Please when you say these conditions are associated to the respective HLA, is it that there is a mutation in these HLA that is causing these conditions or what . Please 🙏🏾 help answer. Thank you
it is a very good question! let me try to explain. lets take HLAB27 as example! as i told HLA is a system. which during development , there can be thousands of variations in the HLA genes A B C D and so on one such variation is HLA B27 ( note that this is not a MUTATION!, just another normal variation.. its found that people with this variation i.e HLAB27, have very high risk of developing ankylosing spondylitis. it DOES NOT mean , that all individuals with HLA B27 will develop ankylosing spondylitis.. there can be absolutely normal individuals too.. hope this clarifies a. It is NOT a mutation b. not everyone with that HLA will develop a particular disease, with which it is associated Good luck :-)
Awesome teaching, thank you. Never a dull moment on this channel. Thank you ❤❤❤
Thanks sir for part 3
I really like your Vedios😊
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First to watch 😊
Expecting critical comment so that it's good to improve upon 😊
@@ilovepathologyVijayPatho 😅great note
Please when you say these conditions are associated to the respective HLA, is it that there is a mutation in these HLA that is causing these conditions or what . Please 🙏🏾 help answer. Thank you
it is a very good question!
let me try to explain. lets take HLAB27 as example!
as i told HLA is a system. which during development , there can be thousands of variations in the HLA genes A B C D and so on
one such variation is HLA B27 ( note that this is not a MUTATION!, just another normal variation..
its found that people with this variation i.e HLAB27, have very high risk of developing ankylosing spondylitis.
it DOES NOT mean , that all individuals with HLA B27 will develop ankylosing spondylitis.. there can be absolutely normal individuals too..
hope this clarifies
a. It is NOT a mutation
b. not everyone with that HLA will develop a particular disease, with which it is associated
Good luck :-)
@@ilovepathologyVijayPatho
Thank you so much, you’ve been very helpful. 🙏🏾🙏🏾🙏🏾🙏🏾
Sir I can't find the notes for this video