12.4 Grignard Reagents | Organic Chemistry

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  • Опубликовано: 30 янв 2025

Комментарии • 58

  • @carlimendelow2569
    @carlimendelow2569 5 месяцев назад +6

    Fellow Pre-Med here...I HAVE to comment and say that I am in Orgo II because of YOU! You taught me how to think in Ochem, and even after practically failing my first Orgo 1 Exam I knew with your videos I would continue to get reps in and do better. Studying for the MCAT now too and totally believe your teaching has showed me what I need to know. Thank you for your content, kindness, and skillset. God Bless you!

    • @ChadsPrep
      @ChadsPrep  5 месяцев назад +1

      Thank you - Glad the channel is helping you out!

  • @neveenbotros3257
    @neveenbotros3257 Год назад +12

    I started enjoying chemistry
    because of you. Thank you!

    • @ChadsPrep
      @ChadsPrep  Год назад +2

      You're welcome and Thank you!

  • @IsaacAdeniruju
    @IsaacAdeniruju 11 месяцев назад +5

    Your videos are AMAAAAAAAZING! God bless you dearly!

    • @ChadsPrep
      @ChadsPrep  11 месяцев назад

      Thaaaaaank you - same to you!

  • @EffigyOfficial
    @EffigyOfficial 5 месяцев назад

    Thanks a ton man, I've been forced to cram a lot of organic them and you've made it a lot easier than it would've been otherwise!

    • @ChadsPrep
      @ChadsPrep  5 месяцев назад +1

      Glad the channel is helping you - Happy Studying!

  • @mayweerajit
    @mayweerajit Месяц назад

    Your channel saved me from Orgo Exam2 (I have a blank knowledge on this thing), 😊😊😊 and today I have the 3rd exam 😍😍

  • @princessphemorahsampsonedu101
    @princessphemorahsampsonedu101 2 года назад +4

    This made it easy for me to understand..so helpful😊

    • @ChadsPrep
      @ChadsPrep  2 года назад

      Excellent - glad to hear it!

  • @Groovy1965
    @Groovy1965 2 месяца назад

    I took organic chemistry in 1985. I wish my professor framed this reaction like you did in your intro. It would have given the reaction some context and meaning to an otherwise rote class. I found the textbook more interesting than the professor. However, it was a long time ago

    • @ChadsPrep
      @ChadsPrep  2 месяца назад

      I'm glad you are enjoying the content!

  • @ilaydamumcuoglu8339
    @ilaydamumcuoglu8339 Месяц назад

    amazing video! Is there a reason why THF is used for the synthesis of Grignard reagent

  • @target__iit
    @target__iit 10 месяцев назад +3

    hmm, this may seem like a silly question but what is the difference between a base and a nucleophile

    • @ChadsPrep
      @ChadsPrep  10 месяцев назад +9

      Not a silly question! The difference is really down to their action. Both bases and nucleophiles are electron rich species which donate electrons to electron deficient species. The definition of a Lewis base is an electron pair donor, so nucleophiles are Lewis bases which donate a pair of electrons to an electron deficient species, for example a carbon in C=O. The definition of a Bronsted Lowry base is 'accepting' i.e. forming a bond to a proton (H+) so the bases in these reaction pathways are Bronsted Lowry bases. So in organic reaction mechanisms we use the term 'Nucleophile' to describe a Lewis base, i.e. an electron rich species that attacks something other than hydrogen and 'Base' to describe an electron rich species that attacks hydrogen. I hope that is clear :)

  • @DaryaEsmaeilshirazi
    @DaryaEsmaeilshirazi Год назад

    you are literally the best THANK YOU!!!

    • @ChadsPrep
      @ChadsPrep  Год назад

      You're welcome and Thank You!

  • @nikitaliasiuk
    @nikitaliasiuk 9 месяцев назад

    would you consider covering organoboron or organoaluminum grignard reactions and synthesis of them?

  • @princeysuryan2561
    @princeysuryan2561 3 месяца назад +1

    Could you please suggest some of your personal favorite chemistry books? I would appreciate your recommendations."

    • @princeysuryan2561
      @princeysuryan2561 3 месяца назад +1

      You deserve millions of views and subscribers for all the valuable knowledge and hard work. 😊

  • @BruceWayne-i2n
    @BruceWayne-i2n Год назад

    thanks for the video, it's great!
    just a quick question, isn't the H3O+ for all 3 of the reactions at 8:00 a type of protic solvent? Or does hydronium not really count as a solvent and something else is supplying it?
    Now that I'm checking again, I'm guessing the fact that it's sequential 1. and then 2. means that it can't take H+ from the H3O+ right?

