+AK LECTURES (Andrey K) same. idk what i'd do without AK me and my friend always say the following after lecture: "time for AK to teach us what just happened"
Medical student from Russia. Thank you a lot for these well explained and high informational lectures! I will recommend you to biochemistry teachers and students here.
Med Student from Bogotá, Colombia, and i want you to know that this video makes me so happy because it was what i were looking for, thank you so much!!
Hello Andrey, I just wanted to start off by saying I ABSOLUTELY LOVE YOU. Your lectures are so well put together and conceivable. I am currently studying for the MCAT while taking biochemistry at university, and your videos supplement my studying like no other resource known to man. So thank you for your time and effort and passion for the sciences, because it is rubbing off on me like no other.
THANK YOU You are saving me the hussle of having to figure out an entire chapter on my own! I love every single video! You make everything sound so logical and easy... Thank you for sharing your wisdom in this perfect way!
You are a gifted person, capable of explaining such a complex matter in a clear, organized, and understandable way. Thank you very much for your video and congratulations on your teaching skills.
I love your lecture so much, they are so clarify and easy to understand. I'm second language, but your pronunciation is really good that I can understand the whole video without any problems. Thank you so much for posting these useful video.
Long time ago i thought ur lectures will not be useful to me But today when i actually watched one till the end i thought mm wrong.... U r seriously a fab teacher.. 🙃❤️
Your lecture are awesome. Just a tiny bit of correction in this one. Protein kinase B [AKT here] gets bound to PIP-3, when PIP2 gets phosphorylated by PI3K. When so bound to PIP3, then PDK-1 acts on it phosphorylating it. {source: Lehninger- 6ed, page-456}. Cheers for your awesome videos!
Excellent videos; all of them. Could you one day do one on insulin resistance, and the role of Threonine/serine receptors, DAG and adipose tissue hormones like resistin, on such insulin resistance? Thanks a bunch
Awesome video but I think there may be a mistake towards the end? Forgive me if I'm wrong. I've learned that Insulin leads to the activation of certain protein phosphatases, which will ultimately dephosphorylate various enzymes: glycogen synthase (active when dephosphorylated) PFK-2/FBase-2 complex (PFK-2 active when dephosphorylated in the liver cell, producing more F26BP and thus allosterically upregulation PFK-1 for glycolysis) glycogen phosphorylase (inhibiting glycogen breakdown) phosphorylase kinase (inhibiting the activation of glycogen phosphorylase) towards the end, you mention that AKT will phosphorylate enzymes that synthesize glycogen from glucose molecules. Are we talking about a different enzyme than glycogen synthase? Thanks! edit: looks like you were likely referring to the phosphorylation of glycogen synthase kinase, deactivating it, and subsequently keeping glycogen synthase in its active form.
Thanks for taking the time to make such a comprehensive lecture. One question: what turns off the pathway? In GPCR systems the GTP is degraded to GDP - how about RK systems?
Enzymes that synthesize glycogen are active when dephosphorylated (glycogen synthase ), so I don't understand how akt phosphorylating activates it? Can you clear this doubt?
In the book Principles of Biochemistry by Lehninger it's mentioned that PKB aka Akt binds to PIP3 which is then activated by PDK1. However in your explanation you mention PDK1 binds to PIP3 for its activation and then the activated PDK1 goes on to activate Akt. So which order is correct?
I've been watching a lot of videos about how insulin and glucagon act together to modulate the concentration of glucose in the blood. If a person is on a carnivore diet and has effectively eliminated carbohydrates from the diet, what are the analogs of insulin and glycogen for moderating the concentration of ketones in the blood? Thanks!!!
Passing here without thanking you is a shame!
So THANKS A LOT!
AK Lectures are LIFE :O I used them for physics and now they're saving me in BioChem, THANK YOU
+Juliette Le Corre YES! you're welcome! :)
+AK LECTURES (Andrey K) same. idk what i'd do without AK me and my friend always say the following after lecture: "time for AK to teach us what just happened"
Very nice lectures
Mate, you explained in 14 minutes something that has troubled me for a whole year! Keep up the good work!
