EX: Cancer Invasion through Extracellular Matrix

Paper Discussed: jcb.rupress.org...
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[@Physionic]

Remember, the paper is linked so you can look through it yourself - as always, let me know your thoughts!
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[@yannishamani1834]

Super content, you're doing a much better job than my uni, you just won a subscriber!

[@Physionic]

Thanks for your support, Yannis! I appreciate the kind words!

[@mahyarsh87]

Thank you for sharing. Helpful information.

[@Physionic]

My pleasure, Mahyar. Thank you.

[@mariams2020]

That was very interesting and helpful! Thank you!

[@Physionic]

My pleasure, mariam - thank you for stopping by!

[@mariams2020]

@@Physionic Definitely gonna check out more of your videos 😊!I just have a question, so conclusively by inhibiting or silencing MTP-1, there will be no metastasis unless the collagen structure has been degraded or crosslinks have been broken. But in the case of MMP 1 and 2, you would still find metastasis even when inhibiting or silencing them, regardless of whether collagen is in its normal structure or collagen is degraded. So does that imply that only the MTP-1 is the one that can be controlled by silencing and is there any way to stop the MMP-1 and 2?

[@Physionic]

mariam s That’s a solid conclusion based on what you outlined. It would imply there are other avenues of migration/metastasis. That’s what makes cancer (among many reasons) a difficult condition to treat.