@@aurapopescu1875 glycine is an amino acid. This is what the study says: GlyNAC provides the precursor amino acids glycine and cysteine (from N-acetylcysteine) for GSH (Glutathione) synthesis. Glycine, cysteine, and GSH make independent and important contributions toward cellular health and organ function. Their combination represents a “Power of 3” to indicate that benefits occur due to the combined effects of all three components. It is not just GSH alone…The “power of 3” refers to the combined action of glycine, NAC, and GSH.
Wow. Sometimes I worry that RUclips is a dumpster fire, and then I come across Elvis Costello's son dishing out some excellent content. Well done! Subscribed.
Agreed. Let’s hope it stays this way. Too often as channels grow they become more commercial with sponsors etc and lose the look and feel of why you subb’d. Maybe Costello’s son will find a way to avoid this.
@@johnreidy2804 Examine the reasons for providing free content, then consider why the target market may want to be drawn to it, and maybe that includes quality? Do ya think, Einstein?
@@Longtack55 Actually it doesn't take an Einstein to figure that one out Bub. Even you should be able to understand that some people are basically C H E A P. Now run along there is other free content that you are missing out on. 😂
I’ve been on glycine and nac for a month now taking ~10,000mg of glycine a day in capsule form with 1000mg of nac before bed with my last round of glycine. So far, my nails are hard as rock and the new growth at the base is losing those terrible ridges one gets in older age. My knees are so solid now that I can run up the subway steps without so much as a twinge of pain. My legs have an extraordinary amount of power I haven’t known since my twenties. My skin ( which has been very good since I started keto five years ago) has a youthfulness to it that I’m still shocked to see. My eyesight has improved and I sleep all the way through the night for 7 hours. Need for urinating is limited to a couple times a day and I no longer need to go in the middle of the night. For your reference , my diet is nose to tail carnivore and I also supplement with a number of other things. But it was when I started adding glycine and nac that my health and energy went stellar. I’m 64. I year later: I no longer take 10,000 mg a day and now take 3000, to 6000 mg per day to great result.
@@spinafex5729 went back to the gym for the first time in three weeks yesterday and the amount of weight I was able to lift went up not down as I expected! I’m also seeing fat loss as well but in places like my legs and arms where I’m beginning to see more veins.
Hey man just wanted to say your content is absolutely stellar and in my opinion you're one of the most valuable sources of information in the fitness industry. I hope you gain a lot more traction in the future so people can learn from your advice and analytical skills. Much love!
BRILLIANT! I love the way you explain the science behind your topics. Yes, I’m old (64) but not going down without a fight! I am a big fan of your videos. Thanks for sharing this information. You rock!
@@Physionic This recent human study was not successful: PMCID: PMC9261343PMID: 35821844 www.ncbi.nlm.nih.gov/pmc/articles/PMC9261343/ "did not increase levels of GSH-F:GSSG" A smaller subset has some benefit. "In summary GlyNAC supplementation is safe, well tolerated, and may increase glutathione levels in older adults with high glutathione demand." It was by the nestlé group who purchased the glynac patent from Baylor. Possibly could be reconciled by too low of a dose for too short a time. The other studies it appears the doses were given all at once and in the unsuccessful trial possibly the liver cleared out some of the smaller doses which were split into two doses. Or possibly the health of the participants were different. " placebo or GlyNAC at 2.4, 4.8, or 7.2 g (1:1 ratio) divided in two doses per day for 14 days. " I assume this means they received glycine and nac each at 2.4, 4.8 or 7.2 and not a combined total.
the corner stones of my stack are: glycine, NAC, MSM and omega-3 all of them are relevant regarding inflammation. sometimes i add glutamine and sometimes citruline malat. and sometimes i take gaba + 5htp to optimize my sleep. all in all, for me that stack turns out to be more of a reverse aging stack than anti-aging.
As usual amazingly researched information , I just turned 65 I did start taking creatine because of all of your research , I've heard you discuss glynac on several of your podcasts still not sure if it's something I should be taking . Have a beautiful day .
Quite probably so, but you can add a little bit in supplement form just to be sure. Also nuts contain lots of glycine. So if you eat meat/fish, an egg and nuts then you won’t have to supplement much - that’s for sure.
i like your channel , i swear to god it makes me happy and it gives me hope that , with fasting or water fasting we can do a lot , i did it and from my experience it works , thank you man
Hi, Physionic. I enjoy your videos immensely for both the science info and for "the creaky knees" (or similar in every video. My request is if you can tackle research on melatonin.
Your videos are very informative and I thank you for putting so much time and effort into bringing about informations that can change a person’s perspective on nutrition. I’ll be very glad and thankful if you could please make a video on Nicotinamide Mono Nucleotide and NAD+ levels in the body and it’s mechanism on aging … Thank you once again
Done: Food - Face Skin (Research) Practical Implications in Daily Life: 1. Supplementation: Consider adding glycine and NAC to your daily routine if you are experiencing age-related decline. 2. Target Audience: This stack is more beneficial for older individuals (e.g., 50+), as younger people may not see significant benefits. 3. Health Monitoring: Regularly monitor liver and kidney health if using this supplement stack long-term.
Yes but the study seems to use very large dosages of NAC. Glycine is fine as there is evidence to suggest a 10 g /day deficiency. Do you need almost equivalent amount of NAC. Maybe as another shorter term study a different dosages showed that nac dose greater than 4.8g/day was needed to effect a increase in a body deficient in glutathione. Any comments
@Physionic well deserved praise, I assure you! You produce quality content that actually empowers people and adds value. Keep doing what you are doing 👏
Awesome content and presentation 👏 I never miss a new video! Small question: I know you can buy GlyNAC but I take it as 2 supplements, Glycine and NAC. Is that okay?