Medical student from Glasgow, Scotland, here. This really helped me!
Medical student from Russia.
Thank you a lot for these well explained and high informational lectures!
I will recommend you to biochemistry teachers and students here.
Awesome! thanks for watching :)
Med Student from Bogotá, Colombia, and i want you to know that this video makes me so happy because it was what i were looking for, thank you so much!!
Hello Andrey, I just wanted to start off by saying I ABSOLUTELY LOVE YOU. Your lectures are so well put together and conceivable. I am currently studying for the MCAT while taking biochemistry at university, and your videos supplement my studying like no other resource known to man. So thank you for your time and effort and passion for the sciences, because it is rubbing off on me like no other.
Great speaker making use of clear bullet points and diagrams. Keep up the good work!
THANK YOU
You are saving me the hussle of having to figure out an entire chapter on my own! I love every single video! You make everything sound so logical and easy...
Thank you for sharing your wisdom in this perfect way!
Hi Andrey. This lecture is excelent, the best I ever seen. Congrats and thank you very much!
You are a gifted person, capable of explaining such a complex matter in a clear, organized, and understandable way. Thank you very much for your video and congratulations on your teaching skills.
God bless you mate. I have never left here unsatisfied
This channel is god sent! I greatly appreciate the clear structured points and use of graphics!
nothing can't express my thank for you. Wonderful & simplified lecture. Good job.
I had to come here when everything else is confusing. But man, you more than delivered on this. Thank you so much.
You're helping another med student here. thank you!
This is explained so well, and the whiteboard step by step summary and associated illustrations work perfectly together.
Your lectures have been helping me in my medical learning, thank you, great work
Best online teacher! regards from Mexico
I love your lecture so much, they are so clarify and easy to understand. I'm second language, but your pronunciation is really good that I can understand the whole video without any problems. Thank you so much for posting these useful video.
thank you for this detailed explanation, i really benefited from this.
Long time ago i thought ur lectures will not be useful to me
But today when i actually watched one till the end i thought mm wrong....
U r seriously a fab teacher.. 🙃❤️
You are a great lecturer. Thank you so much for your vids
Your lecture are awesome. Just a tiny bit of correction in this one. Protein kinase B [AKT here] gets bound to PIP-3, when PIP2 gets phosphorylated by PI3K. When so bound to PIP3, then PDK-1 acts on it phosphorylating it. {source: Lehninger- 6ed, page-456}. Cheers for your awesome videos!
Masters in molecular biology and biotechnology from Uganda
Very helpful video. Would be even greater if we could download your notes for each lecture on your website.
So glad that i found you so early
Respect 🙏
Sir great explained video 🙏🙏
Excellent videos; all of them. Could you one day do one on insulin resistance, and the role of Threonine/serine receptors, DAG and adipose tissue hormones like resistin, on such insulin resistance? Thanks a bunch
Awesome explanation!! The best I have seen so far in RUclips, thank so much!!
best explanation ever THANK U SO MUCH
Awesome video but I think there may be a mistake towards the end? Forgive me if I'm wrong. I've learned that Insulin leads to the activation of certain protein phosphatases, which will ultimately dephosphorylate various enzymes:
glycogen synthase (active when dephosphorylated)
PFK-2/FBase-2 complex (PFK-2 active when dephosphorylated in the liver cell, producing more F26BP and thus allosterically upregulation PFK-1 for glycolysis)
glycogen phosphorylase (inhibiting glycogen breakdown)
phosphorylase kinase (inhibiting the activation of glycogen phosphorylase)
towards the end, you mention that AKT will phosphorylate enzymes that synthesize glycogen from glucose molecules. Are we talking about a different enzyme than glycogen synthase?
