I want to thank you for talking about the strengths and advantages of the ++ COMT allele. Far too many discussions of this gene present it as a curse or a marker of inferiority. Even the "Warrior Vs. Worrier" name seems like a derogatory way of presenting it as inferior. No parent is going to hope and pray that their child becomes a "Worrier" instead of a "Warrior"!
COMT ++ and slow MAO on all of them. What I can say, that I still able to drink coffee and energy drinks, however, I do feel super focused and sometimes indeed you get sad. Hard to focus from too much dopamine sometimes too! Thanks for sharing!
I’m comt +/+. I feel on top of the world when I drink coffee but it also obliterates me in the end with stress, tension, anxiety & insomnia. I’m a thinker. I go on high highs, but will also go on low lows. I’ve always had insomnia since young. Epsom salt baths are my savior. Exercise & stretching really helps reduce my stress levels.
@@pinksupremacy6076 You have to run the raw data from 23 and me through another analytical site such as Genetic Genie or Nutrahacker, They show you how.
@@pinksupremacy6076 I did a genetics test I believe it was called genetics rx. It was a while back I’m sure there are a lot of genetic tests out there now that have the comt option to test for.
Yes, please do a -/- video. There are not many, and hardly and websites with solid information on it. I've been studying by watching +/+ videos and assuming I should just do the opposite.
Thank you for the suggestion! Lots of things are indeed the opposite... try to engage in more brain stimulating activities, caffeine and chocolate are your friends. But of course other things like avoiding xenoestrogens, getting enough protein with each meal, prioritizing sleep, etc. are going to be the same for both groups 😉
Can a slow ++ comt expression cause extreme fatigue? Exercise intolerance? Arthritis? Sugar cravings? What happens if you have the MTHFR along with slow comt expression, which supplements and foods should you eat and which to avoid?
@@gif24gt60 I have COMT ++ and strongly suspect adrenal fatigue. I was a workaholic and really pounded the coffee for years. You might want to look into adrenal fatigue especially videos on the Dr Hyman channel. Dr. Elizabeth Boham on his channel talks about it.
Im also COMT ++ . When I learnt that so many things in my life made sense! I have trouble falling asleep at night, it feels like my nervous system gets “overwhelmed “ at the end of the day even when tired. I also get VERY stressed by little things. I’ve learned they did studies on stress with army jet pilot and COMT ++ type pilots that had lots of training outperformed by far everyone in highly stressful scenarios. It gives me hope I can learn to manage my stress and get better with time. I also have TERRIBLE pms problems, makes so much sense it would be related. I’ll investigate more into that. I never heard about magnesium supplements, i will look into that! Also, i’m an Hypersensitive Person, i wonder if there might be a correlation with COMT ++ ? Would you also happen to be one? Anyway super interesting video!
Hey, thanks for your comment and sharing! So great that you're aware of your genetics! There's definitely so much you can do. Magnesium for sure! Magnesium glycerinate in the morning + magnesium L-threonate in the evening is my favorite way to do it. I would also highly recommend going over to our website and checking out our Reishi Mushroom & Ashwagandha extracts for part of your evening routine. Here's a link to a video I made about all the best things you can do during the day to help with sleep... hope some of this will be helpful for you too! ruclips.net/video/cdvn3aWCdWE/видео.html Regarding PMS, it's a great idea to get a full hormone panel done to understand where you're out of balance so you know what hormones need to be increased or decreased. And on being a hypersensitive person... I don't think I would qualify as one myself. This is of course something that is both genetic and environmental in origin. There are multiple genes involved and COMT could be a contributing factor. Two other interesting genes for this are ADRA2b and 5-HTTLPR. Glad you enjoyed the video!
Being COMT ++, I’m also curious if as I use supplements and try to adjust my lifestyle to better suit my sensitivities if my personality may shift some, feeling so sensitive to stress and how it affects me I believe has increased my introversion, I think feeling better overall could actually shift me more towards the middle, which I would welcome.
Great video! Things make so much more sense, I have both variations of COMT and both are ++. This explains why I do sooo much better without coffee and will make it easier for me to stop slipping up and drinking it now that I understand.
Thanks for taking the time to leave such a nice comment! I know what you mean, it really does make things click when you understand how this gene is affecting the way your body works!
Thank you for getting straight to the point. Are there any supplements one could take with the slow Comt? Hopefully you’ve got other videos I’ve got both c677t homozygous MTHFR and homozygous comt im struggling bad. I was in an accident & having to learn all the stuff is very difficult since concussion. I’m trying to fix myself on my own so far. I have found a doctors in Oklahoma that do it for guidance.
I am a female with one warrior and one worrier gene. I read on my Promethease report that, for all intents and purposes, the mixed model tracks as warrior? I generally feel I resonate more as a warrior I have inattentive adhd and complex PTSD. My filter is generally intact in polite conversation but when being challenged or threatened I’m *very*reactionary. Logic and reason go out the window and I see red. I recognize that it’s actually harmful, especially as a modern day City denizen. I am trying to learn how to better self-regulate. My mother is schizophrenic, she had an abrupt break around age 30. I was 12 when it happened, but we had many stressors before that (poverty, alcoholic father who abandoned us, etc.) Though I love her and she loved ME the best she could, the trauma from growing up with her illness still complicates my adult life and I am in treatment. When I was small I would go into flight mode as a means of self-preservation. I was given a depression diagnosis and was miserable until I was more properly diagnosed and began treatment years later at 43. This makes me want to look at her report to confirm her COMT status . She did have a higher genetic likelihood of folate deficiencies, which also ties in with susceptibility to developing schizophrenia. Very interesting. I can only hope to become more mindful and less reactionary. I have the genes, but knowing about them gives me more power in that I can better proactively self-regulate.
