I really liked Dr. Eric Verdin. I’m always amazed by how someone’s presentation matters. His energy, calmness and knowledge was attractive in what he was saying. Thx for the interview.
*Don't forget to check out the show notes!* Summary, minute-by-minute timeline, glossary, links to studies and many other helpful resources. www.foundmyfitness.com/episodes/eric-verdin If you like the show, make sure to hug a supporter today. Each episodes of FoundMyFitness is made possible by the generous pay-what-you-can subscriptions contributed by people like you each month. Learn more at www.foundmyfitness.com/crowdsponsor Special thank you to Dr. Eric Verdin for taking a little bit of time out of his day to share on his research and insights in the field of aging. If you are on Twitter, please consider following him at twitter.com/ericverdin. He's very active over there and posts a lot of great science-related articles. Thank you for watching!
Foundmyfitness Dr. Rhonda Patrick you are the best out there! You're so passionate and truthful. You definitly don't hold any bars when interviewing top expert scientists in the field. Recently, I spoke wiith a Harvard researcher who is working on a team conducting research on how to increase stem cells in humans as we age and I thought of your podcasts on sauna use and intermittant fasting. I will be on the look out for any reported results published.
FoundMyFitness I have been watching a lot of videos on health, not to prolong life but to improve the quality of it. I am wondering if you have noticed in your personal life what I have noticed in mine. Women(the men usually consumed more meat and died younger)that I have known that were born between 1900-1921 lived into their 80's and their 90's, while there children male and female born in the 1940's died in their 50's-70's. The ones living into the 80's-90's ate diets high in white flour products for most of their lives and Crisco for at least the second half. They also consumed less meat than their children. One thing we all have in common is we were intermittent fasting without knowing what it was because it was just what most people did, after eating dinner between 5-6 pm we didn't eat until the next day. That has always been the norm for me. I enjoy watching your enthusiasm for health education.
What I've Learned The paper was a study on PROCESSED food and not a plant based wholefoods diet as has been consumed by every indigenous tribe through history, EXCEPT the Eskimo who are traditionally short lived and carry heart disease and osteoperosis.
Enriched flour is flour in which most of the natural vitamins and minerals have been extracted. This is done in order to give bread a finer texture and increase shelf life . . . the bran and the germ (the parts of the wheat that contain fiber and nutrients) are removed but they cant put back all that they take out.
5:48 Is a huge source of confusion for so many people. I wonder how many health professionals make this statement without clarifying that the study did not account for the difference between refined carbs and unrefined carbs. HUGE! Nice catch Rhonda!
I don't think I understand that part about the KD requiring so much "discipline." I've been on it 4 1/2 years and it's the easiest diet I've ever come across - except for the high-carb death diet. And it's actually easier, first, because you're never hungry. Second, it's amazingly rich, with butter and seasonings, eggs, cheese, meats and lot's of salt (Dr. Bob's Super Salt - which is 50% Na and 50% K). There are no vegetable oils in my diet, either - just butter and animal fat. I also do daily intermittent fasting, and have no problem going 16 hours or more without eating. People who know me can't understand "how I do it," even after I explain the processes. It takes very little discipline on my part. At this point, I know that anything with even a tiny amount of sugar in it will make me sick. There're no bread, no cookies, no cake, no rice, no snacks, no potatoes, no cereals, etc. Unfortunately, I end up spending an inordinate amount of money on fatty foods, especially butter. I prefer straight-chain fats (saturated) of the bent-chain (mono- and polyunsaturated) fats. This is partly because of the information I found on hydrogenated oils 30 years ago (or more). These are just bent-chain fats, which are just bad for us. My most recent blood tests showed excellent results. Other people my age, 67, are practically decrepit, while I still engage in high-energy sports; cycling, racquetball, running, weight-lifting, and all of this before breakfast, on an empty stomach. In the meantime, I feel fantastic and study astrophysics in my evenings.
Wow! So much good information. Will need to watch and re-watch to really digest this. Thank you for this. I also appreciate the explanatory text inserted into the video. Glad I'm a supporter.
@@cereal_qilla Nope. Lots of nuts and plant based fats, but plenty of meat and some dairy. My annual physical was a slam dunk, all of my numbers were great.
@@RyanKentBarnhart “plenty of meat” seems to suggest that you may not be in full ketosis (but more likely doing a modified Arkins). You also need protein restriction to be in true Ketosis, otherwise your body can get by with gluconeogenesis….
I’m born in 47 and I’ll be 76 next week. I really vary healthy and I just noticed the average age of someone born in 47 is 68 I think the list(wicky) . I’m younger today than I was 5 years ago. I really plan out lasting the expectations. I do no sugar ect but I really like to fast 1-4 days every so often,no schedule. This is a great video.
Would you please write a book? “Human metabolism for the rest of us” Something that could educate the masses so we can make better nutrition and healthcare decisions? There are so many gurus and no understanding.... and since most of us never studied biochemistry we are really just prey to ideology.
The longevity results this researcher is assigning to a Keto diet is really the result of protein restriction. If I was to guess why the low fat mice didn't live as long as the Keto mice would be in order to keep the macros at exactly the same level they used purified ingredients instead of real whole food. So, they fed their high carb mice the equivalent of sugar in processed carbs. And why did the Keto mice get fat when left to eat as much as they wanted? The Protein Leverage Hypostasis tells us that. They were attempting to eat more to get their protein levels to what would be normal for a mouse. That protein range is generally 13.6% minimum to 16.3% optimum for most mice. I wish you would get David Raubenheimer and Stephen Simpson the original researchers of Protein Leverage on the show. Their results for high fat eating mice (not sure if they were low carb enough to be keto) was very different when it came to health and life span.
Just now realized that I've watched all her Rogan podcasts, which means I've listened to this woman talk for 18 hours. I've watched two of those episodes twice which brings me to a total of 24 hours. Not a lot of people can hold my interest for that long. Looking forward to the next one.
