms in the cell: Non-homologous end joining (introduce random mutations) and homology-directed repair ("exchange" parts). Homology-directed repair is much less efficient than NHEJ and requires an additional DNA repair template to work (you introduce that as well). Sometimes you want random mutations, sometimes you want to exchange parts (I am just doing both in different experiments right now). The main concern regarding CRISPR/Cas9 technology are still so called off-target effects. Off-target effects arise when Cas9 starts to cut in undesired genomic regions as well. I have also attended a talk given by Doudna last summer and her data clearly suggests the risks of off-target effects. They do not really hinder your experiment if you work with bacteria, cell lines etc. but are really dangerous if you want to apply Cas9 to embryos/humans. Thus, we need to further develop the technology to make it safer.
From my reading:
CRISPR = Find
CAS9 = Cut
It would be nice to have "Insert" command or something in the toolkit. Right now we're relying on "automatic repair" and stuffing lots of copies of the desired DNA so that the repair mechanism will hopefully be likely to use it. If that sounds tenuous and prone to error, well, it is.
@@Lamarth1 To use CRISPR in this context is quite misleading. CRISPR itself is a DNA region in bacteria, which contains small pieces of DNA, which are used by Cas proteins (as RNA molecules) to destroy bacteriophages. To cut specific regions in DNA molecules, we use Cas9 and a short piece of RNA in the laboratory (comparable to those found in CRISPR regions but we usually make them ourselves) Insert - That's basically the utilisation of homology directed repair (a natural mechanism in which cells which use the second identical ("unbroken") DNA molecule to repair damages in one DNA molecule such as double-strand breaks). I find it thrilling that a lot of people are interested in CRISPR/Cas9!
Crispr, NeuroLink, AI, quantum computing, AR, the world is changing so fast
Its all going to be okay; don't freak out man. Just breathe. Don't let the fear, and paranoia get in.
If you think the world change fast, you are getting old ;)
I know that because I think the world change fast and I'm old :(
Not enough for my definition of fast... I want to see in my life time : Mars&Moon travel for average Joe , 1h to travel half the global, cheap energy.etc
but today's battery technology is still a 50-year-old run.
What a time to be alive!
"This is terrible!...... Did it work?..."
We have yet to analyse these innocent girls as they grow up.
@@miskaalexia how is it 'yours' if joe was the one who said it??
Frankenstiening
Exactly.
The He Jiankui case was a major topic in the ethical genetics course I took a few months back. It formed 10% of the final exam.
At the time, when the lecturer wanted to know who had heard about the Sustech CRISPR case, she was surprised that no one in my class had heard of it, despite it making international headlines at the time. It didn't ring a bell with me either, and she had to explain the full story to class, about the babies' genes being edited without ethical approval, about how he didn't go through peer review, about how Jiankui got jailed for a year.
The only problem? RUclips says I've watched this video before.
I watched it two years ago.
When it first came out.
The video must have left an impression on me, because I remember giving Joe's exact quip about Edward Jenner, *and* quoting Dr Ian Malcolm during the lecture (and remarking it came from a Joe Scott vid). It's just that the details about CRISPR, the name of the scientist, the babies, the legal outcome all got filtered out by my memory.
Clearly, I must have watched this video but forgot about the details in the intervening two years.
I've no idea how I passed that genetics course.
He ain't the first to do this just the first to tell !!
How do you know
💯 Percent true!!!
@@LoresGate I love your naivete. Have you ever disobeyed anyone? It's that simple. Especially if what you believe in is so strong that the end justifies the means.
MyTwoCents my question was to him how did he know and if he did then I would like evidence. Simple. If he had evidence of this then I would be satisfied but I doubt he does. I’m not opposed to the idea that there have been other clones.
@@LoresGate he doesn't have evidence. However we didn't have evidence of MK Ultra at one time either. 🤔
It will be interesting to see when we start to shift from "is it ethical to do" to "is it ethical to not do".
Similar to how or what "they" say when it comes to vaccine testing...
@justin miller "to do", not "do do", sorry, my mistake.
Do it
pharma would go crazy no more sick people to bill $$$$$$
@justin miller Precisely!
I see this being something for the elite if it moves forward. The ability to prevent genetic illnesses like PKD or Cystic Fibrosis etc as well as immunity to diseases is incredible. There is always the chance of error and improper use.
This is exactly how I see this unfolding. The tech will not be available to the masses for disease prevention. It will only be available to the elite for enhancement.
@@mktsmith62 This is how it will go with lots of future treatment discoveries. The costs of new treatments are growing faster than the economic growth. There will not be enough money to make it available to everyone. Only to those who can afford to pay.
@@mktsmith62 this is exactly how everything goes. Every single technological advancement is expensive at first, and only a few can pay for it. Example, just to name a few, are the smartphone, GPS, microwaves, refrigerators, cars, planes, dishwashers...
Every item listed here was very expensive at first, and as time went by their price lowered and the item began to be available for everyone (or almost)
Just wait.
Mark of the beast. It's not a number. Put together it's the symbol of a spirochete. Singley a tail. Like the one of a pig. The one we're not supposed to eat. A corkscrew like "worm", infecting us with evil. Contaminated Forbidden Fruit.
To name something in the bible
Creates a responsibility or power, so it is referred to as a mark or symptom.
Our doctors(modern sentinels/false prophets, white/sheep's clothing) have exploited us and our children by revealing and relabeling this spirochete as things like "autism" and "luekemia" Lues, meaning syphilis, a coincidence? No.
