The immune mechanisms behind neurodegeneration in progressive MS

Hans Lassmann, MD, Medical University of Vienna, Vienna, Austria, gives an overview of what is known about the immune mechanisms behind neurodegeneration in progressive multiple sclerosis (MS). Evidence suggests that both the relapsing and the progressive stages are driven by the inflammatory response. However, the inflammatory response differs between the two phases. In progressive MS, the inflammation resides in the central nervous system (CNS) and is gradually activated, leading to diffuse damage to the brain. Many researchers now aim to develop therapies targeting the inflammation in the CNS to address the need for effective treatments for progressive MS. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2022 in Amsterdam, The Netherlands.
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