I don’t get this video when it comes to Metformin. I’m not prediabetic, but my doctor uses it as an off label drug for me. Due to my assertive colitis and Crohn’s disease, as well as lupus and severe lethargy. Since I’ve been taking metformin, almost all of my symptoms have either gone away or dramatically improved. I have also noticed muscle gain and fat loss although I’m not overweight. From the sound of it, he’s calling it snake oil, but it has definitely changed my life. It makes me now take everything these guys say with a grain of salt.
The ITP only tests for extension of mice lifespan, not other effects on rare diseases. They found it does not increase lifespan in healthy normal mice across 3 independent labs.
How about actually watching the full video? They say nothing of the sort, they say metformin has a safe profile and speak of its utility briefly. It's even in the first half of the video, lol. Some people...
Anecdotally speaking, which is the weakest evidence, I found that metformin added some muscle with lifting about the same amount of weights before I started taking it.
Astaxanthine was the best, tested by ITp so far. GlyNAC is the best, but not tested by ITp. Taurine and Glucosamine prolonged lifespan in mice. Caloric restriction and intermittent fasting prolonged lifespan too.
I found on the ITp website: "Published work has documented major benefits from treatment with rapamycin, acarbose (males > females), and 17a-estradiol (males only), and smaller but significant benefits from three other agents (NDGA, Protandim, glycine). ". Astaxanthine was not added yet. I wonder what happens when you combine all those treatments together.
There are more and more human studies being done on NMN. We need to wait a few years. Anecdotally, it helps me with energy and strength in the gym. But it could be other factors.
Tell me you know nothing about the substance without telling me you know nothing about the substance. Just because it's in the same pathway doesn't mean it cannot have drastically different results. This is why there are many human studies being done on NMN as we speak.@@volos_olympus
As a replacement, many suggest inexpensive Vitamin B3 (Niacin). I've tried it and Sinclair's NMN (9mos) too. It (B3) gives a tingle to the skin which is caused by an opening of the capillaries . It is supposed to have success in clinical trials to improve mitochondrial function. I haven't noticed faster recovery from some nagging injuries or improved performance in the gym with either. I am on a short break (3 weeks) from B3 and may start again shortly.
I checked on human trials on many of these substance ... And there is very recent and solid evidence that that work for longevity and more in humans .. Just not rats
@@Len1977gt OF Course I watched the video ... and Even HE Said That the Fact That something Fails in Mice does NOT mean it will fail in Humans! *Did YOU Watch The Video??? This I why I looked up the Research in HUMAN TRIALS. Human Trials DO show many Benefits ... Including Longevity .... and In Multiple Studies ... He only does ONE study Each in Rats.
fasting mice and shorter lived strains of mice show life extension from resveratrol. NMN preliminary unpublished research shows life extension in mice, similar may be for NR probably errors in ITP protocol. Resveratrol has shown epigenetic age rejuvenation and telomere lengthening of human cells.
Resveratrol has lengthened the lifespan of multiple short lived species at times by 70%, including short lived strains of mice. Why it fails in longer strains of mice could be due to either age related nad+ decline or perhaps fast clearance from the body. Perhaps repeated or time release formulations are necessary. It has been shown to lengthen telomeres and reverse epigenetic aging in human cells.
He said they have a "hit rate" of 10% right now yet he does not mention any effective drugs. I'd like to hear more about the drugs that have had success. Why do we always concentrate on only the negative. If there are some drugs out there that are working then why is no one talking about those?
Surely worth a "hail Mary" to just give all the drugs which have caused the mice to live longer at once and see what happens: there's at least some chance that you'll get a really long lived mouse.
In virtually every setting, I watch for "tells," for indicators, of a person's psychology, politics and biases. It's just a hobby of mine. This doctor referenced how gullible the public is (first tell) and in the same breath mentioned Fox News (alone). Second tell. That's all. Take it for what it's worth.