They control our health and wealth.
Suffer the little children indeed.
The iniquities of our fathers (third and 4th generations) are now presenting as "autism" and spectrum disorder. Gen Z. The end of the alphabet/ life.
Read the characteristics of the Goetia and you will see congruences personality and interests(spectrums), children being born without souls or Valak(demon). Fallen angels(demons) riding in on the double headed dragon.
If our doctors, the Golden Rod, do not start treating us preventatively then we will be overtaken.
Whats different now compared to 20 years ago? Dating sites, exposure access infedility and 1 in 50 children with autism.
In the bible if you were blemished or unclean (spirochetes) you were cast out of town and no one was allowed to eat or drink or associate with you.
Contamination. It is a pathogen.
Jesus infected himself (gave his blood) with the spirochetes/devil/goetia to show everyone what would happen, how to recognize it when you looked on his mangled and deformed body. To save everyone else, if they were aware of it. And him. I am a worm, not a man.
How do you know you have syphilis? A foul and loathsome sore. Rashes on hands and feet. Causes inflammation (fire) in the body. Why did you have to test for syphilis before marriage back in the day? Number one cause of disease and defects. Purity. Not contaminated. Our doctors figured out is causes every th ing and stopped telling us about it. The TRUE test is dna testing or PCR(covid test) we are being tracked. Covid was just another front just as autism and leukemia and any other disease. $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$why do you think china is gene harvesting from pregnant women. To treat us or prepare for mass genocide of "contaminants"?
@@mktsmith62 "Vaccines/antibiotics/cars/air travel will never be available to common people"
You know what's so cool?.
Every time I go looking for a good video to watch, joe allways has something that I find interesting.
As a stem cell researcher it seems to me that most scientists are aware of CRISPR/Cas9 off target effects (this study of course is ethically wrong due to several reasons) - there are however some fatal genetic diseases, which are caused by mutations in single genes. People who suffer for instance from cystic fibrosis have currently a life expectancy of 40 years and experience a lot of pain throughout their lives. There is and should be a lot of discussion if CRISPR/Cas9 should be ever applied in germline cells. The point I want to emphasise, however, is that we can support the application of CRISPR/Cas9 to adult cells (discussion for the cure of hearing loss, cystic fibrosis,...) without these extreme ethical concerns.
Another good job Joe but as a father of a child who has CF I'm gonna say Let's keep looking into it
Yes, my child has a non curable genetic disease and Crisper gives us hope.
Sounds terrible, best wishes to your child! As a stem cell scientist, I am not an expert in CF research but have just read some publications about the development of several new approaches to treat CF. I'll let you know if sth turns out to be promising!
I have a friend with CF, it actually stresses me out a lot because it made me have existential anxiety about her. She is one of the best human beings I’ve ever met, even though she grew up with poor health and a complex family life, and I’m happy that we can do something about CF so people with it can function much better than they could before, so having something that can make it even better is really exciting to me
St0rm Ranger it doesn’t have to be outlawed, just there needs to be a better separation of church and everything. They say there is a separation of Church and State but so many issue-stances politicians have utilize religion as a catering plate. We need a better science system in place to promote critical thinking instead of having our kids just go to school to get test scores
@@TaiWanWaf Now that you've said it, I had to read a review article about current CF trials - actually looks quite good! If youre interested, I could make a small video on my channel about this topic (Im always discussing current research in biomedicine)!
Thats the name of the article: Cooney, A., McCray, P., & Sinn, P. (2018). Cystic fibrosis gene therapy: Looking back, looking forward. Genes, 9(11), 538.
iceberg, more unseen than seen...
Right, the "punch" you don't see coming is the one that puts you down!!
Wat
Yep
Can we call it 'The Iceberg Syndrome' ?
@@ronschlorff7089 well, since we’re all so clever I’ll drop one too...
If you heard the shot..
It wasn’t for you.
Which honestly isn’t as good. Because he could’ve missed lol.
It's been a few years, would love to see a follow-up on this. Maybe on their 4th birthday.
I do agree that rushing it was dumb, but if it worked as intended - hell yea!
If it were done perfectly without failure, then it isn't such a problem. I still think the process is not perfect and DNA is fragile, the chances of having all you DNA damaged is probably certain. I wouldn't want that. Ya we gave you this worthless trait and all you DNA is probably as damaged as if your embryo were eradiated.
@@mykofreder1682 Im not sure about that number, but the body makes 12000 errors in copying the dna every time a new cell is created. Changing a small sequence is not a problem as long as "the scalpel doesnt slip"
@@mykofreder1682 As far as I'm concerned the father was HIV+. The transmission from father to child is comparatively very rare but this might explain why the parents agreed to participate in this study in the first place.
@@salzstangl Due to repair mechanisms in the cell, it is about 100 errors per cell division (in humans) - but I agree, bigger deletions and insertions are mostly more tragic than point mutations
I'm all for Gene editing, but only after we know what the full DNA sequence does. It's is too risky to just go into this Willy Nellie and hope for the best.
Like with new drugs there is a lengthy process to be approved for human trails. Understand how this will effect the body, then start human trials and see if it works as predicted. This guy just skipped to the end, and nobody know the full consequences of his actions.
The 1997 movie Gattaca is the best example of what crisper could mean for the future.
I was going to make a similar comment but figured somebody had beat me to it. I think Gattaca illustrates the most likely scenario of continued human genetic engineering. Unless we can find a way to genetically remove fear, prejudice, selfishness and greed I suspect humans will always find a way to stratify society and subjugate the less powerful.