What a great video - so much of what you've described matches my experience as well. I hadn't tied in the caffeine with the genetics, but it so makes sense. Thanks so much
🫛❤️❗️ This is SO interesting to know that you're a ++ as well! I'm apologize for getting in the way of the fun of coffee, I know how much you enjoy it! For me at least, I can't emphasize enough how much it takes me down emotionally for days after.
So cool that even your boss noticed it with you! Yeah, once you realize the connection to the "filter" you can almost start picking out who of your family and friends has the - - , +- and ++ forms of the gene!
What you said at 3:32 might be the explanation for a lot of my problems. I always knew I had an issue with coffee, but I couldn't understand what. I knew that if I would take a too strong coffee late in the day I would have a hard time falling sleep, but I didn't realize that this effect could last for days! And that may be the explanation for my low motivation for studying and work that I have, despite having all signals of high dopamine and norepinephrine. Thank you!
I have ++, same issue exactly with caffeine. Curious if phosphadidyl serine or tmg would help. Magnesium bisglycinate and vit c are really helpful. Ashwaganda and Reishi at night help with sleep but sometimes I feel "hung over" in the am. Epsom salt bath and pm meditation help a lot with sleep.
Hi, this is such a helpful video, thank you. I’m wondering if you could advise what supplements to take with these gene mutations… A lack of MTHFR, HMNT, DAO and also +\+ for COMT. I’m trying to add in natural mast cell stabilisers but keep getting stuck because they interact with my comt gene. For example, quercitin and luetolin are amazing for helping histamines but will make my comt gene even slower.
I’m ++ as well. I can’t drink coffee or any stimulants due to not being able to sleep for 2 or more days in a row or getting tachycardia. High sex drive all my life. Falling asleep has always been a task. My fiancé says that my blood has cocaine lol. I thrive in high stress work environments as long as my job is not one of dealing with human emotions. People drama, personal problems, moodiness and lack of common sense at work really dry’s me out and fries me emotionally. I struggle understanding how people need to be motivated to do things and most don’t know what they want and have no idea how to get what they want. Now I can see that it may have a genetic component 👍🏼✨
At 56 I can tell u what it’s like to have full expression of this and not know it. It ain’t pretty. Oddly, I was drawn to a lot of the fixes…no soy, no plastic, working out daily. Very informative video.
COMT v158M & H62H +/+, coffee feels like that movie Limitless for like 2 days, and then the Worse migraines of my life. Thank you for shinning a light in the right direction with supplements. My doctors don’t have a clue about many of my symptoms
Oh yeah, I know exactly what you mean with the coffee! The come down is no fun... But it's kind of cool to know that in an emergency you can turn yourself into a superpowered version of yourself for a couple of days 😆 Hope some of the info in here will be helpful for you!
I am having problems with drive, low mood, life enjoyment etc, I have been prescribed Adderall so I can work, which works great, but destroys my mood the days after and I feel much worse, everything sucks. I am COMT ++ and it doesnt sound like me because my symptoms sound more like - -, but your comment about caffeine might be really important, which is why I shared about adderall and how I know it brings me way down after. I didnt drink coffee until I was 25 or so and everyone was like I cant believe you dont drink coffee, but I just didnt need it. I went through a phase where I was staying up late and getting up early so I started drinking coffee, and now I drink coffee and energy drinks all the time. Its possible the constant everyday all day caffeine is giving me an adderall like dopamine crash the next day, but since its every day it a non stop low grade depression situation? I'm going to try and quit caffeine and see what happens, this could potentially be big, thanks for the video!
Thanks for the video. I noticed you didn't mention diet in terms of macronutrients. Do you also recommend low protein as protein increases dopamine even further? What about fat and carb? I can't eat many carbs due to an oxalate sensitivity, so kind of in a hard position having slow COMT.
I just came across this video after receiving my genetic test showing I have the COMT++. This explains so much! I’ve had anxiety and insomnia my entire adult life. I also have a horrible reaction to matcha…which I now understand. Thank you for making this video. I don’t feel like such a crazy person anymore. Taking steps to improve my situation!
How interesting! I'm so glad you found this video! Do you take magnesium by any chance? Keep me posted on your progress, I'm curious to hear what you change and what differences you notice!
@@addictivewellness I do take magnesium. But, I think I need to take a higher dose spread throughout the day. I’ve noticed glycine and L Theanine at night also helps. Thank you again!
Great info Sage! I am already doing all the things you mentioned. so It's good to know I am on the right track!! I also have CYP1A2 so I am drinking decaf brewed with a couple grams of regular grounds for a little boost when I need it and then taper back down. I am happy to watch any videos you make about genes)
Hey James! That's great to hear you're already well on top of it! And you're a slow metabolizer of caffeine too - an intense combination! haha Thanks so much for the support!
How do you know if you are a ++ or the other variants. My daughter had a gene test saying she has the COMPT gene break, but not sure it shows details on the parts you shared
Thank you for the informative video! I didn’t know that with exercice I can burn through the neurotransmitters .. i love exercising, well it’s more like I’m addicted to it because if I don’t I won’t be able to stay emotionally and mentally stable. I always thought this was because of lack of dopamine but it could be excess dopamine 😮 Wish I could be tested but in my country I can’t 😢
I’m extremely confused as I find myself from both ends of the spectrum, but I think I’m naturally on the +\+ side even though I’m quite sensitive (I haven’t done any testing, but I think I’m going to at some point). What confuses me more is that L-tyrosine seems to be a gamechanger for me but it’s normally recommended for the -/- type 🤷♂️
I also have the ++ COMT. Its interesting that yku mention feeling great for one dat and then like crap for days after. This seems to be a regular occurrence for me. I drink a lot of coffee and sometimes tea, black and green. It would be miracle to feel more balanced!
