Volume of Distribution

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  • Опубликовано: 24 янв 2025

Комментарии • 106

  • @siobhanmulhernhaughey4935
    @siobhanmulhernhaughey4935 8 лет назад +41

    Spent hours trying to figure this and this video cleared it up in 6 and a half mins. THANK YOU!!

    • @xDomglmao
      @xDomglmao 7 лет назад

      He is a saint indeed.

  • @nanimilet
    @nanimilet 6 лет назад +2

    I don’t usually comment on videos, but I HAD to come here and thank you for this one. This is a silly concept that I have been struggling with a lot for years and I finally understood it! Thank you very much for your time and effort!

  • @souravthakur1164
    @souravthakur1164 3 года назад

    I got into med school in 2015....and each year since then it's a ritual to see to video as I keep coming across volume of distribution again again....and this video makes me explain the concept so easily...thanks

  • @obaapapapabi3015
    @obaapapapabi3015 Год назад

    Thanks so much. I couldn't figure it out in class, but you made it clearer. God bless you, sir!

  • @dalia9512
    @dalia9512 4 года назад

    Literally the best video on this topic, got the concept within the first 3 minutes, can't thank you enough!!!!!!!!!!!

  • @xDomglmao
    @xDomglmao 7 лет назад +4

    To be sure I understood correctly: It is so much lost via this movement of the particles that I would have needed 50L of blood in order to indeed have my 10mg in the blood?
    Best video concerning this issue on RUclips indeed!

    • @zenzenzense1562
      @zenzenzense1562 4 года назад

      This is exactly my thoughts put into perfect words, hope the concept is correct :D

    • @xDomglmao
      @xDomglmao 4 года назад

      @@zenzenzense1562 It is :-)

  • @tom2rules2
    @tom2rules2 9 лет назад +29

    Best explanation I've found for this, cheers

  • @billanthony8230
    @billanthony8230 6 лет назад +9

    Thank you for explaining in 6 mins what my facilitator failed to do in a two hour lecture

  • @KokoKoko-iy1wx
    @KokoKoko-iy1wx 2 года назад

    Really amazing video ,go on 👏👏👏👏

  • @muhammadn.5139
    @muhammadn.5139 9 лет назад +5

    God Bless you man ... this explanation is mind blowing thx very much sir.

  • @thepowerofpositivity8075
    @thepowerofpositivity8075 9 лет назад +2

    Your video def helped to enhance my comprehension of volume of distribution. Thank you Sir!

  • @notofyourconcern3709
    @notofyourconcern3709 9 лет назад

    I've been looking all over for a good explanation and you nailed it sir! Good job

  • @genmasaotome3503
    @genmasaotome3503 8 лет назад

    Very helpful for those who are paying attention to having volume of distribution being greater than 42L = TBW which doesn't make any sense. Awesome!

  • @WillPower9982
    @WillPower9982 4 года назад +2

    Great video but I'm fairly sure that the concentration of drug in plasma includes that which is plasma protein-bound. Increased strength of drug binding to plasma proteins decreases Vd, and increased strength of binding to tissue components increases Vd.

  • @hinashabeer4922
    @hinashabeer4922 8 лет назад

    Its very helpful.. i use to think that after all duration of my studies i will end up with no understanding of Vd but really thanks to u sir 4 this illustration :)

  • @catharinerutherfoord8618
    @catharinerutherfoord8618 8 лет назад +2

    Thank you!! med school never explained this so well!