Love this Dr. Verdin!! Our biomarkers are so important, but we also need doctors who can analyse these biomarkers correctly and not try to throw unnecessary medications at you & tell you if you refuse to take them you will die! Plus in my opinion, the Ketogenic Lifestyle is an Omnivore Diet, WHOLE FOODS: plant foods and animal foods, but NO processed carbs, highly processed vegetable oils/fats or refined sugars. And many people love this diet and find it easy to stick with, within circles of likeminded people 🤓 So can someone please tell me why and how this could be dangerous in any way and cause cancer!!?? In the middle of this interview this doctor said people must be cautious doing the Ketogenic Diet. My God, it‘s more or less the Mediteranean Diet, which is eating enough balanced Omega-3 & Omega-6 fats, enough probiotics & prebiotic foods to feed your healthy gut bacteria. Exercise, intermitent fasting, sleep, low stress, meditation, etc are also key factors along with your food intake. I think these studies are very interesting, but why don‘t they try to collect more anecdotal data from humans who are actually doing a Clean-Keto diet? All of this data from thousands or hundreds of thousands of people - would be much more interesting than what‘s happening with mice in the lab, in my opinion.
Yes, interviewing people who are on ketogenic diet helps. However, scientists prefer the data from controlled environment. Their own experiments. If they have humans, it can become costly. Mice are a cheaper option.
My close friend was the one who told me about the diet program when she said how she lost her weight. Then I decided to join in because she dropped 18 pounds as a result. Look into *2WeightLossFast. Com*
I am an avid fan of all your prior videos, but I have to say I was disappointed in your response to the definition of carbohydrate at about 6:00. The Okinawan diet high in sweet potatoes, and all the other “blue zone” areas have shown that complex carbohydrates cannot be lumped in with refined HFC’s, milled flour of any kind, and simple sugars. I’m 68 and have been following a whole food plant based diet for about three years - the results- asthma gone, arthritis gone, energy levels through the roof. I’m trying intermittent fasting though.
liutasx I cant see myself committing to intermittant fasting on a vegan diet. It is literally impossible; I'll be hungry again in a few hours. I find it much easier to fast intermittantly on a high fat/complex carbs diet with minimal meat. Consuming grass fed yougurt in the morning allows me to literally go through half of the day without feeling hungry or crave food until way past noon.
There is one line at the end that really scared me. When he says they are in a point of research that allows his company to ride the next wave of investment from big pharma and venture capital to the aging industry. I wonder how this can definitely separate humans in two categories. Up to now, those categories rely only on social and historical separation. But as aging well and living longer is turning into a monopoly of the wealthy, slowly the poor would be "substituted" for the heirs of the rich which will live longer. What can be the consequences of such a rupture?
OK, the byproducts of *fermented vegetable fiber* can prolong life :-) We can be happy about that. Would be useful to find out if the duration of the fermentation has any difference ?
epSos.de if fermentation is so wonderful then why is kimchi associated to so much stomach cancer? Avoid fermented products and eat whole fresh vegetables if your smart. Your gut is the best fermentor.
Dr Tahir MD the real result of the study should not be to eat kimchi but rather eat whole fresh vegetables, fruit, spices. The standard kimchi processing is very high in salt and opens the door to festering bacteria of many kinds. Our bodies are the best natural fermentors without salt. They use salt in processing kimchi because the salt slows the growth of the nasty bacteria. Unfortunately, the salt slows the growth of nasty bacteria but does not eliminate it. Avoid kimchi.
They were speaking of butyrate which is a byproduct of fibers bacterial fermentation in our gut. You can't easily modify the duration of that fermentation.
@@theartificialsociety3373 our gut ferments less than 5% of fibers. Thats very inefficient. There is not enough evidence for me that fiber is needed at all and its likely more important in the SAD diet. Avoid SAD and you may see fiber worsens symptoms, too.
Love Jack la lane ....I followed him all my life ....he was an inspiration ,however he didn't live to 100 he was around 94 ...he developed pneumonia as a complication from heart surgery ...I bet he would of made 100 easy if he didn't have the surgery .Im FB friends with his wife and son....nice family .
The study cited as so amazing did not distinguish simple or processed carbs from carbs in whole foods (which have fiber, vitamins, minerals, micronutrients) and so could only show that substituting fats for bad carbs is even less unhealthy than unhealthy fats. I am amazed that any researcher in 2017 would not recognize this.
Have followed the Buck Institute for nearly 18 years. I knew one of their microbiologists and was fired up about their longevity breakthroughs. Specifically, the work with nematode lifespan extension.
It is encouraging to listen to two brilliant scientists discussing topics of real importance to real people. The discussion was excellent, and displayed both current evidence, and where evidence is lacking. Glad you are back Dr. Patrick! As I used to tell new mothers, "It will get better!" and then raising kids gets to be fun - until they turn teenage!
The Okinawans were not healthy, they were living to the point of starvation with severe nutrient deficiencies. It goes to show the "tradeoff between performance and longevity".
The high fat diet is deadly, causing insulin resistance. Particularly for the overweight with large quantities of stored fat. Sure you might burn fat in ‘ketosis’ but if you burn your daily fat calories, your stored fat wont budge. 1grm of fat = 9 calories. Assuming a high fat diet, there is no way an overweight person will burn their fat stores. Its all a big con. Meanwhile, dog breath, keto rash and insulin resistance makes keto man a very sick puppy.
@foundmyfitness amazing presentation perfect setting (clear audio) and the text boxes and graphs take it to a different level i have seen you on an interview with Dr. Attia, but half of the interview was too advanced and LONG (him talking to hear himself), this format is ABSOLUTELY AMAZING subscribed and i will start watching all your vids Thank you
How in the heck are you going to get optimal micronutrients from such a restrictive keto diet and be plant based? Many foods with ample carbohydrates have some key antioxidants and phytonutrients. What low protein and low carbohydrate foods contain a symphony of micronutrients that would support longevity that one could sustain? Foods with resveratrol: carbs. Foods with sulforaphane: carbs. Foods with beta glucan and inulin: Carbs. Foods with minerals: protein.
