I got my Huntington's test on my 18th birthday. I had to wait 3 weeks for the result. Those were the longest, scariest 3 weeks of my life; I had already been accepted to college and I thought I might eventually forget everything I was about to learn. When I went in to get the result, the first thing the doctor said was "Your test came back normal, you do NOT have Huntington's disease." It was the best day of my life. Ever since, I've been living like I got a second chance and I don't want to waste it, especially after seeing what Huntington's did to my mom, my grandfather, and my aunt. Be grateful for your health, it's not guaranteed.
i cant understand people who don't get tested for huntingtons out of fear... i mean, if its negative: GREAT... if not, suicide srsly becomes an option at that point. X_x anyway, i would want to KNOW.
Congratulations on not having Huntingtons. And I am sorry for all those people who get the result showing they do have it. These bodies are such a gamble. One thing about Crispr that worries me and a lot of other people is genetically editing deadly viruses to make them more deadly and releasing them on the public. There are some real species ending possiblities and there are people out there who would do it.
Fun facts: While the phrase "survival of the fittest" is often used to mean "natural selection", it is avoided by modern biologists, because the phrase can be misleading. For example, survival is only one aspect of selection, and not always the most important. Another problem is that the word "fit" is frequently confused with a state of physical fitness. In the evolutionary meaning "fitness" is the rate of reproductive output among a class of genetic variants.
As a person with diabetes, I am glad that modern medicine has lowered the bar on fit enough. That said, I wonder what the long term impact on humanity will be...
So, survival of the most adaptable. Like the small ground dwelling mammals that, when the asteroid hit and killed the dinosaurs, not only adapted and survived, but evolved into the humans of today.
@@jerryfick613 The bar is lowered for manageable conditions like diabetes, but it is ever heightened when it comes to the brain especially. Hell the same alleles that cause a condition might potentially have a positive impact on intelligence by chance thus selection will favour that allele, despite the relatively insignificant detriment it causes.
@@Chris.Pippin a very important research topic, however is DNA engineering the best tool? Stem cell and scaffold organ, nerve, synapses growth is another research path that has grown substantially. The convergence of biophotonics and informatics is a great revolution to be part of. Makes me happy!
My mom had 6 siblings and only her and one other didn't get Huntington's. All her siblings that had the disease are dead now but a lot of them had children and some even had grandchildren. My mom got tested before having kids but other than her only two people in my entire family have ever been tested for it. The most recent person to get tested got the results back a couple years ago and he's starting to show some signs. To me, there's no moral dilemma between abortion or your child having Huntington's. I've seen how bad it gets and I wouldn't wish that on anybody.
Does end-of-life disease override the potential value of the work of someone's life? What if one of these children cured cancer or built an FTL drive? I don't think it is up to us to decide whether some other one's life will be 'worth living' based on an embryonic test for an end-of-life disease. Shouldn't they get a chance? What if they cured the very disease they suffer from... and cured everyone else like them? You're pretty far down the slippery slope when you judge someone's life before they are born. Think what would happen if you had to confront them in some unimaginable future... "Why did you abort me, Mom?" "Well, we thought we would spare you from the suffering of your sixties and seventies by just nipping you in the bud..." "Spare me? Or you?" "..."
@ConfusionFusion You are correct in stating that I know little about Huntington's disease. I inferred that it was an 'end of life' issue based on the images that Joe provided and the comparisons he made with Alzhiemer's disease, which I am, unfortunately, more conversant with. I will do more research forthwith, and thank you for pointing this out. Re: anti-women's rights comments... I'm not quite sure what you're implying, but it seems irrelevant to the comment. Thanks again
@ConfusionFusion I think the wires are crossed a bit here; I was simply questioning the wisdom of ending someone's life prematurely because of a genetic test for something that would affect them later in life. I may have been mistaken in assuming that Huntington's was similar to Alzheimer's or Parkinson's and if so, I'll own it and rethink. However, I am no opponent of women's rights in general, and it wasn't my intention to imply that; I was not speaking to the general case. Also, I would be careful of sharing the fact that you essentially ended your father's life here on a platform like RUclips. As far as I know, 'assisted suicide' is still illegal here in America; disregard this of course if you (or your father) are (or were) not an American. That must have been the hardest thing to do.
I lost my large intestine at the age of 12 thanks to a genetic digestive tract polyp disease. My family has been studied for it over a few generations. I've opted to not have children to end it in my side of the bloodline, while my brother won the 70/30 coin flip. I'll always be hopeful for genetic engineering as someone who was destined for disease from conception. Just got to hope for the positive to come out and do our best to regulate it on a local level.
Hey I also lost my large intestine due to genetics(18 for me). Familial adenomatous polyposis. Mine was a 50/50 I guess. But I’m also choosing to not have kids. I’d rather adopt anyways. Lot of complications with it and probably many more down the road. I just hope in the future we can get all this sorted out well.
Cashhue Even without any genetic-editing whatsoever, many genetic diseases are being avoided nowadays by using IVF treatments and, then, only implanting the embryos that will not have the disease. This becomes even better when embryos can be implanted that will neither have nor carry the disease. The latter breaks the cycle right there.
@@minepose98 IVF is en.wikipedia.org/wiki/In_vitro_fertilisation (For clarification, because the article is long: IVF can prevent genetic diseases from being passed on by selecting the cells that will become the child. While one could technically instead have the fetus tested and have abortions until by chance the gene is not passed on that sounds quite, um, unpleasant.)
@@UUdoubleU i'm ok messing up with half world economy and psicologically abuse them and shut down civil rights becouse i'm scared by a flue and i point my finger at the idiot complaining for stupid stuff to seem as the kind and altruistic One 😂🤣😂🤣
Its more like nuclear, you can power The world od destroy it. But with The tools ready, superhumans is inevitable. Its like AI war machines. You Know it can goes wrong but if you don't pursue it, your enemies do and than they will be better than you. It could be the end of human race becouse we change it in something totally diferent. Meybe better, maybe not but surrely diferent.
When you mention Watson and Crick in regards to the DNA structure discovery, you should also mention Rosalind Franklin. Her work was integral to the discovery. I really liked seeing both sides of the CRISPR debate in this video! Some people go so hard for the fear-mongering and others go hard about how amazing it is. It's nice to see a balanced take
+1, I'm glad someone mentioned Rosalind Franklin. Had to drag down a ton of comments then CTRL+F for "Rosalind" to make sure this wasn't overlooked by the community at large. Looks like you weren't alone. Gotta go upvote those comments now too haha
@Ruthanne D'Antuono me, is marvelling at the stupidity of the comparison. French fries come from Belgium. The American soldiers that gave the name French Fries crossed the border into Belgium without knowing it and discovered this delegacy in Belgium. It a Belgium food. Saying it is French is like saying 'pizza is from new york because of New York pizza' (It's from Italy). So your comparison should have been... "Me, in Belgium,..." or just take a different example that is not flawed
Watching my dad’s mind slip and deteriorate was one of the hardest things I’ve ever dealt with. He died in an accident before it got bad enough to diagnose, but I suspect he had Lewy body dementia, or another form of dementia. He started hallucinating and acting childlike. He couldn’t sit still and he was constantly in pain from a back injury. It was much more complex than that, but to put it into perspective it was scarier than watching my mom go through stage 4 cancer (because I knew she could beat it based on what her doctors said. She is almost done with chemo and having a final surgery soon! With dad it felt hopeless). I hope I don’t have to go through that, but dementia and Alzheimer’s runs on both sides of my family so wish me luck I guess lol
I know that pain (nobody can know another person’s pain exactly, but you know what I mean). My anger at a supreme being who included suffering like this in our world is indescribable. Not anger - rage. My Dad is 90, and has about a 30 word vocabulary. He doesn’t remember anything about his life, and barely knows that he’s _supposed_ to know me, but obviously just slightly recognizes me. He calls me “buddy” as he doesn’t remember my name. He can no longer remember my late mother's name, and will just sometimes ask “how’s my girl?”. _Nobody_ deserves this! Nobody’s family and friends deserve this for _any_ reason that I can think of. It is sadistic. If this _is_ a created universe, designed by a _Creater_ then at the very least, when I get to the other side, I’m going to be asking where I can file some complaints. I wish you the best. But I won’t be saying “God bless you.”
3rd year Genetics MSci student here, and I heavily approve of the message and presentation of this video. As such, I will be sharing it around a lot. Thanks Joe. :)
@@scenopiachannel I honestly don't care for tribalistic politics. The whole point of my intended work is to have us surpass all this bullshit of "If you don't vote for us, the other side will win!" from the campaigners, and the "If you don't support my team it means you support the opposition, and therefore are my enemy!" from the voters...
@Her Name But he is de facto anti-White (he's really just regurgitating anti-White narratives), he complains about Whites being for eugenics without giving context of how savage all other races were at the time. The same goes for his anti-White superiority comments, since all races think theirs is superior, but Whites were the only ones to invent the scientific method, implement the Roman rule of law, and abolish slavery when they were in complete planetary domination.
@@travelers8607 That would be fair if the Democrats weren't denying essential genetic science like the existence of subspecies or sex or inheritable behavioral proclivities.
@@scenopiachannel I'm not from the U.S.A, dude... Currently studying in the U.K. IMO, both ends of the political spectrum are blind to what needs to be done. Instead of racial politics being the primary topic of concern for you, have you paused to consider how we are fairly likely to witness the extinction of wild Tigers and Orangutans within our lifetime? If so, does it not concern you more that all of humanity generally doesn't seem to give enough of a shit to prevent this type of thing from happening?
