The Life Story of an apoB Lipoprotein: How Cholesterol is Transported Into Your Arterial Wall

A board certified internal medicine physician talks about why you should care about the level of apoB lipoproteins (fat transporters) in your blood. We follow the life cycle of an apoB fat transporter as it emerges from your liver as a VLDL (very low density lipoprotein), morphs into an IDL (intermediate density lipoprotein) and finally ends up as a cholesterol-rich LDL (low density lipoprotein). We see how all of these tiny lipoproteins can invade the walls of your arteries and cause disease.

[@swingtag1041]

Pus filled scabs don't form on my skin without some kind of injury, burn, abrasion, or infection. LDL doesn't cause heart disease. Injury causes heart disease. LDL is part of the damage repair.

[@Birdylockso]

So, what's the latest drug that doesn't just decrease ALL the LDLs, but only decrease the ApoB in the blood? Are all statins simply decrease ALL LDLs, including the good fluffy LDLs? Is that why statins have plenty of side effects that include muscle weakness, memory loss, and even diabetes?

[@jamesgordon8867]

You need to show the glycocalyx hairs on the endothelium

[@DavidJonesImages]

that was great, thanks so much

[@jamesgordon8867]

Problem occurs when glycocalyx are damaged. This needs to be added to this issue.😊

[@stroys7061]

Thanks, this was very helpful.

[@Eagle_Delta]

Why does macrophages engulf modified apoB but not native LDL particles?

[@minanovkiril]

it was helpful, thank you

[@davidstewart4149]

A couple questions: When I eat more carbohydrate than I use immediately, isn't it stored not as fat, but as glycogen? What happens when I eat more fat than my body can use as fuel? Is some of that fat stored in my body, and is any deposited in the wrong places, such as inside the arterial walls, as visceral fat in the abdomen, or in organs such as liver, muscle, heart, and pancreas? Which is most easily converted to or deposited as body fat--carbohydrate excess or fat excess?

[@thomasjust2663]

I'm so confused, I saw a video from a New Zeland professor saying apo b is not relevant

[@2annec97]

Glad to find this video which makes such a difficult topic to be so enjoyable! Thanks!