    • @ChadsPrep
      @ChadsPrep  Год назад +2

      Grignard reactions tend to use ether as a solvent. Protic solvents wouold protonate the Grignard and prevent the reaction from happening. For this reason H3O+ is added in the second step of these reaction (i.e. after the Grignard reagent has already reacted)

  • @사랑첫-g5k
    @사랑첫-g5k Год назад

    thank you my techer,you very good❤❤❤

    • @ChadsPrep
      @ChadsPrep  Год назад

      You're welcome and Thank You.

  • @CaseyLada
    @CaseyLada 11 месяцев назад

    This is so helpful, thank you!
    Would we be able to use other agents besides H3O+ in the second step as an acid workup? Would H2O work?

  • @jaydenallegakoen9974
    @jaydenallegakoen9974 2 года назад +1

    Amazing video thank you so much

    • @ChadsPrep
      @ChadsPrep  2 года назад

      You're welcome - thank you!

  • @abdoulazizdabo9064
    @abdoulazizdabo9064 Год назад +1

    Thank you

  • @rohanpatel1864
    @rohanpatel1864 3 года назад +1

    Thank you!

    • @ChadsPrep
      @ChadsPrep  3 года назад

      You're welcome, Rohan!

  • @kehalyoucef2699
    @kehalyoucef2699 Год назад +1

    Thanks a lot

  • @ramonaparicio6989
    @ramonaparicio6989 Год назад

    Thank you god

  • @suraalsaeedi3822
    @suraalsaeedi3822 3 года назад

    thank you your way so clear

    • @ChadsPrep
      @ChadsPrep  3 года назад

      You’re welcome, Sura! 😊

  • @ryanalani1262
    @ryanalani1262 3 года назад

    Thank you! if there are two groups of aldehyde attached to the same reactant should we use Grignard twice? also what if the reactant were ester or O-CH3-CL or acid chloride?

    • @ChadsPrep
      @ChadsPrep  3 года назад

      Yes. If you have two aldehyde functional groups on a reactant then the reactant could react with 2 equivalents of the grignard. Esters, acid halides, and acid anhydrides can also react with two equivalents of a grignard too. I cover this in lesson 20.4: ruclips.net/video/_1ATaPMZrRQ/видео.html
      Hope this helps!

    • @ryanalani1262
      @ryanalani1262 3 года назад

      @@ChadsPrep Thank you so much! I should watch that lesson before the exam yesterday :)
      The question was Ester carbonyl group attached to O-Ch3Cl
      I am not sure if O-Ch3Cl treated as leaving group or not?

  • @mahla-nb4ki
    @mahla-nb4ki 7 месяцев назад

    can't LiAlH4 lead to a 3° alcohols?

  • @abivaldez9711
    @abivaldez9711 19 часов назад

    buddy needs a noble peace prize

  • @gamewarden2813
    @gamewarden2813 2 года назад

    ty!

  • @athenapaint
    @athenapaint 3 года назад

    Thank you! You've helped me get through all of my chemistry classes. Quick question: If the attachments are 2 ethyl groups and a benzine ring, would there still be a 3rd way to synthesize?

    • @ChadsPrep
      @ChadsPrep  3 года назад

      If any two of the groups were identical there would only be two ways to produce a tertiary alcohol beginning with a ketone. However, you will learn later in the semester that as long as two of the groups are identical you could actually start the synthesis with an ester and add excess grignard. So in this case if you started with a benzene ester (for example methyl benzoate) and then added two equivalents of an ethyl grignard (aka excess) you would get exactly the same product. This will be presented in lesson 20.4. Hope this helps!

    • @athenapaint
      @athenapaint 3 года назад

      @@ChadsPrep Whoa! I understand it now, super helpful. You are the G.O.A.T.

    • @ChadsPrep
      @ChadsPrep  3 года назад

      Thanks!

  • @dylan8951
    @dylan8951 2 года назад

    ur awesome!

  • @KelvinPhiri750
    @KelvinPhiri750 3 месяца назад

    Chad you are the best. your vedios are still useful todate ❤️⭕

    • @ChadsPrep
      @ChadsPrep  3 месяца назад +1

      Thank you!

    • @KelvinPhiri750
      @KelvinPhiri750 3 месяца назад

      @@ChadsPrep you are welcome
      Continue doing the great work❤️

    • @ChadsPrep
      @ChadsPrep  3 месяца назад +1

      @@KelvinPhiri750

  • @itswhoisme
    @itswhoisme 8 месяцев назад

    ofc our professor would want the grignard synthesis 🤡