Overall good video, except: LPS is located in gram-negative bacterias and not in gram-positive. LTA is located in gram-positive bacterias and not in gram-negative.
LPS is in Gram (-ve) not Gram (+ve), and LTA is in Gram (+ve) not Gram (-ve). This should be fixed by now, this could affect someone's grade. I don't mean this in a rude way by the way, I just mean PLEASE fix this so that it doesn't confuse anyone and result in them getting a lower mark.
I cannot thank you enough for this video. I have been struggling to understand TLRs. My textbook did not go into depth about them and my instructor just confused me when it came to them. Thank you thank you thank you!!!!!
In case any one trying to remember thier individual function , TLR 2 gram +ve bacteria LTA(two lines in plus sign) TLR 4 opposite =gram negative bacteria LPS remember TLR 3 and 7 together: 3 for double stranded viral RNA, 7 single stranded viral RNA TLR5 - Five for Flagellin TLR 9-nine for nucleic acid =DNA
Armando, Karin Kolbe is right, peptidoglycan cell wall is huge for Gram positive bacteria and is the outermost "layer" of said bacteria. LPS is only on gram negative bacteria as far as I understand it. So you are right as far as what the TLR recognizes, but I think you got the "+" and "-" signs mixed up. Thanks for all the videos!
Your drawings are amazing!! I searched through your Facebook to find this specific lesson and no luck :( Can you please post it if you still have it? Thanks again for your superb lectures!
I love all this and it is truly interesting to me but, I just dont know how it is possible to remember every name for every protein that does this and that etc. HOW??????
Video is tooooooooooooooooooooooooooo nice!!!! :) Psst ! IF I'M NOT WRONG - Lipoteichoic acid (LTA) is a major constituent of the cell wall of Gram-positive bacteria (and not Gram negative as You mentioned it). But to err is Human!! :) Hope You don't mind me pointing the mistake out.
Your Präsentations are very helpful but there is sometimes minor error. Example you exchanged the peptidoglaycan of gram +ve and gram -ve bacteria's. Lipopolysaccharide (LPS), which also called endotoxin, is found exclusively in Gram-negative bacteria, while lipoteichoic acid (LTA) is specific to Gram-positive bacteria.
Good video overall but at about 4:21, you said that you skipped TLR6 among others and that TLR6 is found in the endosome. That's not true - it's found in the cell surface membrane.
Overall good video, except:
LPS is located in gram-negative bacterias and not in gram-positive.
LTA is located in gram-positive bacterias and not in gram-negative.
Yeah this is what I was pondering about!
It’s gram negative bacteria. The video is correct
@@faresyaziji5791 The video is not correct at this point. He says TLR-4 gram-positive, but it is gram-negative (LPS)
Right
True, thanks for mentioning that
LPS is in Gram (-ve) not Gram (+ve), and LTA is in Gram (+ve) not Gram (-ve). This should be fixed by now, this could affect someone's grade. I don't mean this in a rude way by the way, I just mean PLEASE fix this so that it doesn't confuse anyone and result in them getting a lower mark.
Glad I opened the comment section
This guy deserves all the recognition he has received, these videos are amazing, I wish I could make something half as good as this guys stuff.
you already did ;) by the way I like your videos so much!
I cannot thank you enough for this video. I have been struggling to understand TLRs. My textbook did not go into depth about them and my instructor just confused me when it came to them. Thank you thank you thank you!!!!!
In case any one trying to remember thier individual function ,
TLR 2 gram +ve bacteria LTA(two lines in plus sign)
TLR 4 opposite =gram negative bacteria LPS
remember TLR 3 and 7 together: 3 for double stranded viral RNA, 7 single stranded viral RNA
TLR5 - Five for Flagellin
TLR 9-nine for nucleic acid =DNA
Loving your videos! They are getting me through med school!
CCNM 2018 Breaking New Ground how's med school? Love to learn from people's experiences.