Enjoyed it. You rarely address dosing in these videos, might wanna mention what the dosage was in these studies as a guide for people. Been on the Nutricost Glynac powders (Glycine powder and NAC powder) for a few weeks, getting about 3g each daily.
@@frankyherrebout2094 It is!!! For my weight I need 6 gr NAC but I take 3 gr (with 6 gr Glycine) and already getting good results after 3 weeks. So probably less NAC is also good for most people. Just try and see what works for you. Everyone's body is a bit different.
Great video. I have recently added NAC and Glycine supplementation for many of the reasons in this video. Can you comment on the N.Sato et al. study published on pubmed Dec 2009 that says NAC reduces collagen production. I have also been supplementing with that for some time and, based on my ill-informed read of the literature, it looks like i am undoing some of the benefits of taking collagen. Thank you in advance.
Nicolas, I’m going on 73. I raced bicycles for 30 years and still do high intensity interval 3xs a week. I follow your channel and others to seek reinforcement of important supplements. I take NAC but don’t have Glycine, yet. The only question I really wonder about is should I be taking antioxidants because I’m actively training every day cardiovascular as well as strengthening. I have no health issues. I got lucky in the gene department.
My concern as someone trying to build muscle and avoid sarcopenia is that NAC supplementation at 20mg/kg/day has been shown in men to reduce muscle repair capability. See Yannis Michailidis et al Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise, Am J Clin Nutr 2013;98:233-45. Quote from the abstract conclusion: "Although thiol-based antioxidant supplementation enhances GSH availability in skeletal muscle, it disrupts the skeletal muscle inflammatory response and repair capability, potentially because of a blunted activation of redox-sensitive signaling pathways." I'd like to hear of any human in-vivo research that contradicts this.
This is why I try to only do things that decrease inflammation away from exercise and post-exercise recovery. You don't want to tamp down the acute inflammation that builds muscle.
Interesting . Thanks for sharing bro! But just out of curiosity, how exactly did the researchers gauge markers of liver injury/issues?? Did they assess using ultrasound or fibroscan or just simple blood tests to see if supplementaion greatly elevated liver enzymes? Thanks
Still going. I would love it if you could make a video going over the studies showing low leucine levels and life span. I am interested because of the role of mTor. Also how does the effect of leucine on mTor contrasted with the effect of taurine on mTor?
Really appreciate the detail, presenting research in words and graphs that are accessible for a layperson without glossing over nuance and relevant detail. Almost makes up for the jokes!!!
this is so awesome! thank you! I started glyNac a few weeks ago. One of the two substances I consider an "elixir" of life ... Can you do an updated video on the data regarding Astazanthin?
Hey! Do you have any idea of oils can have phytic acid in them? I consume alot of macadamia nut oil and i wonder if it has no phytic acid in it because the solids are out. Thanks:)
Great content. Thank you Does it matter that the gly and nac be taken at the same time or not? Can the gly be a powder form and the nac be in a pill? Wondering what is the best way to do this. Didn't talk much about the 3rd other than proteins. Maybe Taurine?
That is excellent content you are covering thank you. I wonder whether you had any thoughts on whether NAD boosters are still a good idea. I notice from the trial data that Sirt1 increased but telomere length was unaffected by glynac supplementation. I also wonder what would happen after 1-2 years of glynac ?are the benefits sustained or do they drop off due to other factors.
Hey Seb - I can only answer some of your questions. 1. I know nothing about NAD supplements/boosters, except for what NAD does in the body, so I'm only educated on its mechanisms, but not the functional outcomes. I expect to start diving into that literature soon, so stay tuned. 2. I think GlyNAC will be beneficial long term. Will it offer ever lasting life? No. Why? Because glutathione is one pathway of aging, and while it is powerful, it isn't the only factor to consider. So, while GlyNAC will be beneficial long term (educated guess, I have no data on this), there are still other aspects that will carry on the aging process.
I have been taking 3g of nac and at least 6g of glycine daily for months and have not noticed anything except that when I have a cold, the mucus in my lungs clears up better. But only if I drink a lot. That is also the typical medical application. I'm 54
You could bring the Glycine up of couple grams or so and the NAC could go up another gram or 1200 mg. . . . See where that leads you. Take NAC without food, before a meal, like before breakfast. Another 1200 mg prior to bed. After or before supper. Watch some more videos and kind of jigger your numbers and timing just a bit. I would be interested in how that affects you, if it does. Sometimes a B little experimentation is useful. And the info from other good videos.
💕💕💕💕💕💕wish all would give examples cost....of course we know each is differen if we aren't smart to calculate location as aLL toown...cities are different as NY and midwest....plan to move to Dumaguete area in a short few months ahead....I am ninety nine percent blind....forgive me if any mistakes....LOVE to OUR WORLD thank you
You crack me up! I like your style. I enjoy listening to you, especially while out getting my steps in. I take NAC, and I'll be adding glycine as well. So Fetch! 😂
If you eat a portion of meat/fish along with some nuts everyday, the benefit of supplementing with glycine is questionable as you are already taking in a few grams of glycine a day.
Thanks for your insights! I really have enjoyed listening to you over the last month since subscribing! I’ve been supplementing GlyNAC for the past year and have definitely noticed a difference in my workout outputs. And my skin has seemed to become smoother. I’m getting my blood work reviewed by my Dr next week! HgA1c is one of the tests.
Thx for your excellent and comprehensive presentation, as usual. Actually , as for me, If Glynac can increase your Alkaline Phosphatase level, we definitely could think it is not a really helpful anti-aging supplement. No smoke without fire.
Swanson sells NAC with milk thistle to help protect your liver. Also you should be taking supplements like Tudca to protect your liver anyway if your taking a ton of oral supplements.