  • @mercyzengeni9391
    @mercyzengeni9391 2 года назад

    Kudos Mr Bentley. Now I understand

  • @DeemahAd
    @DeemahAd 8 лет назад

    I was struggling understanding the concept of aVd
    and this have helped me a lot.
    THANKS
    :)

  • @Sali_Levi
    @Sali_Levi 8 лет назад +11

    Thank you!!
    btw im pretty sure you meant Lipophobic 4:28

    • @anthonybacha2521
      @anthonybacha2521 8 лет назад

      If he meant lipophobic then why would the drug want to attach itself to fat? lol

    • @bogcom
      @bogcom 7 лет назад +4

      He says its hydrophobic, which it wants to pass the membrane. He shows the opposite in the example. the drug is hydrophillic/lipophobic

  • @arnoldsatia6137
    @arnoldsatia6137 8 лет назад +8

    Thank you sir,only one issue,I thought the drug that binds to plasma proteins is still in the vascular compartment and hence would mean high protein binding would lead to high plasma drug conc. and hence low v.d and not the opposite...thanks in advance

    • @sauravbhattarai1774
      @sauravbhattarai1774 7 лет назад

      What r u saying mate
      I didn't understand
      Can u plz explain me

    • @yaomintan
      @yaomintan 7 лет назад +5

      No, high protein binding means the drugs are binded to the plasma proteins (mainly) right? But these drugs that are existing in this form does not have any pharmacological action, meaning useless. The only significance of protein binding is that it acts as a reservoir to increase the duration of action of a drug and prevent toxicity. Because again, only free form of a drug which is in the blood volume can have either therapeutic effect or toxicity to a patient.

    • @xDomglmao
      @xDomglmao 7 лет назад

      So a drug bound to plasma proteins does NOT contribute to the concentration measured in the vascular compartment?

    • @yaomintan
      @yaomintan 7 лет назад

      No

    • @xDomglmao
      @xDomglmao 7 лет назад

      Sorry, what do you mean by "no"? Regarding my statement "no", or does it not contribute?

  • @eliajacob9440
    @eliajacob9440 5 лет назад +1

    What an amazing explanation.....THANK YOU!

  • @mdabdulhafeezmalik45
    @mdabdulhafeezmalik45 6 лет назад

    Wonderfully explained sir

  • @skt08
    @skt08 7 лет назад

    Wow sir...thanks a ton...u made it look so easy to apprehend..!

  • @afshanshabbir9739
    @afshanshabbir9739 4 года назад

    Thanks for the video it was very well explained 👍

  • @madhavighumare6524
    @madhavighumare6524 3 года назад

    Very helpful 👍

  • @aiyshaxoxk
    @aiyshaxoxk 7 лет назад

    A very good video that helped me get my mind around this! thank you

  • @aliyadalo3812
    @aliyadalo3812 7 лет назад

    Best explanation on this topic.Thanks a lot!

  • @dr.rakibislam7421
    @dr.rakibislam7421 7 лет назад

    best explanation,amaizing

  • @allahissufficientforus.4015
    @allahissufficientforus.4015 6 лет назад +1

    Thank u very much.. I hava a doubt sir.. why the bound drugs with plasma proteins are not considered as they are also in the same fluid. On the other hand i also know that the plasma and blood is sperate in the other sense, but we have to know the volume of distribution where we consider whole body fluid including plasma.. Plz aware me about sir...

  • @sapanaahirrao1691
    @sapanaahirrao1691 3 года назад

    Nice explanation sir

  • @bogcom
    @bogcom 7 лет назад +1

    at 4:20 you say the drug is not lipophillic its hydrophobic. If its hydrophobic it can cross the membrane. lipophillic and hydrophobic is the same.

  • @allahissufficientforus.4015
    @allahissufficientforus.4015 6 лет назад +3

    So i think the culculation is wrong. Because u are not considering the plasma bound proteins.

  • @abdulrahmanalidris
    @abdulrahmanalidris 9 лет назад

    so what's the use of the volume distribution clinically if it have all these variant effecting factors and we also need to wait for the drug to be distributed through the compartments?
    Good explaining method thanks.

  • @DrSharifulHalim
    @DrSharifulHalim 9 лет назад

    Thanks a lot for the video!! It helped me really to understand this apparently confusion theory..

