TDM-105795, a new hair loss treatment that actually works!
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- Опубликовано: 5 июл 2024
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Sources:
1. Inc HM. Positive Outcome from a Phase Ib Study in Australia Treating Patients with Androgenic Alopecia. Accessed January 15, 2024. www.prnewswire.com/news-relea...
2. Medicines T. Technoderma Medicines Initiates TDM-105795 Androgenetic Alopecia Phase 2 Clinical Trial. Accessed June 4, 2023. www.prnewswire.com/news-relea...
3. Medicines T. Technoderma Medicines Phase 2 Clinical Trial of TDM-105795 Demonstrates Hair Growth in Androgenetic Alopecia. Accessed February 6, 2024. www.prnewswire.com/news-relea...
4. Randall VA, Ebling FJ. Seasonal changes in human hair growth. Br J Dermatol. 1991;124(2):146-151. doi:10.1111/j.1365-2133.1991.tb00423.x
5. Billoni N, Buan B, Gautier B, Gaillard O, Mahé YF, Bernard BA. Thyroid hormone receptor beta1 is expressed in the human hair follicle. Br J Dermatol. 2000;142(4):645-652. doi:10.1046/j.1365-2133.2000.03408.x
6. Miller FG, Colloca L, Kaptchuk TJ. The placebo effect: illness and interpersonal healing. Perspectives in biology and medicine. 2009;52(4):518. doi:10.1353/pbm.0.0115
7. Li JJ, Mitchell LH, Dow RL. Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorg Med Chem Lett. 2010;20(1):306-308. doi:10.1016/j.bmcl.2009.10.109
8. Rastrelli G, Corona G, Maggi M. The role of prolactin in andrology: what is new? Rev Endocr Metab Disord. 2015;16(3):233-248. doi:10.1007/s11154-015-9322-3
9. Hernandez I, Bott SW, Patel AS, et al. Pricing of monoclonal antibody therapies: higher if used for cancer? Am J Manag Care. 2018;24(2):109-112.
10. Al-Chalabi M, Bass AN, Alsalman I. Physiology, Prolactin. In: StatPearls. StatPearls Publishing; 2024. Accessed February 7, 2024. www.ncbi.nlm.nih.gov/books/NBK... 
Хобби
Sup, chooms! People have been asking me my thoughts on Bryan Johnson's latest hair loss video. I'd rather not disclose my opinions about it in the comment section so I will be making a response video to it soon.
Looking forward to it !
try not to Cook him like you do Dr Trash or u will stress him out so badly he will go Telogen effluvium lol
is your stack listed somewhere?
Hey Kev! Could you comment on this paper: PMC7308241 next?:)
I cannot really come to terms with the kidney evidence i found so far on fin.
Do you have a website or post anywhere that tells us hair challenged what's the best we can do with what's available to us today...
babe wake up, new experimental hairloss treatment just dropped
"Honey...that would've helped you 15 years ago. Now go back to sleep."
@szilardfineascovasa6144 " But 15 years ago my ex wife's boyfriend told me that I had to use saw palmetto and broccoli sprouts to save my hair. He said it's ThE ThEOry ThAt ExPLAin EveRyTHiNg ! "
@@exactly1176 "That's gold, Jerry! Gold!"
😂😂😂
@@szilardfineascovasa6144 😂😂😂
"2010... the same year Mass Effect 2 Came Out." This place is awesome
Thank you foe keeping us up to date! You are the GOAT!
Thanks Choom! Only channel I trust to breakdown the latest hair loss news
The best channel Kevin.Thats for sure!
love your energy brother
The best channel by far Kevin!
Cant wait for your “Leg day” video!!
Kevin , your hair looks really good ! i'm very excited towards every hair loss treatment , i'd say that a Lifetime Maintenance Treatment who works on 99% of people would already be enough to see Hair loss as a thing of the past !
Thank you Dr. Solus!!!
Thank you for this video and for keeping us up to date! I hope this one works and comes out before my hair is gone 😩😭
Same😅
Great News. Thanks. Will we be seeing it on the gray market soon?