Now, I seem to understand my condition. I'm struggling with my sleep at night. I've stopped caffeine and have dairy milk instead but still there are nights that my mind won't shut down. So, i will try exercise and maybe more exposure to sunlight. Thank you for this. If you can make a video on COMT -/-, i'd love to watch it since I'm not sure which to categorize myself.
Great video! Thank you Sage. My genetic test showed GG on COMT, so I’m unsure what that means, do you or anyone else know if that is normal, -/- or +/+? Thanks so much!
Hi Dede! Glad you enjoyed the video, thank you very much for your kind words! You would be -/-, so here's the video you'll want to watch: ruclips.net/video/5gNlR-CyMf4/видео.html
My report came out. It says I have COMT ( GG ) gene. I just can't rest but I developed addictions on maryjuana because that was the only thing that calmed me down but over the years, it has slowed me down. And yes the up and downs, the PMS are all real! and I've been called a machine, a human battery, a workaholic and I also can't take care of myself. I can work all day long without a break. I create a great impact but I burnt myself out.
++ here, but I dont have excess dopamine levels. Far from it, my levels are super low and my prolactins are subsequently sky high. I have a pituitary tumour which is possibly causing the hormone imbalance. But hope to regulate my dopamine with the intention of getting my pituitary functioning better. Mentioned in your list of things i should try is magnesium glycinate, magnesium l-threonate, fosfatydyloseryna, but there was two other supplements mentioned? Couldnt quite work out what they were. Appreciate if anyone could let me know. Thank you
Interesting, my daughter is +/+ and things come out of her mouth, she has DMDD, and ADHD. Seems like she matches more with -/- more then +/+. She also needs 12 hours of sleep and can go right to sleep.
Confusing with the plus plus slow - my genetic test results show homozygous val/val - so I had to listen for a while and realized that you were talking met/met according to the test I took. So I'm just the opposite with very low dopamine, high stress tolerance and high pain tolerance. Do you have a video on that genetic mutation?
It's weird,I just got test done saying I have this mutation.And besides from the Extreme stress.I can't Relate. I relate more with the low dopa Symptoms.Now am all kind of Confused.Any help?
Hmm... interesting! I'd be curious if: 1. The test result was erroneous 2. You may have read the result wrong 3. You may have other elements of your health, genetics, or lifestyle that so negatively influence your dopamine that they outweigh the effects of a COMT ++ gene
I think I have the warrior gene 🤔 I drink tea like 5 times a day and don't have any problems? Sometimes I drink coffee 3 times a day? And I feel normal and unaffected? I also have been arrested for possession of weapons.
you have me cracking up about the weapons possession! 😂 a warrior indeed. I'd love for you to watch the other video I made about the warrior gene and see if you think it describes you well! ruclips.net/video/5gNlR-CyMf4/видео.html
@@addictivewellness it was found out that people who carry the MAOA gene were significantly more likely to join a gang or use weapons. Also the GG combination was found significantly higher among MMA fighters vs normal population. I read see articles that also said that carriers of the MAOA gene tend to have higher levels of empathy.
Just found out from my report I not only am MTHFR c677T, but COMT ++, im already tweaking my supplements and looking into how to better improve my diet, i am very curious to know my husband’s results too, he and I are very different in how we handle stress and worry, he falls instantly to sleep regularly, I can’t fall asleep for hours even when exhausted especially if my workday was stressful, I need a big wind down to go bed, he just lays his head on the pillow. I tend to worry easily and let’s just say he lets me handle the worry, cause it’s just not his thing, 😂
I have 3 COMT genes. two are ++ and one is reg +/- I can handle coffee...but not green tea things. That took me forever to figure out that it isnt for eveyone. What about Tulsi Holy Basil? I feel like I have a bit of the worrier and the warrior. Isn't there also a conccection to Neanderthal genetics? There is for me and I thought the COMT/MAO was at the heart of it, but it has been a while. There is schizo in the family. The family member never totally fit that Dx and was one of the kindest and loving people.
I have breast cancer that is 100% estrogen driven even after hysterectomy. I was just told that I have a slow COMT enzyme. I know there is a connection but Dr's don't get it. What is the best to take... magnesium g and B complex? Please help.
I'm so sorry to hear about your breast cancer. It does make sense that being a poor methylator, you would have a hard time detoxifying estrogen. I'm definitely not a doctor and definitely not an oncologist, so I can't tell you what to do. All I can say is what I would do if I had breast cancer, which is cut out all sugar and carbs, eat an organic low-medium protein diet and take Turkey Tail, Chaga w/ betulin, Reishi, Cordyceps, Lion's Mane, liposomal Vitamin C, B Complex, weekly IV drips of high dose vitamin C and glutathione, Meriva Curcumin Phytosomes, liposomal D3/K2, DIM, Maitake D Fraction, Krill Oil, fresh broccoli sprouts, freshly ground flax, black cumin seed oil, liposomal melatonin (make quality sleep a top priority) and magnesium glycerinate and magnesium l threonate. I would also use the infrared sauna and hyperbaric chamber as often as possible, ideally every day. 🙏🏼
I’ve tried a host of supplements including magnesium glycinate/ threonate , Lithium orotate , glycine, Choline , adaptogens ie ashwaghanda Bacopa etc to no avail, I haven’t tried TMG/betaine yet though I’m unsure how I’d handle methylated compounds, a course I discovered recently suggested completely eliminating coffee / tea / chocolate which I’ve done since rvebekty but don’t feel any difference , they suggested it may take several weeks to feel any difference, supposedly chocolate contains tyramine and amphetamines like substances which hinder MAO activity and maybwreak havoc on vulnerable individuals, I’ve consumed it my entire life. I’m not sure what else to do, I’ve become increasingly more paranoid and irritated over a prologued period of time which had become more pronounced after dabbling with psychoactive substances (marijuana in particular) I’m 24. Irrespective of my mental symptoms, my estrogen and homocysteine is low.
