Great video, keep it up. I prefer reading the detailed blog entries instead, but once in a while it's refreshing to get an umbrella "digest" that covers the state of the situation in a form of a more casual presentation.
Thank you for producing this video, Josh. I usually prefer to get new information through reading, but I really appreciated your voice and pictures to put the ideas across. It's also good to hear that there have been 3 labs showing increased lifespan with the use of exosomes. I only knew of Harold Katcher's work.
Thank you for a fantastic presentation! I look forward to reading your website and following your videos. Do you have a link to the study on DHEA extending the life of mice? I was always of two minds with DHEA - it seems to have many benefits and be high in youth, but also stimulates IGF-1 which seems very negative for aging, especially cancer. Thanks again
Thank you for the correction, Kleffbois -- I misspoke about DHEA in mice. "DHEA is essentially a human molecule." I recommend this article for a review of the benefits and risks of DHEA: link.springer.com/article/10.1007/s40265-014-0259-8 "In the elderly, DHEA exerts an immunomodulatory action, increasing the number of monocytes, T cells expressing T-cell receptor gamma/delta (TCRγδ) and natural killer (NK) cells. It improves physical and psychological well-being, muscle strength and bone density, and reduces body fat and age-related skin atrophy stimulating procollagen/sebum production."
Thanks for the presentation Josh. Anti-aging at face value appears as a selfish endeavor but even at the practical level the health care savings are enough to justify it. On a social level, humans seem to need plenty of time to mature and become reliable decision makers. There is a strong chance that we would be a more peaceful and prosperous species if we all just lived a little longer.
I hope you're right. There will certainly be pluses and minuses when lifespan is extended, and we can't be sure that the pluses outweigh the minuses. But I'm optimistic, especially in light of clean energy technologies which I think already exist, but are being kept from us.
Amazing video. Do you think this could extend to the beginning of life itself with single cell organism? Thinking about it there might have been a critical mass that these cells repopulated at when rapidly reproducing creating a famine. Cells die out from lack of nutrients, and eventually due to lack of food eat eachother. We could pinpoint the origin of aging to single cell colonies that evolved. I have more ideas on this but ill see if this sounds palatable.
One possible method of aging is how many PUFAs are in cell membranes. See the membrane pacemaker theory of aging. Species with longer lives have less PUFA in their cell membranes. Genetics is the biggest factor in variation of PUFA concentration in humans. My question is do we find increased cell membrane PUFA concentration as we age?
This is interesting, but Calico hired Cynthia Kenyon and was approaching anti-aging from a genetic perspective, and nothing has happened in over a decade. I wonder what they they have been doing wrong.
I don't believe number 2 at all. The community is not served by individuals selfdestructing. If it was about balance it would be better to not be so fertile. No, it's just a fight against entropy. Nature would like to keep us alive forever if it could. It's doing its best. But humans can renovate a lot of things that nature can't, without creating any harmful side effects.
Hey Carina -- no fair telling me "I don't believe..." before you even listen to the video. If statement #2 was obvious, or if it followed easily from known evolutionary principles, why would anyone need this video? So yes, it's surprising, but please hear the evidence before you put out an opinion that it must be wrong.
@@jmitteld I like the part about Mrna. For the main subject I see no evidence, nothing that can't be explained by normal wear and tear. What would the individual parts know about population regulation anyway, or why even want it? One man can have hundreds of offspring, and that would only be a positive for the species (as long as incest was avoided). Probably saved us from extinction a few times as well. Denis Noble also opposes the selfish gene theory, but does not have a population regulation idea attached to it. The fertility period in healthy humans is also being prolonged, as we live longer, healthier lives. Nature doesn't have to worry about depending on inbuilt systems to make us die, there's enough environmental causes of death. No one will ever be completely indestructable, but I'm sure we will find ways to stay young and healthy for as long as we are alive, and I agree that we should focus on systems that control major aging processes. I just don't agree on your reasoning why these systems exist. To me the systems´ functions are about where to prioritise a limited source of energy and repair. Anything systemic is usually more energy efficient.
@@carinaekstrom1 Have you listened to any of the evidence? How do you explain DAF2 and AGE1 and P66shc? How do you think about hormesis? Are semelparous organisms an exception? Why does epigenetic change consistently turn on self-destructive proteins like FSH and TGF beta late in life?
@@jmitteld I listened to the video. Some things I have not heard about before, but the way you explain away the things I have heard about tells me that the rest is probably the same, which is nothing there. There were several things I wanted to comment on, including epigenetics and hormesis. But there's no space or sense in going into details about all this. I could see that you didn't want to consider other possibilities. An overview of evolution in general tells me that the Idea does not hold water.
I absolutely agree that aging is a programmed self-destruct mechanism that is impossible to override. However, my view comes from the Bible, which explains how the rebellion of man in paradise had far-reaching consequences and brought decay and death into the world. Sin infected our entire genetic structure, which every creature experiences as we chronologically age.
Great video, keep it up. I prefer reading the detailed blog entries instead, but once in a while it's refreshing to get an umbrella "digest" that covers the state of the situation in a form of a more casual presentation.