  • @allinone-js4xl
    @allinone-js4xl 5 лет назад

    This video helped me calculating the volume of concentration. Thanks a lot

  • @virnan
    @virnan 4 года назад

    Yes, I finally found the video to link my understanding after many attempts at other ones.

  • @virnan
    @virnan 4 года назад

    Thank you, you explained it succinctly but thoroughly.

  • @Bradatimrkonja
    @Bradatimrkonja 10 лет назад

    Nice explanation, thanks

  • @maryamyousef8466
    @maryamyousef8466 6 лет назад +1

    GREAT EXPLANATION!!

  • @ibrahimgomaa3051
    @ibrahimgomaa3051 8 лет назад

    IS the Vd is A CONSTANT where its value are the same all the times?

  • @themasry5022
    @themasry5022 9 лет назад

    Amazing video thank you sir but I have a question
    If the drug has high affinity on albumin and all 10 molecules bind on it
    So we need 10 litres??!

  • @adonemmett
    @adonemmett 7 лет назад +3

    I the video is wrong! Only one person on this discussion who noted the problem with the explanation.
    Warfarin is 99% bound and has a low Volume of distribution (of 8 Litres). By Bentley's explanation it should have a very high Volume of distribution as the free concentration is very small.
    If you take another drug which displaces the active drug under consideration - you will increase the free fraction. According to Michael Bentley this should decrease the volume of distribution as you have a larger denominator, but in reality you INCREASE the volume of distribution because more molecules are now free to exit the intravascular space (partitioning along their lipid solubility and tissue affinity propensity) and thus the Total intravascular drug concentration will DECREASE and the Volume of distribution (Dose / Total plasma concentration) INCREASES!
    The video is nevertheless extremely useful as it helps to conceptualize the molecules and how they move.
    Show less
    REPLY

  • @hello80339
    @hello80339 6 лет назад

    would an increase in Vd lead to high potency or low potency of the drug?

  • @elghaziyoussef8777
    @elghaziyoussef8777 5 лет назад

    Thank u duude
    Very helpful

  • @abdohashem9749
    @abdohashem9749 9 лет назад +4

    Mr Bentley, If I remember correctly, a drug being lipophilic makes it also hydrophobic, did you mean to say lipophobic?

    • @SoleaPunx
      @SoleaPunx 9 лет назад +2

      +Abdo hashem At 4:28 he probably meant hydrophilic (which equals to lipophobic - but the term hydrophilic is more commonly used than lipophobic)

    • @briangook
      @briangook 8 лет назад +1

      +Abdo hashem yeah i caught that too - lipophobic=hydrophilic and vis-versa. I'm sure he meant to either say lipophobic or hydrophilic

  • @hassanragab5046
    @hassanragab5046 9 лет назад +1

    great explanation.. thank u

  • @ranaahmedkamal1854
    @ranaahmedkamal1854 5 лет назад

    thanks very much ! this made it so much easier

  • @sukhmindersingh22
    @sukhmindersingh22 9 лет назад

    Nicely explained!!. thanks a lot

  • @wheremakeysat
    @wheremakeysat 3 года назад

    How does Vd increase in acute illness?

  • @User-zk1mz
    @User-zk1mz 5 лет назад

    Thnk u you made my day 😊

  • @Loveangel818
    @Loveangel818 7 лет назад

    This was very helpful! Thank you so much.

  • @brieannakroeger
    @brieannakroeger 7 лет назад

    Thank you, thank you, thank you!!!

  • @2sridhark
    @2sridhark 7 лет назад

    Excellent by far.

  • @jenniferliu7011
    @jenniferliu7011 3 года назад

    Hi, aren't plasma-protein-bound drugs part of the "plasma concentration of drug"? so a highly-protein-bound drug would have lower Vd (because of the larger denominator)? Not as what you said in the video?
    But thank you for the video - it really helps me with conceptualizing Vd regardless! Hope you can clarify the point about protein-bound drug, though. Thank you so so much again!!!