Hang on, wasn't there a study that suggested the opposite, a link between low carb diets and all cause mortality, he brings up a study that suggest the more carbs the more death and yet another study suggest the lower carb = more death, he seems biased towards Keto diet. His cyclic diet seems interesting though, he brought up Valter Longo cause it fits in with Keto, he could have brought up Calorific Restriction, in more detail. When it comes to longevity where are the Keto supercentenarians? There are none that I've heard of anyway. It seems that most of those long lived guys came from the blue zones and they weren't either vegan nor keto, all this science but no common-sense, I mean Keto is super interesting but apart from studies on mice where are the centenarians that have eaten the Keto diet and there are none, that would give these guys more clout. Im sure Ronda was itching to suggest the low carb and early death study but had to keep quite. I've tried Keto diet and felt very sick, it was very bad for GERD/Hiatal hernia, I had massive palpitations and felt awful, I tried 3 times and all times at about the 3 day mark I get terrible symptoms.
Rhonda, would you please consider doing a podcast or article on artificial sweeteners (erythritol, allulose, maltitol, etc)? I know that stevia is preferred, but I've never really understood what the others do to your body (microbiome-wise, effects on blood glucose, etc) and why they're considered inferior. Alternatively, if you or anyone else have legit resources, I would greatly appreciate them! Thank you for all that you do!
Marilyn Kane all sugar alcohols are less sweet than stevia (gram for gram). Since you have to take gram amounts and these will naturally draw water into the colon, you’ll get .....
It's a mistake and misleading not to differentiate between refined carbohydrates and whole plant carbohydrate which is good to eat almost in any amount.
Another amazing interview. I do wince a bit with a lot of these ‘plant based’, ‘ketogenic diet’, or ‘high/low carb’ terms. They are so vague. I like that you try to clarify those terms. As you know, you can have a VERY unhealthy vegan diet as well as a VERY healthy vegan diet. Ketogenic diet using plant based proteins is very different than a ketogenic diet with a lot of bacon and animal fat. I am so dumbfounded by the seemingly complete contradiction in readership interpretations. Some of the best research (personal experience included) seems to indicate huge benefits of scheduled fasting/eating, but who is going to fund research that results in abstinence? Despite any mistrust of pharmaceutical companies, who can blame them for focusing on sustained profitability.
First, congrats on the baby, glad to have you back and wish you both a lot of joy. Regarding the discussion...not all carbs are equal and this is the opposite of the foundings presented by Prof. Stephen Simpson ...ruclips.net/video/x0-Jt7az-54/видео.html in his talk regarding mTOR and AMPK pathways. Science is obviously a contradictive issue.
At 26:05f (Table 3), it seems that, in CR, protein is more satiating than fat. But in an isocaloric context it’s generally the opposite (?). If so, there’s a crossover point of carb intake and/or caloric decrease where this occurs. Am I reading this right? Thanks
The centenarians in the blue zones didn’t get the memo on the ketogenic diet. They eat high carb diets ie the okanawans eat more 60-70% of their calories from purple sweet potatoes. Of course refined carbs will have a negative health impact!
Fasting and comprehensive intake of micronutrients put a damper on the constant intake sugar and glucose, which then causes a constant release of insulin. That's what you are blind to. Sugar is sugar but lifestyle can mitigate to a point. I doubt their teeth were that good though.
I have a suggestion. Maybe not relevant to your topics but I'm going to make it anyway. an interview with David Synder He's more mind healing very smart guy out of San Diego I believe. he cusses somewhat in his video's but is very knowledgeable.
This is a GREAT interview and very informative so I don't mean to dilute the value in any way but, if you cover Dr. Verdin's hair, his profile looks EXACTLY like that of Larry David.
I'm hearing the body is a very very complex ~machine and do NOT expect any thing is going to make us all live to 100 EXCEPT exercise and your food intake... What the F you gonna do at age 89? lol
I don't want to apear contrary to this but the people I know that are well over 90 and still healthy eat what ever they want. The thing in common they have is a low stress life.My mother is one of them, and really pack's down cakes, sodas and candy, plus canned food and some junk food. I think that the level of stress has to be included in all health related studies. Maybe it's a very important variable.
Hi Rhonda, ¿Where would you improve this diet?: *Breakfast* - 150 grams of frozen red raspberries. - 100 grams of oats flakes (soaked for 8 hours with 2 tbsp of apple cider vinegar) - 3 grams of sea salt - 30 grams of unsalted butter *Lunch* - 120 grams of chicken breast - 200 grams of romaine lettuce leaves - 50 grams of avocado - 1 scrambled egg - 2 tbsp of extra olive oil - 2 tbsp of apple cider vinegar *Dinner* - 120 grams of chicken breast - 200 grams of romaine lettuce leaves - 50 grams of avocado - 1 scrambled egg - 2 tbsp of extra olive oil - 2 tbsp of apple cider vinegar With this diet, I achieve this daily goals (roughly speaking): - 100 grams of carbohydrates - 132 grams of fat - 100 grams of protein per day - 32 grams of fiber - 1,500 milliliters of water *But what about my micronutrients?* the vitamin A, D, K and magnesium for example? Am I good? Do you recommend me leaving the diet like that and buying supplements for the micronutrients?
I am so happy to find you. This interview is now4 years old and so many new findings but I love this topic. I saw you in a podcast recently and I’m happy to find a female in the field!
I really tried sticking with the the keto diet, but I just felt awful and it's also really tough to follow. Then I tried the Agoge diet and it was life changing, I highly recommend it to everybody.
More experoments should be starte on 'gender differeses' due to different genetic settings, including body size, tissue compisition as well as metabolic pathways, such as glucose and fatty acid metabolisms.All of which are related with health, disease resistance n longevity. As mentioned here, male mice on caleri ristriction cannot beyond the limit as 'female' because their body/genes are tuned n optimizes through evolution.
I'm interested but I mean, many of my ancestor already lived to 100 or fairly close to it. Sadly both my grandpas where engineers and came to close contact with toxic chemicals without using the right protection, one in the agroindustry and the other working for Coca Cola and brewing companies, they both died of cancer.