I doubt this is an indication of liver damage: if in isolation and only modestly elevated, it is more likely a reflection of elevated osteoblastic activity to undo accumulated osteoporosis.
I started taking Glynac about a month ago. Big improvement in brain-fog\cognition and a general sense of energy! The claims are true! I am a 57yo male.... The only concern I have is that there are studies pointing to the acceleration of certain types of cancers when taking one of the supplements: NAC... I think the jury's still out but this could potentially be problematic for obvious reasons.
Hey Nic! Please make a video about Energy drinks, all the pros and cons of them. How much per day is safe? What ingredients are harmful? Is it the same as coffee? I absolutely love the taste of energy drinks, and that's why I drink them. I've done my part of the research and found it not to be harmful if drinking 1-2 cans a day (250-500ml). The sugar and caffeine content are usually lower than a starbuck coffee.
the problem with energy drinks is not the contents, they are FDA-approved and safe for a cadaver but the danger comes from the cans. The branding is deadly.
You shouldn't think that everything that's in these energy drinks is on the can. There are many ingredients that do not need to be declared. The government will not protect you, politics will protect the industry. It will lie to you and allow the industry to lie and poison you. I would recommend that you only drink water or fruit juice. They're not unencumbered by industrial crap either, but they're still better than this chemical muck
additionally to 2*600mg(...1200mg) NAC and 2*4g of glycine, i also throw in 2*5g glutamine and 2*5 drops of methalene blue 1%. that combination is awesome.
what's your experience with methylene blue particularly? did you try infrared light? they said it's reducing inflammation itself charging mitochondria did you try active B1 maybe? sorry for disturbing
@@szymonbaranowski8184 methylene blue gives me much more energy and a kind of calmness that gives me more focus at work. for reduction of inflammation, the amino acid combination to boost glutathione is already doing a great job. additionally to glynac, i also added glutamine which is also a buildingblock for the TRIpeptide glutathione.
I am currently taking creatine and work out 5 days a week with weights. Will GlyNac supplement enhance workout capacity? Great content! Maybe collab with my faves Dr Stansfield or Dr Attia? One can hope!
I see some potential in these substances doing so. Worth giving it a try. Yet they won't make up for a bad diet and poor sleep. Hope those are dialed in well.
@christianduval8374 Dairy protein is rich in Cysteine. Whey has in the order of 2% of it. Not as much as if you would supplement with GlyNAC. But as much as you can get from any food. Collagen is a good source of Glycine, but it hasn't any Cysteine.
I started taking GlyNAC about 2 weeks ago on a lark. It's cheap. I'm 64. So why not? I'm pretty fit, so I didn't expect to notice much of a change in anything. And sure enough, no noticeable changes in how any of my exercise routines went or how I felt. But when I went to spot check my blood pressure, I was surprised. I the last few years it had inexplicably bumped up to 130-140 over 80. This after having a solid 120/80 (or lower) all of my life. It's been bugging me because I exercise quite a bit (3500 mile/yr cycling) and am pretty active. The one thing I could add is some weight training. Anyway, my BP is now back to its old level. I've checked for the last 6 days and it is consistently right near 120/80. Sometimes as low as 115/70 and sometimes more like 125/80. This is a clear change. It isn't some subtle shift. It is an obvious one. I guess what I'll do now is gradually reduce the dose (I'm currently just below the study dose level) and see if/when the BP goes back up. Ideally, I'd like to drop the dose to something lower than what was used in the study.
I think I just had the easiest 5 day water fast ever. Is that a good thing for a 76 year old to do, I feel great. I’m going to relisten to both of these videos. I feel younger now than I did at 70 by a lot.
No a larger portion of your body is water. There's no need to water fast, it's mandatory for every function. Just don't over hydrate and you'll be fine.
Also, what would be difference between supplementing with glycine, NAC and the third supplement … versus just drinking matcha, green teas and fruits and veggies (rich in antioxydants)
@Dodgerzden Cysteine can be converted to Taurine, which is also anti-aging. But we all need more Glycine for production of Glutathion, as this research was about. But also for production of Collagen and Creatine. If you supplemented with Creatine, you would have saved some Glycine. Collagen supplementation would have helped, because every third molecule in it is Collagen.
@@larsnystrom6698 AFAIK, taking glycine helps to reduce the negative effects of glyphosate. Stephanie Seneff (MIT professor) has said so. I think all people, regardless of age, would benefit from taking glycine as glyphosate is in 99% of foods, water, etc.
Thanks for great content. Aside from increasing antioxydant capacity, what other anti aging mechanisms can you improve? Activating sirtuin genes with resveratrol, fasting (reduce mTOR), supplementing with NMN .. yes im getting this info from david sinclair lol
There seems to be a big bump in the improvement beyond the two-week period. Out at 16 weeks it looks really good. Can you please drop a few lines on the average age of a mitochondrion? And if I haven't lost you completely with this "do it for free" request, what are your top three inflammation markers hs-crp il-6 and homocysteine?
Hi! Hope you don't mind the inquiry. Can you kindly please elaborate what you mean by "a big bump" after the 2 week peroid? Thank you so much in advance for your response.
@@DF-de8ibHi, and thanks for the Q. I was looking at the chart at approximately 4 minutes and 41 seconds into the vid. After two weeks there was a rather radical bump up. This bump up was for old people on glynac The third set of bars to the right, it was 16 weeks out and it was for young people, the control group who had no glynac What I wanted to know is if that positive bump up was sustained for old people on GlyNAC at 16 weeks. It's an absolutely critical result because if the positive result is only for two weeks, and then it goes back to a baseline of "no difference", it's not worth it taking an expensive supplement for 16 weeks, or longer. Kind of hard to capture the response and the subtleties in a RUclips text on a mobile phone....but I hope this may have answered your question?