I mean, the big potential for evilness and eugenics with human gene editing isn't about whether or not the modifications are forced, its about who has access to those modifications, particularly germline ones. If the rich are the only ones who can afford to modify themselves and their children with superior traits, then they're going to be doing that. I shouldn't have to spell out the scary implications of that, especially once the modifieds and their descendants start using their superior traits to justify going back down the eugenics road. Not to say that debilitating genetic diseases shouldn't be fixed with the consent of those who are affected.
"Not to say that debilitating genetic diseases shouldn't be fixed with the consent of those who are affected." What if they don't consent and want you to carry them and theirs?
I feel like it'll be the same as any new technology, that'll be the case for a while, sure. But eventually the technology will be more affordable. In the mean time, pretty sure genetic modification can't make someone bulletproof, so if anyone statts trying to bring back eugenics, well, you know.
The rich tend to sleep around a lot. I imagine those enhanced traits would start to surface in common populations quite soon. Even better the rich could be guinea pigs. If it goes wrong the common man is still healthy, If it works, wel as I said, they sleep around....
There's always been a breeding program where the wealthy get every genetic advantage evolution can create, and the unfit become increasingly unfit until they can't or don't have children. The fit take more wealth, mate with better people, and have superior offspring. There will always be social stratification due to breeding. Gene editing can fix mutations but the complexity involved in creating a better human requires the sort of trial and error that only evolution provides. I think the wealthy will have little reason to keep gene editing to themselves. If anything, they might want more effective workers. Providing free genetic treatment might become commonplace.
One of the major problems with editing our dna to remove unwanted traits or inheritable disease is that we do not fully understand the interactions of the dna code and all it's outcomes. From what I understand, there isn't a code for just blue eyes. The same things in the code that give you blue eyes also interact with other code to give you say, darker skin for example. So, until we fully understand exactly how all the code interacts and is interwoven like that, it is dangerous to alter the code.
I'm one of *6* type 1 diabetic siblings (the current world record) and would sure as hell like to not spend my entire paycheck on doctor visits and insulin. Not to mention being able to just regulate my own blood sugars and not have to deal with the plethora of other health issues that come with diabetes. I am all for this. Teach people ethics and responsibility, don't deny them options.
@Sabrina Redford - I Don't get thius Rsponce. Not only is He using Heaven and Hell Metaphorically, but I Don't see how what Tou said corrects His Point. It seems ot Agree with it.
That may be true, but you don't give the keys to your gun safe to a child, particularly not an unstable, sometimes dim, sometimes psychopathic child that likes to lick the glass at the supermarket. (Humans) Oh, we're brilliant in a lot of ways, but if it only takes one well-trained, unstable, dim, psychopathic, glass-licking moron to kill us, I'm not so sure keeping guns (or knives for that matter) in the house is such a good idea... Edit: With that being said, immortality and an end to disease and hunger would be kind of nice... The problem is that it takes much less time and effort to kill everyone than it would to do the rest of it. I can think of five ways off the top of my head.
I’m in medicine, haven’t watched the video yet, and I can absolutely confirm there’s a dark side to genetic editing. Gene editing in my profession is seen as a breakthrough. So much disease could be eradicated by it, including cystic fibrosis, sickle cell, some forms of hypertension, and way more. Using it to gain an unfair advantage in competition is a nightmare scenario.
@Joe Scott Thank you for bringing up some awareness on what people and their close ones are dealing with Huntington's disease. It would be really heart warming to see a video on most promising cures for this awful disease - something that would bring hope.
Fun fact: Mendel sent all his genetics research to Darwin, but after Darwin's death, the book was found still unpacked. Imagine how much would combining their research move science forward.
Science doesn't Progress that way, Realy, it depends on People. I DOubt Darwin would do much with Meels Work as back then, Scienc wasnot the Formal DIsipline we have today, and Darwin was not Patient with Gardening Eperiments.
@@skwills1629 maybe, but if he had read it he could've had it either added in part to his own work, or published it posthumously for him. Darwin could've also forwarded it to Wallace who might be been interested in how this applied to his work on biography.
@@garret1930 - Yeah but That's a Lot of maybes. I'm not Telling You to Think the Opposite here, I Just Hate Spurious Conclusions. Maybe Darwin simply never got round to Opening it. WHo Knows?
@@skwills1629 true, I like alternative history speculation though, it helps to figure out what the real importance of an event (or lack thereof) was and to try and understand history a little better.
I did a DNA test and when I told my Dad he oddly said "you shouldn't have done that" and did not explain why. Probably got an old serial killer dad lol
@@redbeard8532 Oh my dude, the number of times I have seen this... I've been doing genealogy for 17 years I think it is now? Several years ago I started volunteering to help adoptees as well as people with an NPE (used to stand for Non Paternal Event, basically Daddy is not the Daddy but it happens on the maternal side too so...) tl;dr your Dad was probs just worried about the "putting your DNA on the internet" thing, BUT if something wonky comes back I'd be happy to help you. *fistbump*
I just saw the list with Multiple Myeloma as one thing being researched. My Mom passed away from that and I wish I still had her with me. I hope they find a way to give anyone facing such a diagnosis a fighting chance. Love and miss her so much.
Awesome video again dude. I went home for a while to visit my family and cited some random fact from one of your old videos and my brother said, "I think I saw a video where a guy said that..." and then we realized we had both independently watched almost all of your videos without mentioning it to each other. Love the in depth coverage and that you are always thorough.
Don't worry, what we're closest to being is, extinct by our own actions. You likely won't have to worry about having laser eyes or being part of a hive mind.
@@kurtlindner Nah, how so? What could destroy us? Any threat we face we can manage except potentially AGI. Preconceived notions about extinction or Armageddon you may harbor are utterly unfounded.
*Huntington's Disease...* I cringed when you mentioned that. My ex and her father died from it. It's a horrible way to go, both a physical and a mental illness, and very difficult for their loved ones as well.
My high school Spanish teacher had/has sickel cell anemia. He explained it to us and why he might be unavailable on some days. It's caused by an adaption to malaria. One of the ladies from the band TLC also has it. I'm so happy to learn there's hope for them!
I don't know if that book is a positive or negative depiction of genome editing, but I would like to suggest the Commonwealth Saga und The Void series (continuation of the Commonwealth Saga) by Peter F. Hamilton. They're both one of my favourite book series of all time and in their universe, genetic manipulation is common place everywhere and everyone can have it done on them during their rejuvenation procedures. Of course there are problems, like some people work for multiple lives just to be able to afford their next rejuvenation, but that's a socialised healthcare problem, not a technology problem. In my opinion it is one of the best examples in how we should try to use this technology and quite honestly, I hope it will be like this, because then I could still live to see the centuries to come (rejuvenation was invented in the 2050s).
Great in-depth video! I remember the Mack Weldon commercial you did years ago, that was probably the best ad I’ve seen on RUclips. Certainly the most memorable.
The US did still practiced eugenics until '77 I believe. Clearly I should have watched until the end, but but but, then it's hard to remember things I wanted to comment on
*still is. Fixed that for ya. Even though forced sterilization was overturned in the 70's, coerced blackmailed sterilization is still practiced in the USA.
@Ruthanne D'Antuono Stole? That is a strong word. According to this article (read it, it's quite interesting) there was no stealing. www.theguardian.com/science/2015/jun/23/sexism-in-science-did-watson-and-crick-really-steal-rosalind-franklins-data
My wife has Huntingtons Disease and is starting to be symptomatic and it’s absolutely devastating. We have kids also and didn’t know huntingtons was in her family until her mom was in end stages from it (drs previously thought it was Parkinson’s). Our only hope now is that the kids do not have it and it stops with my wife. I’d do anything to take this suffering away from my wife, it is such an absolutely unfair disease. She is such an amazing person and it’s sucking the life from her.
17:04 thank you so much for including the line “if they choose to”. many still don’t understand that NOT ALL people with disabilities want to be “fixed” or “cured”, we do just fine with what we’re were given. the problem often comes from the way society’s assumptions ABOUT disabilities affect us, not the effect of the disabilities themselves. people don’t always get that many of us are perfectly capable of living our lives happy, if they would just stop making that so hard
Watching our mom suffer from degenerative arthritis, getting stiffer and in so much pain when she had been so busy and independent before. And my sister and I would say, "Previews of coming attractions." So true. My younger sister has diabetes like mom, my older sister has a fast heartbeat, like mom, and I have the arthritis making it harder to get around. Sigh.
Great video, thank you! Could you do a video on the abuses of psychiatry, both past and present, for example lobotomies and electric shock treatment which result in deaths across the world today? As well as the deaths resulting from psychiatric medication? Maybe how the fiction of “chemical imbalance” never originated with any successful before or after chemical tests in psychiatric treatments?
No, its just bad. But thanks for playing...Bob, tell him what he's won! Well batmans pet goldfish, you win a chance to ogle some juicy dong wrapped in this weeks sponsors underpants, enjoy!
One big person about the issue and problems with gene editing was Michael Crichton, who wrote books like Jurassic Park, The Lost World, and the Andromeda Strain. He gave a couple of interviews about his concerns about the power of gene editing, which inspired him to write those books. We even see his concerns about this power in the Jurassic park/ World movies as well.