  • @asmaanasri6773
    @asmaanasri6773 5 лет назад

    Thank you sooo much ... you've helped me a lot.

  • @leahcarpe1869
    @leahcarpe1869 8 лет назад +3

    Very helpful, thankyou!

  • @coolest6
    @coolest6 5 лет назад

    You are a saint

  • @hinashabeer4922
    @hinashabeer4922 8 лет назад +1

    would u please explain pharmakokinetics models analysis ??

  • @Adrienne000
    @Adrienne000 5 лет назад

    thank you legend

  • @parminderminhas7819
    @parminderminhas7819 8 лет назад

    Nicely explained :D

  • @surajsahoo186
    @surajsahoo186 6 лет назад

    Thanku sir...it's awesome

  • @magdymettias7316
    @magdymettias7316 4 года назад

    GREAT

  • @ivnb92
    @ivnb92 7 лет назад +1

    2 years into medical school and I finally got it. Thanks!

  • @JustinRedd
    @JustinRedd 8 лет назад

    VERY helpful! Much appreciated!

  • @YousefSoltan1990
    @YousefSoltan1990 8 лет назад

    Thank you that was really helpful 💪🏼

  • @mayazazu7070
    @mayazazu7070 6 лет назад

    Amazing video thank you!

  • @malazmustafa9314
    @malazmustafa9314 5 лет назад

    Thank you!!

  • @faisalalagel
    @faisalalagel 8 лет назад

    Thank you so much, this video was very helpful.

  • @Avonomss
    @Avonomss 7 лет назад

    Clear explanation! Thankss!

  • @bfurl69
    @bfurl69 8 лет назад

    very helpful

  • @akshaymishra7675
    @akshaymishra7675 6 лет назад

    Good

  • @NurulAfifahawesome
    @NurulAfifahawesome 9 лет назад

    thanks a lot. finally understand Vd!

  • @rayayalmaz9403
    @rayayalmaz9403 5 лет назад

    Thaaaaank U

  • @tranthisau7521
    @tranthisau7521 6 лет назад

    thanks a lot!

  • @akahrom
    @akahrom 8 лет назад

    But what is practical use of Vd?

  • @paulbuschman8318
    @paulbuschman8318 5 лет назад

    Yes it was very helpful. Thank you.

  • @hamzasenni5942
    @hamzasenni5942 8 лет назад

    thank you

  • @rapid2move
    @rapid2move 5 лет назад

    Thanks!!! finaly I understand it! thx

  • @drnoureddine9631
    @drnoureddine9631 6 лет назад

    thank u very much

  • @marcowong1661
    @marcowong1661 6 лет назад

    leave a like =']

  • @Saruno1297
    @Saruno1297 5 лет назад

    ❤️

  • @allahissufficientforus.4015
    @allahissufficientforus.4015 6 лет назад

    Thank u very much

  • @fadilagomes9901
    @fadilagomes9901 3 года назад

    Thanks tout vert much for this helpfull vidéo

  • @phuongdung463
    @phuongdung463 4 года назад

    Rất tuyệt

  • @nyaf-db7tg
    @nyaf-db7tg 9 лет назад +2

    Sir, Vd= dose / [plasma] ... Isn't plasma volume = 3L not 5L ? 5L is 'blood' volume not plasma volume

    • @arslan626
      @arslan626 9 лет назад

      Hikari Elf so whats is the final answer...? should we multiply by 5 or 3 ?
      @Michael Bentley

    • @thepowerofpositivity8075
      @thepowerofpositivity8075 9 лет назад +3

      +Hikari Elf
      You are correct about plasma vol vs.blood vol. BUT for the purpose of explaining the concept of Vd, the number (3L vs. 5L) is not as important as the concept itself.

  • @ansaarazzaq5429
    @ansaarazzaq5429 5 лет назад

    Poor voice quality

  • @asmaanasri6773
    @asmaanasri6773 7 лет назад

    thank you