Hi dear sir ! I have got a problem with a point in the mechanism of hematopoietic stem cells transplantation (graft- versus -tumor effect), you said that mature T- cells and NK- cells present in the transplanted bone marrow recognize the alloantigens on the surface of tumor cells and destroy tumor cells. But my question is!!! Does bone marrow contains mature T-cells and mature NK-cells? I have learned that bone marrow contains the stem cells and progenitor cells or precursor cells. Please answer me dear sir!
Thank you for your question. Peripheral blood is more commonly used as the source of stem cells in the treatment of hematological malignancy due to the potential for a more potent Graft vs Leukemia effect and the avoidance of general anesthetic risks for the donor from bone marrow harvest. In contrast, bone marrow harvest is generally preferred for the treatment of non-malignant conditions due to the reduced incidence of GvHD. In order to collect Hematopoietic stem cell from peripheral blood recombinant human granulocyte colony stimulating factor (G-CSF) is often used to make the stem cells come out of bone marrow. Then the stem cells are harvested by apheresis. Such bone marrow inoculum also contain donor T cells from donor peripheral blood. That is the source of donor T cells. Deliberate induction of graft-versus leukemia effect by infusion of allogeneic T cells can be used to treat chronic myeloid leukemia that has relapsed after HSC transplantation. So the source is peripheral blood of the donor from which the stem cells are harvested by using colony stimulating factor.
Here is link of my new video on type I hypersensitivity, I have used self made 3D animation in this lecture. Take care and stay safe. ruclips.net/video/P9MB9B2dydE/видео.html
Thank you so much sir! Most useful information in just 16min, it was so helpful 🙂
Sir i was reading this topic for an hour
Bt so many prblms had arised..so i just listened ur lecture... And now all are clear😍
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@@RabiulHaque sir i am also from Bangladesh,, and i am connected with you through facebook😁
Very informative
Thanks Sir for such great lecture videos...Covering my sllybus listening to ur lectures💙
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Thank you but how can you explain the graft versus host reaction in blood transfusion from first-group relatives?
Easy Explanation . Thanks a lot .
Great video! Your videos very beneficial during quarantine times
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thank you sir❤❤ ❤
man is just the best
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Thank you so much Sir
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thank you sir
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you are the best
Thank you for your feedback. Take care and stay safe. Best wishes from Bangladesh. :)
Love ❤️ from india 🇮🇳
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jazak Allah
Thank you for your feedback. Take care and stay safe. Best wishes from Bangladesh. :)
Hi dear sir ! I have got a problem with a point in the mechanism of hematopoietic stem cells transplantation (graft- versus -tumor effect), you said that mature T- cells and NK- cells present in the transplanted bone marrow recognize the alloantigens on the surface of tumor cells and destroy tumor cells.
But my question is!!! Does bone marrow contains mature T-cells and mature NK-cells? I have learned that bone marrow contains the stem cells and progenitor cells or precursor cells.
Please answer me dear sir!
Thank you for your question. Peripheral blood is more commonly used as the source of stem cells in the treatment of hematological malignancy due to the potential for a more potent Graft vs Leukemia effect and the avoidance of general anesthetic risks for the donor from bone marrow harvest. In contrast, bone marrow harvest is generally preferred for the treatment of non-malignant conditions due to the reduced incidence of GvHD. In order to collect Hematopoietic stem cell from peripheral blood recombinant human granulocyte colony stimulating factor (G-CSF) is often used to make the stem cells come out of bone marrow. Then the stem cells are harvested by apheresis. Such bone marrow inoculum also contain donor T cells from donor peripheral blood. That is the source of donor T cells. Deliberate induction of graft-versus leukemia effect by infusion of allogeneic T cells can be used to treat chronic myeloid leukemia that has relapsed after HSC transplantation. So the source is peripheral blood of the donor from which the stem cells are harvested by using colony stimulating factor.
@@RabiulHaque
Thank you sir for your deatailed and easy explanation 😊😍🤩
Helpful🤗
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Please upload lecture on Myocardial Infarction
sir please please make video on ECG from basic like ECG LEAD rthm axics ets plz plzz Waqas here from.pakstan
Use little bit music n keep improve vedio quality it will help u to get more viewer
Thank you for your feed back. Take care and stay safe. :)
Sir video bnana kyu band kr diya
Here is link of my new video on type I hypersensitivity, I have used self made 3D animation in this lecture. Take care and stay safe.
ruclips.net/video/P9MB9B2dydE/видео.html