That movie was so terrible, tho. If you had a child or loved one who suffers with a genetic disease then you would not be concerned about B SciFi movie writers' paranoid delusions.
@@chriswood232 Except they don't use genetic engineering in Gattica. They actually just use IVF and DNA-analysis to pick the "best" offspring for a pair of parents. The technology needed to realize Gattica is already well established! Scary when you think about it, isn't it?
Underrated movie right there
I deleted my comment after seeing yours. Gattaca is the logical conclusion of doing this to people.
I too wish I had tweezers that could remove parts of a DNA
Need a hand held tool. Time to invent. Go get at it.
Let me guess, the incriminating part?
Nature : inserts immunity
Humans : inserts immunity
Humans : *You’re going TOO FAR*
Future humans: 👽👽👽👽👽
👽👽👽👽 I think we went to far.
It's not that simple. When we gain an immunity from evolution this doesn't always entail the risk of complications in what amounts to a medical intervention. It's more like:
Born with immunity or gain it:
Nature: This is fine.
Humans: This is fine, but you may get cancer, live a shit life, and suffer if we fuck up, do you like gambling?
The risk that these kids would actually get HIV for example may have been less than the risk that the treatment would kill them. It's also not known if this is a heritable trait. It's also not known what all the potential adverse consequences are.
Sometimes a "condition" becomes discovered to be immunity to a particular a disease.... like sickle cell anemia is a condition that prevents death from malaria.
It may be also be a condition to prevent death from a disease NOT SEEN YET. That is why genetic diversity is the best situation for human (species) survival.
We go and "fix" all the conditions we know about, only to be setting ourselves up to become wiped out by something unforeseen.... coming down the pipe.
@@pheresy1367 Yes, exactly! Evolution is extremely powerful. For 3.7 billion years, evolution has done us well. Meanwhile, humans have not comprehensively learned our genetics/epigenetics nor how our brain works, let alone how to edit our genes with sufficient precision to mitigate genetic errors. In the meantime, I trust evolution a hell of a lot more than I trust humans, especially those humans who aren't willing to conduct their genetic experiments with adequate supervision.
Natural immunity causes disease to less overall. Man made immunity usually extents the disease, like flu shot keeping the Spanish flu alive to this day.
It’s hard to form a strong opinion on human genetic engineering. It seems inevitable, & could benefit humanity in incredible ways. However, the issue arises when it’s only benefiting SOME of humanity, likely only those who can afford it, literally making the rich & powerful BETTER than the rest of us on a GENETIC level. Kinda unsettling.
Taran Alexandre The Great INTERESTING!! I didn’t think of that.
I am not sure what is blowing my mind more... the amazing story it’s self or the fact that I have never heard about this OR the fact people are not talking about this full time. So many great and amazing things can come from this
Also one question please. Would this technology work the same with things like cancer?
"This is terrible.... Did it work?" Line was spot on
As someone with an autoimmune disease I hope gene editing and designer babies become a thing. I would have loved to have grown up normal.
I’m with you Holly. Sadly we miss out on a lot! 😕
agree😭
I'm an in vitro kid from 1987 France. Glad to be here thank you ^^
me too but less than a decade earlier. i was among the first babies and then i was also born premature. i wonder what your experience was like, because i was born in a very catholic town. i wasn't allowed to attend catechism because a lot of parents thought i was a fake child.
@Neocaron
So you wouldn't exist if not IVF you think? How naive.
azrael, that's the whole point of in vitro
Your mother was a testube and your daddy was a knife
Ps. I'm not making fun of you I just really wanted to use that quote since I'll likely will be never able to in the real world
@@azatmingalimov that is literally the only reason people spend the incredibly large amount of money it takes to perform the procedure*! If his parents were capable of conceiving naturally they would have done so. What part are you too dense to get?
... Unless you were making some pseudo-scientific woo filled claim, or worse a completely unscientific argument based in some outdated crackpot religion, in which case it is you who are hopelessly naive. I sure hope you aren't an anti-vaxxer to boot....
Target: Captain America
What happened: Zombies
Oh noo!
🤣
Let them allow to cure mutations, its all about happiness, natural selection will do it's job anyways 🤔
🤣😂🤣
I've had type 1 diabetes my entire life and would give anything to have a change done to the genes involved in producing this illness, diabetes is the bane of my life and would rather live without it.
I understand that. How would you feel if your children or grandchildren were adversely affected as A result? What would happen if their bodies produced to much insulin.. Food for thought.
@@midlifekrisis9060 It'll be fine just crispr them
@@midlifekrisis9060 I can't have children so it wouldn't affect anyone but me, and the reason I can't is diabetes so you understand my hatred of this illness.
I too have type 1 diabetes and would without a doubt do the same
Astraea Star oh I'm sorry Stratospheric aerosol injections..chemtrails are the conspiracy theorist word for em. John Brennan at the CFR said they are doing it. When the people doing the shit are telling you they are doing it and you still deny it. You my friend you are institutionalized. The propaganda is Workin. Look into yourself instead of believing what you hear. They are spraying something
This is what happens when the guy that post "FIRST!!" in RUclips becomes a scientist
Lmao why is this so funny 😂😂😂
🤔😂😍
🤔😂😜😉😍
I can see it.
Lmao
Sometimes the only way forward is to stumble blindly. All efforts create the opportunity to learn, regardless of how successful.