You briefly mentioned the third component of the trio as a protein. What protein? The papers you reviewed seemed to deal with the first two the trio. Did you review research on the third component - the protein? Or is this for a future video?
I think it would be best to assume they don't. Realistically, it all comes down to your level of exposure. Your body is capable of overcoming deleterious substances.... Up to a point.
@@Physionic the online shop I am looking at has L-Glycine and N-Acetyl L-Cysteine, are they the same as Glyine and N-Acetyl Cysteine respectuvely? They both comes in powder, so t just mix the Gly + NAC powder with water and drink them? :) Thanks in advance.
Thank you for this video! I have a guess, of which I wonder what you think? Could the g l y n a c increasing autophagy cause an increase in acidic pH? I'm wondering if perhaps we are releasing alkaline buffers to help mitigate the damage ?
I've been taking NAC ang glycine for over 2 years now and my brain fog has gone and my cognitive function is sharper in my late 50's. My dose is twice a day 2g NAC and 3g glycine each serving. Is there an optimal dose for us older people?
Have you considered a mini series on the Halmarks of aging and how to combat each those through diet/lifestyle/fasting? E.g. What are the hallmarks of aging Hallmark 1: research on how to combat Hallmark 2: " " Etc Etc
The third one (the protein) is glutathione - I seem to have confused some people with my poor wording, my apologies. :)
But glycine is also a protein???
@@aurapopescu1875 glycine is an amino acid. This is what the study says: GlyNAC provides the precursor amino acids glycine and cysteine (from N-acetylcysteine) for GSH (Glutathione) synthesis. Glycine, cysteine, and GSH make independent and important contributions toward cellular health and organ function. Their combination represents a “Power of 3” to indicate that benefits occur due to the combined effects of all three components. It is not just GSH alone…The “power of 3” refers to the combined action of glycine, NAC, and GSH.
@@conscious_choice thank you!
@@conscious_choice Do you supplement (which dose) the "power 3"?
And please let me know, what guided your decision therefor.
tx
@@conscious_choice OK. Got your supplementation from your comment below.
Pls: And please let me know, what guided your decision therefor.
Wow. Sometimes I worry that RUclips is a dumpster fire, and then I come across Elvis Costello's son dishing out some excellent content. Well done! Subscribed.
Agreed. Let’s hope it stays this way. Too often as channels grow they become more commercial with sponsors etc and lose the look and feel of why you subb’d. Maybe Costello’s son will find a way to avoid this.
@@jmc8076 Yeah, and you like your F R E E content to be high quality right Sparky?
@@johnreidy2804 Examine the reasons for providing free content, then consider why the target market may want to be drawn to it, and maybe that includes quality? Do ya think, Einstein?
@@Longtack55 Actually it doesn't take an Einstein to figure that one out Bub. Even you should be able to understand that some people are basically C H E A P.
Now run along there is other free content that you are missing out on.
😂
@@johnreidy2804 My "Einstein" was a response to your "Sparky." That's for free.
I’ve been on glycine and nac for a month now taking ~10,000mg of glycine a day in capsule form with 1000mg of nac before bed with my last round of glycine.
So far, my nails are hard as rock and the new growth at the base is losing those terrible ridges one gets in older age. My knees are so solid now that I can run up the subway steps without so much as a twinge of pain. My legs have an extraordinary amount of power I haven’t known since my twenties. My skin ( which has been very good since I started keto five years ago) has a youthfulness to it that I’m still shocked to see. My eyesight has improved and I sleep all the way through the night for 7 hours. Need for urinating is limited to a couple times a day and I no longer need to go in the middle of the night. For your reference , my diet is nose to tail carnivore and I also supplement with a number of other things. But it was when I started adding glycine and nac that my health and energy went stellar. I’m 64.
I year later: I no longer take 10,000 mg a day and now take 3000, to 6000 mg per day to great result.
What brand do you buy?
Yes same, been on Glynac for 4 months now. The return of muscle power is the first thing I noticed along with loss of fat around my midrift.
Biological or chronological?
@@spinafex5729 went back to the gym for the first time in three weeks yesterday and the amount of weight I was able to lift went up not down as I expected! I’m also seeing fat loss as well but in places like my legs and arms where I’m beginning to see more veins.
@@iche9373 on my test last year my biological age was 53. I’m hoping that has improved by the time I do the next test this July. Wish me luck.
Hey man just wanted to say your content is absolutely stellar and in my opinion you're one of the most valuable sources of information in the fitness industry. I hope you gain a lot more traction in the future so people can learn from your advice and analytical skills. Much love!
Incredibly kind of you, Alyssus. Thank you. :)
@@Physionic agreed 😊
@@Physionica break down of nmn, resveratrol, caakg, quercetin. Are they effective and how to take them would be great.
I think anti aging is an optimistic word. Because this is just anti illness. You can be very illness free but you are old anyway
Brilliant!
BRILLIANT! I love the way you explain the science behind your topics. Yes, I’m old (64) but not going down without a fight! I am a big fan of your videos. Thanks for sharing this information. You rock!
Same here.
Will be 72 in September 24.
Fight .!!
I like the way you organize your videos. Topic, considerations, conditions, and conclusions. Very well organized. Very well expressed.
Love that you make scientific papers so accessible to a wider audience, much needed. Thank you.
Thanks, Myles! I love doing it!
@@Physionic
This recent human study was not successful:
PMCID: PMC9261343PMID: 35821844
www.ncbi.nlm.nih.gov/pmc/articles/PMC9261343/
"did not increase levels of GSH-F:GSSG"
A smaller subset has some benefit. "In summary GlyNAC supplementation is safe, well tolerated, and may increase glutathione levels in older adults with high glutathione demand."