Thanks, Joe. My wife has Huntington's and I'm the primary caretaker. Your presentation is exceptionally fair and balanced. Even though a cure will probably come too late for us, your admonition of not throwing out the baby with the bath water is spot on. Future generations will benefit from continued research.
even funner fact, the majority of eugenicist doctrine, including those of which used by Nazi Germany, were pioneered by American intellectuals and scientists
@@aeringothyk5445 No, I think we just know more about the US eugenicists. This was mainstream thought across the whole of the European left from 1880 onwards.
"Gattaca", "In Time", to an extent "Equilibrium"... Yes. There's absolutely a dark side. Because humanity will NEVER be able to be content. There will ALWAYS be those that abuse power.
I mean, the concept of contempt or satisfaction is something new, that may not be too far way from being widely available look, 100 years ago there wasn't psychotherapy of any kind, today people with chronic depression can find some sort of comfort with their lives, same goes to many other mood disorders, and maybe coincidentally or not, today we have the greatest proportion of human populations living outside of war zones and/or poverty ever to exist imagine 100 years from now maybe some day, true satisfaction will be possible
@@jeremymenning56 it's hard to imagine what happens after the singularity, because we don't have the tiniest clue about how a general A.I. would behave.
@@lemonjuice1988 I agree. Once it takes off we won't be able to grasp that order of "thinking". Richard Feynman's answers on AI help to explain this to layman (which I am very much a layman).
The humans in Star Trek do act radically differently from modern humans. Who’s to say there not abit of history is written by the victors thing going on there? 🤔
@@jamesglenn4151 I have my own idea that a faction of augments won and survived the war. They lack physical augmentation but are hyper intelligent and working in the shadows. They may even have founded Section 31 to do the federations dirty work like removing troublemakers before they get dangeroues. They probably also horde technology for their own use like long range beaming. Voyager for example have at least two encounters with species capable of long range beaming. Sloans ability to just pop up from nowhere faster then a ship could take him hints that they possess this ability.
I would totally use genetic engineering artistically. Change my genes to "cocoon" me and emerge as a gargoyle or a vampire looking dude. That would be awesome!
do it amigo. CRISPR is cheap. Just google the-odin.com You can easily change organisms (though I would advise you not to change anything with potential consciousness) as an art project
Damn, this is a real good summary of my family's problems 😅 my grandfathers mother had huntington, she had 7 sons, 3 had it, 4 did not. My grandpa was one of the lucky ones. It was the worst for the youngest who did have it though. He didn't get tested and was kind of paranoid for years, untill the symptoms started to show and he knew exactly what was comming as two of his brothers had already been going through it. There is still a part of the family left now that may have it, they have kids too. No one is sure if they are tested, we don't see them too often either so I have no idea if any signs have started to show yet. No one dares to really ask to be honest. Is it responsible for them to have had kids even with that chance of passing on a horrible disease? Or would it be unfair to test and abord a child if they have the disease? You'd just take away a whole life, because they have a disease that only shows later in life. Would that life be worth it though, is it fair for a parent to make that decision? It remains tough. I'm just glad I was born on the good 50% side.
Once I saw "Gattaca" I knew the is where we were going. Fact is, business is in the business of making money not products. To make money you must maximize price while minimizing costs. Your raw material cost too much, the company changes vendors or changes the raw material. If the companies employees cost too much the company looks for ways to minimize the need for them. And employees that the company must hire need to cost as little as possible. Never hire someone that is eventually going to cost more than they are worth to the company. It's just business unless it's you be passed over. Genetics will be used in the most horrific ways it can be by businesses just trying to make a profit.
Awesome movie. Another good movie that wouldn´t be made today. No "i" in the name though, they made the title by only using letters gene pairs are marked. A, T, C, G
Don't get me wrong, I liked the movie. However, if we were that scientifically advanced then surely we could of helped the non genetically altered dude with his asthma and any other issues he had?
Yup. Abortions and IVF are essentially a brute force method of gene editing. Embryo might have a chance of not developing properly? *toilet flush noises* End of 1st trimester check up: Baby's heart is growing outside his rib cage? *suction goes vvvvvvrrrrrrr* Just like how early GMO crops involved literally blasting the seeds with massive doses of radiation and seeing what happened. This just takes the guesswork out of the equationand turns it into a neat 1+1=2 scenario
This is how I feel about ms (or at least the disease that my father and grandfather died from that doctors called ms to finally give something a name). It terrifies me that there is a possibility to give it to my kids. Luckily my brother and I seem to have lived past the beginning ages in early to mid 30s. But our combined 5 kids? I’ll be mortified if in 20 years I start seeing signs in them. I’ve seen it destroy 2 people, my grandfather worse, technology and treatment were better for my father, but far from great. Before he died he had limited ability to move his head and talk plus very limited mobility in his left arm. My grandfather could only mumble and move his head around a little. Terrible, just terrible.
5:33 - Apparently RUclips's auto-captions just convert audio to text phonetically because when Joe misspoke and said thalamessia instead of thalassemia, the auto-captions wrote what he said instead of using the context to correct it.
@@jjcoola998 symptoms usually don't show up til you're too old to have kids, so until quite recently, you didn't know you had it until it was too late. Some people think having been born is better than not having been born. We all die, and it's often unpleasant. Are 50 good years worth 10 awful ones?
@@sarasmr4278 Even if the symptoms show up lately, your parents may have already shown them by the time you are old enough to have kids, and of they didn't, with current technology, anyone should just get themselves checked
Reach4 As I have replied on several other posts, even without any genetic-editing whatsoever, many genetic diseases are being avoided nowadays by using IVF treatments and, then, only implanting the embryos that will not have the disease. This becomes even better when embryos can be implanted that will neither have nor carry the disease. The latter breaks the cycle right there.
@@RCSVirginia I have no problem whatever with genetic engineering, provided it is guided and overseen by scientific councils, not the government. That said, I'd still want to know if I had genetic defects with a high likelihood of being passed on.
Great video Joe, your introduction to artificial evolution is spot on (I use the same approach when introducing artificial evolutionary algorithms), and the rest of the video was engaging!
I have been peeling the layers off this can of worms for a while now, thanks to you BTW, it gets verry complicated fast. We do not understand or even come close to understanding the actual language of the genetic code. Our guesses are getting better, and clearly we can generally spot blatent annomolies, but the subtle stuff usually eludes us. Social issues are not trivial either. Still working on that video.... Stay safe, stay healthy.
the right, just like the left, is a very comlpex construct, and not everybody is against/ cares about abortion. That is mostly a religious, not a political issue (what makes a human/is there a soul)
@@mmmmmmolly - A Religion is nothing more than a Philosophy one Believes in and Lives by. It is a Framework used to Understand Our existence e and Values and Culture. It gives us Identity and Focus. It isn't something hat was Created, and it snot something Some people don't Have. This is also why Militant Atheists attack Religion, they want You to follow their religion. They also insist we see them as Non-Religious, because they want to Shield their Beliefs from the same Critisisms they give to others b Pretending not to Have beliefs, even though its Obvious that they do.
@@skwills1629 i understand what you mean but I have to disagree. Religion is defined as the service and worship of God or the supernatural, and people who don't believe in a god can still have a belief system based on their values and moral code and not be religious. For the militant atheists, I don't really have any experience with such a group, but as with pretty much any organization, there will be extremists that don't represent the majority. Belief does not equal religion in my opinion. (This doesn't relate to the topic but are you German?)
@@mmmmmmolly - Can People Please Stop using The Dictionary Definition Argument? It gets Old. Itsa not like Any of You bother to Look it up in The Dictionary, a Popular Atheist's popularised the use of it and now People Blindly repeat it. But what You said isn't True. Religion is not Defined as the service and worship of God or the supernatural. When Bill Maher said this, He Lied, because the Dictionary He got this From has Six definitions for Religion. Why is it then that This is presented as the Only Definition? en.wikipedia.org/wiki/Definition_of_religion The Word Religion has several Definitions. Pretending it has One Universally Agreed Upon meaning is Ridiculous. Militant Atheism is also not an Orginization, Rather it is a Type of Atheist defined by their Hostility. As for me, I Am American of English Background.
Sometimes I have no intelligent, relevant comment cause you cover the subject so well, or I'm just done thinkin' for the day, but I like for RUclips to know that I think your channel is extremely valuable and entertaining both. And, awwwwww, your dog!!
Unfortunately joe, I’m not at a point in my life where I can justify spending $34 on a single pair of underwear. Not trying to hurt your brand deals or anything but yeah
josh setnik it’s released first on nebula I believe but also if you’re a member and donate to his channel you get early access either way. I signed up for curiosity stream a couple months back through joes channel and it came with Nebula which has his and other youtubers vids in there before RUclips. Curiosity steam is genuinely awesome and only a couple bucks a month(not a sponsor) lol
My biggest worry for GE is that whole swaths of people (including myself) do or have dealt with some form of disability. I fear that through removing the suffering that these things have cause, will we see a dark side of people who aren't propelled to get better at something. Basically, I don't think people can get better at anything without struggle and suffering. And if we remove a vector in which that suffering causes inspiration or abilities in people. Then will those kind of people simply find something else, or (more likely) will people just not receive/design a purpose or goal in life at the same extremes people with disability Or more simply, if a particular mental disorder (genetically caused) is removed, we remove the possibility that the state of mind of that person might be perfectly suited for a very specific thing. Limiting that person's potential in that thing, the only next question is that also limiting them as a whole or in just that one thing
It was a little hard to catch but I love that you said “might could” in this. “We might could even alter our bodies..”. I don’t know…I just loved it hahah
I love learning about genetic engineering, as a biology student, it is just mind blowing to me we can actually edit DNA. Hopefully we can use this along with other therapies to get rid of cancer and other disabilities. Anyways great video
Competitive capitalists: *Harnessed the electricity you use, created the car you drive, the platform you post videos on, the technology you use to make videos, etc, etc, etc.* Pfft... *Capitalists*...