Thus, they all have value. Right or wrong are historical concerns, founded in the luxury of other concerns being overcome and past.
We are far beyond blindly. They knew exactly what it would do. Its like going to work, you may step into dogsh*, but you know where youre going to get.
well it sounds good and all, until you become the victim,
these DNA scientist do not engineer their own DNA, because they want to be free of that consequences
@Electron Resonator That does not seem to be an available option yet. Based on the reporting, they can't effectively modify beyond the single cell stage yet. For all we know, they might be happy to modify themselves.
@@Lexekon Yeah, I'm sure the guy who created the small pox vaccine was so sure of it he just wanted to use someone else's child to do it just to impress everyone with how sure he was
Had nothing to do with the fact that up until that point his studies were just conjecture and that he wasn't sure it would work so he didn't want to mess his life up as a result
@ spa man or the idea was that someone elses child was a more valid subject for the vaccine. I don't know if he had already survived the disease himself, but if so, he would not be a valid test subject. We cannot assume details either way.
My feeling about what he did is this: the parents, at a minimum, should have been aware of what he was wanting to do. Doing it without permission or oversight is a real life version of the last Jurassic Park movie, where they had spliced together different genes for various qualities to see if they could create a super dinosaur....which turned around and burnt the place to the ground, so to speak.
That said, genetic modification isn't something new, nature does it on it's own terms and why we have evolution. Forced genetic modification should be monitored just like any other experimental thing. We don't need another Wakefield study. Putting an end to debillitating and catastrophic illness is promising, but are they doing that to make life better until we die, or to try to cheat death altogether? I don't want to reach the age of 150. But I would love to stop the disk degeneration in my back so that I could walk and dance like I used to and eliminate 90% of my pain issues.
Great video!
This is an abomination against Yahuah's laws!
I don't think he didn't have permission from the parents, or he would've been sued in millions by now.
The question is were the parents in a position to decide for another human being
@@pardisranjbarnoiey6356 They couldn’t make the call themselves, so yes? Lots of people who don’t have the mental capacity dont make their own decisions.
@@marcdemell5976 That is not a problem that anyone has to worry about.
I find it hard to believe that in a country like China this could have been done without the governments oversight.
"While the scientific community is universally condemning Dr. Jeng Kui's action, they're also watching with interest at the same time." It's like holding a stop sign, but it's green instead of red.
I like this sentiment.
If we are hearing about it it has been used for some time by the Elites in secret locations.
No it’s not it’s like holding a stop sign and waving them through behind your back
I like your profile picture, gunship is awesome
@@calvinabbott6920 So the Trump kids are the result of genetic engineering? Khan is not impressed.
This is a Pandora's box. It has so many implications the mind boggles, and once it's truly opened, we can't go back.
Time to watch GATTACA again.
I always thought the name of that movie was, like, the name of a place or something in it. But, with you capitalizing every letter, it makes me think of DNA, like a string of genes, with the A, C, G, T thing, you know? I've never seen the movie, btw. Wait, it is a movie, right? Not, like, a TV show? Sorry I'm so ignorant about GATTACA lol
"...And when I say literature, I mean Netflix" hahaha this one made my day xD
I just wanna know when I'll be able to see in infrared and other electromagnetic spectrum waves
Or at least 16 colour receptors like some animals.
Found the Cylon!
You won't. You're already born.
when we have next generation smart glasses we'll be able to superimpose different spectrums onto the glasses
in effect, seeing other light waves.... i want it, so i can 100% without a doubt....
*_make sure there is no bugs in my room_*
You'll be able to do that with contact lenses in a few years.
13:26 basically the entire field of science lmao (coming from a STEM major)
Today: We need time to think this over.
In 266 years: KHAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAANNN!!!!!
apparently @Joe Scott doesn't have enough trek fans....
Glad I'm not the only one screaming at my screen "DID YOU LEARN NOTHING FROM TREK"
@Steven Gulie I could ask for nothing but the quality of cordova's workmanship. :-D
That's hella funny.
Thanks for this.
"If we [scientists] don't play God, who will?"
- James D. Watson
God certainly won't. This bus has no driver, so someone better take the wheel.
@@johnathanmartin1504 Precisely. 😉
Morgan Freeman.
@@Malroth00Returns 😮
You're right!!!
Exactly God is certainly doing a bad job!
"How do we create beauty without creating monsters?"
Damn...
really? none of you think it would be cool to have just a few monsters?
One day you realize that Kerry down the road isn't just f&*k ugly, but is in fact a real life troll, and it suddenly dawns on you, S*!t man! that's what happened to all Mrs Sanchez's cats! I recon you could get some decent mileage out of that story.
Try drawing a portrait of an attractive human. You'll end up drawing 1000 monstrosities before you succeed.
@zach gilmore Not trying to comfort anyone. Just stating the facts, lol.
@zach gilmore I get it... It's kind of a serious subject tho ha ha
I think it's just life. We create both beauty and monsters just like we have been creating within our current human population. Better that way. Maybe we come up with some way to control the monsters. Or kill the monsters in-vitro. ¯\_(ツ)_/¯
When he summed up how scientists see it
"Oh this is terrible"
*Long pause*
"And did it work??"
That's dead on🤣🤣
This topic is controversial but also can seem to be very beneficial..
They condemn it but they can't deny that they are absolutely interested in how this is going to end
Seriously! Like the Nazi medical experiments.Evil shit, but some useful information that couldn't be obtained ethically.
Joe hit the nail on the head.