I'm kind of sad to have only discovered your channel at the age of 20, but at the same time I'm happy that I'll now be well informed during this long fight.
20 is still early, unless you're already a NW3
@@nighteyes360 Nw1 but had agressive thinning and some rarefaction on the crown.
Young bro I wish such channel existed when I WAS 20 back in 2006. You have no idea how lucky YOU ARE to have so much info readily available in the palm of your hand.
did you hop on fin? Is it working?@@manigold3221
@@nighteyes360 17 and norwood 3 what do you think after 10 years there will be any cure or i have to suicide
I really really really hope this can become available soon! I seem to get nothing from minoxidil and having a great alternative stimulant would be amazing.
I just want to say thanks Kevin! I began balding at 17 and it really destroyed my confidence as a young man. I'm 23 now, and I've almost completely reversed my hairloss with finasteride, min (mixed with tretinioin), and microneedling. You've been with me in this journey since day 1. Every month, things keep getting better for me. Thank you, thank you, thank you!
The fact it destroyed ur confidence is a good thing. It means you have a functioning brain and understand the importance of aesthetics
I got thinning faded coloured hair at 17 but literally gave no fks because i was dumb enougj to genuinely fall for the Cope that looks don’t matter. 😳
Where do you purchase your tretinioin if you don’t mind me asking? I need to get on mixing it with my minoxidil. Currently 6 months into fin and have been seeing amazing results. Started minoxidil like a solid year before I hopped on finasteride (I’m 20 btw)
I also micro needle and use essential oils, both around twice a week
@@maalikserebryakov ”understand the importance of aesthetics” 🤓
@julianparra1350 I get tret from a dermatologists prescription. I have acne though so it's easy. dont think you can get this OTC in the USA
Wish me luck and prayers chooms. I have an appointment with my dermatologist next week and I'm going to look into starting dutasteride since can help with dermatitis/sebum. I've been fighting seborrheic dermatitis since last November and I'm still a norwood 1, but I notice my density has changed a bit in the vertex/crown area. It's time to fight a good fight and keep my hair.
You've got this.
After using finasteride for 1 year i switched to dutasteride and dutasteride cured my seborrheic dermatitis. I hope it works for you too.
@Washed1 I appreciate it a lot! How's your experience so far with dutasteride? I'm looking at starting 0.5 mg daily. Generic brand
New to the channel; Thank you so much, you saved me from the fin fearmongering! Just one question as new viewer: Is there some deeper channel lore about Haircafe and "Dim Fool"?
The best thumbnails around!
The GOAT of the industry
Great video Kevin. Even for us 14,469 hair transplanted Norwood 7’s who can’t tolerate Finasteride, it’s great to hear some positive news. Keeping the donor (and recipient scalp area) growing as we age is still important. Luckily 5mg of oral minoxidil has made a huge improvement to my scalp and beard hair. But a second kicker would not go astray. Thanks as always for sharing! 🙏
Even with this treatment, if you aren’t on finasteride, you will go Norwood 7 again with 100% certainty. You might want to reconsider whether to get on finasteride-at least until a replacement is available. Several are in the pipeline.
@@amalekited Actually, he won't. The transplanted hair is resistant to DHT so it will not fall off again. The only hair that would have kept falling would have been the one behind his transplanted hair in the DHT sensible areas, but given that he was a Norwood 7 I highly doubt he'll see considerable recession, if any at all.
So you got your hairline back and don't have to take fin? That's great!
Pyrilutamide was also looking good in phase 2, what's different now?
I'm happy btw, just curious
Since it has a different mechanism of action than Minoxidil is there a chance that the TDM gains could be maintained with an 5 AR inhibitor?
Your finasteride videos are lifesaving man! I dont have any recession/thinning and I haven't started fin yet, but I plan to after puberty since ik baldings prob gonna happen. Cant thank you enough for removing any anxiety I have! U just destroy every doubt that i have about potential ed, gyno, depression, etc.
Sorry if this is a stupid question someone's asked before, but i can't help but worry about this pubmed article I saw by Dr. Mohit Khera. Where DNA is damaged, causing differential gene expression? (cant send link in case yt deletes comment). Did u make a vid about this because I cant seem to find it when googling?