My mother and auntie died of huntingtons. Me and my wife have just gone through PGD to ensure that my son won't contract it. I'm so grateful for the science that allowed me to do this so I don't possible give him this horrible disease
In Gattaca, the technology works perfectly. (I only watched the movie, so I'm working based on that.) It's absolutely flawless. No negative side effects in the tech. The problem of Gattaca is the society. The society judges you based on your genetics, rather than in who you really are. This causes some seriously negative effects. The dangers of Gattaca are honestly relatively easy to avoid, with just a little bit of honest perspective and awareness. It's amazing how many people just bring up Gattaca as a way to say "Gene therapy is bad!" That wasn't the message of the movie. (Although I really should read the book.)
I have been born with both a clef lip and clef pallet, I must say. I often have thought how lucky I was to be born in the 1980's, when medical techniques made corrective surgery's, though, painful, and many in number over a bit over a dozen years, possible, and in my case luckily, very effective. To the point that after all the surgery and another decade or so of practicing speaking, I have to tell people I have a speech impediment / clef pallet when they ask me what part of the country I am from or where I get my accent. I would certainly be very happy with the idea of not having a child with such a condition, but, would i terminate a pregnancy over such? No, the experience gave me a very strong character and taught me to look past superficiality from a very very young age, and the many deep connections I have made along my path in life with such a large amount of people wouldn't be possible if not for the struggles and challenges both physically and socially that come with working through such an experience. However, if given the option, would I allow my offspring to have the "offending" genetic sequence "corrected". Certainly. Spare the suffering and pain, and teach them, hopefully, from my own. I endorse corrective genetic editing, applied carefully and ethically.
Just a credit note: Watson & Crick BUT also let's credit the much overlooked Rosalind Franklin for her double helix insights. I note that the originators of CRISPR are also rarely credited: Jennifer Doudna and Emmanuelle Charpentier (I believe the latter now holds the patent along with UC and the University of Vienna). It would be nice to see folks get credit they deserve. Keep up the good work Joe
What scares me as a disabled and neurodivergent person is the subjective idea of what is and isn’t supposed to be cured. I believe only degenerative and terminal diseases should be edited out of genes, but I’ve heard the argument multiple times of people wanting to cure autism and Down syndrome for example. Those don’t need curing. We don’t need to be eradicated, we need a society that understands and accepts us better. I’ve heard people say if they could test their child for autism in the womb that they would abort them. I’m pro choice, but that is just ableism and eugenics. I fear where people will draw the line and disabled people’s opinions on this are never taken seriously because after all we are the ones they’re discussing erasing from the future. I would love to not have the genetic predisposition to cancer and Alzheimer’s in my family. I’d love to not have ehlers danlos, but at what point is too far? People need to accept and accommodate certain disorders like autism rather than trying to cure them. All of the problems associated with it could be fixed by doing that, so why cure it? It’s a fine line and I just hope this technology doesn’t get into the wrong people’s hands. It would be amazing and life changing to live in a world with no more cancer!!! So many people I know would still be alive or wouldn’t have destroyed their health and wealth to cure it. It worries me to think that people feel that way about something that poses no real risk. I don’t know if I really worded this right by I’m sleep deprived lol
I got my Huntington's test on my 18th birthday. I had to wait 3 weeks for the result. Those were the longest, scariest 3 weeks of my life; I had already been accepted to college and I thought I might eventually forget everything I was about to learn. When I went in to get the result, the first thing the doctor said was "Your test came back normal, you do NOT have Huntington's disease."
It was the best day of my life. Ever since, I've been living like I got a second chance and I don't want to waste it, especially after seeing what Huntington's did to my mom, my grandfather, and my aunt. Be grateful for your health, it's not guaranteed.
I can't even imagine going through that.
i cant understand people who don't get tested for huntingtons out of fear... i mean, if its negative: GREAT... if not, suicide srsly becomes an option at that point. X_x anyway, i would want to KNOW.
You're brave to get that test done. I don't think I could live with that cloud hanging over my head if the test came back positive.
Congratulations on not having Huntingtons. And I am sorry for all those people who get the result showing they do have it. These bodies are such a gamble.
One thing about Crispr that worries me and a lot of other people is genetically editing deadly viruses to make them more deadly and releasing them on the public. There are some real species ending possiblities and there are people out there who would do it.
I’d pick you for all team coin flips!
Fun facts: While the phrase "survival of the fittest" is often used to mean "natural selection", it is avoided by modern biologists, because the phrase can be misleading. For example, survival is only one aspect of selection, and not always the most important. Another problem is that the word "fit" is frequently
confused with a state of physical fitness. In the evolutionary meaning "fitness" is the rate of reproductive output among a class of genetic variants.
what do they use instead?
Survival of the fit enough
As a person with diabetes, I am glad that modern medicine has lowered the bar on fit enough.
That said, I wonder what the long term impact on humanity will be...
So, survival of the most adaptable. Like the small ground dwelling mammals that, when the asteroid hit and killed the dinosaurs, not only adapted and survived, but evolved into the humans of today.
@@jerryfick613 The bar is lowered for manageable conditions like diabetes, but it is ever heightened when it comes to the brain especially. Hell the same alleles that cause a condition might potentially have a positive impact on intelligence by chance thus selection will favour that allele, despite the relatively insignificant detriment it causes.
as someone with a spinal cord injury, id sure like to be able to feel things again
Same here bro I broke my neck when I was 11 on March 3rd, 2000.
Know life know pain.
No life no pain.
howtostopthecycleofpain.blogspot.sg/2009/05/why-do-you-feel-pain.html?m=1
@@cjalisyas That is such a trashy thing to say to someone with such a tragic history. You should be ashamed of yourself.
I would like you to be able to feel things again too.
@@Chris.Pippin a very important research topic, however is DNA engineering the best tool? Stem cell and scaffold organ, nerve, synapses growth is another research path that has grown substantially.
The convergence of biophotonics and informatics is a great revolution to be part of.
Makes me happy!
My mom had 6 siblings and only her and one other didn't get Huntington's. All her siblings that had the disease are dead now but a lot of them had children and some even had grandchildren. My mom got tested before having kids but other than her only two people in my entire family have ever been tested for it. The most recent person to get tested got the results back a couple years ago and he's starting to show some signs. To me, there's no moral dilemma between abortion or your child having Huntington's. I've seen how bad it gets and I wouldn't wish that on anybody.
If you know it runs in your family you can do the invetro thing and screen the embryos. That way you don't have to get an abortion.
Does end-of-life disease override the potential value of the work of someone's life? What if one of these children cured cancer or built an FTL drive? I don't think it is up to us to decide whether some other one's life will be 'worth living' based on an embryonic test for an end-of-life disease. Shouldn't they get a chance? What if they cured the very disease they suffer from... and cured everyone else like them? You're pretty far down the slippery slope when you judge someone's life before they are born.
Think what would happen if you had to confront them in some unimaginable future...
"Why did you abort me, Mom?"
"Well, we thought we would spare you from the suffering of your sixties and seventies by just nipping you in the bud..."
"Spare me? Or you?"
"..."
@ConfusionFusion You are correct in stating that I know little about Huntington's disease. I inferred that it was an 'end of life' issue based on the images that Joe provided and the comparisons he made with Alzhiemer's disease, which I am, unfortunately, more conversant with. I will do more research forthwith, and thank you for pointing this out. Re: anti-women's rights comments... I'm not quite sure what you're implying, but it seems irrelevant to the comment. Thanks again
Have you considered adoption instead ? :-)
@ConfusionFusion I think the wires are crossed a bit here; I was simply questioning the wisdom of ending someone's life prematurely because of a genetic test for something that would affect them later in life. I may have been mistaken in assuming that Huntington's was similar to Alzheimer's or Parkinson's and if so, I'll own it and rethink. However, I am no opponent of women's rights in general, and it wasn't my intention to imply that; I was not speaking to the general case.
Also, I would be careful of sharing the fact that you essentially ended your father's life here on a platform like RUclips. As far as I know, 'assisted suicide' is still illegal here in America; disregard this of course if you (or your father) are (or were) not an American. That must have been the hardest thing to do.
I lost my large intestine at the age of 12 thanks to a genetic digestive tract polyp disease. My family has been studied for it over a few generations. I've opted to not have children to end it in my side of the bloodline, while my brother won the 70/30 coin flip. I'll always be hopeful for genetic engineering as someone who was destined for disease from conception. Just got to hope for the positive to come out and do our best to regulate it on a local level.
Hey I also lost my large intestine due to genetics(18 for me). Familial adenomatous polyposis. Mine was a 50/50 I guess. But I’m also choosing to not have kids. I’d rather adopt anyways. Lot of complications with it and probably many more down the road. I just hope in the future we can get all this sorted out well.