@@addictivewellness I rechecked my gene report and I am actually ++. I was confused because few months ago I asked doctor to try Ritalin and it works like a magic. How come the amphetamine, i. e. Dopamine and NE stimulant works for me, slow COMT guy. I love (probably everybody) the high dopamine periods. I think we can swing between the two and probably COMT is not the only thing which matters. I guess if you cannot make enough Dopamine it does not matter how fast you can break it. Heeeelp! So confusing.
@@addictivewellness Yes, I took a genetic test. It indicated that I have COMT Met/Met. Also, I have ADRA2A, which reduces my response to the ADHD medications. And it could be a good thing since ADHD meds are not really good for COMT ++.
A potential dietary protocol tailored to slow COMT activity ?: Low protein, low phenol sulfurous cruciferous vegetables supplemented with magnesium glycinate vitamin C and possibly samE
@@addictivewellnessI’ve tried a host of supplements including magnesium glycinate/ threonate , Lithium orotate , glycine, Choline , adaptogens ie ashwaghanda Bacopa etc to no avail, I haven’t tried TMG/betaine yet though I’m unsure how I’d handle methylated compounds, a course I discovered recently suggested completely eliminating coffee / tea / chocolate which I’ve done since rvebekty but don’t feel any difference , they suggested it may take several weeks to feel any difference, supposedly chocolate contains tyramine and amphetamines like substances which hinder MAO activity and maybwreak havoc on vulnerable individuals, I’ve consumed it my entire life. I’m not sure what else to do, I’ve become increasingly more paranoid and irritated over a prologued period of time which had become more pronounced after dabbling with psychoactive substances (marijuana in particular) I’m 24. Irrespective of my mental symptoms, my estrogen and homocysteine is low.
Consult with a functional medicine doctor specializing in genetics, but it if was me, as a starting point I would avoid high tyramine foods and go all out on stress management (exercise, meditation, sleep, magnesium, reishi mushroom, ashwagandha). And consider supplements like omega 3s and b vitamins that can also support neurotransmitter balance.
Im gonna describe my symptoms and if someone could help me that'd be great. I have trouble focusing for long periods, I'm always late to things, ive been diagnosed with adhd. I have a bad temper. I also struggle keeping things clean and have struggled with addictions. I basically am always wanting a dopamine fix somehow. I also can get depressed easily at times
Hey Koby, sorry to hear things have been so challenging for you. I'm glad to see you also found the other video on COMT - -, as that definitely sounds more like you.
@@addictivewellness met/met genes are good at studying, val/val genes are good at sports, what about us val/met genes we aren't good at studying or sports, how to improve our stress ressistant in stressful situations and if want to learn something how to improve our focus and concentrate?
@@addictivewellness keep up with mini doses of folate and eat folate rich foods. I'm also seeing a functional dr to help me through this process of getting better despite my genes.
I have the contrary the supposed warrior kind... homozygothic to that. due to my low brain power I have an degree in mathematics... ;) I speak 5 languages... you are +/+ I guess I am -/- ... With stress you are not better, and I excel with stress situations... :D
Well that's great proof that there's certainly more than 1 gene that determines our reality and our destiny! Yes, I'm sure you are able to perform under stress with much more precision than I am. I'm working on language #4, trying to catch up to you! 😄 Huge respect! 🙌🏼
I want to thank you for talking about the strengths and advantages of the ++ COMT allele. Far too many discussions of this gene present it as a curse or a marker of inferiority. Even the "Warrior Vs. Worrier" name seems like a derogatory way of presenting it as inferior. No parent is going to hope and pray that their child becomes a "Worrier" instead of a "Warrior"!
Thanks for this video! So difficult to find good information on COMT +/+
COMT ++ and slow MAO on all of them. What I can say, that I still able to drink coffee and energy drinks, however, I do feel super focused and sometimes indeed you get sad. Hard to focus from too much dopamine sometimes too! Thanks for sharing!
I’m comt +/+. I feel on top of the world when I drink coffee but it also obliterates me in the end with stress, tension, anxiety & insomnia.
I’m a thinker. I go on high highs, but will also go on low lows.
I’ve always had insomnia since young. Epsom salt baths are my savior. Exercise & stretching really helps reduce my stress levels.
Unfair
How can you tell if you have it or not in e.g 23andme?
@@pinksupremacy6076 You have to run the raw data from 23 and me through another analytical site such as Genetic Genie or Nutrahacker, They show you how.
@@pinksupremacy6076 I did a genetics test I believe it was called genetics rx. It was a while back I’m sure there are a lot of genetic tests out there now that have the comt option to test for.
Sounds bipolar to me? I was diagnosed this but also have COMT Val/val, which I believe is ++… also heterozygous MTHFR.
Yes, please do a -/- video. There are not many, and hardly and websites with solid information on it. I've been studying by watching +/+ videos and assuming I should just do the opposite.
Thank you for the suggestion! Lots of things are indeed the opposite... try to engage in more brain stimulating activities, caffeine and chocolate are your friends. But of course other things like avoiding xenoestrogens, getting enough protein with each meal, prioritizing sleep, etc. are going to be the same for both groups 😉
Can a slow ++ comt expression cause extreme fatigue? Exercise intolerance? Arthritis? Sugar cravings?
What happens if you have the MTHFR along with slow comt expression, which supplements and foods should you eat and which to avoid?
@@gif24gt60 I have COMT ++ and strongly suspect adrenal fatigue. I was a workaholic and really pounded the coffee for years. You might want to look into adrenal fatigue especially videos on the Dr Hyman channel. Dr. Elizabeth Boham on his channel talks about it.
Im also COMT ++ . When I learnt that so many things in my life made sense! I have trouble falling asleep at night, it feels like my nervous system gets “overwhelmed “ at the end of the day even when tired. I also get VERY stressed by little things. I’ve learned they did studies on stress with army jet pilot and COMT ++ type pilots that had lots of training outperformed by far everyone in highly stressful scenarios. It gives me hope I can learn to manage my stress and get better with time.