I think you are referring to this article, Differential Gene Expression in Post-Finasteride Syndrome Patients? Just reply with the title, not a link if it's a different article you mean. Dr. Khera has written a lot of PFS related articles, and he was the subject of an interview with Dr. Attia that I did this video on, ruclips.net/video/DG2jeY-Feq4/видео.html
Basically the study compared up regulation and down regulation of genes in penis foreskins of men with erectile dysfunction claiming to have PFS, versus completely healthy men. The problem with the study is that erectile dysfunction from any cause could cause differential gene expression versus healthy men. The fact that these men at one time took finasteride doesn't show that either their erectile dysfunction or the gene expression changes were due to finasteride. For all we know ED from any cause could have caused changes in gene expression. There's no way from the study design to conclude that finasteride caused the changes in gene expression.
@@haircafekevin yea thats the study, thanks for clearing that up man. Do u have any advice on how to find reputable sources that don't subtly try to imply causation like in this study? Honestly thought pubmed was a reputable source and im not sure how to distinguish good sources from dumb ones like journals that encourage bludflow
Legend 👌
These research names are so crazy like yeah lemme just apply some JX283e-71 to my head
“Leg training to promote hair growth”
i damn near fell off my chair laughing at that sh*t 🤣🤣🤣
First time hearing about this. Sounds really promising. Thanks Kevin.
Do you reckon you'll ever do a video on liposomal topical finasteride? I've heard some good things but there seems to be relatively little info out there. Would love to hear your take on it.
Thanks again :)
Maybe, but I haven't seen any particularly good research on it.
A lot of its alleged benefits beyond standard topical finasteride seem theoretical and unproven.
It might be worth exploring nevertheless, but it isn't a huge priority right now.
@@haircafekevin Fair enough. Hard to assess something for which there's very little good studies eh. I might do my own little experiment with it to see how I respond. Thanks Kevin :)
Hi Kevin has nothing to do with the video. But I found Minoxidil solution in my cupboard. It was unopened, but the bottle says it is good until February 2024. Can Minoxidil still be used even if the expiration date has passed?
A few hours ago, Bryan Johnson had a video on his channel called "How I Reversed My Hair Loss + Greying"
In the video, he mentioned that he uses microneedling and that him and his team were a bit worried that he was causing too much trauma to his scalp. Using information on learned from your channel, I made a comment advising him and others to use tretinoin instead and how it was a more effective, less scalp-damaging alternative to microneedling. I mentioned two of your videos and mentioned your channel for people to check out.
While I agree with 99% of what Kevin says in regards to hair loss, I have to say, I've been using a dermapen once a week @ 1.5mm for the last 3 months in conjunction with topical minoxidil and I must say, I've been noticing some significant gains. Not one to tell people what they should or should not do, but I wouldn't knock it until you try it, you might be surprised. Cheers 🍻
Try ceasing the use of minoxidil, and you'll see. There is no evidence whatsoever to support the efficacy of microneedling as a standalone treatment.
@@evansheridan0491
@@evansheridan0491minoxidil is doing 99% of the weightlifting there.
@@evansheridan0491 I normally am not one to tell people what to do either, but since he did say that he is concerned that is scalp is experiencing trauma due to microneedling, I gave him a suggestion of something else he could do and gave him some information so he and anyone else could look at it if they were interested. This is not to say that microneedling will damage everyone's scalp that uses it or that it does absolutely nothing.
Bryan Johnson is the world’s biggest larper
Hey Kevin, do you think finasteride or dut could maintain hair growth promoted by tdm?
Hello Kevin, what can I use to style my hair harmlessly?
Awesome video as always. Thanks to you I started taking finasteride 7 months ago, 0 sides but I’m still losing ground and way below baseline. Keeping my hopes up and hope to see improvement by 12 months, if not moving to dut.
I switched to dutasteride. Even if finasteride is working, dutasteride will always give better results. Anyway, don’t be worried about initial hair loss-that’s actually a great indicator you’re responding because it caused a new hair growth cycle for you (which starts with shedding old hair as new is produced).