One problem is that it will be years to find out the consequences. So I guess the words here are patience and caution.
Let them allow to cure mutations, its all about happiness, natural selection will do it's job anyways 🤔
I never knew anyone was cured of AIDS. I really love this channel.
Not cured but born resistant to hiv
Jour Namehere I’m pretty sure he said in the video that someone was cured of AIDS. He was not referring to the twins when he said it. If I have time to go back and watch this again I’ll put in the time stamp.
@@inomad1313 you got that time stamp?
ih8TrumpTardzz 4:46
There've been two of them, but none of them had AIDS, but HIV. It's not the same thing.
The dawn of the Gucci Baby. Genetically engineered prime citizen basicary.
Oh my god guurll how much did it cost to give your baby a gucci birthmark?
Basically?
@@TheShiftingSounds Nope. Basicary, like f*ckary or bribery. You know... basicary. Or is that not a werdh??!
@Chally wally Woo Charrwy wharrwy woo*
if we think about it, natural selection has low key been doing the same
X-men and Blade Runner doesn't raise even a little bit of concern in me...
Gattaca does...
Yes!
@Fábio Duarte
Not going to happen. Humans like to imagine themselves to be that powerful. While in reality they're just so ignorant they can't see how weak and wrong they are.
Altered Carbon on netflix does it better than gattaca.
In Gattaca anyone can do it if they have the money
Gattaca has a stupid premise (SPOILER) glorifying the stupid decision by parents who had safe option to cure their sons heart condition. It's really a no brainer that when we understand genetics well enough, we should take over the wheel. The other option is we stay on a rollercoaster of diseases and unnecessary suffering.
Last I read that doctor went missing. China has a very effective way of getting rid of embarrassments smh
He was sentenced to 3yrs jail in 2018 for "illegal medical practices." Official story at least.
@@ctdieselnut Jack Ma enters the room.
Then disappears.
And the billionaires...
"Society free of HIV? DISGUSTING!! More diseases please" - dumbass scientists
@@theofficialdislikebutton6766 False characterization of events. He Jiankui tampered with genetic information in an imprecise way. The goal was to make the offspring more resiliant to HIV albeit with the risk of being more prone to other diseases. The entire experiment was unethical, from the lack of transparency to the goal itself.
This video left me thinking...”is that a jar of peanut butter on the desk?”
I'm from South Africa and I love your channel, Carrie on brother, keep on informing us
Sihle R 🇿🇦🇿🇦💕💕
Thanks man!
Likwise!
As someone who suffers from certain gene mutations, I can’t help but see this as a generally positive thing. There are downsides to everything, even if we don’t know it at first, so that’ll still have to be considered. However, that’s a long way off considering my ailments are comparatively less researched than most... I do not doubt people will eventually have a future where they can pick and choose certain genes for their baby lol
And when the excellent film "Gattaca" came out in 1997, critics universally panned it, saying that the scenario was far-fetched. How those criticisms did not age well.
Well at least this isn’t the first time some doctor has done something without approval. Like the first smallpox vaccine and it ended up working and saving millions of lives
True but that was in the 1700s, before we knew what the consequences of scientific ethics could be and built a system around it.
The genetic mutation that prevents HIV entry into T-Cells also makes that same T-Cell more susceptible to Hep-C.
Hep-C is curable. HIV is not.
Human DNA: Exists
CRISPR: Snip snip mother***er!
Zanshin 🤣
LMAO
11:22
As an autistic person I can say that the amount of genes that would have to be edited would cause a host of problems. Autism is a spectrum and our brains are structurally different that neurotypical people. I don't think Autism should be 'cured' because that removes a huge amount of human diversity that can allow for amazing scientific discoveries.
And besides, the research about neurodivergence and autism is minimal at best.
Thinking like that, it's obvious you are autistic. It's obvious that autism is a horrible, debilitating disease that brings suffering to the life of the diseased and everyone around them. It's moronic to suggest we shouldn't treat it because it "brings diversity"
Want to know what happens if we push this through without proper ethics?
Monsanto will happen.
Progress is nothing without ethics.
who's ethics?
I once bartendend a congratulatory house party for Jennifer and Emmanuelle. I was pretty starstruck. I had no idea what it was before I got there. The company would send me all over the place with just small ingredient prep and it's a wedding,a birthday party, notes. never any details about the hosts. One of my favorite events ever. I'm also pretty sure i bartendend an arranged mafia wedding but that a story for another time.
Another great informative and entertaining video Joe. Thanks.
“They weren’t at large risk so did this medical procedure even need to be done?”
Boy how things have changed and quickly
Do you seriously think there aren’t other geneticists performing similar experiments in secret?
Im happy with full on genetic engineering. If we can make healthier smarter stronger longer lived people im fully in favor of it. Im in favor of experimentation and testing and any religious or moral reasoning that it is not "natural" is the same bullshit we see on every bit of medicine that has ever been found/invented.
There can certainly be things that go wrong but remember people are being born with horrible conditions every day, people live with horrible conditions every day, and people die of horrible conditions every day. "natural" is not helping any of those people and helping people should be something we all aspire towards.
then have you donate yourself as their lab rat to speed up the process? ...what? no??
as expected, everything sounds good, until you become the victim
I would volunteer, my life is a living hell from a genetic disease. Death isn't always the worse thing that can happen to you. Can't possibly make it worse than it currently is.
