Seeing Pain: New approach to diagnosing and treating nerve damage | Chris McCurdy | TEDxUM
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- Опубликовано: 28 май 2024
- Peripheral nerve injury, as a consequence of trauma, surgery, inflammation, or other causes, is a major medical problem. Diagnosis and treatment are still considered as unmet medical needs. This TED talk discusses exciting new paths to treating nerve damage.
Chris McCurdy is Professor of Medicinal Chemistry and Pharmacology, Research Professor in the Research Institute of Pharmaceutical Sciences. The reality of drug abuse is that people become addicted so quickly that withdrawal becomes intolerable and the addicts are stuck. McCurdy’s work is to rescue people from addiction to drugs like cocaine, heroin, and methamphetamine. He does this by working to make withdrawal more endurable and thus more likely to succeed. His work uses kratom, a mixture common in Southeast Asia used to treat more common ailments.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at ted.com/tedx
There us a significant difference between dependency and addiction. By running dependency, abuse and addiction all together, you are doing a disservice to those of us who function with chronic pain with opioids. Society shames us enough without professionals not making clear that dependency is not addiction.
beckamax yes!!!!
Yes, but it's very easy to slip from dependancy to addiction. I was functional. I made my regular pills last but when I got certain ones, they went quickly. I've told myself for years it's dependancy and not addiction. I've had to face that it wasn't just dependancy.
Sara Beth
That says something about you.
I have a friend that was addicted to alcohol and street drugs. Clean now for years.
*He decided that he was going to stop me from addiction when he saw me with a drink, playing the lottery (caused me to lose $2,500), trying to judge me by his faults. *HE HAS THE ADDICTION PROBLEM LIKE YOU*, I DON'T! *YOU CAN'T PREDICT THAT I OR ANYONE ELSE WILL BECOME ADDICTED.*
I already explained my situation.
beckamax I agree with you! Clumping it all together is causing a Stigma for those of us who are prescribed pain meds for legitimate chronic intractable pain or a chronic illness which causes pain!
Yes and speaking this way could also hinder those of us with chronic pain thinking we shouldn't take meds that help us
5 years later and chronic pain patients are still suffering.
Now worse than ever.
Its misery having to suffer from severe chronic pain every day all day, year after year..
Jason Chacon AMEN!!!! I got severe fibromyalgia along w other problems ... COPD, THYROID, & Venus insufficiency. Very miserable!! Kratom gives a lot of relief!!🙏🏻🙏🏻🙏🏻
Yes it is
Not certain about the points made but ,if anyone else trying to find out peripheral neuropathy pain try Tarbally Neuro Remedy Tactics (just google it ) ? Ive heard some awesome things about it and my m8 got excellent success with it.
I hear You. Hope you are doing better.
That is great for diagnosis. I am a year into nerve damage and am still waiting for a nerve test to say that I have it. It's affected so much of my life!
This was 4 years ago, have we made progress in this field? The ability to target specific damage and possibly use stem cells for treatment sounds interesting
Someday is to long for people to wait!
Would love to have Dr McCurdy do an updated Ted talk about his research here. He's done some trials and had some success with this per some of his articles and other videos. They are more deep than this talk and harder for medical laymen to understand.
big difference bw addiction and tolerance!
I can't believe he doesn't know the difference - just dumbfounding!
Thanks so much for dedicating your time and attention - your life, given the complexity - to this research. Especially when people in pain can be such a cranky naysaying lot. Your concise, informative, honest presentation is giving me hope.
A leaf of faith brought me here.
Looove that documentary!! A Leaf of Faith is so awesome & informative!! I personally have been using Kratom for 2 yrs now...I am a Recovering Alcoholic & Addict. I also suffer from debilitating Chronic Pain & Anxiety. I've been clean & sober now for almost 3yrs. Kratom is such an amazing tool when used responsibly. I love this plant!! It has allowed me to be free of the bondage of Addiction while having quality of life as well. I am not on any prescription drugs except my blood pressure medication. Although I am not knocking anyone who is on prescription meds! We ALL recover differently & no matter what your personal Recovery Journey looks like- YOU ARE A BADASS 👊🙏💙😍 Much Love Recovery Warriors 👊🙏💙
I am thrilled that you are well on your way to finding a cure. But what happens to those of us who are in excruciating pain between the time you find an acceptable cure and now when we are just left to suffer?
Yes.
