How To Calculate The Isoelectric Point of Amino Acids and Zwitterions

This biochemistry video tutorial explains how to calculate the isoelectric point of amino acids. It also explains how to identify the zwitterion structure of an amino acid.
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How did you determine which charged group gets deprotonated first?

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You saved my life, I’m about to cry at how badly my professor taught this lol

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i'm sorry, professor? dude i learned this on high school wtf? is this college level?

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@@Synexcu that's great for you then! :) don't know why you are on this video if you already know the content :))

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@@smallnoob7577 I am from India, learning this in 12th grade. And my teacher seemed to speak Chinese for this😐, had to come here

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WAIT! you all learned from your professor and teachers? this just appeared in our manuals without our prof teaching it.

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are you me?

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seriously you need this is med school for refreshers!!! This stuff doesn't go away after pre med classes.

[@lh9591]

Thank you so much! My biochem professor just told us "use the pKa values that are closest to each other, that is usually the answer."

[@bobbykang5332]

thats what my prof said too...

[@redpilledbachelor7776]

use only two pka, not three.

[@RirichiyoShirakiin]

but at 12:04 9.1 and 10.5 is closer than 2.2 and 9.1

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literally me

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i was literally having a breakdown over how complicated my teacher made this, youre a lifesaver dude

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read for 2hrs without understanding it,and just 9mins into this vid,everything started piecing up....thnk you soo much

[@janelonton]

I have watched so many videos on this topic, but you have the most to-the-point, precise explanation I’ve ever watched. You explain things as it is and never have I ever seen you advertise for your tutoring business. Nothing is wrong with that, but to me it just shows your genuine and passion in teaching. Know that your work has built a community and it continues helping a large amount of students!

[@Chromedesu444]

WOW so much easier to comprehend with the number line...understood it instantly

[@sebastianelben4795]

Quick tip that helped me understand „zwitterions“ better: „zwitter“ is the german word for hermaphrodite, so a zwitterion, (or „hemaphrodite-ion“) is hemaphroditical by having both a positive and negative charge

[@ironcrown2383]

My Biochem exam is on monday. Thanks for uploading the video

[@MayMoorefield]

Why do the pKa values for the amino group and carboxylic acid change from problem to problem?

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i also wonder why

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Bro this helped me so much I can't even tell you. My biochem professor did a VERY poor job explaining this

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You explained it so easily, while my teachers made it seem like mandarin😐😐

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My God,,,u have no idea how much this video has helped me..Tysm .

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Thanks man
You’re better than my lecturers

[@sreemahalakshmivlogs]

iam very fear about this topic when ever i saw your video of calculation of ISP of amino acids . now i got very good confidence in this concept. you explanation is awesome. thank you so much sir

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So helpful since my Ochem days...Thank you as always!

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Thank you sir , for helping me understand the application of the formula

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you did a really great video to understand the phenomena, thank you

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This is so well put together

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[@animeshhb]

Best video on this topic. Thankyou so much 🧡

[@henrydillon2115]

You just helped a dude who randomly selects two pka values to calculate for the pI and just hope for the best, whenever the pka values are 3..........and now you make him wanna speak spanish: gracias

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If you have not put this video on RUclips, I would not have understood any content about PI from references. Thanks a lot!

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This was such a good explanation! No more crying into my biochem textbook

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[@bethelsamson7434]

great video! at 0:11 you say glycine has chiral carbon, but it's actually the only AA without a chiral carbon because the R group is just hydrogen

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He says _an achiral carbon_

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[@ozumeceozcan6231]

umm i thought glycine did not have a chiral carbon. am i wrong to assume that a chiral carbon is a carbon atom that has 4 different groups binded to it?

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Best video on isoelectric point

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I’m watching this while in class

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Genius technique to teach..... Txns sir

[@BossAwesome11]

Glycine doesn’t have a chiral alpha carbon. In the beginning of the video you said chiral carbon but Glycine isn’t chiral. Thank you for all you do just wanted to clarify.

[@veronicachauke2031]

He said achiral

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Merciiii pour cette explication rigoureuse !

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[@aprajitapaliwal9217]

Glycine does not have a chiral carbon ( it is the only amino acid without an asymmetric carbon)

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totally agree

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He said Achiral meaning not Chiral...

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So

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[@86756309bm]

How do you know the charge of the groups in different pKas? Hopefully this isn't a stupid question..

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Saved life. Thank you, thank you.

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[@Honestpath4]

Please make a video on Newton's 2nd law of motion (Physics) specially on problems like . " YOU ARE MOVING A DESK ACROSS A ROOM AND MUST USE A FORCE OF 467 N . IF THE MASS OF THE DESK IS 65.0KG AND ITS ACCELERATING AT 1.22m/s,WHAT IS THE COEFFICIENT OF FRICTION BETWEEN THE DESK AND THE FLOOR?

[@harshilpatel7855]

I think the answer is 0.733
Here is what i thought -
You need atleast a force 467 N to move it which must be equal to the limiting force of friction.
Also limiting force of friction = umg ( since mg=N by FBD and u is coefficient of friction)
So 467=umg
467/(65*9.8) = u
u= 0.733
If g= 10 then u=0.71

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You saved my 4 fkin marks which is worth many many ranks if a question comes with mltiple charge carriers love this video subbed :)

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very good explanation.

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Excellent explanation

[@attran25]

I have a question, When you are writing out examples of the amino acids, you have NH2, -C-COOH then the R group is attached and the Hydrogen on the other side of the carbon. In your other video memorize the 20 amino acids you begin to have NH3+ instead of NH2 so I'm confused about which one it should be when writing the amino acid.

[@nisargbhavsar25]

Amino acids are usually written in there Zwitter ion form.

[@fatimaalsadoon6686]

thank you , this explanation is very helpful