Unless the edits are free or assigned by chance, it's likely to create an upper class of rich superhumans. The rift in society would become very literal and insurmountable. Going slow is probably a good idea, like not allowing unnecessary upgrades before every human is cured, upgrading from the bottom up, etc. Anything to keep the differences small.
Or with any other technology ever invented. 'Oh no, cars will kill us all!' People are afraid of change. But I'm suprised how open minded Joes community is. Lot's of positive comments.
@@electronresonator8882 If there was anyway that i could do so to benefit science, yes. I have several major health issues that gene therapy could probably fix and have suffered all my life. If i could die and it would cause others to not have to deal with what i have i would gladly do so. As it is when i do die my will states that my body should be donated to medical research(at osu specifically) if it is possible.
Not sure where you get the idea that people or myself in particular would oppose testing done if it included our own bodies but you are very wrong.
"Even scalpels can cut where they're not supposed to."
Infant circumcision.
@@gregorymalchuk272 eeew
@@gregorymalchuk272 Yeah, that's really wrong and needs to stop!
Hi Joe,
Could you do a video on cloning?
It's a fascinating subject and I believe a lot of your viewers would love it. 🙂
I highly doubt he altered both of them. As identical twins, they are a perfect control study
Thats actually true. One girl wasn´t fully altered.
Today they call him crazy
Years from now he’ll be know as a courageous man
Courage and Insanity are not mutually exclusive things.
Lets split the difference and call him "reckless".
Nearly every famous explorer was reckless in some way or another.
I think the only significant difference is that explorers risk the lives of themselves and other consenting adults.
If pLaying God is brave...
Nope. When will we learn, for something so significant, a process is needed that involves humanity and NOT some vain individual wanting recognition. The people who created CRISPR-Cas9 knew not to try something so irresponsible.
@@derekgassen8460 luckily we have laws and good scientist who will think this through carefully. Maybe we should consider preserving our current DNA just in case we mess up, at least we will have a copy of our original DNA to go back to just in case we go wrong.
@@softan terrible destructive inherited genes are common in nature, especially in the human race since we force them to survive as much as possible.
Use Wooly Mammoth geans to bring back Elephants? Don't you mean that the other way around?
Considering gene editing seems to have an effect on even adult age subjects, I think a more ethical path would be to test it on people who can consent to these kinds of experiments before making potentially disastrous changes to embryos that we plan on bringing to term.
To be effective the genetic modification really needs to be done at the single cell stage.
The most important thing said in this video is: "Assuming the man is telling the truth." PROOF!
I really hope for the sake of the twins that the experiment went well. I think this technology has the potential to do so much good in the world, but of course we have to master it first we dont cause more harm then good.
Crispy on m'uh jeens? Sign me up!
But remember, there's a 50% you'll get cancer from that
I don’t get why some people are so mad over genetically engineering humans, if we can change the human genome for the better, shouldn’t we be glad ?
If we could make humans that are immune to diseases that can make us suffer, just do it. Why even care about „morality“ ? If we are concern about the technology being manipulated, just place down regulations but nothing is impossible to be manipulated
We may/will make errors along the way, but what we can gain out weighs far more than the errors we make. We can save countless billions from diseases that we have no cure for, in my opinion, there are no price we shouldn’t be afraid to pay
I'm low-key concerned somebody gonna make a 'master race' . Humanity doesn't have the best history with eugenics lol. But like all tech there will be good and bad too it.
Map all the gene effects. Weigh all the pros and cons. Get informed consent divulging said pros and cons. Go for it! Track all long-term effects!
Unfortunately... the "Island of Dr Moreau" becoming reality is what's most disturbing.
bc they're scientists and can grow an ear on the back of a mouse the Drs think they are close to Godliness! horrorweird
The thing we were worrying about when I was taking Genetics classes in college (1990s) was that once you know enough about different race's genomes, you could easily make a virus that only attacks, say, Asians.
I wrote a book series about what the WHO was most worried about back then. Human overpopulation. If I wasn't dying of ALS, I would absoultely write another series about targeting racial groups with viruses as a form of warfare. You could even target individuals. This is serious and at this point, a college student could easily do it.
David Buschhorn that’s terrifying!
That's amazing
@@angelacole1270 My instructors were seriously worried about someone tweaking smallpox to wipe out an ethnic group. And it would just look like an accidental genocide. :(
“Eyes! I just make eyes!”
Lovely! And still soooooo creepy........
@@claudiamiller7730 hope you got the reference 😉
The light that burns twice as bright lasts for half as long
Shouldn't we fix something easy to identify like great vision or sickle cell.
Unfortunately I’m not a fan of removing sickle cell mutation from our gene pool. People who don’t have both recessives so that the problem is expressed in their blood(so just one gene for sickle cell) apparently have a higher tolerance for malaria than those without the mutation... so thanks but I’d way rather keep my resistance to malaria, especially with how stupid the herd immunity of things is these days
@@TaiWanWaf Malaria third world problem, sickle cell (real)first world problem.
Fulmer Duckworth I understand that, I’m just a little more cautious, I was thinking of the case of what would happen in a messed up world where we get rid of the sickle cell gene and don’t do much for malaria... third world problems are still our world problems,
Travis Romig I understand, see belowwww in Fulmer duckworth response.
go ahead of course, I wanna live till I can upload my mind into a cyborg!
NaoTa MF clone your mind*
I want to become part machine.
Aw, Joe, that Star Trek reference should've been of Kahn!
Said beautifully “Oh! This is terrible.. did it work?”