I also suffer from debilitating Chronic Pain & Anxiety. But I have found a freedom that I never knew existed by taking Kratom. I use two different vendors- Wonderland Gardens & Alaska Green Clover Kratom. They have the best prices & products. Google them...I promise you, this wonderful plant can change your life!! 🌿💚✌️
Yes
They won't even pay for stem cells for arthritis patients. It's been used for years.
p much
Great video, Chris's speaking style, and rhythm remind me of Marlon Brano in the Godfather.
What has happened here?? This sounds amazing. But it’s been 5 years and this is the first I’ve heard of this 🧐
That's not surprising in my opinion. It's because research takes long. There haven't been any completed clinical trials on kratom yet, which is not because the interest isn't there but much more so because of bureaucracy and legal restrictions. I actually think the rise of kratom's popularity has been rather impressive, given that 20 years ago essentially no one in the west had heard about it.
Nice job! well done!
I’ve never abused drugs( my physician prescribed medication in over 17 yrs of opioid pain treatment . In 2016 my dr was forced to close his small private practice. I can’t get my medical records proving all the alternative to opioids . I’m in my 60 s now only get offered surgery & injections that I spent yrs trying but they all failed to give pain relief. Should I just give up & get street drugs to end my suffering? I’m st the end of my life rope!!! My GP knew my opioid treatment for all the yrs but refuses to help me. You give me no hope to function again !! I’ve needed pain help yesterday I need Help now.
Christine Horan please try to find a pain management doctor you might have to keep trying and they might be a little far pain management is still allowed to prescribe under the new guidelines... it won't be as much as before and you'll still be in some pain because of it that's why everybody's complaining.
but you need a pain management doctor and you need to start writing your letters to Congress and also please join Facebook --- it's called operation Starburst his name is Robert D Rose jr.
like the flower! Robert is a war vet who's filing a criminal complaint against the government because of the suicides and the number of people that it's impacted negatively and cannot now receive treatment for their chronic illnesses and diseases.. please jump on board now
Christine Horan let me know
Christine Horan I’m in the same boat. Pray and hang on and find a doc if you can.
Any updates?
NOBODY'S messing with my back. I'm in enough pain. I've told my kids, " no body parts, blood, or life support".
All the B vitamins help build back a damaged myelin sheath, especially B12. My damage came from Systemic Cobalt Poisoning from Metal on Metal hip implements. Symptoms don't show up fully for up to 6 to 10 years, well beyond the statute of limitations for my 4 hip surgeries. Now Zimmer has recalled these THRs in me. I may get a 5th and a 6th as my cobalt is rising.
mickey morgan There's a new Netflix documentary The Bleeding Edge, on medical devices. This orthopedic surgeon had a cobalt hip replacement surgery and developed Alzheimer's like symptoms. Best of luck to you.
Greys anatomy had an episode about this very issue. Scary!
Chris is one of the very few and the leading researcher in the medical field who has studied Kratom extensively, and he says the results thus far have been outstanding. He sincerely believes that Kratom has great potential in treating opioid addiction or as a much safer substitute for those using opiates. This man deserves a lot of credit for Kratom remaining legal so far because of the extensive research they he's done and is still doing, and he has been the most credible voice that the important people who have the authority to either ban Kratom or keep it legal have been listening to, and if that day should come that Kratom eventually remains legal and even used in traditional medicine, then we will owe this man a huge debt of gratitude for leading the way.
I have CRPS which is considered the most painful disease known to man. It is nerve pain. I’m allergic to opioids. Gabapentin just makes you so sleepy I can’t function and treat it. It also doesn’t help with extreme flare ups. I’m looking for any options that can help. I live in a bubble of pain at times.
Me same how are you know ? I get face n head tingling n some facial pain n ear ringing , Dr says all somatic mri normal, did you got any damn solution? Pls share
Trigeminal neuralgia is the worst pls Google symptoms
I’m going to ask my doctor to use this method to see where my nerves are damaged! Omg this could be a game changer in my life! And I’m close to Stanford!
How did that go?
I found kratom over a decade ago it had saved my life from years of opiate use from a injury I received years ago, I took a journey to bring this plant into our lives and grow it and had quickly found that I was maybe 1 of 3 that grew this tree within the USA, well years later we now have trees over 40ft tall and multiple genetics from all over south East Asia, our goal over the years is to get a tree into as many households as possible across the country.
Yes please. I'll try anything. :(
Lawren Haggerty / Please research kratom!! I'm amazed... no more pain, no narcotic pain pill withdrawals... I'm a nurse, and I wish I could scream it from the roof!