Smart move! I know I shouldn’t be worried about the initial loss but it’s hard to still be patient after 7 months. I recently compared my photos from when I started and to be honest the hairline looks slightly worse and not as bad as I expected, however I feel like the photo comparison doesn’t capture how much thinner my whole scalp region feels now compared to when I started. I’m hoping it will recover or at least stop thinning. Even if I end up bald I’m happy that I did something about it
kevin what would you say is a likely timeline for this treatment to become avaialiable for use (non grey market).
Anyway you could do an update video on cosme rna? Unfortunately it seems to be a huge let down...
Hi. I am confused whether igf-1 promotes or inhibits hair growth. It is known that it promotes the formation of androgens, but if we block DHT, will IGF not have a good effect? similarly, could Growth Hormone also have a positive effect?
I can't stop laughing at the thumbnails dude. You should put asmongold too, he is the perfect candidate.
Awesome news choom! Science is awesome!
Hi Kevin, I've been taking fin for almost 3 months 3 times a week MWF, no real side effects (just gave myself a nocebo effect few times). I see a lot of regrowth and I think I'm getting my NW1 back big thanks to you, but i have a question: should i increase my dose (lets say 4 times a week?) or should I stay on the current regimen since it's working well?
Nah, your stack is working so if it ain't broke don't fix it. I'd stay the course.
Hey Kev! Been using 0.5mg Dut ED (every day) now for a year now and had great results, but I’m kinda on a budget now since I just changed jobs and I was wanting to know that if it would be ok to use Dut EOD (every other day) to save money? Since Avodart is kinda expensive here in the country that I live, or if that would hinder my results in some way
Hi Kevin, I want to start using Finasteride but you have a lot of videos and its dizzying
My point is, I hope you could make a video that can settle things once and for all
On behalf of people with hair loss problems, I appreciate everything you have done for us, thank you
Maybe some kind of summary of my hair loss treatment philosophy?
@@haircafekevin Thank you so much for replying!!! I'm so sorry for my bad English and grammar.
What I really mean't was,
A guide on how to properly use finasteride, like the Do's and Don'ts, how much mg to take, etc.
@@chongque1mg everyday, you can buy the 5mg versions and cut it into quarters so it’s 1.25mg everyday. That’s really it now you keep your hair and keep enjoying life
@@haircafekevinlike Kevin’s 2024 philosophy bc I know info has involved ever since you started
@@Smoshylife things could change by the end of 2024 so he should call it
“The Mann’s Ultimate Hairloss Stack - 2023”
Hey man, what do you think about licorice root as an anti-androgen? (Yes I know its natural and whatnot) but its been shown one tbsp of oral licorice daily lowered testosterone by like 50%, and could be effective for hairloss if applied topically. Let me know what you think, i might try that in combination with dutasteride
Might as well try saw palmetto if you’re going that route
@@BeeVee-zz9ip why
Hey man! Thank you for the great content! I've been on Dut 0,5mg/day for a week, probably went too fast and didn't start with fin. I've head some lightheadedness and dizziness. It seems to be going away. Other thing that happened is some constipation, not sure if it is related. Would you reccomend to stick with the dose? Maybe switch to dut EOD, or even switch to fin, as I had just began treatment?
Thanks for all again! 💪
I wouldn't make any changes yet. Let your body adjust to the changes and any sides you may experience will lkely go away on their own in a few months.
Hey Kev, are there different reasons other than dht that causes male pattern baldness?
Hey man love your work. Do you have any comments on Liposomal Fin? Trying get around onset gyno from fin, no sexual sides or anything just a growing nipple haha so no nocebo effect. Thanks Kevin!
hey Kevin. I started taking finasteride like a year and a half ago and its seemingly halted my hairloss. But I also have eyebrows that seem to have been thinning. Now they havent gotten noticably worse since I noticed they seem thin, but I can tell there are hairs there that are thinner than the rest and so I was just curious if that is possible with Androgenetic Alopecia. I heard that happens with scarring alopecia, God forbid I have that. Is that also possible with Androgenetic Alopecia? Im only 19
Same problem Rock solid hair shitty eyebrows. Might get an eyebrow transplant. Or might get checked for thyroids first.
