Dose makes the poison: how to think reasonably about your meds

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  • Опубликовано: 15 сен 2024

Комментарии • 44

  • @Lumpycheeses
    @Lumpycheeses 5 месяцев назад +77

    Ik this video spawned from some person either refusing their kid adhd meds or spending 20 minutes convincing a patient that adhd meds are okay to take. 😂

    • @itspresro
      @itspresro  5 месяцев назад +61

      Lmao people were spamming comments on my schizophrenia video asking if their adderall would cause psychosis and if they should stop taking it

    • @jonicole7762
      @jonicole7762 5 месяцев назад +3

      The timing of this video in my life is impeccable

  • @zacharytavallaee5916
    @zacharytavallaee5916 5 месяцев назад +30

    Have not yet found the upper dose limit on this content that I like

  • @RougeRogue52
    @RougeRogue52 5 месяцев назад +17

    Presto discovers medical toxicology! You should come to one of our conferences sometime. Nowhere else can you talk about psilocybin for SUD and the next session is like, environmental vinyl chloride in East Palestine, OH.
    All things are poison and nothing is without poison; sola dosis facit venenum.

  • @kaifeng6649
    @kaifeng6649 5 месяцев назад +19

    As a inpatient clin pharmacist I approve this msg. And I really like the new style format but the funny ones are good too. 😅

  • @hannahlewis1245
    @hannahlewis1245 5 месяцев назад +54

    My pharm prof said "there is no such thing as a safe drug, but a safe dose"

  • @steviereads4267
    @steviereads4267 5 месяцев назад +11

    Super important fundemental concept to understand about medicine, and really life in general. Maintenance of your personal golden means, ratios, concentration... whatever synonym you want to use for average for whatever important factor.
    And unfortunately people dont have constant, reliable monitors for all of the trackable ranges deemed necessary for a healthy life (and arguably we shouldn't, looking at you anxiety).
    Whether that's electrolytes, hormones, or nutrients, when life inevitably gets these balances out of whack, sometimes medicine is the best way to bring them into bounds.

  • @swandizzle_
    @swandizzle_ 5 месяцев назад +4

    My patient refused to take their sertraline because they were worried about the

  • @Justin-sb7ew
    @Justin-sb7ew 5 месяцев назад +1

    Happy to see you also use the razor thin 0.38mm G2 pens, I'd spot them anywhere lol sick of them getting stolen from me

  • @theotherredmeat
    @theotherredmeat 5 месяцев назад +4

    You can also take meth at prescribed doses! It's called desoxyn :)
    But this really just speaks to the overall point here that the dose is what matters

  • @finlaysinbarstorm619
    @finlaysinbarstorm619 5 месяцев назад

    Every substance has an LD50, and every medication has a risk v benefit (including risk of not taking it), love the vids doc

  • @cheetahgoldenfire
    @cheetahgoldenfire 5 месяцев назад

    I've been preaching this for years everything can kill us in excess. I tell my clients and patients this everytime. It's informed consent.

  • @ThePandaByte
    @ThePandaByte 5 месяцев назад +7

    Paracelsus moment

  • @awgezu7387
    @awgezu7387 5 месяцев назад

    I love these videos going more in depth about medicine itself

  • @vasilyjameson
    @vasilyjameson 5 месяцев назад +1

    "all homecall day" good one preston

  • @Hgtp2_Hat
    @Hgtp2_Hat 4 месяца назад

    Thank you for talking sense…so much nonsense & ignorance all around me, as a psych doctor. The hype around adhd meds being amphetamines drives me nuts. Alcohol is a much worse poison.

  • @mattmaco9065
    @mattmaco9065 5 месяцев назад +6

    Not to brag but I think I’m your number one fan 😂

    • @leightonolsson4846
      @leightonolsson4846 5 месяцев назад +1

      Ahem methinks not. This is a crowded field my friend 😂

  • @leightonolsson4846
    @leightonolsson4846 5 месяцев назад +1

    Yes yes yes yes yes YES to everything in this clip

  • @benforno3354
    @benforno3354 5 месяцев назад +4

    I'm pretty sure Paracelsus first posited this in 1538. His language was far harder to understand than yours, though.

    • @itspresro
      @itspresro  5 месяцев назад +9

      I don’t have any novel ideas, im just parroting what other people have said hahah

    • @benforno3354
      @benforno3354 5 месяцев назад +2

      ​@@itspresro if all you ever do is take medical arcane gibberish and translate it into easily digestible information as you did here, you'll be one of the best doctors of the age. Possibly THE best psychiatrist. In 2024, it's a Thing Humanity Needs Most.
      Love your work mate keep it up!

