Understanding Pathology for Breast Cancer
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- Опубликовано: 28 сен 2010
- Dr. Sean Thornton, a pathologist with Cellnetix Laboratories and Pathology, talks about the pathology and biology of breast cancer and the role a pathologist plays in your care. To learn more about Cellnetix, please visit www.cellnetix.com
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Of all the video's I have watched on this subject matter, this one video helped me to understand the most. Thanks Doc! 😀
We are happy to hear that you found this video informative, James!
Thank you for your kind words. I truly hope my presentation has helped, informed, comforted and empowered breast cancer patients and their families.
Excellent and very clear information.
Wonderful presentation...I appreciate all that pathologist do in BC diagnosis 🎀
Impressive with the clear explanation. Many thanks.
Great video and I wish I could thank my Pathologist!
Thank God for pathologists!
Thank you for the information.
Thank you for you information I am a newly diagnosed breast cancer patient
Thank you, Deana, for your kind words. Having a cancer diagnosis is a dance with uncertainty. I hope you've learned to tango with the best of them.
hats off to pathologists !
William Pathologists are hardworking and more knowledgeable than many other fields. Although I’m not going into pathology, I still respect the field. Try being more positive William, we are not perfect and doctors over the world are trying to find cures to disease.
@William You are correct, William. Pathologist don't heal anyone. We virtually never treat disease directly ourselves. We diagnose. But 70% of all medical decisions are made based on the work of pathologist (when laboratory test, which are run by pathologists, are included.) That's why we're the "doctors' doctor".
@William Modern medicine is based on, steeped in and functions (at its best) solely in the realm of science, and the scientific method including peer-reviewed studies. Religion and superstition have no place in treating physical illness.
Thank you😊
awsome !!!
Hi there,
My sister had one side of her breast removed few days ago, but the surgeon found no cancer cells in the lymph nodes. The surgeon said the cancer is at stage 1 or 2A depending on the report from Pathologist. In this case, is chemotherapy needed or not? Thanks in advance for your feedback on this.
I'm getting a 2nd opinion.
what happened with your sister...I just got diagnosed and wanting all info I can get before we proceed. I hope all went well.
Can i ask.. about the relathionship between clinicopathologi and the breast cancer subtype.. and the relationship with ki67
Sure! I am not exactly sure what you mean by the clinicopathology and cancer subtype. But, I will guess that means is there a difference in the aggressiveness of the different tumor types. Among ductal tumors, the less they make tubules, the larger the cell nuclei and the more cells that are in active proliferation (more later), the worse the tumor TENDS to behave. The histologic grade, which is included in every pathology report, includes these 3 factors. As for the proliferation rate, it is measured in 2 ways. First, the pathologist literally counts the number of cells that are in mitosis, that is, the cells we can identify under the microscope in active division. Secondly, we can use special (immunohistochemical) stains to highlight certain tumor attributes. You asked about Ki-67. That is a protein that is present in cells that are near, or in, the act of dividing (multiplying). The more cells that contain this protein, the more aggressive tumors TEND to be. So, the Ki-67 score is a secondary evaluation of the proliferative capacity of the tumor cells. It is common that Ki-67 is evaluated, in part because it is a component of other tumor proliferation indices, such as Oncotype. As for the other common histologic type of epithelial tumor, lobular carcinoma, stage for stage it is about the same as ductal carcinoma in its aggressiveness. However, because it is difficult to visualize on breast imaging and tends not to form palpable masses that patients (and doctors) can feel, lobular carcinoma tends to be at higher stage (ie, larger size, already spread) at the time of diagnosis than ductal tumors. Therefore, unfortunately, for many patients, lobular carcinoma too often can be more aggressive because the "horse is already out of the barn". -4/22
Who does the staging information come from, the pathologist or my surgeon? I’ve now had 2 surgeries and nobody has told me my stage/grade
You have to ask questions. You must be your own advocate dealing with your doctors.
@@celticfiddle7605 yes I agree and in America we have a right to have a copy of everything that they do !
@@celticfiddle7605 Celtic Fiddle is correct. Patients need to take control as much as possible when facing a frightening and new diagnosis. Thankfully, most doctors are well versed in giving patients this info, and discussing the importance of the finer points. That was what I was advocating in my video. Be your own best advocate! Good doctors will welcome that kind of patient input as it makes explaining the many new ideas these tumors present easier for patients to get their head around and generally leads to better patient happiness and outcomes. And that is important to make the best decisions for her treatment. If you find that your treatment team is underperforming, ASK QUESTIONS! As for the OP's question, the pathologist gathers most of the items that go into the Stage. Most modern pathology reports include the stage. It is always appropriate for patients to ask what the stage is and what it's importance is. As I taught my medical students and residents, the stage is the single most important thing to understand about a cancer. -4/22
My name is Diane and I am a 6 year breast cancer survivor. My story began November 2014 when I felt a slight burning sensation in my right breast. I was working as a daycare provider and neglected to do anything, hoping the burning sensation was temporary.
On New Years Eve, 2011, the pain was so severe that I scheduled a mammogram the first week of 2015. A few days after I received a letter telling me to return for a second test.
A few more days passed and I received a letter telling me that there were suspicious findings on my film that needed further testing. My previous mammogram had been in October 2011. What could possibly be wrong?
I had nowhere to turn. I did not know what to do because the place that did the mammogram only told me to ask my primary care doctor. At that time I did not have a primary doctor.
I called my older sister and she told me to go to a gynecologist. I explained the situation to the gynecologist and immediately she found a doctor to give me a biopsy which i did and it was all to no avail until i met a old time high school mate friend Dana who is a survivor who introduced me to a pythothrapist DR HARVEY to God alone i give all the glory and i'm forever greatful to DR HARVEY for being a hand of God in my life....He cured me with his natural herbs and roots today i'm a living testimony. Do not die in silence contact DR HARVEY today VIA
EMAIL:[Drharveyphytotherapy@yahoo.com]
WHATSAPP:+19716663103
Awesome
Note thickening of the overlying skin!
Wow! Great observation! You would make a good radiologist.
8:16 sential ld procedure
take sentiel ln and look under micro to see if affected, n to remove other ln
@@calication2487 Correct, cali. Sentinel lymph node procedure. As time has gone on, we have reduced the use of this technique. But for certain patients, it can be a very good thing. -4/22
Very interesting you didn’t mention that only 5% of cancers are genetic (we are in 2019) why would you neglect to say this .... this has been proven with studies. You also didn’t mention that having a biopsy allows circulating stem cells to be released a pathologist should include this information ....
Jackie, thanks for your correct observations! The latest data (as of Dec. 2021) states that 5-10% of primary breast adenocarcinomas are based on genetic inheritance, primarily with the few identified genes, including BRCA1 and BRCA 2 originally identified at the Fred Hutchinson Cancer Research Center in the 1990's. Why didn't I include that information? I had time limitations when writing the content, and could have included many more items of interest and importance (such as non-epithelial tumors), but I could not. Please discuss these topics with your doctors. They have the latest info. As for your second point, it is theoretically possible that both cancer cells and stem cells are released any time a tumor is sampled. In fact, I remember (as I am now retired) several cases where there was evidence suspicious of tumor cells having been displaced in subsequent resections by the original biopsy, but these instances are extremely rare and their significance is not known. I am not aware of any studies that suggest there is, for most tumors (excepting sarcomas), any significant future risk to the patient by initial sampling of tumors. IT IS FAR MORE IMPORTANT to determine the histologic type of tumor for proper treatment than reduce an almost undetectable risk of that same sampling. -4/22