Do we know if the subjects kept their gains after drug discontinuation? Or is it as Minoxidil (the rewgrown hair is "TDM-dependant")?
No data on that.
How often is it applied?
Hey kevin i have question to ask , my hair now is starting to receding a little bit and my family history is so bad with hair im 23 and maybe in nw1.5 do you think fin is enough for me or i should add min ( don’t want it because it life commitment i only want just one pill every single day )i don’t want to regrow that left hair i only want to keep what i have and slightly improvement on hair density and thickness do you think fin is enough to keep my hair ?
Hey bro i had prp done while i was on minoxodil and finasteride prior of that, my hair is worse , how common is shockloss from prp and is it just like telogen effluvium
Hey kevin, do you think that it's a good idea to use RU (on my test subjects) for further protection? I am on 0.5mg of dutasteride and a NW1 but I always have the lingering fear that even that wouldn't be enough to stop my NW7 genetics on both sides long term. Thanks in advance
No, it sounds like hair greed. Dutasteride is very powerful so you should be good especially since you are a norwood 1. I'd up my dutasteride dosage before adding RU.
Could anyone inform me on what brand of minoxidil I should use?? I’ve always used the standard Kirkland signature from Amazon, mainly because it’s affordable. But if there’s any other I should try or switch to I would appreciate it. Also, is it that necessary to apply twice a day? Thanks in advance
Does finastride/dutastride affect liver can you do a video
hey, how long after being on dut can i go for a HT? should i wait a year for full results?
HI Kevin! I noticed that you don't have any video regarding libido specifically and how much finasteride really affects it. I would be really interested in knowing what the scientific data says and if its just a myth or a rare side effect that only few have like for example ED
Great video, any video/news about scube3?
Only thing I can confirm is it is still being researched. No new data but it is coming as of today.
@@haircafekevin thanks for the answer!
Man this is exciting. Especially if said regrowth could be maintained with 5AR inhibitors without using tdm. One reason I dont use midoxinil is because I dont want to have to rub something on my head every morning and evening. I wonder how effective this will be compared to midoxinil.
Finally something that works! 👏
Hey kevin great video! Can you talk about minoxidil and how dangerous it is for pets? too many people that use minoxidil don't know about this and it could save many lives
Took my first finasteride pill today chooms
You've got this, choom.
Cool.
just remember
Finasteride doesn’t regrow hair.
It just stops further damage, giving your body the chance to heal your miniaturised follicles within a year or so.
hey kevin,
where can i get oral dutasteride if my dermatologist refused to prescribe it to me (i am in Europe)?
thanks.
You can buy it online from websites like all day chemist....for research purposes of course 😉.
Hey bro kevin i need some help, if multiple things and enviromental changes could decrease dht , or certain drugs like fin and dut, what enviromental factors or lifestyle factors or drugs increases 5ar activity so i can avoid, i searched and they say high dietary fat increases 5ar activity so idk? What things are shown to increase dht like certain medications or vitamins or lifestyle factors , cause tbh if there are some factors that decreases 5ar activity then 100% there is factors that increases 5ar activity
Hey Kevin. I almost got swallowed by the nocebo crowd but a year ago today you saved me - and finasteride completely halted my hair loss at a nw2. Whew, just made it
Well done bro. I’m glad you caught it early.
Hello Kevin, first of all, thank you very much for answering all my questions. Judging by the results of KX-826, I do not have much hope for Kintor. Do you think Kintor will be successful for GT20029 or do you think GT20029 will really end this hair loss? If this fails, what are our other treatment options?
I still have hope for GT20029. There are other treatments on the horizon like Scube3 and TDM which I am optimistic for so even if GT tanks we still have other novel therapies on the horizon.
The Tim Pool thumbnails just never get old. Thank you Kevin.
How far is tdm from being released for public use? 2 years? 3 years?
I cant wait for this one! Do you think it will be available on grey market soon or make us wait for official release?
It probably will slip onto the grey market well before its official release.