Cashhue
Even without any genetic-editing whatsoever, many genetic diseases are being avoided nowadays by using IVF treatments and, then, only implanting the embryos that will not have the disease. This becomes even better when embryos can be implanted that will neither have nor carry the disease. The latter breaks the cycle right there.
I'm curious, what stops you from doing IVF?
@@mat_name_whatever Nothing stops them having children, they're just choosing not to so they don't pass their disease down.
@@minepose98
IVF is en.wikipedia.org/wiki/In_vitro_fertilisation
(For clarification, because the article is long: IVF can prevent genetic diseases from being passed on by selecting the cells that will become the child. While one could technically instead have the fetus tested and have abortions until by chance the gene is not passed on that sounds quite, um, unpleasant.)
“The saddest aspect of life right now is that science gathers knowledge faster than society gathers wisdom.”
― Isaac Asimov
@R DOTTIN unfortunately.
@R DOTTIN I WILL NOT WEAR A MASK IT HUTTS MY FWACE!!!!!!!! It hARd TO BReATHe!!!!!
@@UUdoubleU i'm ok messing up with half world economy and psicologically abuse them and shut down civil rights becouse i'm scared by a flue and i point my finger at the idiot complaining for stupid stuff to seem as the kind and altruistic One 😂🤣😂🤣
@@BresciGaetano shut
Sadly true
To answer the question with a question: what technology in history DIDN'T/DOESN'T have a dark side? Which tech can't be missused?
Considering the license agreement for *iTunes* has clauses against using it to further NUCLEAR WEAPONS development...
@@sechran You never know what a mad scientist can do when you put on some good tunes.
Deadeye Duncan 😎😎😎
water dispenser ? Like there are many things ,but who cares ?
the Fleshlight
Its like a hammer, you can build a house for the homeless, or you can beat someone to death with it.
Why not both? ¯\_(ツ)_/¯
Just hammering that house into existence ;)
OMG Jimmy Carter is a serial killer??
Beat the house to death and build a homeless
Its more like nuclear, you can power The world od destroy it. But with The tools ready, superhumans is inevitable. Its like AI war machines. You Know it can goes wrong but if you don't pursue it, your enemies do and than they will be better than you.
It could be the end of human race becouse we change it in something totally diferent. Meybe better, maybe not but surrely diferent.
"It actually gives me a lot of optimism for the future" ... is not a phrase I expected to hear in 2020...
Well, when you hit rock bottom, the only way to go is up! Except I don't think we've hit bottom yet......
When you mention Watson and Crick in regards to the DNA structure discovery, you should also mention Rosalind Franklin. Her work was integral to the discovery.
I really liked seeing both sides of the CRISPR debate in this video! Some people go so hard for the fear-mongering and others go hard about how amazing it is. It's nice to see a balanced take
+1, I'm glad someone mentioned Rosalind Franklin. Had to drag down a ton of comments then CTRL+F for "Rosalind" to make sure this wasn't overlooked by the community at large. Looks like you weren't alone. Gotta go upvote those comments now too haha
Same, was searching for this comment.👍🏽
Someone somewhere is definitely doing illegal gene editing.
(Coughs) CCP....
checkout 'Splice'
Chinese scientist did alter a germline already at least once
Didn't a Chinese scientist genetically edit some embryos to be immune to HIV?
@@nielsssg I have and i do feel bad for the girl who was stolen in splice. Not so much for her after she kills so many people.
My mom has dementia and parkinson's. It's heartbreaking.
😢 I am so sorry...
That's unlucky
@Sabrina Murphy Thank you. She's still with us.
@@marlonmoncrieffe0728 Thank you. She's still with us.
@Sabrina Murphy Thank you. She's still with us.
"How weird is it that Christian Doppler found the thing that just happened to have the same name..." My kinda humor Joe! hahaha
@Ruthanne D'Antuono me, is marvelling at the stupidity of the comparison. French fries come from Belgium. The American soldiers that gave the name French Fries crossed the border into Belgium without knowing it and discovered this delegacy in Belgium. It a Belgium food. Saying it is French is like saying 'pizza is from new york because of New York pizza' (It's from Italy). So your comparison should have been... "Me, in Belgium,..." or just take a different example that is not flawed
@@ingmarhendriks8172 you're fun at parties
@@ingmarhendriks8172 Her example is flawed, like the OP's.
my dad got Parkinson at 28. one of the youngest cases ever recorded. Alzheimer's at like 45. Died at 57. If we can cure this stuff. DO IT. DO IT NOW.
Watching my dad’s mind slip and deteriorate was one of the hardest things I’ve ever dealt with. He died in an accident before it got bad enough to diagnose, but I suspect he had Lewy body dementia, or another form of dementia. He started hallucinating and acting childlike. He couldn’t sit still and he was constantly in pain from a back injury. It was much more complex than that, but to put it into perspective it was scarier than watching my mom go through stage 4 cancer (because I knew she could beat it based on what her doctors said. She is almost done with chemo and having a final surgery soon! With dad it felt hopeless). I hope I don’t have to go through that, but dementia and Alzheimer’s runs on both sides of my family so wish me luck I guess lol
I know that pain (nobody can know another person’s pain exactly, but you know what I mean). My anger at a supreme being who included suffering like this in our world is indescribable. Not anger - rage.
My Dad is 90, and has about a 30 word vocabulary. He doesn’t remember anything about his life, and barely knows that he’s _supposed_ to know me, but obviously just slightly recognizes me. He calls me “buddy” as he doesn’t remember my name. He can no longer remember my late mother's name, and will just sometimes ask “how’s my girl?”.
_Nobody_ deserves this! Nobody’s family and friends deserve this for _any_ reason that I can think of. It is sadistic.
If this _is_ a created universe, designed by a _Creater_ then at the very least, when I get to the other side, I’m going to be asking where I can file some complaints.
I wish you the best. But I won’t be saying “God bless you.”
3rd year Genetics MSci student here, and I heavily approve of the message and presentation of this video. As such, I will be sharing it around a lot. Thanks Joe. :)
Just make sure you don't fall for this anti-White socialist bias Joe has.
@@scenopiachannel I honestly don't care for tribalistic politics.
The whole point of my intended work is to have us surpass all this bullshit of "If you don't vote for us, the other side will win!" from the campaigners, and the "If you don't support my team it means you support the opposition, and therefore are my enemy!" from the voters...
@Her Name But he is de facto anti-White (he's really just regurgitating anti-White narratives), he complains about Whites being for eugenics without giving context of how savage all other races were at the time. The same goes for his anti-White superiority comments, since all races think theirs is superior, but Whites were the only ones to invent the scientific method, implement the Roman rule of law, and abolish slavery when they were in complete planetary domination.
@@travelers8607 That would be fair if the Democrats weren't denying essential genetic science like the existence of subspecies or sex or inheritable behavioral proclivities.
@@scenopiachannel I'm not from the U.S.A, dude... Currently studying in the U.K.
IMO, both ends of the political spectrum are blind to what needs to be done.
Instead of racial politics being the primary topic of concern for you, have you paused to consider how we are fairly likely to witness the extinction of wild Tigers and Orangutans within our lifetime? If so, does it not concern you more that all of humanity generally doesn't seem to give enough of a shit to prevent this type of thing from happening?
I mean, the big potential for evilness and eugenics with human gene editing isn't about whether or not the modifications are forced, its about who has access to those modifications, particularly germline ones. If the rich are the only ones who can afford to modify themselves and their children with superior traits, then they're going to be doing that. I shouldn't have to spell out the scary implications of that, especially once the modifieds and their descendants start using their superior traits to justify going back down the eugenics road.
Not to say that debilitating genetic diseases shouldn't be fixed with the consent of those who are affected.
"Not to say that debilitating genetic diseases shouldn't be fixed with the consent of those who are affected."
What if they don't consent and want you to carry them and theirs?
I feel like it'll be the same as any new technology, that'll be the case for a while, sure. But eventually the technology will be more affordable. In the mean time, pretty sure genetic modification can't make someone bulletproof, so if anyone statts trying to bring back eugenics, well, you know.
They already can do that by just choosing a sexual partner. They already can choose to automate their business and get rid of some employee
The rich tend to sleep around a lot. I imagine those enhanced traits would start to surface in common populations quite soon. Even better the rich could be guinea pigs. If it goes wrong the common man is still healthy, If it works, wel as I said, they sleep around....
There's always been a breeding program where the wealthy get every genetic advantage evolution can create, and the unfit become increasingly unfit until they can't or don't have children. The fit take more wealth, mate with better people, and have superior offspring.
There will always be social stratification due to breeding. Gene editing can fix mutations but the complexity involved in creating a better human requires the sort of trial and error that only evolution provides.
I think the wealthy will have little reason to keep gene editing to themselves. If anything, they might want more effective workers. Providing free genetic treatment might become commonplace.
Do you know why he chose this video to promote Mack Weldon? Because you find them under jeans...
...Eh? Eh?
Oh jeans! It's like he's making a joke cuz the video is about genes! I get it 😂
Nice
Scott didn't bring the booty to 'show and tell' in his Weldon's 😔
One of the major problems with editing our dna to remove unwanted traits or inheritable disease is that we do not fully understand the interactions of the dna code and all it's outcomes. From what I understand, there isn't a code for just blue eyes. The same things in the code that give you blue eyes also interact with other code to give you say, darker skin for example.