Maybe look at the Hadza. The last known hunter/gatherers. The men go out hunting, but are successful only once every 7-10 days. The rest of the time they all live on the fruit and roots and often honey the women gather. A largely plant-based diet high carb with no added oils and lots of walking. Those that survive the natural dangers and get to old age appear to be free of heart disease and diabetes. And then there is a very interesting clip on youtube showing the blood flow in the capilleries of some animal before and after a high fat meal. Then there is the evidence shown in the Kempner diet (rice and fruit, no fat) and Denise Minger, darling of the keto world who had the integrity to correct herself and admit that really low fat diets did appear to be curative of heart disaease and diabetes, ie. modern interpretations of low fat were not really so low and truly low fat meant 10-15% of calories from fat.
Just blaming carbs without going deeper on type of carbs and looking at other groups seems like a bias observation. I can't keep listening once I realize the guess is so superficial in his analysis. Okinawans eat mostly carbs, 85% carbs to be exact.
I was curious because my friend had lost weight and I wished to know how. They will suggested that I visit *2WeightLossFast. Com* . Once I listened to their advice, I lost 16 and a half pounds.?
Can you please clarify the high-fat diets inhibiting NAD salvaging? (Comment by Dr. Verdin at 37:30). Wouldn't that be a mechanism that makes keto reduce healthspan? Says also in the chart that a high-fat diet promotes inflammation. How can then keto be healthy? Or how can limiting carbs and protein be healthy then, as it means you have to get your energy from fat? I would really like to have a comment on this contradiction.
Good questions. The confusion is created by the term "high fat diet." The conventional use of it means, "high fat combined with high carbohydrate." It is also often called the "Standard American Diet." I call it the ice cream diet (sugar + fat). The high carb level activates the insulin/IGF pathways and directly impinges on redox homeostasis. A ketogenic diet by contrast is very, very high in fat (70% or more of calories) and very very low in carbohydrate (0-30 grams per day). The carb restriction blocks the insulin response... and, like fasting, upregulates genes active in redox homeostasis (among other things). So yes, NAD+/NADH levels and NADP/NADH levels are impaired by a sugar-fat diet but strongly enhanced by a fasting mimicking diet like keto. Same goes for all of the body's major redox couples. Hope this helps!
Another amazing interview. I do wince a bit with a lot of these ‘plant based’, ‘ketogenic diet’, or ‘high/low carb’ terms. They are so vague. I like that you try to clarify those terms. As you know, you can have a VERY unhealthy vegan diet as well as a VERY healthy vegan diet. Ketogenic diet using plant based proteins is very different than a ketogenic diet with a lot of bacon and animal fat. I am so dumbfounded by the seemingly complete contradiction in readership interpretations. Some of the best research (personal experience included) seems to indicate huge benefits of scheduled fasting/eating, but who is going to fund research that results in abstinence? Despite any mistrust of pharmaceutical companies, who can blame them for focusing on sustained profitability.
I really liked Dr. Eric Verdin.
I’m always amazed by how someone’s presentation matters. His energy, calmness and knowledge was attractive in what he was saying. Thx for the interview.
I am grateful to see these two experts of sciences
*Don't forget to check out the show notes!* Summary, minute-by-minute timeline, glossary, links to studies and many other helpful resources. www.foundmyfitness.com/episodes/eric-verdin
If you like the show, make sure to hug a supporter today. Each episodes of FoundMyFitness is made possible by the generous pay-what-you-can subscriptions contributed by people like you each month. Learn more at www.foundmyfitness.com/crowdsponsor
Special thank you to Dr. Eric Verdin for taking a little bit of time out of his day to share on his research and insights in the field of aging. If you are on Twitter, please consider following him at twitter.com/ericverdin. He's very active over there and posts a lot of great science-related articles. Thank you for watching!
FoundMyFitness Thank you Rhonda. I really missed these podcasts!
Foundmyfitness Dr. Rhonda Patrick you are the best out there! You're so passionate and truthful. You definitly don't hold any bars when interviewing top expert scientists in the field. Recently, I spoke wiith a Harvard researcher who is working on a team conducting research on how to increase stem cells in humans as we age and I thought of your podcasts on sauna use and intermittant fasting. I will be on the look out for any reported results published.
FoundMyFitness
I have been watching a lot of videos on health, not to prolong life but to improve the quality of it. I am wondering if you have noticed in your personal life what I have noticed in mine. Women(the men usually consumed more meat and died younger)that I have known that were born between 1900-1921 lived into their 80's and their 90's, while there children male and female born in the 1940's died in their 50's-70's. The ones living into the 80's-90's ate diets high in white flour products for most of their lives and Crisco for at least the second half. They also consumed less meat than their children. One thing we all have in common is we were intermittent fasting without knowing what it was because it was just what most people did, after eating dinner between 5-6 pm we didn't eat until the next day. That has always been the norm for me.
I enjoy watching your enthusiasm for health education.
"And what they showed in this paper is all-cause mortality was directly correlated to the amount of carbohydrate one eats." Daymn
Wait, what? Tell me how that was misleading?
What I've Learned
The paper was a study on PROCESSED food and not a plant based wholefoods diet as has been consumed by every indigenous tribe through history, EXCEPT the Eskimo who are traditionally short lived and carry heart disease and osteoperosis.
Mooch Maza
Refined Wheat is only one item in a world of factory processed carbohydrate
Enriched flour is flour in which most of the natural vitamins and minerals have been extracted. This is done in order to give bread a finer texture and increase shelf life . . . the bran and the germ (the parts of the wheat that contain fiber and nutrients) are removed but they cant put back all that they take out.
What I've Learned was here!
5:48 Is a huge source of confusion for so many people. I wonder how many health professionals make this statement without clarifying that the study did not account for the difference between refined carbs and unrefined carbs. HUGE! Nice catch Rhonda!
My sentiments exactly....that IS a huge difference....thereafter I took the rest of his data with a grain of salt.
exactly, i mean a poptart and a sweet potatoe arent even in the same realm of food imo, but they are both considered "carbs" its Ridiculous!!