I also have TERRIBLE pms problems, makes so much sense it would be related. I’ll investigate more into that.
I never heard about magnesium supplements, i will look into that!
Also, i’m an Hypersensitive Person, i wonder if there might be a correlation with COMT ++ ? Would you also happen to be one?
Anyway super interesting video!
Hey, thanks for your comment and sharing! So great that you're aware of your genetics! There's definitely so much you can do. Magnesium for sure! Magnesium glycerinate in the morning + magnesium L-threonate in the evening is my favorite way to do it. I would also highly recommend going over to our website and checking out our Reishi Mushroom & Ashwagandha extracts for part of your evening routine. Here's a link to a video I made about all the best things you can do during the day to help with sleep... hope some of this will be helpful for you too! ruclips.net/video/cdvn3aWCdWE/видео.html
Regarding PMS, it's a great idea to get a full hormone panel done to understand where you're out of balance so you know what hormones need to be increased or decreased.
And on being a hypersensitive person... I don't think I would qualify as one myself. This is of course something that is both genetic and environmental in origin. There are multiple genes involved and COMT could be a contributing factor. Two other interesting genes for this are ADRA2b and 5-HTTLPR.
Glad you enjoyed the video!
@@addictivewellness Interesting you mentioned Ashwagandha.. I have severe insomnia with this as well as holy basil.. COMT ++ and MTHFR++
Holy crap, I can relate 100% to every issue you just described.
Being COMT ++, I’m also curious if as I use supplements and try to adjust my lifestyle to better suit my sensitivities if my personality may shift some, feeling so sensitive to stress and how it affects me I believe has increased my introversion, I think feeling better overall could actually shift me more towards the middle, which I would welcome.
I too am comt ++ suffering severe insomnia, nothing seems to help
I have this warrior gene. I was in Iraq as a soldier for many years & actually loved my job. I love MMA & combat sports of all kinds.
So you have comt -- not like in this video
Great video! Things make so much more sense, I have both variations of COMT and both are ++. This explains why I do sooo much better without coffee and will make it easier for me to stop slipping up and drinking it now that I understand.
Thanks for taking the time to leave such a nice comment! I know what you mean, it really does make things click when you understand how this gene is affecting the way your body works!
You’re the best Sage. Thanks for sharing all your wonderful insights.
Thank you for getting straight to the point. Are there any supplements one could take with the slow Comt? Hopefully you’ve got other videos I’ve got both c677t homozygous MTHFR and homozygous comt im struggling bad. I was in an accident & having to learn all the stuff is very difficult since concussion. I’m trying to fix myself on my own so far. I have found a doctors in Oklahoma that do it for guidance.
I am a female with one warrior and one worrier gene. I read on my Promethease report that, for all intents and purposes, the mixed model tracks as warrior? I generally feel I resonate more as a warrior
I have inattentive adhd and complex PTSD. My filter is generally intact in polite conversation but when being challenged or threatened I’m *very*reactionary. Logic and reason go out the window and I see red. I recognize that it’s actually harmful, especially as a modern day City denizen. I am trying to learn how to better self-regulate.
My mother is schizophrenic, she had an abrupt break around age 30. I was 12 when it happened, but we had many stressors before that (poverty, alcoholic father who abandoned us, etc.) Though I love her and she loved ME the best she could, the trauma from growing up with her illness still complicates my adult life and I am in treatment. When I was small I would go into flight mode as a means of self-preservation. I was given a depression diagnosis and was miserable until I was more properly diagnosed and began treatment years later at 43.
This makes me want to look at her report to confirm her COMT status . She did have a higher genetic likelihood of folate deficiencies, which also ties in with susceptibility to developing schizophrenia.
Very interesting. I can only hope to become more mindful and less reactionary. I have the genes, but knowing about them gives me more power in that I can better proactively self-regulate.
What a great video - so much of what you've described matches my experience as well. I hadn't tied in the caffeine with the genetics, but it so makes sense. Thanks so much
🫛❤️❗️ This is SO interesting to know that you're a ++ as well! I'm apologize for getting in the way of the fun of coffee, I know how much you enjoy it! For me at least, I can't emphasize enough how much it takes me down emotionally for days after.
The strong filter thing makes sense. I was asked by a boss how I do that. I had no idea biology played a part.
So cool that even your boss noticed it with you! Yeah, once you realize the connection to the "filter" you can almost start picking out who of your family and friends has the - - , +- and ++ forms of the gene!
What you said at 3:32 might be the explanation for a lot of my problems. I always knew I had an issue with coffee, but I couldn't understand what. I knew that if I would take a too strong coffee late in the day I would have a hard time falling sleep, but I didn't realize that this effect could last for days! And that may be the explanation for my low motivation for studying and work that I have, despite having all signals of high dopamine and norepinephrine. Thank you!
I have ++, same issue exactly with caffeine. Curious if phosphadidyl serine or tmg would help. Magnesium bisglycinate and vit c are really helpful. Ashwaganda and Reishi at night help with sleep but sometimes I feel "hung over" in the am. Epsom salt bath and pm meditation help a lot with sleep.
Hi, this is such a helpful video, thank you. I’m wondering if you could advise what supplements to take with these gene mutations…
A lack of MTHFR, HMNT, DAO and also +\+ for COMT.
I’m trying to add in natural mast cell stabilisers but keep getting stuck because they interact with my comt gene. For example, quercitin and luetolin are amazing for helping histamines but will make my comt gene even slower.