@@saulloll8547 its hard
It's easy
Thank you a lot for a bright and legible overview.
Thanks so much for doing these videos! you don't know how much they have helped me! thanks a ton~
I really wish to buy the pdf image of this but I cant find it on your website, please advise. Thanks!
Great! Thank you. very clear and concise.
Great job, Armando!
Great page! Extremely helpful
You are just amazing,I love you Armando ❤️
Great explanation, thank you very much.
hi ! amazing video as usual,please add it to the immunology video series ,you're awesome ! thanks !
Loved it. Thanks so much.
Awesome animated lesson. I like it very much.
Thank you so much and it is very useful for me. May I suggest to talk more about NF-kB and pro-inflammatory cytokines?
Armando you are the best! Thank you!
amazing work
Good description, thanks
Armando, Karin Kolbe is right, peptidoglycan cell wall is huge for Gram positive bacteria and is the outermost "layer" of said bacteria. LPS is only on gram negative bacteria as far as I understand it. So you are right as far as what the TLR recognizes, but I think you got the "+" and "-" signs mixed up. Thanks for all the videos!
Hey Ivan, Yes you are right, its a mistake. Didn't realise it when I was doing the video! cheers
Armando Hasudungan wait what? where's the mistake?
Armando Hasudungan Thanks I was a bit confused too
@@armandohasudungan hi. First of all, thanks for tutorial. What do you do with your papers after filming?
this is really helpful
thank you
Thank you so much for the amazing explanation!
Any chance to get this drawing? Couldn't find it on fb..
Pretty good your video, I've undesrtood very well about this topic, thank`s you
Thank you so. Much
Ty so much
In single word you are GREAT
great presentation. I like it.
Thank you very much. It was very useful.
I really did enjoy the vidéo Thank you ❤
Thank you
God bless your soul.
Fantastic video of TLRs, Armando.
such a nice video. thank you
Perfect video! Help me very much!
You have severely reduced the 'Toll' this topic was having on me. Great diagrams btw.
Your drawings are amazing!! I searched through your Facebook to find this specific lesson and no luck :( Can you please post it if you still have it? Thanks again for your superb lectures!
U are brilliant 💖
Hello, could I ask what the red strand represents on CpG? Thank you
So nice to find u : )
Can anyone please tell me where do the toll like receptors come from in the first place? Like where did they evolve from? How are they synthesized?
what's the difference between TCR or BCR and Toll Like Receptor?
such amazing our body
What about the transcription of genes that make co-stimulating molecules such as CD80 and CD86??
How can we get that image?
are toll like receptors,TL3 and TL7 present in ALL cells?
Very nice explation ,new subscriber
TLR receptors are localized on both Extracellular & Endosomal membranes.
I love all this and it is truly interesting to me but, I just dont know how it is possible to remember every name for every protein that does this and that etc. HOW??????
I feel your pain...
Which of these pathways result in fever?
TLR 4 Gram neg bacteria since it recognizes Lipopolysaccharide.
TLR 2 for Gram pos bacteria since it recognizes peptidoglycans and lipoproteins
Good video
Video is tooooooooooooooooooooooooooo nice!!!! :)
Psst ! IF I'M NOT WRONG - Lipoteichoic acid (LTA) is a major constituent of the cell wall of Gram-positive bacteria (and not Gram negative as You mentioned it). But to err is Human!! :) Hope You don't mind me pointing the mistake out.
Exactly my thought!
