okay.. see we know that 4 oxygen at C terminal and 4 NH at N terminal dont involve in H bonding in an alpha helix. But these groups form attractive forces with side chains of other amino acids at the termini. eg basic side chains at N terminal satisfies NH groups by forming hydrogen bonds. That is called N capping or similarly you have C capping as well. some refences may be helpful to have more clarity: pubs.acs.org/doi/10.1021/acs.biochem.5b01002 www.ncbi.nlm.nih.gov/pmc/articles/PMC2143812/pdf/9514257.pdf @Saurabh Gangwar
Sir there is 4 NH group free at N and 4 CO gp free at c , no of maximum H bond formation is 8 so ans must be 92 h bond in polypeptide chain.... Sir plz explain....🙏🙏 At 9:00
@@proteinengineering007 I watched this video once more time and all my doubt regarding with this cleared .. Thank you so much sir ...this was really very helpful
N+4 system has best stability in term of steric conflicts and attractive forces so found abundantly in comparison to 3-10 or Pi helices. Thats what was actually also predicted by Linus Pauling in 1952. @Ms Apaarna
Thankyou so much sir. This was very helpful 😊 But sir when i read the paper wherein Pauling, Corey and Branson has proposed the structure of alpha helix. I couldn't understand few lines. I really want your help. Can you please help me out with it ? How should i contact you ?
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sir, can you explain helix capping?
okay.. see we know that 4 oxygen at C terminal and 4 NH at N terminal dont involve in H bonding in an alpha helix. But these groups form attractive forces with side chains of other amino acids at the termini. eg basic side chains at N terminal satisfies NH groups by forming hydrogen bonds. That is called N capping or similarly you have C capping as well. some refences may be helpful to have more clarity:
pubs.acs.org/doi/10.1021/acs.biochem.5b01002
www.ncbi.nlm.nih.gov/pmc/articles/PMC2143812/pdf/9514257.pdf
@Saurabh Gangwar
Ok thank u sir
Sir there is 4 NH group free at N and 4 CO gp free at c , no of maximum H bond formation is 8 so ans must be 92 h bond in polypeptide chain....
Sir plz explain....🙏🙏
At 9:00
@short videos
one H-bond is made between 2 groups, 1 CO---1 NH....so 8 free groups means 4 h-bonds..hope its clear
@@proteinengineering007 I watched this video once more time and all my doubt regarding with this cleared ..
Thank you so much sir ...this was really very helpful
@@arsala7779 I glad it helped u
Why H bond is formed as only n+4 , why not less or greater than that ?
N+4 system has best stability in term of steric conflicts and attractive forces so found abundantly in comparison to 3-10 or Pi helices. Thats what was actually also predicted by Linus Pauling in 1952. @Ms Apaarna
@@proteinengineering007 Beta sheets ki video kaha hai ?
@@apaarnasrivastava4126 coming soon
@@proteinengineering007 please also add alpha and beta turns
@@apaarnasrivastava4126 ok
Thankyou so much sir. This was very helpful 😊
But sir when i read the paper wherein Pauling, Corey and Branson has proposed the structure of alpha helix. I couldn't understand few lines. I really want your help. Can you please help me out with it ? How should i contact you ?
pleasure @Sonali Adhikari
u can drop an email on nagendra@gbu.ac.in
Sir, how will we calculate the axial length and full extended length of 78 amino acid in alpha helix?
rise per residue is 1.5A in alpha helix...so length of 78 residues in helix = 78 x 1.5A
@@proteinengineering007sir, what about for fully extended ?
@@chandraratan2564
length of fully extended around 3.6A per residue
@@proteinengineering007 sir, how?
@@chandraratan2564 .calculate all bond lengths in an amino acid residue, NH group to CO...