Have you seen how many snake oil ads are on Fox News? Their demographic is geriatric and evangelical. It’s no surprise Fox News watchers will buy sugar pills on a whim when it’s packaged as an elixir
@@cursedrr8647 I'm very suspicious of the ITP, with astaxanthin they used megadoses of synthetic astaxanthin rather than use natural astaxanthin. I don't know why they decided to do that. Megadose might cause toxicity or blunt benefits, and synthetic some say is far worse than natural. From then on I've suspected that rather than looking to prove effectiveness of longevity supplements their goal may be to dismiss promising substances, perhaps big pharma is involved.
metformin should work,it decrease cell oxygen consumption and therefore its oxidation,less oxidation,less cell stress,more prolonged cell life,at least on paper,it also directly helps you with "eating less"/absorbing less carbs,and we all know the less you eat the more you eat as the holy grail of what you can do to live longer,just eat as close to your maintenance as possible while also being at an indeal lvl of body fat/weight for your height/age/gender
With this logic, vitamin b12/iron/folic acid deficiency works, sedentary lifestyle works - all of these decreases oxygen consumption. What a great logic
yeee,its unfortunate,even if it did exactly what is should,forcing the cell to live more like this in the real world wont matter that much unless you also maybe use it in conjunction with other more drastic measures,lime mtor manipulation and gene manipulation,for me ive used it and i am using it and i notice it,my workout output is diminished,and im guessing this is because the reduced oxygen utilization,if i quit it a lot of reps/strength comes back,id say i lost about 30% maybe 25% depending on the exercise,surprisingly i dont notice it that much on cardio but i do in weightlifting.@@BiZii1024
"people made a lot of money with resveratrol" - wonder why Sinclair ended his podcast so quickly.....
sinclair is a fraud. none of this drugs worked in the ITP. lol
Thank you so much. David Sinclair is a pusher of many of these drugs!
which tells you how much of a corrupted snake oil salesman he really is
I don’t get this video when it comes to Metformin. I’m not prediabetic, but my doctor uses it as an off label drug for me. Due to my assertive colitis and Crohn’s disease, as well as lupus and severe lethargy. Since I’ve been taking metformin, almost all of my symptoms have either gone away or dramatically improved. I have also noticed muscle gain and fat loss although I’m not overweight. From the sound of it, he’s calling it snake oil, but it has definitely changed my life. It makes me now take everything these guys say with a grain of salt.
What dose do you take? And extended release or instant release?
They don't say metformin is snake oil. They say it's plausible but we don't know.
The ITP only tests for extension of mice lifespan, not other effects on rare diseases. They found it does not increase lifespan in healthy normal mice across 3 independent labs.
How about actually watching the full video? They say nothing of the sort, they say metformin has a safe profile and speak of its utility briefly. It's even in the first half of the video, lol. Some people...
Metformin for me has been a life changer and helped me finally get my weight under control.
Me too. And I’m not even pre-diabetic. But it has done wonders for me.
Anecdotally speaking, which is the weakest evidence, I found that metformin added some muscle with lifting about the same amount of weights before I started taking it.
can someone make a simple list what drugs worked and didnt work in the ITp
phenomeDOTjaxDOTorg/projects/ITP1
Astaxanthine was the best, tested by ITp so far.
GlyNAC is the best, but not tested by ITp.
Taurine and Glucosamine prolonged lifespan in mice.
Caloric restriction and intermittent fasting prolonged lifespan too.
Where did u learn about intermittent fasting and caloric restriction. is it also from the ITP?@@HvdHaghen
Rapamycin and acarbose are the winners so far.
I found on the ITp website: "Published work has documented major benefits from treatment with rapamycin, acarbose (males > females), and 17a-estradiol (males only), and smaller but significant benefits from three other agents (NDGA, Protandim, glycine). ". Astaxanthine was not added yet.
I wonder what happens when you combine all those treatments together.
What about all the papers in NIH website about other benefits of resveratrol? This dude responses sound very anecdotal.
I would like to see the papers
What IS 'the ITP?'
I would like to see NMN tested and metformin has been shown to have many benefits outside of life extension
There are more and more human studies being done on NMN. We need to wait a few years.
Anecdotally, it helps me with energy and strength in the gym. But it could be other factors.
If NR failed, so will NMN.
Tell me you know nothing about the substance without telling me you know nothing about the substance. Just because it's in the same pathway doesn't mean it cannot have drastically different results. This is why there are many human studies being done on NMN as we speak.@@volos_olympus
As a replacement, many suggest inexpensive Vitamin B3 (Niacin). I've tried it and Sinclair's NMN (9mos) too. It (B3) gives a tingle to the skin which is caused by an opening of the capillaries . It is supposed to have success in clinical trials to improve mitochondrial function. I haven't noticed faster recovery from some nagging injuries or improved performance in the gym with either. I am on a short break (3 weeks) from B3 and may start again shortly.
@@volos_olympus Dose of NR might have been issue, preliminary unpublished results from other labs have seen life extension in mice from NMN.
I've had good luck / results with Niagen brand NR and curious to see what future testing shows.