Thanks Hayley, I'm glad you enjoyed the video! I think you might enjoy this one on DAO and MCAS 😊 ruclips.net/video/YHSPIMPWBWU/видео.html
I’m ++ as well. I can’t drink coffee or any stimulants due to not being able to sleep for 2 or more days in a row or getting tachycardia. High sex drive all my life. Falling asleep has always been a task. My fiancé says that my blood has cocaine lol. I thrive in high stress work environments as long as my job is not one of dealing with human emotions. People drama, personal problems, moodiness and lack of common sense at work really dry’s me out and fries me emotionally. I struggle understanding how people need to be motivated to do things and most don’t know what they want and have no idea how to get what they want. Now I can see that it may have a genetic component 👍🏼✨
People with slow COMT should limit their protein intake. Can you recommend any protein that I can take daily? I try to gain mass :c
At 56 I can tell u what it’s like to have full expression of this and not know it. It ain’t pretty. Oddly, I was drawn to a lot of the fixes…no soy, no plastic, working out daily. Very informative video.
COMT v158M & H62H +/+, coffee feels like that movie Limitless for like 2 days, and then the Worse migraines of my life. Thank you for shinning a light in the right direction with supplements. My doctors don’t have a clue about many of my symptoms
Oh yeah, I know exactly what you mean with the coffee! The come down is no fun... But it's kind of cool to know that in an emergency you can turn yourself into a superpowered version of yourself for a couple of days 😆 Hope some of the info in here will be helpful for you!
Doctors what a joke
Really appreciate this video! Explains so much.
My pleasure, I'm glad you found it helpful Leann! Thanks for the good vibes!
I am having problems with drive, low mood, life enjoyment etc, I have been prescribed Adderall so I can work, which works great, but destroys my mood the days after and I feel much worse, everything sucks. I am COMT ++ and it doesnt sound like me because my symptoms sound more like - -, but your comment about caffeine might be really important, which is why I shared about adderall and how I know it brings me way down after. I didnt drink coffee until I was 25 or so and everyone was like I cant believe you dont drink coffee, but I just didnt need it. I went through a phase where I was staying up late and getting up early so I started drinking coffee, and now I drink coffee and energy drinks all the time. Its possible the constant everyday all day caffeine is giving me an adderall like dopamine crash the next day, but since its every day it a non stop low grade depression situation? I'm going to try and quit caffeine and see what happens, this could potentially be big, thanks for the video!
Thank you so much for making this video💜🙏🏼💚
My pleasure! I'm so happy to know you enjoyed it!
Thanks for the video. I noticed you didn't mention diet in terms of macronutrients. Do you also recommend low protein as protein increases dopamine even further? What about fat and carb? I can't eat many carbs due to an oxalate sensitivity, so kind of in a hard position having slow COMT.
I just came across this video after receiving my genetic test showing I have the COMT++. This explains so much! I’ve had anxiety and insomnia my entire adult life. I also have a horrible reaction to matcha…which I now understand. Thank you for making this video. I don’t feel like such a crazy person anymore. Taking steps to improve my situation!
How interesting! I'm so glad you found this video! Do you take magnesium by any chance? Keep me posted on your progress, I'm curious to hear what you change and what differences you notice!
@@addictivewellness I do take magnesium. But, I think I need to take a higher dose spread throughout the day. I’ve noticed glycine and L Theanine at night also helps. Thank you again!
Great info Sage! I am already doing all the things you mentioned. so It's good to know I am on the right track!! I also have CYP1A2 so I am drinking decaf brewed with a couple grams of regular grounds for a little boost when I need it and then taper back down. I am happy to watch any videos you make about genes)
Hey James! That's great to hear you're already well on top of it! And you're a slow metabolizer of caffeine too - an intense combination! haha Thanks so much for the support!
How do you know if you are a ++ or the other variants. My daughter had a gene test saying she has the COMPT gene break, but not sure it shows details on the parts you shared
Thank you. PLEASE make video about - - COMT
Here you go! ruclips.net/video/5gNlR-CyMf4/видео.html
this is so interesting!!
Thanks Sofia! I'm glad you enjoyed the video!
Thank you for the informative video!
I didn’t know that with exercice I can burn through the neurotransmitters ..
i love exercising, well it’s more like I’m addicted to it because if I don’t I won’t be able to stay emotionally and mentally stable.
I always thought this was because of lack of dopamine but it could be excess dopamine 😮
Wish I could be tested but in my country I can’t 😢
I’m extremely confused as I find myself from both ends of the spectrum, but I think I’m naturally on the +\+ side even though I’m quite sensitive (I haven’t done any testing, but I think I’m going to at some point). What confuses me more is that L-tyrosine seems to be a gamechanger for me but it’s normally recommended for the -/- type 🤷♂️
I also have the ++ COMT. Its interesting that yku mention feeling great for one dat and then like crap for days after. This seems to be a regular occurrence for me.
I drink a lot of coffee and sometimes tea, black and green. It would be miracle to feel more balanced!
If you decide to take a break from coffee for a while, let me know how it goes! I'm curious to hear what your experience will be like!
Now, I seem to understand my condition. I'm struggling with my sleep at night. I've stopped caffeine and have dairy milk instead but still there are nights that my mind won't shut down. So, i will try exercise and maybe more exposure to sunlight. Thank you for this.
If you can make a video on COMT -/-, i'd love to watch it since I'm not sure which to categorize myself.
Here's the link to the -/- video 😊 ruclips.net/video/5gNlR-CyMf4/видео.html
very interesting
What test do you recommend to find out
Great video! Thank you Sage. My genetic test showed GG on COMT, so I’m unsure what that means, do you or anyone else know if that is normal, -/- or +/+? Thanks so much!
