Thanks very much) it's very userful things) I'm postgraduate first year internist, and i glad to find your chanel) It's very knowlegeble) Thanks again))))
Very nicely explained Dr. Have a request, please request to post more clinical scenarios. Enjoyed this presentation and understood Renal tubular acidosis well. Thank you Dr
You are absolutely right: BMP test; commonly used in US and means basic metabolic panel. includes Na, K, CO2, glucose, BUN, Creat. and Ca. Generally, the serum bicarbonate comprises about 95% of the total CO2 content; thus we can use this measurement as an excellent estimator of serum bicarbonate. The total CO2 content normally equals 23 to 30 mEq/L of serum. Means= Measuring serum CO2 as in this cases =17 reflects the total HCO3 which is 17. Thank you for pointing out this important issue.
+PEDIATRIC BOARD A LAST MINUTE REVIEW thank u sir for clarifying this point ..here in Egypt we usually measure paCO2 in Arterial sample...first time I know about measure co2 in venous sample as indicator of HCO3 thanx again
Yes I know ! in Egypt I have to order everything separate e.g. Na, K, glucose etc, I wish one day to see the lab corporations implementing BMP and CMP panels, and HCO3 or CO2 not to be through blood gas only. Its critical to be all together in many cases in order to understand the case.
Just a comment about (nail-patella) syndrome: patella ossification start at age of 3years, before that it is cartilaginous. I guess knowing this help not to falsely diagnose absent patella in very youngs.
VERY NICE AND SIMLIFIED , THANK YOU FOR YOUR EFFORT BUT I THINK ALPORT IS XL DOMINANT NOT RECESSIVE IN 85 % OF CASES ....I THINK THIS POINT NEED TO BE REVIEWED , THANKS
XLAS (X-linked Alport Syndrome) - The most common form that accounts for 80% to 85% of the cases and results from mutations of the alpha-5 chain type IV collagen (gene COL4A5), alportsyndrome.org/alport-syndrome/alport-syndrome-genetics/ , Alport syndrome can have different inheritance patterns. About 80 percent of cases are caused by mutations in the COL4A5 gene and are inherited in an X-linked pattern, ghr.nlm.nih.gov/condition/alport-syndrome#inheritance Mutations in the COL4A5 collagen gene are responsible for the more common X-LINKED DOMINANT form of the disease , jasn.asnjournals.org/content/11/4/649.full ARAS (autosomal recessive Alport Syndrome) - This form accounts for 15% of the cases and is caused by mutations in the alpha-3 or alpha-4 chains (genes COL4A3 or COL4A4) , alportsyndrome.org/alport-syndrome/alport-syndrome-genetics/ , In approximately 15 percent of cases, Alport syndrome results from mutations in both copies of the COL4A3 or COL4A4 gene and is inherited in an autosomal recessive pattern. , ghr.nlm.nih.gov/condition/alport-syndrome#inheritance
You are absolutely correct and I am wrong. Its X-linked dominant. Its clarified on OMIM website. I will add an annotation on the video to correct this mistake. Thank you so much. Regards.
This is a general definition in RTA. In Type II. The distal tubules are intact and producing enough hydrogen to keep the urine acidic. In the Proximal tubules, the urine was not acidic. Because of too much HCO3.
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Best explanation on RTA I've heard in years. Thank you.
You are very welcome! Thanks.
Agree
Thanks very much) it's very userful things) I'm postgraduate first year internist, and i glad to find your chanel) It's very knowlegeble) Thanks again))))
You are very welcome. Thanks.
Excellent job ..very thankful for such a easy way to memorize kidney diz
wonderful .....the best and simplest explanation of RTA that I hear ..... really thank you for your great effort ..... God with you
You're very welcome! Thanks
Well Done that's Informative
Thank you!
First time to really understand and digest RTA. Bless you!
Fantastic doc,keep it up! And Thanks a lot.
Most welcome!
Wonderfull! Alport - x linked dominant 85%
Have enriched my knowledge from this lecture. Thank you so much Dr. Naga
You're most welcome
@@pediatricboardalastminuter1892 ن٤٣
٠
Superb! You are favourite!!
Thanks
You are such an inspiration!
Thank you!
Thank you very much!
I need the slides that you explained, can you share it with me?
جزاك الله خيرا وجعلها في ميزان حسناتك
You are welcome
Thank you so much 👏🙏🏻
You’re welcome 😊
thanks Dr 😀
Thank u😇
Thank you!
