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PANCREAS

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  • Опубликовано: 25 май 2014
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    HUMAN ENDOCRINE SYSTEM :PANCREAS :Pancreas is a mixed gland -- A portion of pancreas acts like exocrine gland and another portion acts like an endocrine gland. The cells of endocrine pancreas are called Islets of Langerhangs representing 1 to 2% of pancreatic tissue. They secrete 2 hormones -- Insulin and Glucagon.Insulin : The hormone is produced by β-cells of Islet of Langerhangs. It is a peptide hormone, which plays a major role in the regulation of glucose homeostasis. Insulin promotes the conversion of glucose to glycogen in liver and muscle that is stored in these tissue for future use. Insulin is liberated when the blood glucose levels are high, usually when food is digested and absorbed. If sufficient insulin is not produced glucose level in blood increases and it is excreted through urine. This is called DIABETES MELLITUS. Diabetes is identified by the presence of sugar in urine. ∴ Diabetic patients take insulin injections regularly. Insulin also affects the metabolism of fats and proteins. Unattended diabetis results in wasting of body tissue, reduced healing power, ketone bodies, blurred vision and kidney problems. They may end up with gangrene and coma.Glucagon is a peptide hormone secreted by α cells of islets of Langerhans. Glucagon acts on liver cells and stimulates glyconeolysis resulting in an increased blood sugar -- hyperglycemia. This hormone stimulates the process of gluconeogenesis which also contributes to hyperglycemia. Glucagon reduces the cellular glucose uptake and utilization. Thus glucagon is hyperglycemic hormone.

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