@@haircafekevin awesome Im buying it asap! I wonder if it will require daily application like minox? Or will cause big shed if stopping
Kevin, I have a question. I've been taking branded 1 mg finasteride for 6 months, and noticed improvements in my hair quality as well as no more excessive hair loss in the shower. Sadly where I live, the pharmacy is all out of the branded finasteride I've been buying and got accustomed to, and I'm thinking of getting the 5 mg generic stuff with a pill cutter route until they could resupply with the good stuff. I'm scared my body might respond differently to the generic stuff and I might lose ground, do you think this is cause for concern or should I just bite the bullet and take generic?
Thank you so much for the supreme content you are a godsend.
Don't worry about it, it is the exact same drug. 5 mg split Proscar is what I use and it works great.
@@haircafekevin thanks for the help. I HATE DHT!!!!
Hi Kev, I use 0.5 mg dutasteride every day. Do you think does it make sense to use 1mg or 1.5mg dutasteride before switching to 2.5mg?
Yes. It might be a good way to see how you respond to higher doses.
Finally a potential new growth stimulant for us non minoxidil responders
Use Tretinoin with Minoxidil. It increases its effectiveness exponentially for non-responders. Kevin has a video on it.
and / or for the people who had sides from topical and oral minox.
If topical Minox doesn't work for you, try oral.
damn bro i see u everywhere on bb'ing shiz lol!@@ytsux9259
Yes, I can't use it because of the side effects, so this could be wonderful if it works.
There's already people that group bought it. So i'll see from them, but I'm also worried that its a 4 month treatment study, but also that the placebo gains were 14, which is not a good sign. But hopefully it works.
Hey Kevin I had a question I was watching a video about Finasteride the other day and the doctor claimed that there’s a possibility that if you block the 5 AR enzyme that your body will make DHT via other pathways and I was wondering if this is true and would like more info about this topic because I never heard it before. The video I’m referring to is this one ruclips.net/video/DlSjaW0nlVo/видео.htmlsi=Y6EJpRXZc6Pegc6C
😂 the intro 😂😂😂❤
Garrus Vakarian is my head of security.
Hi Kevin,
Does finasteride cause any negative effects to memory, mental processing, brain fog or fatigue?
Cheers a lot Kevin
My dad is 53 he is like almost bald not bad but deff on the lowe end of the Norwood scale which i guess is bad lol. Would using monoxidle at night for him be enough to grow something?
Hey Kevin quick question if you have the time. Do you know if adderall can accelerate hair loss? If so, is that only when it’s abused or can it happen by taking it as prescribed?
It can rarely cause hair loss, I think mostly in people who overuse or abuse it. It's very rare though.
@@haircafekevin thanks for the response, appreciate all the info you give, keep doin what you’re doin
Stepfather is taking Thyrex (L-Thyroxin) high dose since 90's and is now 55, not one grey hair nor lost any compared to his relatives. I was always wondering how, but maybe...
@haircafe when will fin initial shed stop????? Seeing lot of hair fall after fin
3 months.
Where's the control for the Phase II trial? I'm dubious of these findings tbf
The control group increased hair counts by 14 hairs.
Sorry about that, I spit out this comment before watching the remainder of your video. Keep up the good work, my man@@haircafekevin
Kevin, how do you think the Mass Effect timeline would have been altered if Dr. Mordin Solus took finasteride instead of allowing himself to go bald at the mature Salarian age of 3?
Spreading the word of the hair gods!
AMEN Brothers and Sisters! Amen.
Hi Kevin, unrelated but what are your thoughts on GT now that pyri seemingly failed?
A bit more jaded but I still have hopes for it. It works differently from Pyrilutamide, after all.
Interesting since there was already a trial with actual T3 for alopecia and that one failed.
Just wondering if you were planning on making a response to Russo’s Pfs cure vid?
Probably not. I'm actually OK with PFS people believing they have found a 'cure' whether it is legitimate or not. If Russo's protocol gives PFS people a benefit, I'm fine with that even if the benefit is just placebo.
Hi Kevin, I have completed 1 year of finasteride but it still does not grow fast and there is still no regrowth. Do you think I should give it some more time (it has contributed a lot to the hair loss and it is still the same as when I first started but it is still as weak and there is still hair loss although not as much as before, 30 hairs a day) do you think so? What should I do? Can you help me? By the way, greetings from Turkey.