This is one of those things that really depends on the results. If it works, people will say he's a genius. If it ends up failing or having some terrible side effect, then they'll label him a monster. The cost we as a society will accept is dependent on the prize. In this case the prize could be freedom from diseases and disorders, improved physical and mental capacity, and possibly even life extension or immortality. While we should always strive to keep the cost low, in this case I think even a fairly high price is worth paying.
I for one, welcome our Chinese X-Men Overlords.
LOL.
Amen.
We, watching this video in 2019, may never know how this will change humanity.
I escaped 2020 just to tell you... you had no idea, really.
I am 100% behind this as well as stem cell research and anything else that could potentially hasten our ability to eradicate painful, debilitating and/or life threatening conditions.
I want to actually be okay at maths and.. um.. not have epilepsy. 😅
I also would like to not be epileptic.
Required reading for scientists should be Mary Shelley's, "Frankenstein." It was published just over two hundred years ago, yet here we are.
There's so much wrong with this I don't know where to start..
G'day from NZ!
I am honestly all for it. Hello designer babies!!!!
*_"What could POSSIBLY go WRONG??"_*
Once we can certain beyond reasonable doubt that it will work as intended I'd say it would be unethical NOT to remove "objectively" bad genes from the gene pool.
[Edit] Via genetic modification of course, just in case anyone gets the wrong idea about this comment.
Right. Would we choose to let people be susceptible diseases that kill millions because "its not natural"...
And before that, we will (or already) reach a point, where it will work most of the time, and can be checked with the sideoption of discarding the badly edited cell/embryo and we could save millions, but "my ethical virtue signalling" will condemn them to many genetic or other illness.
The HIV immune state is already present around 1% of the human population, with this concept (and a lots of money, this is really expensive now) we could simply remove HIV infection and with that a large portion of AIDS, but that would be unethical...
@@geekfreak5100Nope, that and many other illness to be removed would be the ideal situation, but currently the "ethical opposers" of genetic modifications are against this.
There is always the concept of unintended consequences.
12:20 watching this in 2021 hits different
Life, uh, finds a way
I dont think we have a choice except to attempt this kind of genetics. Having said that, we are not yet capable enough to forecast the long term effects of such a thing.
I guess thats my issue with it. I would be in the "don't play God" camp alot of the time but in certain circumstances i can accept the value over risk factor. It is the long term that is beyond the current scope that concerns me. Time will tell.
Why don’t we have a choice exactly?
@@spuknoggin5273 Because they are people dying if illnesses we can cure when we know enough.
Mac Kettner well learning about these things doesn’t necessarily mean we will ever be able to find an effective cure. And even if the changes we make to another person’s genome actually has the effect we are looking for, it could open the door to a load of other problems we previously had no knowledge of. Remember, dna is actually relatively fragile and some genes determine many characteristics of a person. So by changing one gene to change one characteristic, you could be affecting many others.
I would be very happy if my parents changed my DNA to make me resistant to HIV. 😐😐
Fun fact: A small percentage of people is actually resistant to HIV due to certain mutations (I guess this gave the researcher some inspiration). I don't know if this sounds interesting to you, but otherwise I could make an episode about beneficial mutations in humans on my channel - sounds quite cool now that I'm thinking about it
Yup, I carry 2 copies of the ccr-5 delta 32 mutation that gives me functional immunity to HIV. About 10% of people of European decent carry 1 copy and about 1% carry 2 copies.
@@MissMTurner That's awesome!
@@Sciencerely yeah it's kinda neat having a literal mutant superpower!
there are diseases like malaria which are much easier to be infected with and kill more people each year
"you cant have a purple cow"
says the neon green and blue fox
We already have been taking control of Mother nature for a while now.
What do you think those crutches, wheelchairs and glasses are for? to look pretty?
We are already in a spiral of going downhill genetically due to our constant fight against natural selection (which I still think its good).
So I definitely support genetic modification for the BETTERMENT of humanity.
True, but if the crutch breaks, you can get a new one. You can't fix a broken genetic code.
Personally, if there was a way for genetic predispositions towards mental illness to be eradicated, I'd be all in. There's so much terrible suffering there. But there's a huge problem there, on that Joe addressed - our genes work in concert.
For instance, of the top ten genes associated with major depression, eight are immune system genes. And we still don't know exactly what each of those variants are doing, or how they're working together, to give rise to a mental illness. And I do not want some doctor taking hopes, theories and ego into a complex system like a human being's immune system and mental faculties.
So, I’m all for slow going here, because we are *decades* away from the kind of knowledge we need to successfully help future generations. It's one thing to genetically modify a tomato, or a mouse, or a pig. It's a whole other to alter a human being with the kind of "Let's see how it goes" attitude this doctor did.
@@lunacouer Agreed, but we cant really change anything if we don't start anything.
Agree 10000000%
I thinks it would be theasable to learn what there is to learn about genes in 1 or 2 lifetimes, a few batches of experiments, a couple humdred test subjects enginiered and observed troughtout thier life give or take a few failures, a couple hundred lives of worst case scenario agony and misery, to ensure the well being and survival of the entire species (billions and billions to come) untill the end of ends sounds like a reasonable price to pay especiall considering that more lives are lost due to pointless wars.
It will become necessary because bad genes will spread virulently because natural selection is removed.
11:49
"There is probably one behind you"
Looks behind
Oh no
My wall is a secret chinese super soldier
I know, I posted him there.
"He wants to make a name for himself"
Josef Mengele.