So, until we fully understand exactly how all the code interacts and is interwoven like that, it is dangerous to alter the code.
I'm one of *6* type 1 diabetic siblings (the current world record) and would sure as hell like to not spend my entire paycheck on doctor visits and insulin. Not to mention being able to just regulate my own blood sugars and not have to deal with the plethora of other health issues that come with diabetes. I am all for this. Teach people ethics and responsibility, don't deny them options.
Check out the type 1 grit group
"science gives you the key , the same key can open gates of heaven and hell. It's up to you how to use it"
- idk someone
@Sabrina Redford - I Don't get thius Rsponce. Not only is He using Heaven and Hell Metaphorically, but I Don't see how what Tou said corrects His Point. It seems ot Agree with it.
That was Richard Feynman...
-idk that quote came from some book he wrote
That may be true, but you don't give the keys to your gun safe to a child, particularly not an unstable, sometimes dim, sometimes psychopathic child that likes to lick the glass at the supermarket. (Humans)
Oh, we're brilliant in a lot of ways, but if it only takes one well-trained, unstable, dim, psychopathic, glass-licking moron to kill us, I'm not so sure keeping guns (or knives for that matter) in the house is such a good idea...
Edit:
With that being said, immortality and an end to disease and hunger would be kind of nice...
The problem is that it takes much less time and effort to kill everyone than it would to do the rest of it. I can think of five ways off the top of my head.
I’m in medicine, haven’t watched the video yet, and I can absolutely confirm there’s a dark side to genetic editing. Gene editing in my profession is seen as a breakthrough. So much disease could be eradicated by it, including cystic fibrosis, sickle cell, some forms of hypertension, and way more. Using it to gain an unfair advantage in competition is a nightmare scenario.
@Joe Scott Thank you for bringing up some awareness on what people and their close ones are dealing with Huntington's disease. It would be really heart warming to see a video on most promising cures for this awful disease - something that would bring hope.
Another great video. Every week I watch the subscribers climb. Been watching for years, can't wait to see 1million. Good show old chap!
Touching on the most taboo subjects with dignity and grace 🖤 this is why we love Joe and this channel .
Fun fact: Mendel sent all his genetics research to Darwin, but after Darwin's death, the book was found still unpacked. Imagine how much would combining their research move science forward.
Science doesn't Progress that way, Realy, it depends on People. I DOubt Darwin would do much with Meels Work as back then, Scienc wasnot the Formal DIsipline we have today, and Darwin was not Patient with Gardening Eperiments.
@@skwills1629 maybe, but if he had read it he could've had it either added in part to his own work, or published it posthumously for him. Darwin could've also forwarded it to Wallace who might be been interested in how this applied to his work on biography.
@@garret1930 - Yeah but That's a Lot of maybes. I'm not Telling You to Think the Opposite here, I Just Hate Spurious Conclusions. Maybe Darwin simply never got round to Opening it.
WHo Knows?
@@skwills1629 true, I like alternative history speculation though, it helps to figure out what the real importance of an event (or lack thereof) was and to try and understand history a little better.
"People don't complain about cosmetic surgery" you are so naive people complain about everything
I did a DNA test and when I told my Dad he oddly said "you shouldn't have done that" and did not explain why. Probably got an old serial killer dad lol
That, or he is not your biological father
relativeus oh shit!!!
Some people worry about the companies that do the sequencing selling your data to insurance companies
@@relativeus...
Now he has to track down the milkman, and the mailman, etc... for testing.
@@redbeard8532 Oh my dude, the number of times I have seen this... I've been doing genealogy for 17 years I think it is now? Several years ago I started volunteering to help adoptees as well as people with an NPE (used to stand for Non Paternal Event, basically Daddy is not the Daddy but it happens on the maternal side too so...)
tl;dr your Dad was probs just worried about the "putting your DNA on the internet" thing, BUT if something wonky comes back I'd be happy to help you. *fistbump*
I just saw the list with Multiple Myeloma as one thing being researched.
My Mom passed away from that and I wish I still had her with me. I hope they find a way to give anyone facing such a diagnosis a fighting chance.
Love and miss her so much.
Awesome video again dude. I went home for a while to visit my family and cited some random fact from one of your old videos and my brother said, "I think I saw a video where a guy said that..." and then we realized we had both independently watched almost all of your videos without mentioning it to each other. Love the in depth coverage and that you are always thorough.
1:16 - it didn't change for those parents who chose to have kids knowing what they would be subjecting them too, though.
onlyonewhyphy such a selfish thing to inflict on your kids
@@sosig8332 Or hopeful? A lot of medical advances can be made in the 30-40 years between conceiving a child and the onset of Huntington's.
Life is such a selfish thing to inflict on someone atm, society will crash or we will have immortality in our life times. Its worth waiting to see
Aaaah society
It's called life.
I can't believe we are closer to becoming mutants than cyborgs
We already are both.
CRISPR vs Neuralink. Which one will win?
Don't worry, what we're closest to being is, extinct by our own actions.
You likely won't have to worry about having laser eyes or being part of a hive mind.
@@myscreen2urs They'll both work together.
@@kurtlindner Nah, how so? What could destroy us? Any threat we face we can manage except potentially AGI. Preconceived notions about extinction or Armageddon you may harbor are utterly unfounded.
My sister has Huntington. My niece was the 1st without it. I cried 2gen I found out. Truly tears of joy.
*Huntington's Disease...* I cringed when you mentioned that. My ex and her father died from it. It's a horrible way to go, both a physical and a mental illness, and very difficult for their loved ones as well.
My high school Spanish teacher had/has sickel cell anemia. He explained it to us and why he might be unavailable on some days.
It's caused by an adaption to malaria. One of the ladies from the band TLC also has it. I'm so happy to learn there's hope for them!
Joe, read "Old Man's War". Genetic editing plays a huge role in that. Remember, it's sci-fi so you have to allow for a bit of futurism in it.
Calan Darklighter Great story by John Scalzi
I don't know if that book is a positive or negative depiction of genome editing, but I would like to suggest the Commonwealth Saga und The Void series (continuation of the Commonwealth Saga) by Peter F. Hamilton. They're both one of my favourite book series of all time and in their universe, genetic manipulation is common place everywhere and everyone can have it done on them during their rejuvenation procedures. Of course there are problems, like some people work for multiple lives just to be able to afford their next rejuvenation, but that's a socialised healthcare problem, not a technology problem.
In my opinion it is one of the best examples in how we should try to use this technology and quite honestly, I hope it will be like this, because then I could still live to see the centuries to come (rejuvenation was invented in the 2050s).
I worked at a dog daycare for years and my favorite "regular" was a dog just like yours. An absolute asshole but my absolute favorite.
Man, Joe. You rock. Great video to brighten my morning. Was having a shitty time, now I'm not anymore.
"The road to hell is paved with good intentions."
As relevant now as when it was written.
Great in-depth video!
I remember the Mack Weldon commercial you did years ago, that was probably the best ad I’ve seen on RUclips. Certainly the most memorable.
The US did still practiced eugenics until '77 I believe.
Clearly I should have watched until the end, but but but, then it's hard to remember things I wanted to comment on
*still is.
Fixed that for ya. Even though forced sterilization was overturned in the 70's, coerced blackmailed sterilization is still practiced in the USA.
You could take notes.
@@allhumansarejusthuman.5776 lol thanks
@@craigcorson3036
I had this thought 😅
63 million black babies aborted because of the racism that is planned parenthood
Be sure to name rosalind franklin when talking about the understanding of the structure of DNA.
Came here to say this too.
@Ruthanne D'Antuono Stole? That is a strong word. According to this article (read it, it's quite interesting) there was no stealing. www.theguardian.com/science/2015/jun/23/sexism-in-science-did-watson-and-crick-really-steal-rosalind-franklins-data
The only one out of the 4 to actually have a degree in chemistry. She is too often overlooked.
My wife has Huntingtons Disease and is starting to be symptomatic and it’s absolutely devastating. We have kids also and didn’t know huntingtons was in her family until her mom was in end stages from it (drs previously thought it was Parkinson’s). Our only hope now is that the kids do not have it and it stops with my wife. I’d do anything to take this suffering away from my wife, it is such an absolutely unfair disease. She is such an amazing person and it’s sucking the life from her.
17:04 thank you so much for including the line “if they choose to”. many still don’t understand that NOT ALL people with disabilities want to be “fixed” or “cured”, we do just fine with what we’re were given. the problem often comes from the way society’s assumptions ABOUT disabilities affect us, not the effect of the disabilities themselves.
people don’t always get that many of us are perfectly capable of living our lives happy, if they would just stop making that so hard
Watching our mom suffer from degenerative arthritis, getting stiffer and in so much pain when she had been so busy and independent before. And my sister and I would say, "Previews of coming attractions." So true. My younger sister has diabetes like mom, my older sister has a fast heartbeat, like mom, and I have the arthritis making it harder to get around. Sigh.
Great video, thank you! Could you do a video on the abuses of psychiatry, both past and present, for example lobotomies and electric shock treatment which result in deaths across the world today? As well as the deaths resulting from psychiatric medication? Maybe how the fiction of “chemical imbalance” never originated with any successful before or after chemical tests in psychiatric treatments?