Hey, I think maybe I asked this but are you using topical minoxidil? Finasteride can take up to 2 years to fully flex its muscles but minoxidil will help if you want regrowth.
If so then dutasteride is the next step.
Thoroughly enjoyed that intro. Pretty sure I have retrograde alopecia/ dupa. Neither finasteride or dutasteride are working, the situation only gets worse. Have been on fin over a year and half now, any advice?
Add topical minoxidil if you aren't already on it. Try to max out dutasteride at 2.5 mg daily. I do have a video coming on retrograde/DUPA.
2,5mg daily? bro dutasteride is expensive. do you have access to cheaper source?@@haircafekevin
Haircafe Kevin hi mate.
Is it still possible to check my dht levels After 4 months of taking oral dutasteride? I know I should have checked them before starting the treatment, but it's like a way to check if the generic brand of dutasteride i am taking is not fake, or let me say is as efficient as the original one. You know online companies selling drugs are not always correct.
But I the same time, i see less chest and abdomen hair since I started which could be a sign that the medication is having some kind of effect , though my hair is still shedding heavily....
Thanks
You're going to have to be patient. As in several months. It's out of your control at this point. Just leave Santa his 1mg finasteride and a tall glass of minoxidl to wash it down, and hope you've been a good boy this year.
I don't think a blood test is going to help. I think you just need to wait and see.
Yes get a blood test for DHT.
It will verify if the brand you’re taking is fake or not and put you at ease.
Compare it the serum dht found in dutasteride studies
Idk why the two guys above are ignoring ur actual concern and just telling you to keep taking it lol.
Waste of time checking them after you’ve started, trust me been there done it
Hi Kevin, sorry, this is unrelated to the video, but I don't know where else to ask you a question.
I used minoxidil in the past for about 18 months but never seen any improvement (that I could see myself). I have some hair thinning all over the top of my head. Nothing too excessive yet, but a bit noticeable when my hair isn't put together strategically.
Do you think this means I am not responsive to minoxidil, and if so, is there any safe way to fix it?
I am thinking of getting into a fin regiment in the future but for now it's not an option for me
For those that aren’t responding to minoxidil alone, adding tretinoin usually fixes it. There are several companies that can sell it premixed for you. The first sign you’re responding will actually be more shedding. This indicates a new hair cycle has begun and you’ll eventually grow back in thicker. Lastly, minoxidil won’t stop the eventual hair follicular death. The hair gains will be temporary if you aren’t protecting hair folicals from DHT with finasteride/durasteride.
@@amalekitedThanks, I know, it's a temporary fix, before I use finasteride. "Tretinoin", that's what I was looking for, thank you.
Do u know where i can buy this compound? I want to add it to my stack
Sorry, it isn't available yet. Hopefully it will be on grey market sources like anangeninc soon.
Kevin how much men actually responds to minoxidil is it every 6/10 men or 5/10 & also can it fully recover minimal temples if your 22 from a few years back I have been using way less than 1 ML I’m just hoping it works as people claim they have no success on their temples with minoxidil.
About 60 percent of people are good responders. Lots of people who claim to be non responders actually are, they just don't get the regrowth they hoped for.
Completely forgot about it. Awesome news!
Yo, have been taking finasteride for a year after some minor thinning on the crown, and my hair has restored to a point where I have no visible hair loss.
Would you recommend still taking topical minoxidil on top of that? My Derm said I can take it, but he doesn’t think it is necessary. Do you think I should take it to be safe?
Finasteeide only takes down 40% of scalp dht
Go on 2.5mg duta
if ur satisfied dont take it. If u have hairgreed then go ahead and add it. Minoxidil is cheap and low mantaince. Only needs to be applied once a day. So if u want to go for it and stack it if u think u can make even more gains.
@@akilbarboni4198 I am satisfied with how my hair is currently. It would only be to prevent further hair loss and to help with anxiety that I will begin losing hair again in the future. Does it make sense to use it in that situation?