Not only this, the study had poor control for economic classes.
More on it here: ruclips.net/video/o_l7gDTvs-s/видео.html
Blaming carbs is the new cult. Maybe it is needed to stop the vegan nonsense but ideological nevertheless
@@Marco-jx9rr Insulin.
Great interview and info. I like this woman, great researcher that want to spread scientific and new informations... and also a wonderful woman
Dr Rhonda back at it again! Looking hella healthy too
Amazing xhe looks so well when being 63 years old. It's almost unbelievable.
@@patron7906 shes not 63 no way!
jsorro
She looks young. Because she is. Lets see what she looks like at 60
@@patron7906 LMAO
@@davedewsnap288 she’s almost in her mid 40s I believe
This was one of my favourite and most informative interviews yet
nothing beats in video citation, good production.
So much data. So much pausing. So much appreciated. Looking forward to more :D
I love having the charts and data along with the video.
I don't think I understand that part about the KD requiring so much "discipline." I've been on it 4 1/2 years and it's the easiest diet I've ever come across - except for the high-carb death diet. And it's actually easier, first, because you're never hungry. Second, it's amazingly rich, with butter and seasonings, eggs, cheese, meats and lot's of salt (Dr. Bob's Super Salt - which is 50% Na and 50% K). There are no vegetable oils in my diet, either - just butter and animal fat.
I also do daily intermittent fasting, and have no problem going 16 hours or more without eating. People who know me can't understand "how I do it," even after I explain the processes. It takes very little discipline on my part. At this point, I know that anything with even a tiny amount of sugar in it will make me sick. There're no bread, no cookies, no cake, no rice, no snacks, no potatoes, no cereals, etc. Unfortunately, I end up spending an inordinate amount of money on fatty foods, especially butter.
I prefer straight-chain fats (saturated) of the bent-chain (mono- and polyunsaturated) fats. This is partly because of the information I found on hydrogenated oils 30 years ago (or more). These are just bent-chain fats, which are just bad for us.
My most recent blood tests showed excellent results. Other people my age, 67, are practically decrepit, while I still engage in high-energy sports; cycling, racquetball, running, weight-lifting, and all of this before breakfast, on an empty stomach.
In the meantime, I feel fantastic and study astrophysics in my evenings.
Always great to see how willing she is to learn more from her guests.
Thank you Rhonda for everything you do!
Wow! So much good information. Will need to watch and re-watch to really digest this. Thank you for this. I also appreciate the explanatory text inserted into the video. Glad I'm a supporter.
The mental clarity and memory enhancements that I've experienced on Keto were astonishing. Laser focus...
Was it super clean keto? What did u consume
@@cereal_qilla Nope. Lots of nuts and plant based fats, but plenty of meat and some dairy. My annual physical was a slam dunk, all of my numbers were great.
Agree ❤
@@RyanKentBarnhart “plenty of meat” seems to suggest that you may not be in full ketosis (but more likely doing a modified Arkins). You also need protein restriction to be in true Ketosis, otherwise your body can get by with gluconeogenesis….
Dr Rhonda looks really good with a tan.
Such a great interview
I’m born in 47 and I’ll be 76 next week. I really vary healthy and I just noticed the average age of someone born in 47 is 68 I think the list(wicky) . I’m younger today than I was 5 years ago. I really plan out lasting the expectations. I do no sugar ect but I really like to fast 1-4 days every so often,no schedule. This is a great video.
Would you please write a book? “Human metabolism for the rest of us” Something that could educate the masses so we can make better nutrition and healthcare decisions? There are so many gurus and no understanding.... and since most of us never studied biochemistry we are really just prey to ideology.
So glad you are doing interviews again Rhonda. All the best to you and your family.
She’s back !!
The longevity results this researcher is assigning to a Keto diet is really the result of protein restriction. If I was to guess why the low fat mice didn't live as long as the Keto mice would be in order to keep the macros at exactly the same level they used purified ingredients instead of real whole food. So, they fed their high carb mice the equivalent of sugar in processed carbs. And why did the Keto mice get fat when left to eat as much as they wanted? The Protein Leverage Hypostasis tells us that. They were attempting to eat more to get their protein levels to what would be normal for a mouse. That protein range is generally 13.6% minimum to 16.3% optimum for most mice. I wish you would get David Raubenheimer and Stephen Simpson the original researchers of Protein Leverage on the show. Their results for high fat eating mice (not sure if they were low carb enough to be keto) was very different when it came to health and life span.
My favorite Joe Rogan guest of all time!!!
Just now realized that I've watched all her Rogan podcasts, which means I've listened to this woman talk for 18 hours. I've watched two of those episodes twice which brings me to a total of 24 hours. Not a lot of people can hold my interest for that long. Looking forward to the next one.
Love this Dr. Verdin!! Our biomarkers are so important, but we also need doctors who can analyse these biomarkers correctly and not try to throw unnecessary medications at you & tell you if you refuse to take them you will die! Plus in my opinion, the Ketogenic Lifestyle is an Omnivore Diet, WHOLE FOODS: plant foods and animal foods, but NO processed carbs, highly processed vegetable oils/fats or refined sugars. And many people love this diet and find it easy to stick with, within circles of likeminded people 🤓
So can someone please tell me why and how this could be dangerous in any way and cause cancer!!?? In the middle of this interview this doctor said people must be cautious doing the Ketogenic Diet. My God, it‘s more or less the Mediteranean Diet, which is eating enough balanced Omega-3 & Omega-6 fats, enough probiotics & prebiotic foods to feed your healthy gut bacteria. Exercise, intermitent fasting, sleep, low stress, meditation, etc are also key factors along with your food intake. I think these studies are very interesting, but why don‘t they try to collect more anecdotal data from humans who are actually doing a Clean-Keto diet? All of this data from thousands or hundreds of thousands of people - would be much more interesting than what‘s happening with mice in the lab, in my opinion.
I believe he just said that lower protein and intermittent fasting were needed for the most benefit.