Great, now I need a "People gonna people." T-shirt (14:45)
"Nazis gave eugenics a bad name."
-Moviebob
No, its just bad. But thanks for playing...Bob, tell him what he's won! Well batmans pet goldfish, you win a chance to ogle some juicy dong wrapped in this weeks sponsors underpants, enjoy!
@@nathanweese3812 ???
@@nathanweese3812 ???
Yikes
One big person about the issue and problems with gene editing was Michael Crichton, who wrote books like Jurassic Park, The Lost World, and the Andromeda Strain. He gave a couple of interviews about his concerns about the power of gene editing, which inspired him to write those books. We even see his concerns about this power in the Jurassic park/ World movies as well.
Thanks, Joe. My wife has Huntington's and I'm the primary caretaker. Your presentation is exceptionally fair and balanced. Even though a cure will probably come too late for us, your admonition of not throwing out the baby with the bath water is spot on. Future generations will benefit from continued research.
Absolutely none whatsoever! *grabs coffee with octopus arm*
everything acquires a "dark side" the moment you add the human element to the equation.
;)
Fun fact: Sweden operated a Eugenecist policy into the 1970's.
Don’t many governments have similar policy’s except under a different name. Till this day
North Carolina had a racist eugenics program also.
even funner fact, the majority of eugenicist doctrine, including those of which used by Nazi Germany, were pioneered by American intellectuals and scientists
@@aeringothyk5445 No, I think we just know more about the US eugenicists. This was mainstream thought across the whole of the European left from 1880 onwards.
That explains ABBA.
Joe's face when he says "when I randomly pulled it out of the drawer in the morning I knew it was gonna be a good day"
Is priceless!
An answers with Joe that has an optimistic ending is a nice change of pace
Anything our species is involved with has a dark side eventually.
"Gattaca", "In Time", to an extent "Equilibrium"... Yes. There's absolutely a dark side. Because humanity will NEVER be able to be content. There will ALWAYS be those that abuse power.
That's why the power should be given to everybody. If you prohibid such tech, the rich and powerful will still have it.
Imagine when the algorithms go to work on large genetic data pools after the singularity?
I mean, the concept of contempt or satisfaction is something new, that may not be too far way from being widely available
look, 100 years ago there wasn't psychotherapy of any kind, today people with chronic depression can find some sort of comfort with their lives, same goes to many other mood disorders, and maybe coincidentally or not, today we have the greatest proportion of human populations living outside of war zones and/or poverty ever to exist
imagine 100 years from now
maybe some day, true satisfaction will be possible
@@jeremymenning56 it's hard to imagine what happens after the singularity, because we don't have the tiniest clue about how a general A.I. would behave.
@@lemonjuice1988 I agree. Once it takes off we won't be able to grasp that order of "thinking". Richard Feynman's answers on AI help to explain this to layman (which I am very much a layman).
Well Star Trek have the eugenic wars in its lore. It could happen.
Hey maybe I'll be Khan Noonien Singh
The humans in Star Trek do act radically differently from modern humans. Who’s to say there not abit of history is written by the victors thing going on there? 🤔
@@dayalasingh5853 Indeed. Racealtering khan as they did in "Into Darkness" is an outrage that destroyed a well designed villian.
KHAAAAAAANNNN!!!
@@jamesglenn4151 I have my own idea that a faction of augments won and survived the war. They lack physical augmentation but are hyper intelligent and working in the shadows. They may even have founded Section 31 to do the federations dirty work like removing troublemakers before they get dangeroues. They probably also horde technology for their own use like long range beaming. Voyager for example have at least two encounters with species capable of long range beaming. Sloans ability to just pop up from nowhere faster then a ship could take him hints that they possess this ability.
watching your videos feels like a conversation with an old friend
Also, as someone with a debilitating incurable illness with a genetic factor, this idea kind of gives me hope.
Huntingtons is like having Alzheimers, Parkinsons, and schizophrenia.
"Good intentions"?
My mother had a saying,
"The road to hell is paved with good intentions"
I would totally use genetic engineering artistically. Change my genes to "cocoon" me and emerge as a gargoyle or a vampire looking dude. That would be awesome!
Would you still provide for yourself?
Would you still have instincts to `other-ize outsiders of your type?
Me too I want some fucking horns
Would you be cool with the locals shooting you because you scared the hell out of them and they thought you were the devil?
do it amigo. CRISPR is cheap. Just google the-odin.com
You can easily change organisms (though I would advise you not to change anything with potential consciousness) as an art project
@@incognitotorpedo42 yes. If that's how I go out, that's how I go out.
Damn, this is a real good summary of my family's problems 😅 my grandfathers mother had huntington, she had 7 sons, 3 had it, 4 did not.
My grandpa was one of the lucky ones. It was the worst for the youngest who did have it though. He didn't get tested and was kind of paranoid for years, untill the symptoms started to show and he knew exactly what was comming as two of his brothers had already been going through it. There is still a part of the family left now that may have it, they have kids too. No one is sure if they are tested, we don't see them too often either so I have no idea if any signs have started to show yet. No one dares to really ask to be honest.
Is it responsible for them to have had kids even with that chance of passing on a horrible disease? Or would it be unfair to test and abord a child if they have the disease? You'd just take away a whole life, because they have a disease that only shows later in life. Would that life be worth it though, is it fair for a parent to make that decision? It remains tough. I'm just glad I was born on the good 50% side.
Once I saw "Gattaca" I knew the is where we were going. Fact is, business is in the business of making money not products. To make money you must maximize price while minimizing costs. Your raw material cost too much, the company changes vendors or changes the raw material. If the companies employees cost too much the company looks for ways to minimize the need for them. And employees that the company must hire need to cost as little as possible. Never hire someone that is eventually going to cost more than they are worth to the company. It's just business unless it's you be passed over. Genetics will be used in the most horrific ways it can be by businesses just trying to make a profit.
Joe: Does genetic editing have a dark side?
Me: Did you ever see Gattaca?
Awesome movie. Another good movie that wouldn´t be made today. No "i" in the name though, they made the title by only using letters gene pairs are marked. A, T, C, G
@@uegvdczuVF I didn't know that, thank you!
Amazing movie.
@@uegvdczuVF I have no idea how I never noticed this. TY
Don't get me wrong, I liked the movie. However, if we were that scientifically advanced then surely we could of helped the non genetically altered dude with his asthma and any other issues he had?
Thanks, this has been exactly my view on the whole eugenics / gene editing concept. Don't throw the baby out with the bathwater.
we are already actively selecting for some people/DNA sequences over others.
Yup.
Abortions and IVF are essentially a brute force method of gene editing.
Embryo might have a chance of not developing properly? *toilet flush noises*
End of 1st trimester check up:
Baby's heart is growing outside his rib cage?
*suction goes vvvvvvrrrrrrr*
Just like how early GMO crops involved literally blasting the seeds with massive doses of radiation and seeing what happened.
This just takes the guesswork out of the equationand turns it into a neat 1+1=2 scenario
This is how I feel about ms (or at least the disease that my father and grandfather died from that doctors called ms to finally give something a name). It terrifies me that there is a possibility to give it to my kids. Luckily my brother and I seem to have lived past the beginning ages in early to mid 30s. But our combined 5 kids? I’ll be mortified if in 20 years I start seeing signs in them. I’ve seen it destroy 2 people, my grandfather worse, technology and treatment were better for my father, but far from great. Before he died he had limited ability to move his head and talk plus very limited mobility in his left arm. My grandfather could only mumble and move his head around a little. Terrible, just terrible.
5:33 - Apparently RUclips's auto-captions just convert audio to text phonetically because when Joe misspoke and said thalamessia instead of thalassemia, the auto-captions wrote what he said instead of using the context to correct it.
The thalamessia comment broke me! 😩
I'd want to know. If I got the gene defects for Huntington's I'd know not to have children. It's a horrible way to die.
Yeah that's fuckrd up ppl who knowingly would have kids like that instead of adoptin.. so selfish
@@jjcoola998 symptoms usually don't show up til you're too old to have kids, so until quite recently, you didn't know you had it until it was too late.
Some people think having been born is better than not having been born. We all die, and it's often unpleasant. Are 50 good years worth 10 awful ones?
@@sarasmr4278 Even if the symptoms show up lately, your parents may have already shown them by the time you are old enough to have kids, and of they didn't, with current technology, anyone should just get themselves checked
Reach4
As I have replied on several other posts, even without any genetic-editing whatsoever, many genetic diseases are being avoided nowadays by using IVF treatments and, then, only implanting the embryos that will not have the disease. This becomes even better when embryos can be implanted that will neither have nor carry the disease. The latter breaks the cycle right there.
@@RCSVirginia I have no problem whatever with genetic engineering, provided it is guided and overseen by scientific councils, not the government. That said, I'd still want to know if I had genetic defects with a high likelihood of being passed on.
I don't know what an "Arnold Palmer" is, but I'm guessing it's roughly equal parts (American) lemonade and (sweet) iced tea.
Yes
And it turns out you *do* know what and Arnold Palmer is!
Hey, Joe, have you recently changed the lens on your camera? The picture seems quite a bit nicer now with that bokeh effect and slightly bigger frame
Great video Joe, your introduction to artificial evolution is spot on (I use the same approach when introducing artificial evolutionary algorithms), and the rest of the video was engaging!