  • @terrarium_minded
    @terrarium_minded 5 месяцев назад

    he's so done with it 😂

  • @shad3128
    @shad3128 4 месяца назад

    would really be a big help if you could make a video on visual snow syndrome and mental health. In the recent months theres been more than 4 suicides linked to the condition, and its concerns grow as its a neurological disorder often brought on with overdosing or inappropriate dosing of SSRIs or SNRIs. There are cases of it happening outside of this of course, but the end result is the same. Many with the condition end up with poor mental health and the medications often used in mental health exacerbate the syndrome, so you can see how the syndrome becomes complex.
    I got visual snow syndrome when my neurologist added zoloft to my seizure meds to "help make me feel better." I know she meant well, but a year and 2 months later i have a disorder i cant get rid of. Many others have documented the same occurance.

  • @bosstowndynamics5488
    @bosstowndynamics5488 5 месяцев назад +1

    You already alluded to it alongside the more specific point about dose, but just for onlookers I'd like to make this explicit - safety is always relative. Everything has risk, including doing nothing. If a doctor says a medication is safe and you get a side effect, that doesn't mean the doctor was lying, what it means is that the potential benefit when they prescribed it was assessed as being higher than the risks when accounting for the likelihood of either.
    This was really driving me up the wall during all of the COVID anti vaccine stuff and obsession with ivermectin - the COVID vaccines were and are safe, *not* because they are flawless and never cause any problems, but because the percentage of people who get problems from them is very low and the percentage who benefit is very high. It's just that a very small percentage of billions of people still looks like a lot when you focus really hard on the very small number who had severe reactions and completely ignore all the people dying from COVID. And the same goes in reverse for ivermectin - ivermectin is safe when used to treat worms under medical supervision, that does not magically make it safe when used in much higher doses for much longer periods of time with no supervision to prevent a disease it has no effect on, because when used for COVID the significant side effects of ivermectin still exist but you don't get the benefit of getting rid of your worms.

  • @alexrogers777
    @alexrogers777 4 месяца назад

    I'm kinda pedantic but using methamphetamine as the example for getting too high of a dose of adderall doesn't work because methamphetamine is also a prescribed ADHD med. I get what he's trying to say but in reality there are safe doses of meth too

  • @Arturosuelto
    @Arturosuelto 5 месяцев назад +1

    El mejor

  • @thamuswitwill
    @thamuswitwill 5 месяцев назад

    "If grab an industrial amount of codeine and chug it in my basement, could I get high?"
    What about my attic?

  • @ayyyy_lmao
    @ayyyy_lmao 4 месяца назад

    I am forced to be on clozapine on a CTO and I want off of it because it isn't right.

  • @bigbufobufo
    @bigbufobufo 5 месяцев назад

    What if I watch too much presro? What is the upper limit? What are the risks??

  • @atlas8667
    @atlas8667 5 месяцев назад

    " Everything is poison nothing is poison its the dose that is the poison "

  • @ayyyy_lmao
    @ayyyy_lmao 4 месяца назад

    also I have recreationally used meth and adderall and I had worse effects from adderall but I don't really use anymore

  • @UUwUU80
    @UUwUU80 5 месяцев назад

    Preston, your hair is looking too done. I miss the wild locks 😁

  • @Andrew-kh7rz
    @Andrew-kh7rz 5 месяцев назад +1

    Nah this is bs.Is alcohol good for you? Apparently no, the less you consume the better it is.And just because lower doses make it safer doesn t mean you should just take it.

  • @gabeg132
    @gabeg132 5 месяцев назад

    Is my Adderall causing my psychosis? Should I stop taking it!?

    • @im1385
      @im1385 5 месяцев назад +3

      Instructions uncleaar. My psychosis is causing Adderall.

    • @mitalishinde6890
      @mitalishinde6890 5 месяцев назад

      Lol that' was the point of this video

  • @user-xy4ff5yp7b
    @user-xy4ff5yp7b 5 месяцев назад

    The more I watch your videos the more I notice some degree of mental instability. I get the impression that underneath this hyper and opinionated façade there are some issues.

  • @creachiecritter6214
    @creachiecritter6214 5 месяцев назад

    Not exactly related, but I'm curious and maybe you could do a video if you have time
    What exactly are "brain zaps"? I started taking Luvox, and if I miss just one morning dose I have brain zaps all day. Why does this happen?

  • @m5073
    @m5073 5 месяцев назад

    More than half of my medical school class was on adderall easy. I have family in it who definitely don’t need it. I know so many people who take it. I know way too many children who are prescribed it because their parents want to control them with less effort. It has a purpose but is abused, even if prescribed at “safe” doses. Just my opinion though.