Lawren Haggerty / Join "Kratom Support Group" on Facebook.
Hey! Where do you get your Kratom? Thanks!
Ppl who are willing to try anything with no proof of relief. Must have much more time on their side. I don’t have time for someday. I need relief now. To not die in pain to lose my normal sanity from untreated chronic pain. Please. I’ve never taken more than my physician prescribed. I only pray to function at a low level of self care without chronic pain I’ve dealt with more than 30 yrs. I have no more time to suffer because of other ppl who chose to abuse medication that would regain my functioning life again. Stop this forced suffering on ppl who Never thought of abusing Any medication. Please speak out for the senior who’s never had a health problem or a drug abuse problem to stop them from being prescribed opioids for chronic pain relief ???
Christine Horan Look up kratom suppory groups on fb. It has helped me tremendously. They have vetted sellers that are very reliable.
WHERE DO I SIGN UP
The human body has 95 to 100 billion neurons or nerve cells in it, does this mean that a person would have to have 95 to 100 billion medical surgeries to fix their nerves??
Because if so I seriously doubt my health insurance would approve that many surgical procedures?
Neurontin made me go from 119 lbs (at 5'9"), to 189 lbs! Messed up. Now I take GABA, a supplement (as in BigPharma Gabapentin). One has to have nerve-brain damage to use GABA, which I certainly do.
Have you tried Lyrica? I can’t take gabapentin the Generic it made me nauseous.
Gabapentin is genetic Neurontin. It’s the same thing. Not getting your comment.
Me same how are you know ? I get face n head tingling n some facial pain n ear ringing , Dr says all somatic mri normal, did you got any damn solution? Pls share
so what was the outcome from this old video...did the fail?
Nerve conduction studies show pretty close where the pain comes from.
Whoever struggles with abdominal neuropathic pain look up Maxima Hospital in Eindhoven, The Netherlands. They saved my sister!
Fibromyalgia population have reduced blood flow to muscles.
“Our results support the suggestion that muscle ischemia can contribute to pain in FM, possibly by maintaining the central nervous changes such as central sensitisation/disinhibition. “
Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: A contrast media enhanced colour doppler study, 2005
Maybe why niacin can counteract pain sometimes?
It’s starting to look borderline ischemic areas/impaired or reduced blood flow is a common theme in chronic pain e.g. hypercoagulation (coffee, iron) and diabetic neuropathy
Yes:
“While it is widely recognized that pain can raise blood pressure (BP) acutely, the evidence that hypertension is associated with a reduced sensitivity to acute pain is less known”
The Relationship Between Blood Pressure and Pain, 2013
And? 7 years later where is this at?
I lost both legs at the age of 9 months old in a car train accident. I'm 46 now and my pain is off the charts. Methadone does nothing anymore. The only relief is medical cannabis. But Illinois is taking advantage of patients by ungodly high prices. in Denver med patients pay less than 100 a oz fro meds. Here I have to pay 400 for same thing. I live on disability and can't afford what helps. So my question is how has this helped in post amputee pain, or as it's called generically residual limb pain? It's getting bad. I'm having suicidal thoughts. Fighting to live every day. I need help and can't find any.
Grow your own
judotapout: I truly hope that you have found relief somehow and are doing better.
@Hunter Gatherer: Your comment is telling about your intellect. Hopefully you will experience the pain that judotapout is/was going through so you can maybe get a little empathy.
7 years later its 2023. where the pain relief at? I still have chronic debilitating pain and there's still no meds that works!
Me same how are you know ? I get face n head tingling n some facial pain n ear ringing , Dr says all somatic mri normal, did you got any damn solution? Pls share
Am suffering from brachial plexis anjury with chronic neuropathic pain ...help me plz...
Javed Anjum I also do suffer from BP and much more spine problems (Chiari Malformation:Syringomyelia) 2 op on my spine that were of no use except to leave me with more pain than ever. I take Palexia 100 twice daily and not one more. Still with this med I have days with great pain... Cannabis and Hemp balms take care of my shoulder pain greatly!!!!
Let's hear, please the research on the wonder plant, Kratom . . . It is helping thousands and not killing.
do your research. the FDA has associated 44 deaths with kratom...
Jenny Ferguson Do your research!! Those deaths were found to have outside contributing factors not related to Kratom...ie other substances etc...
@@FourSeasonsNorth4x4 you are exactly correct! The deaths were Kratom in combination with drugs! Kratom has saved my life!!!