Yes, interviewing people who are on ketogenic diet helps. However, scientists prefer the data from controlled environment. Their own experiments. If they have humans, it can become costly. Mice are a cheaper option.
Thanks for the new video mummy :)
My close friend was the one who told me about the diet program when she said how she lost her weight. Then I decided to join in because she dropped 18 pounds as a result. Look into *2WeightLossFast. Com*
What a great interview! Full of new and interesting information that it is hard to come-by elsewhere. Congrats!
I am an avid fan of all your prior videos, but I have to say I was disappointed in your response to the definition of carbohydrate at about 6:00. The Okinawan diet high in sweet potatoes, and all the other “blue zone” areas have shown that complex carbohydrates cannot be lumped in with refined HFC’s, milled flour of any kind, and simple sugars. I’m 68 and have been following a whole food plant based diet for about three years - the results- asthma gone, arthritis gone, energy levels through the roof. I’m trying intermittent fasting though.
liutasx
I cant see myself committing to intermittant fasting on a vegan diet. It is literally impossible; I'll be hungry again in a few hours. I find it much easier to fast intermittantly on a high fat/complex carbs diet with minimal meat. Consuming grass fed yougurt in the morning allows me to literally go through half of the day without feeling hungry or crave food until way past noon.
I wish you would do an episode of the best way to decalcify the heart arteries for diabetics!
I have no problem with not smoking, not using alcohol, not eating bread, pasta, processed carbs.
Me too! Keep up good work!
There is one line at the end that really scared me. When he says they are in a point of research that allows his company to ride the next wave of investment from big pharma and venture capital to the aging industry.
I wonder how this can definitely separate humans in two categories. Up to now, those categories rely only on social and historical separation.
But as aging well and living longer is turning into a monopoly of the wealthy, slowly the poor would be "substituted" for the heirs of the rich which will live longer.
What can be the consequences of such a rupture?
OK, the byproducts of *fermented vegetable fiber* can prolong life :-) We can be happy about that.
Would be useful to find out if the duration of the fermentation has any difference ?
epSos.de if fermentation is so wonderful then why is kimchi associated to so much stomach cancer? Avoid fermented products and eat whole fresh vegetables if your smart. Your gut is the best fermentor.
So confusing , look at : www.greenmedinfo.com/blog/how-eating-kimchi-prevents-lethal-cancer-1
Dr Tahir MD the real result of the study should not be to eat kimchi but rather eat whole fresh vegetables, fruit, spices. The standard kimchi processing is very high in salt and opens the door to festering bacteria of many kinds. Our bodies are the best natural fermentors without salt. They use salt in processing kimchi because the salt slows the growth of the nasty bacteria. Unfortunately, the salt slows the growth of nasty bacteria but does not eliminate it. Avoid kimchi.
They were speaking of butyrate which is a byproduct of fibers bacterial fermentation in our gut. You can't easily modify the duration of that fermentation.
@@theartificialsociety3373 our gut ferments less than 5% of fibers. Thats very inefficient. There is not enough evidence for me that fiber is needed at all and its likely more important in the SAD diet. Avoid SAD and you may see fiber worsens symptoms, too.
Love Jack la lane ....I followed him all my life ....he was an inspiration ,however he didn't live to 100 he was around 94 ...he developed pneumonia as a complication from heart surgery ...I bet he would of made 100 easy if he didn't have the surgery .Im FB friends with his wife and son....nice family .
ElmwoodParkHulk yeah sure he would have stayed alive with an Myocardial infarction, faulty valve or arrhythmia.... sure
You caught that too. I heard age 93. Maybe k2 would have helped his cacification of arteries, i am on k2 supp.
Congrats on your daughter and good to see you back!
The study cited as so amazing did not distinguish simple or processed carbs from carbs in whole foods (which have fiber, vitamins, minerals, micronutrients) and so could only show that substituting fats for bad carbs is even less unhealthy than unhealthy fats. I am amazed that any researcher in 2017 would not recognize this.
❤️ thank you !
Have followed the Buck Institute for nearly 18 years. I knew one of their microbiologists and was fired up about their longevity breakthroughs. Specifically, the work with nematode lifespan extension.
It is encouraging to listen to two brilliant scientists discussing topics of real importance to real people. The discussion was excellent, and displayed both current evidence, and where evidence is lacking.
Glad you are back Dr. Patrick! As I used to tell new mothers, "It will get better!" and then raising kids gets to be fun - until they turn teenage!
Joe brought me here.
Thank you! 🧠⚡
The healthiest populations from the elderly Okinawans to the 7th Day Adventists eat a diet very high in whole plant food and very low in animal foods.
David Johnson they actually eat the whole animal which is loaded with soooo many goodies for health ..
They survuve much longer because human beings are herbivores.
The Okinawans were not healthy, they were living to the point of starvation with severe nutrient deficiencies. It goes to show the "tradeoff between performance and longevity".
You're making stuff up, Orbifold.
The high fat diet is deadly, causing insulin resistance.
Particularly for the overweight with large quantities of stored fat.
Sure you might burn fat in ‘ketosis’ but if you burn your daily fat calories, your stored fat wont budge. 1grm of fat = 9 calories. Assuming a high fat diet, there is no way an overweight person will burn their fat stores. Its all a big con.
Meanwhile, dog breath, keto rash and insulin resistance makes keto man a very sick puppy.
Thank you for making this information accessible to us non-medically trained people.
@foundmyfitness amazing presentation
perfect setting (clear audio) and the text boxes and graphs take it to a different level
i have seen you on an interview with Dr. Attia, but half of the interview was too advanced and LONG (him talking to hear himself), this format is ABSOLUTELY AMAZING subscribed and i will start watching all your vids Thank you
How in the heck are you going to get optimal micronutrients from such a restrictive keto diet and be plant based? Many foods with ample carbohydrates have some key antioxidants and phytonutrients. What low protein and low carbohydrate foods contain a symphony of micronutrients that would support longevity that one could sustain? Foods with resveratrol: carbs. Foods with sulforaphane: carbs. Foods with beta glucan and inulin: Carbs. Foods with minerals: protein.
