Advancements in Severe Erectile Dysfunction Treatment

Erectile dysfunction (ED) is a common issue characterized by the inability to achieve or maintain an erection for satisfactory sexual activity. This video explores how low-intensity shockwave therapy (LiST) can help improve ED, particularly in mild to moderate cases. LiST is a non-invasive treatment that uses low-energy shockwaves to enhance blood flow and stimulate tissue regeneration in the penis, aiming to improve erectile function in men with vasculogenic ED.
However, treating severe ED, especially in patients who do not fully respond to standard PDE5 inhibitors (ED medications), is more challenging. This video highlights a recent study that combined LiST with daily low-dose tadalafil (a medication that enhances blood flow) to see if it can improve erectile function in men with severe ED who partially respond to PDE5 inhibitors.
Key Points Covered:
The study included men aged 40-70 with severe vasculogenic ED, partially responsive to PDE5 inhibitors.
Participants were randomly assigned to receive either LiST or a sham treatment (placebo) combined with daily tadalafil for four weeks.
Both treatments were designed to appear identical to ensure unbiased results.
Sexual activity and erectile function were evaluated one and three months after treatment using the International Index of Erectile Function (IIEF) scores.
Results showed significant improvement in erectile function in the LiST group compared to the placebo group at both 1 and 3 months.
Mild pain was reported with LiST, but no serious side effects occurred.
The study concludes that combining LiST with daily tadalafil offers short-term improvement for severe ED compared to tadalafil alone. Despite the promising results, further research with larger sample sizes and longer follow-up periods is needed to confirm the long-term effectiveness and potential benefits of this combined treatment approach.
Watch the video to learn more about the potential of LiST combined with tadalafil in managing severe erectile dysfunction and its implications for future treatments.
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▶️DISCLAIMER: This video is purely educational and does not constitute medical advice. The content of this video is my personal opinion and not that of my employer(s). Use of this information is at your own risk. Fabio Castiglione Md PhD will not assume any liability for any direct or indirect losses or damages that may result from the use of the information contained in this video including but not limited to economic loss, injury, illness, or death.