I have been peeling the layers off this can of worms for a while now, thanks to you BTW, it gets verry complicated fast. We do not understand or even come close to understanding the actual language of the genetic code. Our guesses are getting better, and clearly we can generally spot blatent annomolies, but the subtle stuff usually eludes us. Social issues are not trivial either. Still working on that video....
Stay safe, stay healthy.
To be fair though Joe. Everything has a dark side.
Join the dark side...
This is the way.
...we have cookies! ;-)
@@anonymous_bacon2383 This is the way. #shinyarmorftw
@1:28, it's not an "ethical quandary" for a rightwinger.
They would insist that the you have the child, regardless of any factors whatsoever.
Well the duhmerican /western "left" better shape up then...
@SLCPunked fearmonger
@@cee8mee you misspelled facts.
@@toserveman9317 would you care to clarify that remark?
the right, just like the left, is a very comlpex construct, and not everybody is against/ cares about abortion.
That is mostly a religious, not a political issue
(what makes a human/is there a soul)
My religious parents don’t appreciate this at all xD
Im religious as well but I wouldn’t say no to blue eyes xD
I prefer my Black Eyes. With that said, Everyone is Religious, the illusion of Non-Religion is us making Definitions up that don't apply.
@@skwills1629 what do you mean illusion of non-religious?
@@mmmmmmolly - A Religion is nothing more than a Philosophy one Believes in and Lives by. It is a Framework used to Understand Our existence e and Values and Culture. It gives us Identity and Focus. It isn't something hat was Created, and it snot something Some people don't Have. This is also why Militant Atheists attack Religion, they want You to follow their religion. They also insist we see them as Non-Religious, because they want to Shield their Beliefs from the same Critisisms they give to others b Pretending not to Have beliefs, even though its Obvious that they do.
@@skwills1629 i understand what you mean but I have to disagree. Religion is defined as the service and worship of God or the supernatural, and people who don't believe in a god can still have a belief system based on their values and moral code and not be religious.
For the militant atheists, I don't really have any experience with such a group, but as with pretty much any organization, there will be extremists that don't represent the majority. Belief does not equal religion in my opinion. (This doesn't relate to the topic but are you German?)
@@mmmmmmolly - Can People Please Stop using The Dictionary Definition Argument? It gets Old. Itsa not like Any of You bother to Look it up in The Dictionary, a Popular Atheist's popularised the use of it and now People Blindly repeat it. But what You said isn't True. Religion is not Defined as the service and worship of God or the supernatural. When Bill Maher said this, He Lied, because the Dictionary He got this From has Six definitions for Religion. Why is it then that This is presented as the Only Definition?
en.wikipedia.org/wiki/Definition_of_religion
The Word Religion has several Definitions. Pretending it has One Universally Agreed Upon meaning is Ridiculous.
Militant Atheism is also not an Orginization, Rather it is a Type of Atheist defined by their Hostility.
As for me, I Am American of English Background.
Sometimes I have no intelligent, relevant comment cause you cover the subject so well, or I'm just done thinkin' for the day, but I like for RUclips to know that I think your channel is extremely valuable and entertaining both.
And, awwwwww, your dog!!
this really needs a followup video - like would having digitized families have a dark side (like digital children, spouses, oneself, etc.)
Unfortunately joe, I’m not at a point in my life where I can justify spending $34 on a single pair of underwear. Not trying to hurt your brand deals or anything but yeah
Then don't lol
Anthony Hutchins I know right it's a fucking add read dudes acting like it's a personal crusade of Joe's or some shit
I'm at the point in my life when I CAN afford to spend $34 on a single pair of underwear. I just choose not to because that's stupid.
jjcoola998 lol guy, you’re taking this comment way more seriously than anyone ever should
At my point in life my future underwear will be ... well it depends.
"the moment mankind took the wheel from mother nature" and promptly drove into every power poll along the road... sorry spoiler alert!
"I Dream Of Genie"...
*i dream of a better world where chickens can cross roads without having their motivations being questioned by others*
josh setnik it’s released first on nebula I believe but also if you’re a member and donate to his channel you get early access either way. I signed up for curiosity stream a couple months back through joes channel and it came with Nebula which has his and other youtubers vids in there before RUclips. Curiosity steam is genuinely awesome and only a couple bucks a month(not a sponsor) lol
@josh setnik bro this guy has membership of channel you can watch video earlier before upload
That doppler joke, that actually made me lol, joe. That and the pug...damn you Joe! You always make me chuckle at least once a video.
I’m glad someone put some info out there for Huntington’s disease
"Ctrl+F and Ctrl+R"? Ctrl+H you mean?
Google it
My biggest worry for GE is that whole swaths of people (including myself) do or have dealt with some form of disability. I fear that through removing the suffering that these things have cause, will we see a dark side of people who aren't propelled to get better at something.
Basically, I don't think people can get better at anything without struggle and suffering. And if we remove a vector in which that suffering causes inspiration or abilities in people. Then will those kind of people simply find something else, or (more likely) will people just not receive/design a purpose or goal in life at the same extremes people with disability
Or more simply, if a particular mental disorder (genetically caused) is removed, we remove the possibility that the state of mind of that person might be perfectly suited for a very specific thing.
Limiting that person's potential in that thing, the only next question is that also limiting them as a whole or in just that one thing
"AND ONCE THAT GENNIE'S OUT OF THE BOTTLE!!-"
"I can cure you, too."
"Okay, I'm in."
It was a little hard to catch but I love that you said “might could” in this. “We might could even alter our bodies..”. I don’t know…I just loved it hahah
I love learning about genetic engineering, as a biology student, it is just mind blowing to me we can actually edit DNA. Hopefully we can use this along with other therapies to get rid of cancer and other disabilities. Anyways great video
Imagine in future everybody is a beautiful super human being
Frankie Boyle would still look ugly. No matter what
All for that!
Imagine how much easier space exploration would be, if we adapted to space/mars etc.
Competitive capitalists: *Harnessed the electricity you use, created the car you drive, the platform you post videos on, the technology you use to make videos, etc, etc, etc.*
Pfft... *Capitalists*...
I just want a dog that will live for twenty years.
Get a small race. They live that long.
One thing I REALLY love about your videos is that you don't explain your jokes! Thank you for assuming we're not dummasses!
My mother and auntie died of huntingtons. Me and my wife have just gone through PGD to ensure that my son won't contract it. I'm so grateful for the science that allowed me to do this so I don't possible give him this horrible disease
also im guessing u havent used a dating app. eugenics is alive and well.
In Gattaca, the technology works perfectly. (I only watched the movie, so I'm working based on that.) It's absolutely flawless. No negative side effects in the tech. The problem of Gattaca is the society. The society judges you based on your genetics, rather than in who you really are. This causes some seriously negative effects.
The dangers of Gattaca are honestly relatively easy to avoid, with just a little bit of honest perspective and awareness. It's amazing how many people just bring up Gattaca as a way to say "Gene therapy is bad!" That wasn't the message of the movie. (Although I really should read the book.)
I have been born with both a clef lip and clef pallet, I must say. I often have thought how lucky I was to be born in the 1980's, when medical techniques made corrective surgery's, though, painful, and many in number over a bit over a dozen years, possible, and in my case luckily, very effective. To the point that after all the surgery and another decade or so of practicing speaking, I have to tell people I have a speech impediment / clef pallet when they ask me what part of the country I am from or where I get my accent. I would certainly be very happy with the idea of not having a child with such a condition, but, would i terminate a pregnancy over such? No, the experience gave me a very strong character and taught me to look past superficiality from a very very young age, and the many deep connections I have made along my path in life with such a large amount of people wouldn't be possible if not for the struggles and challenges both physically and socially that come with working through such an experience. However, if given the option, would I allow my offspring to have the "offending" genetic sequence "corrected". Certainly. Spare the suffering and pain, and teach them, hopefully, from my own. I endorse corrective genetic editing, applied carefully and ethically.
Just a credit note: Watson & Crick BUT also let's credit the much overlooked Rosalind Franklin for her double helix insights. I note that the originators of CRISPR are also rarely credited: Jennifer Doudna and Emmanuelle Charpentier (I believe the latter now holds the patent along with UC and the University of Vienna). It would be nice to see folks get credit they deserve. Keep up the good work Joe
What scares me as a disabled and neurodivergent person is the subjective idea of what is and isn’t supposed to be cured. I believe only degenerative and terminal diseases should be edited out of genes, but I’ve heard the argument multiple times of people wanting to cure autism and Down syndrome for example. Those don’t need curing. We don’t need to be eradicated, we need a society that understands and accepts us better. I’ve heard people say if they could test their child for autism in the womb that they would abort them. I’m pro choice, but that is just ableism and eugenics. I fear where people will draw the line and disabled people’s opinions on this are never taken seriously because after all we are the ones they’re discussing erasing from the future. I would love to not have the genetic predisposition to cancer and Alzheimer’s in my family. I’d love to not have ehlers danlos, but at what point is too far? People need to accept and accommodate certain disorders like autism rather than trying to cure them. All of the problems associated with it could be fixed by doing that, so why cure it? It’s a fine line and I just hope this technology doesn’t get into the wrong people’s hands. It would be amazing and life changing to live in a world with no more cancer!!! So many people I know would still be alive or wouldn’t have destroyed their health and wealth to cure it. It worries me to think that people feel that way about something that poses no real risk. I don’t know if I really worded this right by I’m sleep deprived lol