Thank you Dr. Patrick and Dr. Verdin. Excellent discussion but more importantly, the inserting of slides to breakdown the discussion was fantastic!
Children born after 2007 are not going to live 100 years, and they are gonna get sicker than ever. At least lifestyle changes.
Especially now that they are vaccinated.
Really useful thanks
My question is, how about the concept of Dr Esselsyn's about no oil and no meat diet?
Hang on, wasn't there a study that suggested the opposite, a link between low carb diets and all cause mortality, he brings up a study that suggest the more carbs the more death and yet another study suggest the lower carb = more death, he seems biased towards Keto diet. His cyclic diet seems interesting though, he brought up Valter Longo cause it fits in with Keto, he could have brought up Calorific Restriction, in more detail.
When it comes to longevity where are the Keto supercentenarians? There are none that I've heard of anyway. It seems that most of those long lived guys came from the blue zones and they weren't either vegan nor keto, all this science but no common-sense, I mean Keto is super interesting but apart from studies on mice where are the centenarians that have eaten the Keto diet and there are none, that would give these guys more clout.
Im sure Ronda was itching to suggest the low carb and early death study but had to keep quite.
I've tried Keto diet and felt very sick, it was very bad for GERD/Hiatal hernia, I had massive palpitations and felt awful, I tried 3 times and all times at about the 3 day mark I get terrible symptoms.
Rhonda, would you please consider doing a podcast or article on artificial sweeteners (erythritol, allulose, maltitol, etc)? I know that stevia is preferred, but I've never really understood what the others do to your body (microbiome-wise, effects on blood glucose, etc) and why they're considered inferior. Alternatively, if you or anyone else have legit resources, I would greatly appreciate them! Thank you for all that you do!
Marilyn Kane all sugar alcohols are less sweet than stevia (gram for gram). Since you have to take gram amounts and these will naturally draw water into the colon, you’ll get .....
Stevia give me migraines with aura😢
It's a mistake and misleading not to differentiate between refined carbohydrates and whole plant carbohydrate which is good to eat almost in any amount.
Fact Check- Jack La Lane died at 94
Another amazing interview. I do wince a bit with a lot of these ‘plant based’, ‘ketogenic diet’, or ‘high/low carb’ terms. They are so vague. I like that you try to clarify those terms. As you know, you can have a VERY unhealthy vegan diet as well as a VERY healthy vegan diet. Ketogenic diet using plant based proteins is very different than a ketogenic diet with a lot of bacon and animal fat. I am so dumbfounded by the seemingly complete contradiction in readership interpretations. Some of the best research (personal experience included) seems to indicate huge benefits of scheduled fasting/eating, but who is going to fund research that results in abstinence? Despite any mistrust of pharmaceutical companies, who can blame them for focusing on sustained profitability.
Vegan diets are never ever fully healthy. Never. They are just better than the normal American one, but that's a low bar.
First, congrats on the baby, glad to have you back and wish you both a lot of joy. Regarding the discussion...not all carbs are equal and this is the opposite of the foundings presented by Prof. Stephen Simpson ...ruclips.net/video/x0-Jt7az-54/видео.html in his talk regarding mTOR and AMPK pathways. Science is obviously a contradictive issue.
At 26:05f (Table 3), it seems that, in CR, protein is more satiating than fat. But in an isocaloric context it’s generally the opposite (?). If so, there’s a crossover point of carb intake and/or caloric decrease where this occurs. Am I reading this right?
Thanks
The centenarians in the blue zones didn’t get the memo on the ketogenic diet. They eat high carb diets ie the okanawans eat more 60-70% of their calories from purple sweet potatoes. Of course refined carbs will have a negative health impact!
Fasting and comprehensive intake of micronutrients put a damper on the constant intake sugar and glucose, which then causes a constant release of insulin. That's what you are blind to. Sugar is sugar but lifestyle can mitigate to a point. I doubt their teeth were that good though.
Foundmyfitness, could you please talk about the biochemistry of nitrates coming from plants, in our body?
I have a suggestion. Maybe not relevant to your topics but I'm going to make it anyway. an interview with David Synder He's more mind healing very smart guy out of San Diego I believe. he cusses somewhat in his video's but is very knowledgeable.
I wish Rhonda I was Rohnda's younger brother ! She's such an amazingly intelligent person !
Of mice and men...
Humans are not mice!
Dont you think that thought came into their mind, ma'am?
Cited study didn’t differentiate between fruits/vegetables and….table sugar? So add butter to your coffee
This is a GREAT interview and very informative so I don't mean to dilute the value in any way but, if you cover Dr. Verdin's hair, his profile looks EXACTLY like that of Larry David.
Ketogenic diet rocks!
Okay so pasta, bread, potato, carrot, legumes are ancient carbs... claiming they are refined is bs
Melatonin + BHB + Butyrate + Niacin B3 Flush= 💫💥🙏
Entering ketosis takes about 48h with training low carb and fasting, 16-24h fast won't do it might empty liver glycogen but not muscle glycogen
Not to everyone. Some people take a lot longer. With human bodies, one size does not fit all.
I'm hearing the body is a very very complex ~machine and do NOT expect any thing is going to make us all live to 100 EXCEPT exercise and your food intake... What the F you gonna do at age 89? lol
Glad i found this so many interesting points i had to take notes which is rare for me!
I don't want to apear contrary to this but the people I know that are well over 90 and still healthy eat what ever they want. The thing in common they have is a low stress life.My mother is one of them, and really pack's down cakes, sodas and candy, plus canned food and some junk food. I think that the level of stress has to be included in all health related studies. Maybe it's a very important variable.
Fact check: Jack Lalanne did NOT live to 100. Died of Pneumonia at 96. He is a legend though
So happy to tap into this just now 😊
Love you all so much! Such smart people! Most intelligent keto discussion I ever heard!!
A more perfect woman does not exist
My wife Lora is more perfect. Lol.
Hi Rhonda, ¿Where would you improve this diet?:
*Breakfast*
- 150 grams of frozen red raspberries.