Ah my pillow and heating bad are super soldiers nice now I'm protected while I sleep XD
All hail our genetically superiour lords Lulu and Nana!
Without Doctors like that just doing it it’ll be held back by bureaucracy.Those that just do it make the break throughs.I imagine pharmaceutical companies don’t want humans becoming immune to disease , sicknesses & disabilities
Imagine all the accidentally created genetic diseases they will be able to treat though.
Rather sure the bureaucracy funded this experiment and had been funding it for a while. These are the first viable offspring of the process to be introduced to the west. Lots of shady shit is done by the Chinese government, but it never sees the light of day.
Id 100% agree about Pharmaceutical companies lol! . However, that may be a minut topic here. My opinion is based on the fact that I am a mother to a child with cerebral palsy & spastic quadriplegia. It is not genetic however, it yields many severe disabilities similar to many genetic disorders. And I think this is absolutely wrong, in the wrong hands. Not bc of a pioneer taking possibilities and moving humanity forward by nipping out disease but bc unregulated...who is to say where the line is drawn? I've seen things many parents never will. My daughter has been through surgeries and pain that could bring down a grown man. However...knowing what I do, I'd not change one thing about my daughter. EVER. why? Bc she is Important to the world. The differences that make her who she is, SHOULD exist. Ask a person with Down syndrome how they feel about people like them being totally eradicated from the human race, bc a doctor thought the world would be better off. People that are not steeped with in our community do not know, nor understand the gifts that these differences bring to the landscape of humanity. Sure.. popular thought is I am a mother, so these are lullabies I tell myself to get through life. Lol!!! ..why? Bc it's easier to think that, then expose themselves to what life for different people is actually like. This surpasses big pharma by a long shot. We are talking about a whole world of people being turned into what someone's idea of perfect might be. If you sat with my daughter, who can not speak, walk, talk, or see but watch her extremely fine tuned ability to communicate, her excitement, watch her laugh, learn, love, and ability to be the down right happiest individual I know despite her hardship, using only what she knows ... youd be blown away!!! I promise! ☺️And would prob come away with the understanding people (ones that *normal people* brand less than) are infact teachers. They open doors in knowing the depths of our humanity, the strength of our humanity, and our ability to reconcile life in total through adversity. The blessing in ones burden should not be robbed from people. Im sure no one would choose these things for their child, I did not. However... To think of a world with out these people is a world with less compassion & People who will perpetually turn a blind eye to really remarkable things that deserve attention that are derived solely from knowing someone with a major disability. There are FAR MORE IMPORTANT things in life than the creation of perceived classes. Class dehumanizes. The world SHOULD be full of differences, bc that is in fact LIFE. I can't put it more simply than saying this goes far beyond sketchy. Of course people base their opinion on the scope of what their experience has been. Lots couldn't possibly look at my daughter and see anything but hardship, so of course they say.. *yeah.. sure...let's make this, and every other disability go away!* but...thats a view based on.. well nothing really lol. This goes waaaaay deeper than wanting to get rid of diabetes lol. There are people that believe my daughter...should not exist. People that believe mental retardation and people with it, should not exist. Eugenics. Yeah..it's a thing. And in my opinion, is based on the complete farce of classes with in humanity. Put in the wrong hands, in the hands of someone that believes only to breed and yield pedigrees.. it would be a nightmare. Without some kind of regulation, this could cause the overall detriment to the human race... and we can all sit back and watch humanity become... less human.
6:35 shoot crap my tally pod
🤔🥴😆 🔫 💩👇 🧮 🌽
Did I just hear that right?😂
I love how you have a manual typewriter ready for when a Neutron bomb
wipes out all electronic communications!
For what appears to be a relatively intellectual channel, it’s almost reassuring to see the comments section is still 80% conspiracy theorists, comments that contain words but don’t actually seem to say anything, random pop culture references and off-topic bitching.
I actually prefer conspiracy theory and religious nuts to those comments that are quirky "jokes" that are absolutely not funny. At least the conspiracy comments are entertaining
So you're saying that it's an intellectual channel but the people in the comments that you disagree with must just be stupid or something , Maybe they're intellectuals as well And just don't blindly believe things like you do
@@williamkelly5689 you referred to the entire population of Seattle as being ‘generally incompetent’ and take issue with my fairly innocuous comment?
Cure everything! Cure cancer, psychopaths and stupid! Cure everything at all costs!
Andrew Magdaleno , you can’t cure stupid. 😂😂😂😂
@@johnnz4375 with CRISPR we edit our genes to be smarter!
Preventing those things is easier and cheaper than designing a technique that will be very expensive and weaponised for sure by hard governments.
@@halgraves4800 I fully agree, that the "hard" governments are going to use gene edit to weaponize humans. That means we have to weaponize it also. No nuclear power ever nukes another nuclear power.
Mother nature wrote our code. You ever seen Planet Earth? Mother nature is a cruel BITCH!
Within 50 years we will be able to rewrite the code that made us great at Killing each other, raping each other and Fear of the other. That code doesn't work in a modern world.
We all need to understand who the real enemy is here! Its our programming. Its the foundation of every atrocity. Lets End it.
But then we are no longer human...
Exactly what you said at 8:40 is exactly what I thought about first. I can't imagine it being possible to say these babies are absolutely guaranteed to be immune to HIV, without taking the risk in actually giving one of them HIV in testing this. Just like you said, there's only so much that can be tested and done in a petri dish
I am not educated enough on the subject but off the cuff, I’m for it. Thanks Joe.