Hi Dede! Glad you enjoyed the video, thank you very much for your kind words! You would be -/-, so here's the video you'll want to watch: ruclips.net/video/5gNlR-CyMf4/видео.html
My report came out. It says I have COMT ( GG ) gene. I just can't rest but I developed addictions on maryjuana because that was the only thing that calmed me down but over the years, it has slowed me down. And yes the up and downs, the PMS are all real! and I've been called a machine, a human battery, a workaholic and I also can't take care of myself. I can work all day long without a break. I create a great impact but I burnt myself out.
thank you for sharing your experience! I hope you'll be able to use some of the things I shared in this video to help you take good care of yourself!
I have the warrior gene and I can relate to the description of choosing words carefully. Also I am a workaholic
Are you sure you have the warrior and not the worrier gene? It sounds much more like the worrier that you're describing (I'm the worrier too)
I’d Val Val positive positive or negative negative ? Thank you
++ here, but I dont have excess dopamine levels. Far from it, my levels are super low and my prolactins are subsequently sky high. I have a pituitary tumour which is possibly causing the hormone imbalance. But hope to regulate my dopamine with the intention of getting my pituitary functioning better. Mentioned in your list of things i should try is magnesium glycinate, magnesium l-threonate, fosfatydyloseryna, but there was two other supplements mentioned? Couldnt quite work out what they were. Appreciate if anyone could let me know. Thank you
Interesting, my daughter is +/+ and things come out of her mouth, she has DMDD, and ADHD. Seems like she matches more with -/- more then +/+. She also needs 12 hours of sleep and can go right to sleep.
Interesting! Well it goes to show that there can certainly be more than just one gene that shapes someone's personality and behavior!
Confusing with the plus plus slow - my genetic test results show homozygous val/val - so I had to listen for a while and realized that you were talking met/met according to the test I took. So I'm just the opposite with very low dopamine, high stress tolerance and high pain tolerance. Do you have a video on that genetic mutation?
Sorry for the confusion... here's the one you're looking for! ruclips.net/video/5gNlR-CyMf4/видео.html
It's weird,I just got test done saying I have this mutation.And besides from the Extreme stress.I can't Relate. I relate more with the low dopa Symptoms.Now am all kind of Confused.Any help?
Hmm... interesting! I'd be curious if:
1. The test result was erroneous
2. You may have read the result wrong
3. You may have other elements of your health, genetics, or lifestyle that so negatively influence your dopamine that they outweigh the effects of a COMT ++ gene
I think I have the warrior gene 🤔 I drink tea like 5 times a day and don't have any problems?
Sometimes I drink coffee 3 times a day? And I feel normal and unaffected?
I also have been arrested for possession of weapons.
you have me cracking up about the weapons possession! 😂 a warrior indeed. I'd love for you to watch the other video I made about the warrior gene and see if you think it describes you well! ruclips.net/video/5gNlR-CyMf4/видео.html
@@addictivewellness it was found out that people who carry the MAOA gene were significantly more likely to join a gang or use weapons.
Also the GG combination was found significantly higher among MMA fighters vs normal population.
I read see articles that also said that carriers of the MAOA gene tend to have higher levels of empathy.
Just found out from my report I not only am MTHFR c677T, but COMT ++, im already tweaking my supplements and looking into how to better improve my diet, i am very curious to know my husband’s results too, he and I are very different in how we handle stress and worry, he falls instantly to sleep regularly, I can’t fall asleep for hours even when exhausted especially if my workday was stressful, I need a big wind down to go bed, he just lays his head on the pillow. I tend to worry easily and let’s just say he lets me handle the worry, cause it’s just not his thing, 😂
How interesting! I wonder if he's a COMT -- Would be curious to see! Hope the adjustments you make for yourself end up being helpful! :)
Would you please comment on CMC minus minus ? Thank you.
When you say CMC minus minus, do you perhaps mean COMT - - ? If so, here you go! ruclips.net/video/5gNlR-CyMf4/видео.html
What happens if u have both comt and mthfr?
That's me! But I'm not sure what you mean exactly when you say "what happens"? Both can benefit from methylation support
I have 3 COMT genes. two are ++ and one is reg +/-
I can handle coffee...but not green tea things. That took me forever to figure out that it isnt for eveyone. What about Tulsi Holy Basil? I feel like I have a bit of the worrier and the warrior. Isn't there also a conccection to Neanderthal genetics? There is for me and I thought the COMT/MAO was at the heart of it, but it has been a while. There is schizo in the family. The family member never totally fit that Dx and was one of the kindest and loving people.
I have breast cancer that is 100% estrogen driven even after hysterectomy. I was just told that I have a slow COMT enzyme. I know there is a connection but Dr's don't get it. What is the best to take... magnesium g and B complex? Please help.
I'm so sorry to hear about your breast cancer. It does make sense that being a poor methylator, you would have a hard time detoxifying estrogen. I'm definitely not a doctor and definitely not an oncologist, so I can't tell you what to do. All I can say is what I would do if I had breast cancer, which is cut out all sugar and carbs, eat an organic low-medium protein diet and take Turkey Tail, Chaga w/ betulin, Reishi, Cordyceps, Lion's Mane, liposomal Vitamin C, B Complex, weekly IV drips of high dose vitamin C and glutathione, Meriva Curcumin Phytosomes, liposomal D3/K2, DIM, Maitake D Fraction, Krill Oil, fresh broccoli sprouts, freshly ground flax, black cumin seed oil, liposomal melatonin (make quality sleep a top priority) and magnesium glycerinate and magnesium l threonate. I would also use the infrared sauna and hyperbaric chamber as often as possible, ideally every day. 🙏🏼
I’ve tried a host of supplements including magnesium glycinate/ threonate , Lithium orotate , glycine, Choline , adaptogens ie ashwaghanda Bacopa etc to no avail, I haven’t tried TMG/betaine yet though I’m unsure how I’d handle methylated compounds, a course I discovered recently suggested completely eliminating coffee / tea / chocolate which I’ve done since rvebekty but don’t feel any difference , they suggested it may take several weeks to feel any difference, supposedly chocolate contains tyramine and amphetamines like substances which hinder MAO activity and maybwreak havoc on vulnerable individuals, I’ve consumed it my entire life. I’m not sure what else to do, I’ve become increasingly more paranoid and irritated over a prologued period of time which had become more pronounced after dabbling with psychoactive substances (marijuana in particular) I’m 24. Irrespective of my mental symptoms, my estrogen and homocysteine is low.
thank you sir
Most welcome!
