Eliminating brain cancer at its source | Natalie Artzi | TEDxMIT
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- Опубликовано: 12 сен 2022
- Glioblastoma is a lethal, aggressive brain cancer with a dismal median overall survival rate of 15 months, a number that has remained unchanged for decades. Treatment for this devastating disease involves surgical resection followed by chemotherapy and radiation therapy; however, tumor recurrence is inevitable as it is impossible to eliminate all tumor cells with current strategies. One of the biggest impediments to the development of more effective therapies is the low penetration of drugs to the brain when delivered systemically because of a very selective membrane, the blood-brain-barrier (BBB), that is designed to prevent more than 98% of the molecules from getting into the brain to protect it from pathogens. The Artzi lab at MIT and Harvard developed an adhesive hydrogel that can be sprayed or injected directly into the brain during surgery, eliminating the need to cross the BBB while enabling the local release of a cocktail of drugs and nanoparticles that activate the immune system. Their technology educates our body’s own immune cells to detect and kill cancer cells. The local delivery of the gel coats and attacks the tumor without causing harmful side effects and would only need to be administered once.
Dr. Artzi is an Assistant Professor at the Department of Medicine, Division of Engineering in Medicine, Brigham and Women’s Hospital, Harvard medical School.She is a Principal Research Scientist at MIT and an Associate Member of the Broad Institute of Harvard and MIT. She completed her postdoctoral studies at MIT focusing on studying tissue:biomaterial interactions and designing smart biomaterials for therapy and diagnosis applications.
Dr. Artzi is the recipient of multiple grants and awards, including the inaugural Kabiller Rising Star in Nanomedicine and Nanotechnology, One Brave Idea award, Stepping Strong Innovator Award and Breakthrough Award, Controlled Release Society Young Investigator Award, Mid-Career Award from the Society for Biomaterials, Bright Futures Prize, and the Massachusetts Life Science Center for women entrepreneurs.
Currently, Dr. Artzi directs multiple research venues aiming to integrate science, engineering and medicine to rationally design personalized materials to improve human health, and has co-founded a startup company, BioDevek, which develops the next-generation biomaterials to improve outcomes following internal surgeries. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
Thank you cancer researchers for all your hard work! This looks very promising!
I would like to see this apply to my brother right now who just got his tumor removed and now in stage 4.
Wow!! Great thinking!! xxxx
bravo lady, blessings
Surgery, radiation, and TMZ in two weeks.
I WANT TO LIVE.
Great job 😊😊
Amazing technology 😲
Prayers and blessings to everyone who has cancer or a loved one going through cancer. I wish nothing but the best to each and everyone of you. I would never wish this disease on even my worse enemy.
Unfortunately, these techniques and new drugs will probably not come out in the next decades or so until it's too late. Funny how COVID vaccines get approved crazy fast by the FDA but these take forever, sometimes we might never see them at all.
How many lectures and Ted Talks about cancer research have there been? You go back to this channel by years and you get these researchers (God bless their hearts) talking about new techniques and give us all hope. But yet where are these promising new drugs? Where are all these new promising techniques. Nowhere to be found, or their just going through their "testing" by the FDA. And yet the vaccine is approved within a damn year.
You know cancer is a business? Yeah, in 2021 according to stats, oncology drugs brought in 176 BILLION dollars to big pharma. You really think that the FDA and pharma want you to get well? No no no, it hurts their bottom line. I was watching a documentary and an FDA employee was told by his superiors that their client IS NOT THE PEOPLE. Their clients are the industry. Until we the people stand up, nothing will be done. All these chemo and radiation therapies are all carcinogenic, and the FDA admits that. Yet these therapies are the PRIMARY ways to treat cancer. By 2026, it's estimated that oncology sales will go up to over 300 billion dollars. Chemo drugs are one of the very few drugs where oncologists can actually make a profit. The cost of cancer treatment is 100,000 dollars per patient (not taking into account what your insurance will cover). But there are economists that actually are estimating that this will eventually dry up the insurance companies. It's all a house of cards, that's why if someone actually discovers the cure, the FDA and Big Pharma will do everything they can to suppress that cure. They know that chemo and radiation f*cks up your system. They don't care as long as they get your money. Medicine is the only industry where people still get paid even if their clients die. They still get paid even if none of their treatments work.
I don't mean to be a downer but we need the truth. I pray and hope that everyone suffering directly and indirectly from cancer gets a miracle. None of you or any of us should ever have to go through this. We the people should be aware of this and stand up. Instead of cancer awareness month, we should be doing FDA and Big Pharma corruption awareness. We already know cancer exists, we don't need awareness of them. But the corruption of these institutions should be brought to light. Bless you and everyone who reads this. I wish nothing but the best for everyone one of you.