It was by the nestlé group who purchased the glynac patent from Baylor.
Possibly could be reconciled by too low of a dose for too short a time. The other studies it appears the doses were given all at once and in the unsuccessful trial possibly the liver cleared out some of the smaller doses which were split into two doses. Or possibly the health of the participants were different.
" placebo or GlyNAC at 2.4, 4.8, or 7.2 g (1:1 ratio) divided in two doses per day for 14 days. " I assume this means they received glycine and nac each at 2.4, 4.8 or 7.2 and not a combined total.
the corner stones of my stack are:
glycine, NAC, MSM and omega-3
all of them are relevant regarding inflammation.
sometimes i add glutamine and sometimes citruline malat.
and sometimes i take gaba + 5htp to optimize my sleep.
all in all, for me that stack turns out to be more of a reverse aging stack than anti-aging.
What about taurine🤔
I’ve recently added R-alpha lipoic acid.( the active isomer)
Excellent info as always... Truly appreciate your sense of humor my friend! :cheers! 🌱
Thanks
Thank you!
Thanks!
Thank you, Doug!
As usual amazingly researched information , I just turned 65 I did start taking creatine because of all of your research , I've heard you discuss glynac on several of your podcasts still not sure if it's something I should be taking . Have a beautiful day .
isnt it enough to eat eggs meat fish which contain those Cysteine and glycine ?
Quite probably so, but you can add a little bit in supplement form just to be sure. Also nuts contain lots of glycine. So if you eat meat/fish, an egg and nuts then you won’t have to supplement much - that’s for sure.
Thanks for your effort and making these scientific topics accessible for more people, can't be overstated enough how much people like you are needed.
You are hilarious and it's much appreciated. Thank you for your valuable work.
i like your channel , i swear to god it makes me happy and it gives me hope that , with fasting or water fasting we can do a lot , i did it and from my experience it works , thank you man
Thanks for the fabulous content and summary of NAC benefits! Hopefully the Alp elevation issue can be figured out some time.
Thanks, Talia - hope all is well!
Hi, Physionic. I enjoy your videos immensely for both the science info and for "the creaky knees" (or similar in every video. My request is if you can tackle research on melatonin.
Your videos are very informative and I thank you for putting so much time and effort into bringing about informations that can change a person’s perspective on nutrition. I’ll be very glad and thankful if you could please make a video on Nicotinamide Mono Nucleotide and NAD+ levels in the body and it’s mechanism on aging … Thank you once again
Done: Food - Face Skin (Research)
Practical Implications in Daily Life:
1. Supplementation: Consider adding glycine and NAC to your daily routine if you are experiencing age-related decline.
2. Target Audience: This stack is more beneficial for older individuals (e.g., 50+), as younger people may not see significant benefits.
3. Health Monitoring: Regularly monitor liver and kidney health if using this supplement stack long-term.
Just ran across you channel. Good stuff man, keep the content coming.
Thanks!
Yes but the study seems to use very large dosages of NAC. Glycine is fine as there is evidence to suggest a 10 g /day deficiency. Do you need almost equivalent amount of NAC. Maybe as another shorter term study a different dosages showed that nac dose greater than 4.8g/day was needed to effect a increase in a body deficient in glutathione. Any comments
Sorry, what dosage do you recommend for each ?
Can you comment on NAC reducing collagen in the body? Does Glycine compensate?
You actually give me hope for humanity. Legend!
High praise - not sure I deserve that, but thank you, Haydon.
@Physionic well deserved praise, I assure you! You produce quality content that actually empowers people and adds value. Keep doing what you are doing 👏
How many grams of NAC and glycine do you recommend based on these analysis for someone in 50s?
Is there a dosage recommendation? Sorry if I missed it in the video
So far - loving your content !! .. soo on point! ..quickly becoming my Fav 🙏🙏🙏 thank you sir !!
Awesome content and presentation 👏 I never miss a new video! Small question: I know you can buy GlyNAC but I take it as 2 supplements, Glycine and NAC. Is that okay?
Sure, that's how they did it in the official study.
Enjoyed it. You rarely address dosing in these videos, might wanna mention what the dosage was in these studies as a guide for people. Been on the Nutricost Glynac powders (Glycine powder and NAC powder) for a few weeks, getting about 3g each daily.
100 mg/kg for both glycine and NAC each. So 73 kg (160 lbs) needs 7.3 gr glycine and 7.3 gram NAC.
@@conscious_choice Hi Joyce where did you get those recommendations from on how much to take each day?
@@illement7 From the official study. Sorry comments with links are deleted.
@@conscious_choice Wow, that’s a lot of NAC !!!
@@frankyherrebout2094 It is!!! For my weight I need 6 gr NAC but I take 3 gr (with 6 gr Glycine) and already getting good results after 3 weeks. So probably less NAC is also good for most people. Just try and see what works for you. Everyone's body is a bit different.
Great video. I have recently added NAC and Glycine supplementation for many of the reasons in this video. Can you comment on the N.Sato et al. study published on pubmed Dec 2009 that says NAC reduces collagen production. I have also been supplementing with that for some time and, based on my ill-informed read of the literature, it looks like i am undoing some of the benefits of taking collagen. Thank you in advance.
GREAT INFORMATION DELIGHTFUL NARRATION COMPELLING PRESENTATION!!!
You are my new super star ❤❤❤❤❤❤❤❤
Was very interesting and informative, but at the end was not sure what supplements i should take, especially rhe third one?
Yes I’m also not clear on the third item on the power of 3
Nicolas, I’m going on 73. I raced bicycles for 30 years and still do high intensity interval 3xs a week. I follow your channel and others to seek reinforcement of important supplements. I take NAC but don’t have Glycine, yet. The only question I really wonder about is should I be taking antioxidants because I’m actively training every day cardiovascular as well as strengthening. I have no health issues. I got lucky in the gene department.