@@jennyferguson1353 There are an estimated 3-5 million people who use Kratom for pain relief. When you really dig deep, you find zero deaths associated with Kratom used by itself - the deaths are always in combination with other drugs. Now compare the statistics for deaths directly attributed to overuse of NSAID's. Go ahead look it up. Over 16 thousand... Kind of puts things into a different perspective, doesn't it?
@@FourSeasonsNorth4x4 yes!! Absolutely!! I don't know why so many ppl are spreading these lies!! Kratom has not been the cause of death, NOT ONCE!! In those "44 Deaths associated with Kratom" it was found to be that they were mixing drugs...NOT BECAUSE OF KRATOM. KRATOM SAVES LIVES!! Kratom has saved my life & the lives of literally millions of people all over the globe!! Pls ppl... educate yourself BEFORE making these ridiculous comments 🙏 Follow The Science!
If you take the knife away from surgern it'll help.
Sharp random stabbing pains
All over my body.
Everywhere I have nerves
Thousands of times a day.
Hezett314 kratom will save you. go to kraydo organics,happy hippo,kratom crazy
Any updates here……🤷🏼♂️
Listening to him speak was painful.
Place me on your contact list for testing..., From a car accident, not at fault; I've been dealing with Peripheral Neuropoly on my left leg and foot, which feels just like when you hit your ulnar nerve..., only; I feel it continuously. I am allergic to Lyrica! I also suffer from a spinal stenosis and feel electrified when I sit or lay on my back. I take 20mg 'Melatonin,' for sleep. 'Cannabis,' is very helpful and I feel considerable relief..., However; to renter the workforce, I have abstained from consuming cannabis throughout 2017, since New Years. Please Help!
Michael Simpson hi that sounds similar to phantom limb or CRPS. Have you tried ketamine infusion? Some academic hospitals offer a week-long treatment. Doesn't help for all patients with neuropathic pain but it's worth a shot. Best of luck to you Michael.
I highly recommend you look up Wonderland Gardens or Alaska Green Clover Kratom....those two vendors are just wonderful!! I've been using them for my Kratom needs for 2 yrs now & the quality of my life has completely changed!! I suffer from severe debilitating chronic pain and anxiety & Kratom has given me a new freedom from pain & anxiety like I never knew existed!!
3/13/2023 I have been suffering from P. Neuropathy for over 10 years. Please, somebody tell me how to get rid of this thorn in my flesh. I am not diebetic, just have neuropathy.
I have NON Diabetic Peripheral Neuropathy in my hands and feet. My father has it he takes opioids, and my brother had it so bad he died of a morphine overdose just looking for relief. When my symptom's hit me in my late 40s, it felt like my feet and fingers were on fire, all the time. I had several doctors refer me to other doctor's. I was eventually accused of being a drug seeker and left to deal with my pain. ALONE. The only thing that has worked for me with Neuropathy pain is Kratom and a no sugar diet.
What you have described sounds like a condition called erythromelalgia. It's a subset of small fiber neuropathy. It comes from a genetic mutation that most often runs in families, NOT from diabetes, alcoholism, HIV, etc. My mother, myself, one of my children, and one of my aunts suffer greatly with this. All you can do is treat the considerable pain of this awful genetic malady. After 30 years of trial and error, I have found Lyrica (pregabalin) to be the most effective. The opiates are generally worthless.
I wish you well and hope you will research the condition. Anne Louise Oaklander of Mass Gen has some excellent RUclips videos that explain it quite well.
@@katlewi I tried Lyrica and although it worked better than Gabapentin "which did nothing" I had crazy side effects. Just walked around in a haze on Lyrica. So, I decided to use the system to my benefit after I read an article about treating nerve pain with Suboxone. I faked having and opioid problem and got on Suboxone. I know, that sounds ... desperate but, the Suboxone works great for nerve pain, and I only take 8mgs a day. I figured if I'm going to be labeled a drug addict for pain relief why not? I know it's an opioid, but it does work and I'm not high all the time.
I have damaged nerves inside my abdomen from gallbladder removal surgery. I’m in horrible pain every day. I’m dying for relief
Kratom has TOTALLY changed my life!! I suffer from debilitating Chronic Pain & Anxiety- I have been taking Kratom now for 2 yrs & it has shown me a freedom I never knew existed!! I researched tons & tons of vendors, strains, etc. I have found 2 amazing vendors who test their products for safety & efficacy & the customer service feels more like family! I had so many questions in the beginning & still do sometimes & they're both always willing to answer my questions. The first vendor is Wonderland Gardens (Brandon Howell) & the second is Alaska Green Clover Kratom & they are just amazing!! You can look up Wonderland Gardens on Google & get their menu. The prices & the quality of their product is out of this world!! For pain & anxiety relief I usually stick to the reds & golds. But I hope you do try them because their product has literally changed my life 🌿💚🔥😍
Cari Bray- Pitts I will look into this. Do you know if it helps nerve pain?