- 100 grams of oats flakes (soaked for 8 hours with 2 tbsp of apple cider vinegar)
- 3 grams of sea salt
- 30 grams of unsalted butter
*Lunch*
- 120 grams of chicken breast
- 200 grams of romaine lettuce leaves
- 50 grams of avocado
- 1 scrambled egg
- 2 tbsp of extra olive oil
- 2 tbsp of apple cider vinegar
*Dinner*
- 120 grams of chicken breast
- 200 grams of romaine lettuce leaves
- 50 grams of avocado
- 1 scrambled egg
- 2 tbsp of extra olive oil
- 2 tbsp of apple cider vinegar
With this diet, I achieve this daily goals (roughly speaking):
- 100 grams of carbohydrates
- 132 grams of fat
- 100 grams of protein per day
- 32 grams of fiber
- 1,500 milliliters of water
*But what about my micronutrients?* the vitamin A, D, K and magnesium for example? Am I good? Do you recommend me leaving the diet like that and buying supplements for the micronutrients?
its good, I would sub the chicken breast for beef or seafood though
Dr. Patrick, thanks for grilling these specialists. Really appreciate the content.
You look so great Rhonda
18:23 - mechanism of fasting and carb/protein restriction
I am so happy to find you. This interview is now4 years old and so many new findings but I love this topic. I saw you in a podcast recently and I’m happy to find a female in the field!
There are a lot of female in this field, don’t buy into illusion of inequality.
I really tried sticking with the the keto diet, but I just felt awful and it's also really tough to follow. Then I tried the Agoge diet and it was life changing, I highly recommend it to everybody.
Trolling much? Americans have eaten whatever they wanted already.
More experoments should be starte on 'gender differeses' due to different genetic settings, including body size, tissue compisition as well as metabolic pathways, such as glucose and fatty acid metabolisms.All of which are related with health, disease resistance n longevity. As mentioned here, male mice on caleri ristriction cannot beyond the limit as 'female' because their body/genes are tuned n optimizes through evolution.
I'm interested but I mean, many of my ancestor already lived to 100 or fairly close to it. Sadly both my grandpas where engineers and came to close contact with toxic chemicals without using the right protection, one in the agroindustry and the other working for Coca Cola and brewing companies, they both died of cancer.
Limiting protein, carbs ( not fat?)... just eat less.anti aging and current health is not same. Seems less carbs is answer everywhere. Bad ones..
Omg thank for saying calorie restrictions isn't proven yet cause I can't do it
Maybe look at the Hadza. The last known hunter/gatherers. The men go out hunting, but are successful only once every 7-10 days. The rest of the time they all live on the fruit and roots and often honey the women gather. A largely plant-based diet high carb with no added oils and lots of walking. Those that survive the natural dangers and get to old age appear to be free of heart disease and diabetes. And then there is a very interesting clip on youtube showing the blood flow in the capilleries of some animal before and after a high fat meal. Then there is the evidence shown in the Kempner diet (rice and fruit, no fat) and Denise Minger, darling of the keto world who had the integrity to correct herself and admit that really low fat diets did appear to be curative of heart disaease and diabetes, ie. modern interpretations of low fat were not really so low and truly low fat meant 10-15% of calories from fat.
WOW ! You look very good !
Just blaming carbs without going deeper on type of carbs and looking at other groups seems like a bias observation. I can't keep listening once I realize the guess is so superficial in his analysis. Okinawans eat mostly carbs, 85% carbs to be exact.
That’s a good point
Thank you very much!it was vey informative! I will start fasting from next year on!
Have you looked at NMN to help at hearing loss and does NMN work at SIRT 1 or 3?
I think Child can live till 100 because of safe situation not burger world
How is exogenous BHB different than the narcolepsy GHB drug?
Any info on long term use of beta hydroxybuterate taken with acv?
Love Dr Rhonda !!!
I was curious because my friend had lost weight and I wished to know how. They will suggested that I visit *2WeightLossFast. Com* . Once I listened to their advice, I lost 16 and a half pounds.?
Children's diet today means that many of them won't reach 40, 104 my ass
Wow, a true master class
excited for this more than any series out there
Can you please clarify the high-fat diets inhibiting NAD salvaging? (Comment by Dr. Verdin at 37:30). Wouldn't that be a mechanism that makes keto reduce healthspan?
Says also in the chart that a high-fat diet promotes inflammation. How can then keto be healthy? Or how can limiting carbs and protein be healthy then, as it means you have to get your energy from fat? I would really like to have a comment on this contradiction.
Good questions. The confusion is created by the term "high fat diet." The conventional use of it means, "high fat combined with high carbohydrate." It is also often called the "Standard American Diet." I call it the ice cream diet (sugar + fat). The high carb level activates the insulin/IGF pathways and directly impinges on redox homeostasis. A ketogenic diet by contrast is very, very high in fat (70% or more of calories) and very very low in carbohydrate (0-30 grams per day). The carb restriction blocks the insulin response... and, like fasting, upregulates genes active in redox homeostasis (among other things). So yes, NAD+/NADH levels and NADP/NADH levels are impaired by a sugar-fat diet but strongly enhanced by a fasting mimicking diet like keto. Same goes for all of the body's major redox couples. Hope this helps!
Damn Rhonda you look better than ever!
So informative!!
Some of his info comrs from Dr. Panda in So California
Another amazing interview. I do wince a bit with a lot of these ‘plant based’, ‘ketogenic diet’, or ‘high/low carb’ terms. They are so vague. I like that you try to clarify those terms. As you know, you can have a VERY unhealthy vegan diet as well as a VERY healthy vegan diet. Ketogenic diet using plant based proteins is very different than a ketogenic diet with a lot of bacon and animal fat. I am so dumbfounded by the seemingly complete contradiction in readership interpretations. Some of the best research (personal experience included) seems to indicate huge benefits of scheduled fasting/eating, but who is going to fund research that results in abstinence? Despite any mistrust of pharmaceutical companies, who can blame them for focusing on sustained profitability.