Please, please - - COMT
Thank you for the request! Will do this very soon! Be sure to subscribe to our channel so you don't miss it 😉
@@addictivewellness I rechecked my gene report and I am actually ++. I was confused because few months ago I asked doctor to try Ritalin and it works like a magic. How come the amphetamine, i. e. Dopamine and NE stimulant works for me, slow COMT guy. I love (probably everybody) the high dopamine periods. I think we can swing between the two and probably COMT is not the only thing which matters. I guess if you cannot make enough Dopamine it does not matter how fast you can break it. Heeeelp! So confusing.
Me with COMT +/+ and ADD: “What did you say about the focus and memory? I didn’t pay attention, and already forgot.”
wow, interesting! are you sure you're ++?
@@addictivewellness Yes, I took a genetic test. It indicated that I have COMT Met/Met. Also, I have ADRA2A, which reduces my response to the ADHD medications. And it could be a good thing since ADHD meds are not really good for COMT ++.
@@itsalexhello9804 there are no stimulant ADHD meds.
@@studentaccount4354 adderall is one of the most popular ADHD meds
@itsalexhello9804 That's me too!! Have you been successful with any non-stimulant med? I'm trialing Intuniv....
A potential dietary protocol tailored to slow COMT activity ?:
Low protein, low phenol sulfurous cruciferous vegetables supplemented with magnesium glycinate vitamin C and possibly samE
I'd go for SamE only as a last resort and with medical guidance... TMG/Betaine is something I would use first to help with methylation.
@@addictivewellnessI’ve tried a host of supplements including magnesium glycinate/ threonate , Lithium orotate , glycine, Choline , adaptogens ie ashwaghanda Bacopa etc to no avail, I haven’t tried TMG/betaine yet though I’m unsure how I’d handle methylated compounds, a course I discovered recently suggested completely eliminating coffee / tea / chocolate which I’ve done since rvebekty but don’t feel any difference , they suggested it may take several weeks to feel any difference, supposedly chocolate contains tyramine and amphetamines like substances which hinder MAO activity and maybwreak havoc on vulnerable individuals, I’ve consumed it my entire life. I’m not sure what else to do, I’ve become increasingly more paranoid and irritated over a prologued period of time which had become more pronounced after dabbling with psychoactive substances (marijuana in particular) I’m 24. Irrespective of my mental symptoms, my estrogen and homocysteine is low.
Thnx
So ++ COMT is worrier?
I know it's not best name but I'm familiar with it that way.
Yes that's correct, ++ is the worrier.
i have +/+ and never could do coffee
I can 100% relate!
what to do about slow Mao-A and fast Comt together. can't work it out.
Consult with a functional medicine doctor specializing in genetics, but it if was me, as a starting point I would avoid high tyramine foods and go all out on stress management (exercise, meditation, sleep, magnesium, reishi mushroom, ashwagandha). And consider supplements like omega 3s and b vitamins that can also support neurotransmitter balance.
You are literally me.
Q: is AA the same as ++?
Hi Glen! Yes, that's correct
Im gonna describe my symptoms and if someone could help me that'd be great. I have trouble focusing for long periods, I'm always late to things, ive been diagnosed with adhd. I have a bad temper. I also struggle keeping things clean and have struggled with addictions. I basically am always wanting a dopamine fix somehow. I also can get depressed easily at times
Another thing is I've always had trouble holding jobs. Idk if that's relevant
Hey Koby, sorry to hear things have been so challenging for you. I'm glad to see you also found the other video on COMT - -, as that definitely sounds more like you.
Please COMT -/- video, hardly any information out there.
Thank you Alisa, I'll be making a video on this very soon!
Just posted! :) ruclips.net/video/5gNlR-CyMf4/видео.html
Is the ++ always AA?
yes
How do you know if your ++
Have you ever had a genetic test done?
Yes, please do -/- !!!
Here you go! 😊 ruclips.net/video/5gNlR-CyMf4/видео.html
Guys how to fix +- gene? Does anyone know?
Can you please expand on what it is you feel you need to “fix?”
@@addictivewellness met/met genes are good at studying, val/val genes are good at sports, what about us val/met genes we aren't good at studying or sports, how to improve our stress ressistant in stressful situations and if want to learn something how to improve our focus and concentrate?
++ is the homogeneous Met Gene right?
Yes, the ++ COMT is also sometimes called the ValMet polymorphism 😊
This is the worrier gene.
Is CoMT ++ the worrier or warrior, all I know is warrior is Val, Val.
++ is the worrier... you are the warrior, so you'll want to watch this video: ruclips.net/video/5gNlR-CyMf4/видео.html
Is Val Val positive or minus ? Thank you
I have 2 comt gene mutations, both are ++. Help!
Ok! Of the things I shared in this video, what do you plan to do?
@@addictivewellness keep up with mini doses of folate and eat folate rich foods. I'm also seeing a functional dr to help me through this process of getting better despite my genes.
I have the contrary the supposed warrior kind... homozygothic to that. due to my low brain power I have an degree in mathematics... ;) I speak 5 languages... you are +/+ I guess I am -/- ... With stress you are not better, and I excel with stress situations... :D
Well that's great proof that there's certainly more than 1 gene that determines our reality and our destiny! Yes, I'm sure you are able to perform under stress with much more precision than I am. I'm working on language #4, trying to catch up to you! 😄 Huge respect! 🙌🏼
9l😊
999😊l