I like how you add a humor to your explanation
Thanks, Joel!
My concern as someone trying to build muscle and avoid sarcopenia is that NAC supplementation at 20mg/kg/day has been shown in men to reduce muscle repair capability. See Yannis Michailidis et al Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after
intense eccentric exercise, Am J Clin Nutr 2013;98:233-45. Quote from the abstract conclusion: "Although thiol-based antioxidant supplementation enhances GSH availability in skeletal muscle, it disrupts the skeletal muscle inflammatory response and repair capability, potentially because of a blunted activation of redox-sensitive signaling pathways."
I'd like to hear of any human in-vivo research that contradicts this.
Hmm. Maybe L-cysteine would be better than NAC.
This is why I try to only do things that decrease inflammation away from exercise and post-exercise recovery. You don't want to tamp down the acute inflammation that builds muscle.
I love it! A Mean Girls reference! This video was made for me, from creaking knees to "that's so fetch"😂❤️
Interesting . Thanks for sharing bro! But just out of curiosity, how exactly did the researchers gauge markers of liver injury/issues?? Did they assess using ultrasound or fibroscan or just simple blood tests to see if supplementaion greatly elevated liver enzymes? Thanks
Still going. I would love it if you could make a video going over the studies showing low leucine levels and life span. I am interested because of the role of mTor. Also how does the effect of leucine on mTor contrasted with the effect of taurine on mTor?
Where is the best place to buy these supplements and what brands do you suggest?
Really appreciate the detail, presenting research in words and graphs that are accessible for a layperson without glossing over nuance and relevant detail. Almost makes up for the jokes!!!
Thanks, Chris :)
this is so awesome! thank you! I started glyNac a few weeks ago. One of the two substances I consider an "elixir" of life ... Can you do an updated video on the data regarding Astazanthin?
Hey! Do you have any idea of oils can have phytic acid in them? I consume alot of macadamia nut oil and i wonder if it has no phytic acid in it because the solids are out. Thanks:)
Another great video. Thank you.
Great information. Thank you
Great content. Thank you
Does it matter that the gly and nac
be taken at the same time or not? Can the gly be a powder form and the nac be in a pill? Wondering what is the best way to do this.
Didn't talk much about the 3rd other than proteins. Maybe Taurine?
That is excellent content you are covering thank you. I wonder whether you had any thoughts on whether NAD boosters are still a good idea. I notice from the trial data that Sirt1 increased but telomere length was unaffected by glynac supplementation. I also wonder what would happen after 1-2 years of glynac ?are the benefits sustained or do they drop off due to other factors.
Hey Seb - I can only answer some of your questions.
1. I know nothing about NAD supplements/boosters, except for what NAD does in the body, so I'm only educated on its mechanisms, but not the functional outcomes. I expect to start diving into that literature soon, so stay tuned.
2. I think GlyNAC will be beneficial long term. Will it offer ever lasting life? No. Why? Because glutathione is one pathway of aging, and while it is powerful, it isn't the only factor to consider. So, while GlyNAC will be beneficial long term (educated guess, I have no data on this), there are still other aspects that will carry on the aging process.
I have been taking 3g of nac and at least 6g of glycine daily for months and have not noticed anything except that when I have a cold, the mucus in my lungs clears up better. But only if I drink a lot. That is also the typical medical application. I'm 54
You could bring the Glycine up of couple grams or so and the NAC could go up another gram or 1200 mg. .
. . See where that leads you. Take NAC without food, before a meal, like before breakfast. Another 1200 mg prior to bed. After or before supper. Watch some more videos and kind of jigger your numbers and timing just a bit.
I would be interested in how that affects you, if it does. Sometimes a B little experimentation is useful. And the info from other good videos.
💕💕💕💕💕💕wish all would give examples cost....of course we know each is differen if we aren't smart to calculate location as aLL toown...cities are different as NY and midwest....plan to move to Dumaguete area in a short few months ahead....I am ninety nine percent blind....forgive me if any mistakes....LOVE to OUR WORLD thank you
You crack me up! I like your style. I enjoy listening to you, especially while out getting my steps in. I take NAC, and I'll be adding glycine as well.
So Fetch! 😂
If you eat a portion of meat/fish along with some nuts everyday, the benefit of supplementing with glycine is questionable as you are already taking in a few grams of glycine a day.
LOL, I read your thumbnail as "...to the power of 3 factorial"
Exactly, I first thought this is about some kind of maths fun fact. I do have this sort of videos pop up in my recommendations every now and then.
Love your content! But I’m puzzled after watching this video. What is the ‘third” item? All you say about it it is that its a “protein.”
Pinned comment. I didn't make it clear.
Great video! It seems in the 16 weeks, w can see GlyNac's benefit. I'm wondering how long GlyNac's benefit can be washed out.
Where can people get the supplement. I don’t trust anything from amazon.
How much did they need to supplement with to see these changes?
Thanks for your insights! I really have enjoyed listening to you over the last month since subscribing! I’ve been supplementing GlyNAC for the past year and have definitely noticed a difference in my workout outputs. And my skin has seemed to become smoother. I’m getting my blood work reviewed by my Dr next week! HgA1c is one of the tests.
All the best at your appointment, Sean.
Osteoporosis too? Bone health. I was doing all the things recommended for the condition except aging couldn’t stop.
Aging only stops at death 😌👌
Thank you for this video! I’m so pleased that I can confirm supplement worthiness from your explanations
Thx for your excellent and comprehensive presentation, as usual.
Actually , as for me, If Glynac can increase your Alkaline Phosphatase level, we definitely could think it is not a really helpful anti-aging supplement. No smoke without fire.
