Super-resolution microscopy reveals the secret of neuronal architecture | Dr. Christophe Leterrier

In this episode, we speak with Christophe Letterrier, PhD, the leader of the NeuroCyto research group at the Institute of Neurophysiopathology, Aix-Marseille University. We dive deep inside neurons, discussing the structural support and trafficking system in the cells - the cytoskeleton. Visualising molecules comprising this structure requires super-resolution microscopy, hence, we explore cutting-edge techniques from the world of imaging. Dr. Leterrier emphasises the importance of the community and open science principles in research and tool development. Finally, we address challenges in the publishing system and the mindset required for an academic career.
Our channel is supported by International Max Planck Research School (IMPRS) for Neurosciences as well as Cluster of Excellence Multiscale Bioimaging (MBExC) in Göttingen, Germany. The views presented on this channel are not representative of IMPRS or MBExC.
Timestamps:
00:00:00 Intro
00:03:00 Early career and motivation for doing science
00:09:17 Establishing own research group in Marseille, France
00:11:47 Cell architecture, trafficking, cytoskeleton and the molecules involved
00:17:54 Origin of action potentials - electric pulses in the neurons.
00:21:23 Relevance of basic research
00:24:25 Neuronal cultures: studying neurons in a dish
00:29:42 Super-resolution microscopy
00:34:27 Single molecule localisation microscopy: STORM, SIM and imaging living cells
00:45:57 Open science algorithms for image analysis (SRRF)
00:51:19 Combining different techniques: platinum replica electron microscopy and STORM
00:55:39 Social media as a way of fostering scientific community
01:02:47 Failures in academia
01:07:07 Problems in academia: publishing and reviewing system
References:
Immunofluorescent images provided by Dr. Christophe Leterrier
andor.oxinst.com/learning/vie...
www.nature.com/articles/s4146...
Follow us on social media for the latest updates!
Twitter: / neuro_beyond
Instagram: / neurosciencebeyond
TikTok: / neurosciencebeyond
Facebook: / neurosciencebeyond
Neuroscience and Beyond team:
Svilen Georgiev
Kristina Jevdokimenko
Sabina Nowakowska
#neuroscience #brain #science #podcast #göttingen #IMPRS #MBExC
#AcademicChatter #SciComm #PhD #microscopy #imaging #OpenScience #OpenAccess

[@ashuelvisndip7534]

Thanks, Dr Christophe, a physiologist friend recommended this channel. The human body has been a mystery for a long time, but today people like you are breaking the myths and extending boundaries. Continue the good work for humanity. I like the video and I am now a subscriber at the Neuroscience and Beyond channel.

[@neurosciencebeyond]

We are glad that you like our video! Thank you for subscribing and welcome to our small but growing community! Stay tuned for more cool content. :)

[@peterwong7933]

For sim, mi-sim from csr-biotech could be a choice