I checked on human trials on many of these substance ... And there is very recent and solid evidence that that work for longevity and more in humans .. Just not rats
Did you watch the video? Peter is not a believer in these supps for lifespan
@@Len1977gt OF Course I watched the video ... and Even HE Said That the Fact That something Fails in Mice does NOT mean it will fail in Humans! *Did YOU Watch The Video??? This I why I looked up the Research in HUMAN TRIALS. Human Trials DO show many Benefits ... Including Longevity .... and In Multiple Studies ... He only does ONE study Each in Rats.
fasting mice and shorter lived strains of mice show life extension from resveratrol. NMN preliminary unpublished research shows life extension in mice, similar may be for NR probably errors in ITP protocol. Resveratrol has shown epigenetic age rejuvenation and telomere lengthening of human cells.
To me health span is as or more important than lifespan.
Resveratrol has lengthened the lifespan of multiple short lived species at times by 70%, including short lived strains of mice. Why it fails in longer strains of mice could be due to either age related nad+ decline or perhaps fast clearance from the body. Perhaps repeated or time release formulations are necessary. It has been shown to lengthen telomeres and reverse epigenetic aging in human cells.
He said they have a "hit rate" of 10% right now yet he does not mention any effective drugs. I'd like to hear more about the drugs that have had success. Why do we always concentrate on only the negative. If there are some drugs out there that are working then why is no one talking about those?
Thank you for this great information!
Surely worth a "hail Mary" to just give all the drugs which have caused the mice to live longer at once and see what happens: there's at least some chance that you'll get a really long lived mouse.
In other words take it because your doctor says it safe even though they never taken it themselves
Performing is a prescription drug the other two are supplements..
Resveratrol helps with poor diet. It also raises HDL for people needing it.
Proof?
@@volos_olympus pubmed.ncbi.nlm.nih.gov/27085216/
@@volos_olympus I also worked for me. N=1.
@@volos_olympus pubmed.ncbi.nlm.nih.gov/27085216/
@@volos_olympus
Proof? Probably the OP's N of 1 anecdotal 'evidence'
In virtually every setting, I watch for "tells," for indicators, of a person's psychology, politics and biases. It's just a hobby of mine.
This doctor referenced how gullible the public is (first tell) and in the same breath mentioned Fox News (alone). Second tell.
That's all. Take it for what it's worth.
@anathamon I'm not "trying to say" anything other than what I said.
Agreed. His use of word snake oil triggered me because there hundreds on papers on the NIH websites about usefulness of these drugs/supplements
Have you seen how many snake oil ads are on Fox News? Their demographic is geriatric and evangelical. It’s no surprise Fox News watchers will buy sugar pills on a whim when it’s packaged as an elixir
@@cursedrr8647 I'm very suspicious of the ITP, with astaxanthin they used megadoses of synthetic astaxanthin rather than use natural astaxanthin. I don't know why they decided to do that. Megadose might cause toxicity or blunt benefits, and synthetic some say is far worse than natural.
From then on I've suspected that rather than looking to prove effectiveness of longevity supplements their goal may be to dismiss promising substances, perhaps big pharma is involved.
All the ones David Sinclair claims as his personal intellectual property
Trying NMN - seems to be improving my idiopathic familial neuropathy. Haven done objective measurements though. No side effects at 900 /day.
metformin should work,it decrease cell oxygen consumption and therefore its oxidation,less oxidation,less cell stress,more prolonged cell life,at least on paper,it also directly helps you with "eating less"/absorbing less carbs,and we all know the less you eat the more you eat as the holy grail of what you can do to live longer,just eat as close to your maintenance as possible while also being at an indeal lvl of body fat/weight for your height/age/gender
But then some studies shows that increasing reactive oxigen species(sometimes) increase lifespan so its not that simple :(
Should work but doesn't in mice
With this logic, vitamin b12/iron/folic acid deficiency works, sedentary lifestyle works - all of these decreases oxygen consumption. What a great logic
yeee,its unfortunate,even if it did exactly what is should,forcing the cell to live more like this in the real world wont matter that much unless you also maybe use it in conjunction with other more drastic measures,lime mtor manipulation and gene manipulation,for me ive used it and i am using it and i notice it,my workout output is diminished,and im guessing this is because the reduced oxygen utilization,if i quit it a lot of reps/strength comes back,id say i lost about 30% maybe 25% depending on the exercise,surprisingly i dont notice it that much on cardio but i do in weightlifting.@@BiZii1024
Gobbledygook
Sinclair, the charlatan
I think he meant CNN 😂
Nah