Swanson sells NAC with milk thistle to help protect your liver. Also you should be taking supplements like Tudca to protect your liver anyway if your taking a ton of oral supplements.
I doubt this is an indication of liver damage: if in isolation and only modestly elevated, it is more likely a reflection of elevated osteoblastic activity to undo accumulated osteoporosis.
this was rad. thanks for posting.
I started taking Glynac about a month ago. Big improvement in brain-fog\cognition and a general sense of energy! The claims are true! I am a 57yo male.... The only concern I have is that there are studies pointing to the acceleration of certain types of cancers when taking one of the supplements: NAC... I think the jury's still out but this could potentially be problematic for obvious reasons.
The cancer side of things makes me hesitate as well. Hoping future studied can clear those concerns up.
Which studies?
Just don't take nac daily
Nope! Just take curcumin and alpha lipoic acid as well. NO CANCER!
I understood that the "studies" you mentioned were proven false.
Thanks for your content. Is there anyway you can allow us to change the viewing speed in settings?
Hey Nic! Please make a video about Energy drinks, all the pros and cons of them. How much per day is safe? What ingredients are harmful? Is it the same as coffee?
I absolutely love the taste of energy drinks, and that's why I drink them. I've done my part of the research and found it not to be harmful if drinking 1-2 cans a day (250-500ml). The sugar and caffeine content are usually lower than a starbuck coffee.
the problem with energy drinks is not the contents, they are FDA-approved and safe for a cadaver but the danger comes from the cans. The branding is deadly.
Zero energy drinks are safe. Coffee, in moderation, without sugar, will make you live longer.
@@Burnrate The FDA is a branch of the industry that is supposed to sell you the crap of the industry as "approved".
You shouldn't think that everything that's in these energy drinks is on the can. There are many ingredients that do not need to be declared. The government will not protect you, politics will protect the industry. It will lie to you and allow the industry to lie and poison you. I would recommend that you only drink water or fruit juice. They're not unencumbered by industrial crap either, but they're still better than this chemical muck
@John Recker You do it for me please. And send me the sources too at the same speed that you replied without actually reading my whole question.
additionally to 2*600mg(...1200mg) NAC and 2*4g of glycine, i also throw in 2*5g glutamine and 2*5 drops of methalene blue 1%.
that combination is awesome.
what's your experience with methylene blue particularly?
did you try infrared light? they said it's reducing inflammation itself charging mitochondria
did you try active B1 maybe?
sorry for disturbing
@@szymonbaranowski8184 methylene blue gives me much more energy and a kind of calmness that gives me more focus at work. for reduction of inflammation, the amino acid combination to boost glutathione is already doing a great job. additionally to glynac, i also added glutamine which is also a buildingblock for the TRIpeptide glutathione.
@stefanweilhartner4415 How much methylene blue were you taking and what time of the day were you're taking it?
@@sncnutrition7118 5 to 10 drops in the morning
Have you done any research on methylene blue?
Have video on it
Got it. Thanks. Our bodies are amazing in the way they function.
I just watched a video where you said that niacin could increase insulin sensitivity .
Does taking the mix of 3 help to prevent that at all ?
I am currently taking creatine and work out 5 days a week with weights. Will GlyNac supplement enhance workout capacity? Great content! Maybe collab with my faves Dr Stansfield or Dr Attia? One can hope!
I see some potential in these substances doing so. Worth giving it a try. Yet they won't make up for a bad diet and poor sleep. Hope those are dialed in well.
@gordonwho
If GlyNAC improves the health of the mitocondria, that would improve the performance.
So, the research supports that!
For those who don't have access to NAC, what akternatives do they have?
@christianduval8374
Dairy protein is rich in Cysteine.
Whey has in the order of 2% of it.
Not as much as if you would supplement with GlyNAC. But as much as you can get from any food.
Collagen is a good source of Glycine, but it hasn't any Cysteine.
I started taking GlyNAC about 2 weeks ago on a lark. It's cheap. I'm 64. So why not? I'm pretty fit, so I didn't expect to notice much of a change in anything. And sure enough, no noticeable changes in how any of my exercise routines went or how I felt. But when I went to spot check my blood pressure, I was surprised. I the last few years it had inexplicably bumped up to 130-140 over 80. This after having a solid 120/80 (or lower) all of my life. It's been bugging me because I exercise quite a bit (3500 mile/yr cycling) and am pretty active. The one thing I could add is some weight training.
Anyway, my BP is now back to its old level. I've checked for the last 6 days and it is consistently right near 120/80. Sometimes as low as 115/70 and sometimes more like 125/80. This is a clear change. It isn't some subtle shift. It is an obvious one.
I guess what I'll do now is gradually reduce the dose (I'm currently just below the study dose level) and see if/when the BP goes back up. Ideally, I'd like to drop the dose to something lower than what was used in the study.
I think I just had the easiest 5 day water fast ever. Is that a good thing for a 76 year old to do, I feel great. I’m going to relisten to both of these videos. I feel younger now than I did at 70 by a lot.
No a larger portion of your body is water. There's no need to water fast, it's mandatory for every function. Just don't over hydrate and you'll be fine.
Do you take this forever? Cycle on and off?
Also doesn't supplementing selenium and Sulphur(MSM) increase glutathione?
Ok so how much of each to supplement?
Does glynac affect muscle strength and growth I have heard not too taken on days that you workout great show again
Yes, improvements in muscle strength.
Whats your supplement stack?
Did you see the longevity diet research? Reversed age in just 8 weeks? They've published a follow up study on this too.
Where?
@Francesco pub med but the main author has done a number of interviews on YT. The report has also caught the headlines in mainstream media too
Might be worth combining with fasting?