@@akilbarboni4198 I am satisfied with my current hair. I would only be taking it to prevent future hair loss and to have better peace of mind about keeping my hair in the future. With that being said, would it still be worth?
@@akilbarboni4198 I'm satisified with my current hair. It would only be to prevent future hair loss and for peace of mind that I won't experience further hair loss in the future. With that being said, should I start minoxidil?
Hey bro, i want to ask u sth about microneedling, i know that they would argue that microneedling is good for hairloss, but tbh I don’t know i want to ask u sth, if microneedling really helps it should be reaching the dermis, reaching the dermis by needling would cause damage so the tissue would be replaced with not the same tissue it would be replaced with a scar tissue , no matter how small it is , scalp getting microneedled by alot of needles wouldn’t that cause scarring a bit even tho u do it wonce evey once a while , and scar tissue has less bloodsupply , wouldn’t that actually worsen the hair condition?
Honestly, stuff like that does work. Along with that red light therapy. Platelet rich plasma injection works. All kinds of stuff works. Hormone (dht) blockers. Just matters how much time you are willing to invest in the upkeep of your hair. Because it’s going to go away no matter what. My hair has been thinning for 20 years now. Unless we can clone hair (and Japan is doing trials this year or next year on cloned hair follicles) then you are going to spend the rest of your life managing follicles on your head that are just gonna fall out anyway. So much maintenance. All that money and work for some thing that 80% of men will deal with by the time they reach their 40s. Like myself. My four years younger brother went bald in his low 20s. He is obsessed with whatever it takes to get his hair back. And sometimes I wonder if the hormone blockers he took ended up speeding up the process. Since I still have my hair and never took anything besides ketoconazole. He only used minoxidil, but I don’t see the sense in five different routines to keep my hair when it’s going to eventually fall out anyway.
your thumbnails are hilarious
Hey Kevin I heard people saying that a higher dose of dutasteride than usual (more than 0,5mg to 2,5mg) could be bad for your liver or kidney. Is that true? Should I be afraid of getting a higher dose of dut than usual if current dose isn't enough?
You can get mild elevation of liver enzyme tests on dutasteride, regardless of the dose, but this is not associated with any liver disease. To quote the source LiverTox, "These elevations were transient and rarely required dose modification. There have been no published reports of clinically apparent liver injury due to dutasteride therapy." This is true regardless of the dose used.
Nick Cage been working on that mewing
Do you think those on Minoxidil who try to transition to something like this without continuing use will experience a massive shock loss?
Probably not since they're both effective growth stimulants even though they work differently. We still need a bit more data on TDM but so far things look good.
Is it good idea to crush and solve fimastride to apply it topical?
No, just take it orally.
Yo
Recently came across a guy on reddit who showed 2 diffrent blood test claiming hes been in fin for a devent time and yet has high dht levels his were like 650 and the usual range is 200-900 i think.
Are there some people who dont respond to fin at all or just poor? And if yes how common is this?
He just needs a bigger dose.
People always respond to 5ar blockers
Unless this dude is a genetically different species.
@@laniakeas92 dont know like mutations in the enzyme, or some altered enzyme in digestion
@kanalteriniger9967 there are no possible existing mutations you described
He takes a low dose, he should increase it
@@laniakeas92 no he took 1.25mg should be more than enough usually
I don't know the details of that guy, but he could have had an unusually high baseline DHT before starting. In the end it is scalp DHT suppression that matters, and whether or not his hair is being preserved. If his hair is doing well, I wouldn't worry about the lab tests.
Kevin, is it the frontal temples and hairline that first recede for most men?
I ask because it seems by the time you notice temporal recession, it's already beyond repair.
If Finasteride is started early enough in most men, would it prevent even the slightest recession?
Theoretically Norwood 1 status would likely remain?
Yes, basically the earlier you use finasteride the more effective it is. Starting before losing ground is gives you the best possible chance to stop hair loss indefinitely.
I talk about it here.
ruclips.net/video/LsF9MwIM_AM/видео.html
@@haircafekevin Thank you, Kevin. I can't believe 1 year ago I though I'd have to "Just shave it, bro!" I am very lucky to have found your glorious channel!