@@redmixxie yes- I have heard that it does...my Mom & Aunt have nerve pain & they said that Kratom helps them more than anything
Kratom made me thirsty and that was it. Tried every kind available and was thirsty on each and every one. It’s not a miracle cure for all of us.
dont put all in a bag and shake us up and shake and bake! plz b careful!
Not everyone develops tolerance, like me for 20 years on opioid meds for pain I have not developed tolerance and my guess is that is a non- fact and while some do develop tolerance most actually do not. And the doctor hears, blah blah blah blah bluh blabba blabba blah blah. Oxycodone is a miracle drug for me yet I get less than 1/3 of my ideal dose and still in misery they want to run me down to zero. It is maddening.
You haven't developed a tolerance to opioids or kratom?
@@Shurmash Some tolerance but nothing significant. I have not tried Kratom.
Kratom did nothing for me. So disappointed.
I have Cmt disease
Not substance abuse.
Ingesting Decarboxylated cannabis is the only thing I use for pain
i just learned how to process and big pharma has a issue at hand. if i looked down from mars and had to chose cannabis over opiates i would pick processed cannabis 1000 times over their concoction. i had no idea. i always burned it
He won't go into the details because its INCREDIBLY CRUEL on the animal. Thats why. Why not use those already in pain who are willing? We are hortibly cruel to animals.
All pain is processed in the nervous system.
Ya think?
So if you have fybromyalgia which for me affects every nerve in my body how will this help? There is no way you can cut me open every where and correct it...no. .I'm sorry but I'm a believer in the poppy plant which produces the opioids used for pain. .. Chemists always want to make something from their lab like some mad scientist when instead we have natural herbs and plants that was given to us for the purpose of medicine
I'm so tired of hearing the words addiction and addicts as long as there has been humans on earth and continue to have humans there will always be those that will find a way to get their "high" ..sorry but that's reality. .and governments and officials and dr's know this. ..this is all propaganda
This guy sounds like a commercial trying to sell his get rich product. .oh and by the looks of it he is also an addict. .to food. .and that wasn't meant to be mean. .just saying that you can be an addict to just about anything. .but letting millions of innocent people lay in in cruciating pain or take their lives. ..think about that. .how much agony do you have to be in to take your own life. ..all because there is relief out there but it's not being given to these people. .why. .mostly. .money and greed. ..
I to have fibromyalgia and I’m not an addict I’m probably dependent at this point though. Why is it when I had to take large doses of ibuprofen for a year no one called me an addict but any opioid for more than a week and all of sudden I’m an addict? I also have nerve damage in my neck and back plus ruptured discs between my vertebrae as well as severe carpal tunnel in both wrists and a number of other painful conditions.
So yes I want a painkiller that works and for me that’s an opioid based painkiller, not OxyContin either, just basic Vicodin. I’d say let them walk a mile in my shoes but I can’t walk a mile so let them cry
a hundred feet in my shoes.
Kratom
Dont sound like this speech has aged well......
Y’all need to go back to your roots, ditch you doctor and start learning about the medicines are ancestors have used for millennia. Lots of nervines, lots of adaoptogens, lots of anti inflammatories. These things not only cured what my doctors were saying was incurable, it’s done this for people for thousands of years
Why you can't you do a better job, Us drug enforcement act, simple next video
Did this "Dr." just equate dependence and addiction? No "Dr" dependence and addiction are not the same!!!! I cannot stand these Ted talks! Another quack. Stem cells can also make the pain worse!
"we" lose 52 billion in lost revenue"? whos "we"? is that the only metric you know to gauge societies worth? Are you out of your mind? millions of homeless, millions of unemployed or underemployed, and you are worried about production?? shame on you...
By the look of him he addicted to food ! Alot of people have chronic pain from surgery try living with no pain meds .Just a big ad all about the money
Actually, Mr. McCurdy in the video isn't after money...as he explains in this video, this is an issue that's very close to his heart. He has helped change ppl's view & treatment of Chronic Pain, Anxiety & Addiction. He is not a vendor, trying to make money from selling Kratom.... Pls educate yourself before making rude comments 🌿💚✌️