Hi there- what is the ratio between Glycine and cysteine- I can only purchase it separately-
su Rudolf
Also, what would be difference between supplementing with glycine, NAC and the third supplement … versus just drinking matcha, green teas and fruits and veggies (rich in antioxydants)
too much external antioxies can lower your internal production...
wasn't green tea good for girls but not so much for boys? (lower testo)
Potency, far greater potency, is the difference
So I've been taking NAC for a few years. Has it been all worthless without combining it with glycine?
@Dodgerzden
Cysteine can be converted to Taurine, which is also anti-aging.
But we all need more Glycine for production of Glutathion, as this research was about.
But also for production of Collagen and Creatine.
If you supplemented with Creatine, you would have saved some Glycine.
Collagen supplementation would have helped, because every third molecule in it is Collagen.
@@larsnystrom6698 AFAIK, taking glycine helps to reduce the negative effects of glyphosate. Stephanie Seneff (MIT professor) has said so. I think all people, regardless of age, would benefit from taking glycine as glyphosate is in 99% of foods, water, etc.
Thanks for great content. Aside from increasing antioxydant capacity, what other anti aging mechanisms can you improve? Activating sirtuin genes with resveratrol, fasting (reduce mTOR), supplementing with NMN .. yes im getting this info from david sinclair lol
Sinclair is a scammer
@@M1kl00 evidence that david sinclair is a scammer? He’s a harvard professor, you can see on their website
Hello,
I am not sure if you will see this but I am wondering, is this advantageous over taking glutathione itself?
I have a short answering that, check it out.
There seems to be a big bump in the improvement beyond the two-week period.
Out at 16 weeks it looks really good.
Can you please drop a few lines on the average age of a mitochondrion?
And if I haven't lost you completely with this "do it for free" request, what are your top three inflammation markers hs-crp il-6 and homocysteine?
Hi! Hope you don't mind the inquiry. Can you kindly please elaborate what you mean by "a big bump" after the 2 week peroid? Thank you so much in advance for your response.
@@DF-de8ibHi, and thanks for the Q.
I was looking at the chart at approximately 4 minutes and 41 seconds into the vid.
After two weeks there was a rather radical bump up.
This bump up was for old people on glynac
The third set of bars to the right, it was 16 weeks out and it was for young people, the control group who had no glynac
What I wanted to know is if that positive bump up was sustained for old people on GlyNAC at 16 weeks.
It's an absolutely critical result because if the positive result is only for two weeks, and then it goes back to a baseline of "no difference", it's not worth it taking an expensive supplement for 16 weeks, or longer.
Kind of hard to capture the response and the subtleties in a RUclips text on a mobile phone....but I hope this may have answered your question?
I increase glutathione with broccoli sprouts via sulphoraphane. Do you think this would work
What about NAC with Taurine ! It does work as the same as glycinate !
Thank you! Great content!
You briefly mentioned the third component of the trio as a protein. What protein? The papers you reviewed seemed to deal with the first two the trio. Did you review research on the third component - the protein? Or is this for a future video?
Think the protein he's talking about is glutathione, the "antioxidant protein" he references at 3:23.
Unless I misunderstood, Glycine + NAC produces Glutathione... the latter being your 'missing' protein.
@@zer0thzero428 Glycine, NAC, and Cysteine
Sorry for the confusion, Ken. Patricia and Zer0th nailed it.
Any particular GSH brands?
Nic, are there any studies showing whether the body can get rid of pesticides?
I think it would be best to assume they don't. Realistically, it all comes down to your level of exposure. Your body is capable of overcoming deleterious substances.... Up to a point.
IIRC Chlorella (marine algae) powder has promising data about chelating and binding heavy metals/pesticides and excreting via the bowel
@@ChuckleberrySoup Spirulina too?.
@@markaguilera493 l think there is something about Chlorella's cell wall structure that allows it to bind to contaminants
What are your thoughts on taking TMG?
Hi
Isnt it better to take glutathione supps instead of glycine+NAC?
Hey Star, I have a video explaining why GlyNAC may be better. It’s in the Shorts.
@@Physionic Thank you very much, handsome!
@@Physionic the online shop I am looking at has L-Glycine and N-Acetyl L-Cysteine, are they the same as Glyine and N-Acetyl Cysteine respectuvely?
They both comes in powder, so t just mix the Gly + NAC powder with water and drink them? :)
Thanks in advance.
I’m now an insider …. Got enough great content for free … need to help our excellent host produce more great content.
I not as versed as others here seem to be.
I should have thought that
R-alpha lipoic acid would have played a role in the “power of three” .
Taking 200 mg. Magnesium Glycinate daily. Does that provide enough glycine?
So, is it better to supplement with precursors for glutathione? Or to just inject glutathione? What is the best approach?
I have a short video on it on the channel. :)
It’s helpful if you can link the short? It’s difficult to find.
I have low blood pressure. When I take GlyNac, it tends to make me dizzy.
Very good.
At 7:49, is that fasting insulin level or something else like average insulin level? Thank you!
Fasting, I believe.
Thank you for this video! I have a guess, of which I wonder what you think? Could the g l y n a c increasing autophagy cause an increase in acidic pH? I'm wondering if perhaps we are releasing alkaline buffers to help mitigate the damage ?
I've been taking NAC ang glycine for over 2 years now and my brain fog has gone and my cognitive function is sharper in my late 50's. My dose is twice a day 2g NAC and 3g glycine each serving. Is there an optimal dose for us older people?
Up your dose of Glycine.
Lower your dose of Glycine.
Then up it again
Have you considered a mini series on the Halmarks of aging and how to combat each those through diet/lifestyle/fasting?
E.g.
What are the hallmarks of aging
Hallmark 1: research on how to combat
Hallmark 2: " "
Etc
Etc
Yes, but I need to do a lot more analysis before I feel educated enough to put that together. :)