Art of Science 2023 | Into the Matrix

Into the Matrix by Raymond Qin, Niall Geoghegan
Music by Margaret Wozniak
Immune cells need to move through a range of body tissues to hunt out and kill infected or cancerous cells. But many organs and tissues contain fibres made of collagen, a protein found throughout the body, particularly in skin, bones, teeth, ligaments, tendons, and other connective tissues. 
Using a lattice light-sheet microscope, researchers Raymond and Niall have been able to show in 3D how an immune cell (magenta) contorts into different shapes to find the best route through the dense matrix of collagen fibres (grey). 
A better understanding of how immune cells navigate is crucial in helping researchers understand the immune response and find new treatments for a range of diseases. 
Visit the online gallery at www.wehi.edu.au/artofscience

[@gracianne]

Magnificent

[@sparXKuijper]

Lightsheet Microscopy

[@ngeoghegan87]

Lattice light-sheet microscopy to be specific!

[@darthPixel]

i feel like the same sequence is played 3 times :/

[@DreamChaserEiRi]

So much of interesting everything must hapen at once in biology 🧫

[@MarinaKokhan]

What is this in the matrix?

[@ngeoghegan87]

The matrix is made from collagen to provide a 3D environment for the T-cell to move around in. The pink object moving through the matrix is a T-cell.

[@lakastusmanatus]

B

[@edwin2413]

*promosm*