Thank you for producing this video, Josh. I usually prefer to get new information through reading, but I really appreciated your voice and pictures to put the ideas across. It's also good to hear that there have been 3 labs showing increased lifespan with the use of exosomes. I only knew of Harold Katcher's work.
Thank you for the video!
Thank you, Josh. It's a Great video.
Thank you for a fantastic presentation! I look forward to reading your website and following your videos. Do you have a link to the study on DHEA extending the life of mice? I was always of two minds with DHEA - it seems to have many benefits and be high in youth, but also stimulates IGF-1 which seems very negative for aging, especially cancer. Thanks again
Thank you for the correction, Kleffbois -- I misspoke about DHEA in mice. "DHEA is essentially a human molecule." I recommend this article for a review of the benefits and risks of DHEA: link.springer.com/article/10.1007/s40265-014-0259-8 "In the elderly, DHEA exerts an immunomodulatory action, increasing the number of monocytes, T cells expressing T-cell receptor gamma/delta (TCRγδ) and natural killer (NK) cells. It improves physical and psychological well-being, muscle strength and bone density, and reduces body fat and age-related skin atrophy stimulating procollagen/sebum production."
@@jmitteld Thank you for the reply! I'll read that article you've linked with interest
thank you
Very interesting
Thanks for the presentation Josh. Anti-aging at face value appears as a selfish endeavor but even at the practical level the health care savings are enough to justify it. On a social level, humans seem to need plenty of time to mature and become reliable decision makers. There is a strong chance that we would be a more peaceful and prosperous species if we all just lived a little longer.
I hope you're right. There will certainly be pluses and minuses when lifespan is extended, and we can't be sure that the pluses outweigh the minuses. But I'm optimistic, especially in light of clean energy technologies which I think already exist, but are being kept from us.
@@jmitteld They're not being kept from us. They were ust massively underfunded and under-researched for a long time
Amazing video. Do you think this could extend to the beginning of life itself with single cell organism? Thinking about it there might have been a critical mass that these cells repopulated at when rapidly reproducing creating a famine. Cells die out from lack of nutrients, and eventually due to lack of food eat eachother. We could pinpoint the origin of aging to single cell colonies that evolved. I have more ideas on this but ill see if this sounds palatable.
One possible method of aging is how many PUFAs are in cell membranes. See the membrane pacemaker theory of aging. Species with longer lives have less PUFA in their cell membranes. Genetics is the biggest factor in variation of PUFA concentration in humans. My question is do we find increased cell membrane PUFA concentration as we age?
This is interesting, but Calico hired Cynthia Kenyon and was approaching anti-aging from a genetic perspective, and nothing has happened in over a decade. I wonder what they they have been doing wrong.
I don't believe number 2 at all. The community is not served by individuals selfdestructing. If it was about balance it would be better to not be so fertile. No, it's just a fight against entropy. Nature would like to keep us alive forever if it could. It's doing its best. But humans can renovate a lot of things that nature can't, without creating any harmful side effects.
Hey Carina -- no fair telling me "I don't believe..." before you even listen to the video. If statement #2 was obvious, or if it followed easily from known evolutionary principles, why would anyone need this video? So yes, it's surprising, but please hear the evidence before you put out an opinion that it must be wrong.
@@jmitteld I like the part about Mrna. For the main subject I see no evidence, nothing that can't be explained by normal wear and tear. What would the individual parts know about population regulation anyway, or why even want it? One man can have hundreds of offspring, and that would only be a positive for the species (as long as incest was avoided). Probably saved us from extinction a few times as well. Denis Noble also opposes the selfish gene theory, but does not have a population regulation idea attached to it. The fertility period in healthy humans is also being prolonged, as we live longer, healthier lives. Nature doesn't have to worry about depending on inbuilt systems to make us die, there's enough environmental causes of death. No one will ever be completely indestructable, but I'm sure we will find ways to stay young and healthy for as long as we are alive, and I agree that we should focus on systems that control major aging processes. I just don't agree on your reasoning why these systems exist. To me the systems´ functions are about where to prioritise a limited source of energy and repair. Anything systemic is usually more energy efficient.
@@carinaekstrom1 Have you listened to any of the evidence? How do you explain DAF2 and AGE1 and P66shc? How do you think about hormesis? Are semelparous organisms an exception? Why does epigenetic change consistently turn on self-destructive proteins like FSH and TGF beta late in life?
@@jmitteld I listened to the video. Some things I have not heard about before, but the way you explain away the things I have heard about tells me that the rest is probably the same, which is nothing there. There were several things I wanted to comment on, including epigenetics and hormesis. But there's no space or sense in going into details about all this. I could see that you didn't want to consider other possibilities. An overview of evolution in general tells me that the Idea does not hold water.
I absolutely agree that aging is a programmed self-destruct mechanism that is impossible to override. However, my view comes from the Bible, which explains how the rebellion of man in paradise had far-reaching consequences and brought decay and death into the world. Sin infected our entire genetic structure, which every creature experiences as we chronologically age.