Eduardrssl Thanks for confirming!! :)
There is one mistake. TLR4 is for gram (-) negative bacteria.
whats the difference between toll like receptors and the PRR ( pattern recognation receptor) ??? plz answer me
+Imene Bda there are different types of PRRs , among them the toll like receptors
Gram positive's do not have LPL's(it is in gram -) they have teichoic and lipoteichoic acids
Lipopolysaccharide (LPS) are on Gram negative Bacteria. This is recognized by the TLR-4 recptor
This tol reseptort Can bé found in all type of celles or juste the immunologique cells
3:39, TLR5 doesn't dimerise? it does!
correct me if m wrong. please
look here: www.ncbi.nlm.nih.gov/pmc/articles/PMC3727914/ seems that TLR5 does dimerize
Your Präsentations are very helpful but there is sometimes minor error. Example you exchanged the peptidoglaycan of gram +ve and gram -ve bacteria's. Lipopolysaccharide (LPS), which also called endotoxin, is found exclusively in Gram-negative bacteria, while lipoteichoic acid (LTA) is specific to Gram-positive bacteria.
good info, needs volume....
Nucleus has a double membrane, not a simple one as we can find in the plasmatic membrane
I like your style!!! Great info and drawings.
Subscribe
anyone else notice that Armando was high af in this video
listen to how much slower he talks compared to his other videos
A small correction. Lipopolysaccharides are found on gram-negative bacteria, while LTA is found on gram-positive bacteria!
What is the meaning of toll-like? Why we call these receptors as toll-like? Thank you.
TLR4 = gramnegative (LPS) , not grampositive
Thanks, good description.
good
I thought nfkb produces Il1, Il6 ?
LPS : Gram-negative
LPS are on the cell wall of gram negative
How could the arn bé found out the virus cell !?
Correction: TLRs are not only extracellular/plasma membrane-bound!
3:22 Gram negative not positive
Love u
I am very confused. Why does TLR 2 and 6 form a dimer to detect the same things as the dimer of 1 and 2?
Also shouldn't you mention that triacylated lipoproteins are detected for the 1 and 2 dimer, however for 2 and 6 diacylated lipoproteins are detected?
where did u get that info??
It doesn't. TLR1/2 and TLR2/6 recognize different types of lipoproteins (triacylated and diacylated, respectively).
Update from 2024 there are 13 TLR now , hope it helps
big liiiiiiike & thaaaaaaaaaaanks
You say that TLR - 4 recognise the lipopolysacharide LPS in Gram +ve .
Wrong because the LPS found in Gram -ve 👍👍👍❤❤❤❤
Your my best teachers 😍
If you ever think to leave youtube, do not complain if a stranger hits you in the street...that will be me jajajaja! Thanks!!!
Which molecule(s) is/are NOT normally induced by TLR signaling (TLR=Toll‐Like Receptor)?
A. TNF‐alpha
B. IL‐1
C. iNOS
D. IL‐6
E. IL‐4
IL 4 because it is released by Th cells to activate B cells ?
@@karthininageshwaran7143 bro i needed this answer 4 years ago for an exam haha thanks for answering 😁
WOW
Hi dear, LTA is on Gram (+) not Gram (-)
Good video overall but at about 4:21, you said that you skipped TLR6 among others and that TLR6 is found in the endosome. That's not true - it's found in the cell surface membrane.
TLR10 stimulation suppresses the TLR2 responce via the production of il-1ra
Can you quickly explain, in layman's terms, what a TLR-7 agonist is? Thanks.
Emmanuel Nogueira it detects viral genomes single stranded RNA
This isn’t right according to my microbiology book.
TLR 2 = G+ (PEPTIDOGLYCAN, LIPOTECHOIC ADIC)
TLR4 = G- (LIPID A)
3,7,8,9 = NUCLEIC ACIDS
LPS is for gram negative Bacteria... Please correct it!
You have switched Gram- with Gram+
Toll like receptors recognize gram negative bacteria not positive
TLR 4 for gram negative Lipopolysaccaride
it's leviosa no leviosaah: it´s kappa-b no kb
it doesnt help when scientists call it il 18 and il 1B esp if you're writing it out lol great vid btw
Are you half indonesian?
TLR4 supposed to be gram negative
TLR5 do dimerize, dont they?
they do! I read that in kuby and now cross checked on google too.
TLR 7 & Herpes & SarsCov19 . . . . . . . . . . . . . . . . . . . .. . . . . Help
LPS = gram (-)