Thanks!
edit: looks like you were likely referring to the phosphorylation of glycogen synthase kinase, deactivating it, and subsequently keeping glycogen synthase in its active form.
Shoudn't it Glycogen Synthase [Enzyme that synthesize glycogen] be "de"phosphorylated to be activated?
Phosphorylate:
Glycogen Phosphorylase = Activate
Glycogen Synthase: = Deactivate
Dephosphorylate:
Glycogen Phosphorylase = Deactivate
Glycogen Synthase: = Activate
Thanks for taking the time to make such a comprehensive lecture. One question: what turns off the pathway? In GPCR systems the GTP is degraded to GDP - how about RK systems?
there are various phosphatases that regulate the RK pathways...
The best video ever... clear explanation👌👌.... had just what I wanted.... THANK YOU!!🙏🙏
You are just amazing and you just made biochemistry more interesting! Love your videos!
One of the best videos iv'e ever seen!! thank you :)
thank ak lectures, you helped me understand about signal transduction
Thank you so much for your videos. Just finished with an A and B+ in physics 2 and biochem and your videos were a life saver!!!
I always love watching your videos Sir. Thank you so much 💖
can you talk about the regulatory points, negative and positive feedbacks
SO HELPFUL THANK YOU!!
Enzymes that synthesize glycogen are active when dephosphorylated (glycogen synthase ), so I don't understand how akt phosphorylating activates it? Can you clear this doubt?
Thanks for these great lectures. always
Thanks Andrey! Incredible!
I got an A on my biochem test because of you!! (something I never thought was possible for me!!)
very clear explanation. Thank you
thank you for the biochemistry help !!! you are an amazing lecturer
and this is coming from a professional college tutor you know your methods well
Excellent 👍
i wish you are my bio and anatomy prof for 4 years of uni. i really do
I don't read the textbook anymore I just watch your videos.
Congrats! Simple and clear
You should be the Biochem professor at FIU
thank you so much, your lectures save me
Awesome, Thank you for the great explanation!
wow, I'm so thankful ! Understood everything!
Great work ❤🎉
In the book Principles of Biochemistry by Lehninger it's mentioned that PKB aka Akt binds to PIP3 which is then activated by PDK1. However in your explanation you mention PDK1 binds to PIP3 for its activation and then the activated PDK1 goes on to activate Akt. So which order is correct?
wow what a clear explanation.
You've just saved my brain cells, thank you lol
thank you!! your lecture are incredibly clear!
Thanks this makes much more sense!
This is pure gold
THANK YOU FOR LIVING ON PLANET EARTH !
Excellent video thanks for sharing
Brilliant explanation. Thanks a lot!!
Well organized lectures!
love love love this thank you so much!
very useful lecture, simplifies everything! Thanks! ;)
I've been watching a lot of videos about how insulin and glucagon act together to modulate the concentration of glucose in the blood.
If a person is on a carnivore diet and has effectively eliminated carbohydrates from the diet, what are the analogs of insulin and glycogen for moderating the concentration of ketones in the blood?
Thanks!!!
brilliant channel
Brilliant as always. Thank u 🙏
Beautiful
Excellent video
excellent content!
WOW for the effort.. that board...
Thanks! Wonderful explanation.
another great video,with clear drawings.thank you! :)
Thank you sir! You are a big help and life saver! :D
please upload lecture of pharmacology microbiology and pathology
absolutely fantastic, thanks a lot.
very clear explanation. thanks heaps....
This face = great lectures!
IRS is everywhere
:D
Thank you, you‘re saving me once again :)
Great
Thankyou sir
This is great. Thank you
thanks a lot ...
U r amazing sirr..alaw vedio
Great lecture!!
Great video, thanks a lot!
Nailed it! Thanks is too little to say...
Really helpful, thank you!
Great!
Thank you very much
love you so much! thank you!!!!!!!
thankyo
biochemistry would be hell without you
Amazing!!! Thank u so much!