This is so much helpful
Thank you!
Very nicely explained Dr.
Have a request, please request to post more clinical scenarios. Enjoyed this presentation and understood Renal tubular acidosis well. Thank you Dr
شكرا #20 🤩🤩
Thanks sir
شكرًا جزيلا دكتور
You are very welcome!
nice sir..thank u
+Asmat Ullah You are very welcome!
Thank you very much 👍🌷🌷🌷
Welcome 😊
مشكور د اسامه
very good lecture
I think in the case HCO3 is 17
not CO2
23.45
You are absolutely right: BMP test; commonly used in US and means basic metabolic panel. includes Na, K, CO2, glucose, BUN, Creat. and Ca. Generally, the serum bicarbonate comprises about 95% of the total CO2 content; thus we can use this measurement as an excellent estimator of serum bicarbonate. The total CO2 content normally equals 23 to 30 mEq/L of serum. Means= Measuring serum CO2 as in this cases =17 reflects the total HCO3 which is 17. Thank you for pointing out this important issue.
+PEDIATRIC BOARD A LAST MINUTE REVIEW
thank u sir for clarifying this point ..here in Egypt we usually measure paCO2 in Arterial sample...first time I know about measure co2 in venous sample as indicator of HCO3
thanx again
Yes I know ! in Egypt I have to order everything separate e.g. Na, K, glucose etc, I wish one day to see the lab corporations implementing BMP and CMP panels, and HCO3 or CO2 not to be through blood gas only. Its critical to be all together in many cases in order to understand the case.
Amazing lectures
May God bless you 🌸
Thanks.
Just a comment about (nail-patella) syndrome: patella ossification start at age of 3years, before that it is cartilaginous. I guess knowing this help not to falsely diagnose absent patella in very youngs.
Thank you sir.
you're welcome!
VERY NICE AND SIMLIFIED , THANK YOU FOR YOUR EFFORT
BUT I THINK ALPORT IS XL DOMINANT NOT RECESSIVE IN 85 % OF CASES ....I THINK THIS POINT NEED TO BE REVIEWED , THANKS
XLAS (X-linked Alport Syndrome) - The most common form that accounts for 80% to 85% of the cases and results from mutations of the alpha-5 chain type IV collagen (gene COL4A5), alportsyndrome.org/alport-syndrome/alport-syndrome-genetics/ ,
Alport syndrome can have different inheritance patterns. About 80 percent of cases are caused by mutations in the COL4A5 gene and are inherited in an X-linked pattern, ghr.nlm.nih.gov/condition/alport-syndrome#inheritance
Mutations in the COL4A5 collagen gene are responsible for the more common X-LINKED DOMINANT form of the disease , jasn.asnjournals.org/content/11/4/649.full
ARAS (autosomal recessive Alport Syndrome) - This form accounts for 15% of the cases and is caused by mutations in the alpha-3 or alpha-4 chains (genes COL4A3 or COL4A4) , alportsyndrome.org/alport-syndrome/alport-syndrome-genetics/ , In approximately 15 percent of cases, Alport syndrome results from mutations in both copies of the COL4A3 or COL4A4 gene and is inherited in an autosomal recessive pattern. , ghr.nlm.nih.gov/condition/alport-syndrome#inheritance
You are absolutely correct and I am wrong. Its X-linked dominant. Its clarified on OMIM website. I will add an annotation on the video to correct this mistake. Thank you so much. Regards.
THANK YOU SO MUCH PROF . APPRECIATING ALL YOU EFFORT AND HARD WOORKING FOR THESE EXCELLENT SERIES OF VEDIOS ...
You are very welcome ! Thank you.
Do I need 3 positive consecutives urines to diagnose hematuria.?
You are amazing.. thank you so much. You saved me really. Thank you so much!
You are very welcome!. Thank you.
وكذلك type 4 RTA
سؤال بعد اذن حضرتك
عند دقيقة ٣٠ فى renal 2
ذكرت أنه urine pH هتكون اقل من ٥ يعنى acidic
والتعريف المذكور failure to acidic urine?
This is a general definition in RTA. In Type II. The distal tubules are intact and producing enough hydrogen to keep the urine acidic. In the Proximal tubules, the urine was not acidic. Because of too much HCO3.
plz can u explain non anion gap acidiosis in type 1 RTA and how does K go into urine
I think it was well explained in the video. Thanks.
thank u sir
You are very welcome.