Wernicke-Korsakoff Syndrome (WKS) - Biochemistry - Diet and Nutrition
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- Опубликовано: 27 авг 2024
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My father (lifelong excessive beer drinker), stopped eating and slipped into a severely declining state over the pandemic resulting in him being unconscious on the ground for 2 days having lived off beer for a few weeks. He was diagnosed with WKS and spent 54 days in hospital (was stable and could've been released 2 weeks earlier but he was still recovering and his final discharge assessment would determine if he kept his medical power of attorney, so we kept him there hoping to get him over the bar).
Luckily his organs recovered quickly in hospital but his walking (ataxia) and his memory (new short to long term memory) were severely compromised. We were told he would likely need full time care for rest of his life and he may never walk. I worked with him daily starting on day 15 in hospital through discharge for 60 days both physically and mentally and slow recovery was noticed, i got him to shuffle walk and remember things for 1 hr, then 2 then a day, but progress started to noticeably taper and was almost stagnant at around day 120.
All the research I did basically said there is basically no treatment (given neuron brain damage) other than 100% no alcohol and vitamin B.
But then I started looking into TBI and stroke recovery since there are some parallels and found some recent stem cell trial results that looked very hopeful. I tried to contact several research doctors but no response and there weren't any new trials soon or that i wanted to risk him being in the 50% placebo group so I looked for clinics internationally and found a few. after looking up reviews and distances we ended up choosing Bioexcelerator in Colombia. The clinic didn't have any experience treating his condition and was hesitant because of the rate of progression from continued alcoholism, but I advocated hard and they accepted him as a patient.
6 months after his hospitalization we were in Colombia and he got 110 million stem cells injected via IV(Not as needed) and 40 million stem cells injected intrathecally into his spinal cavity fluid to migrate to the brain (this was the main hopeful treatment).
48 hrs later he was noticeably sharper and clearer eyed, 72 hrs later he could remember details from earlier in the day or a movie he was watching much better, 2 weeks later he could still remember his trip to Colombia and what connecting flights he was on and where we stayed on the route from Colombia to Canada, etc. 3 weeks later he drove himself to his dental appointment, settled the bill and drove back home all on his own with his face frozen! and now he recites summaries of articles he read in the paper 1-3 days before.. It's been like a miracle.
I felt like I needed to share my experience in case it helps even one other person, we still have a long road ahead and we pray his recovery continues at the current pace, we are now on week 4 after treatment.
As positive as my father's response has been, I can't say it would be the same in all cases (i don't want to give false hope, but I do want to give hope and credit where it's due) we also don't know yet how far the treatment will help him get back to his former baseline, as you may know, WKS is considered as a spectrum from acute /temporary(Wernicke) to more chronic/permanent (korsakoff), FYI in my dad's case the doctors indicated based on his clinical diagnosis and MRIs he was likely mid spectrum with some definite permanent damages but hopeful prognosis on some recovery over many mths/yrs.
Thank you, My dad is having the same thing.
@@CesarLopez-iy8bq excellent, where is he getting treatment?
Thank you for relaying this to us . God bless and you are a champion ! God speed . Thx again .
Thank you for sharing, my dad just got diagnosed with this
@@nina-go7ws no problem, sorry to hear, I hope and pray for the best possible outcome for your family
I've never laughed so hard at a biochem lecture! Thanks for helping this stuff stick with humor 🤣
You’re such a wonderful person, Liz...Thank you so much 😊
Good luck 🍀
I just came here to learn about WKS. Didn't know I'd be laughing so hard. I think I'm in love
Thank you so much 😊
this marks the day i am going to be following your videos through thick amd thin
Thank you so much!
I can listen to these jokes for hours 😂
Thank you so much, dear :)
I never thought that I was funny ☺️
So, thank you 😊
@@MedicosisPerfectionalis Can confirm, you're hilarious 😂
🤣🤣🤣🤣🤣🤣🤣
IM GLAD I FOUND THIS CHANEL, THANK YOU SO MUCH!
Glad you enjoy it!
I really really Like how this guy speaks!!!!
Hehe 😉
Thank you 🙏
this is so amazing! Discussed briefly but very informative. Thank you for the lecture!
Thank you so much 😊
i have never been so happy and educated, you are such a good teacher
I appreciate you!
This is so freaking good. Laughed so hard, and learned so much...
Awesome 👏
most impressive, as a person with korsakoffs syndrome you explained it exactly
Thank you!
my favorite youtuber that calls me stupid i love it thank you!!! Also i recommend the pharma and cardio course it wasnt expensive and was helpful for step1
this should clearly be the most viewed channel in history of Medicine Hahahahahaha.
Thank you 😊
As a nerdy chemical engineer with an unhealthy love for biochemistry (.. is there such a thing??) whose mother was exhibiting signs (and was ultimately diagnosed), this video made me laugh in a nearly unlaughable moment with the jokes, song, and evisceration of roman numerals (I hate them too!!). Who could possibly not ADORE THIS VIDEO?!?! There may be tough times ahead for my family (there's light at the end of the tunnel, and knowing 2020, it's probably a train!) but this video is basically nerd therapy
Wow...I am so honored and humbled! You're such a good person...I wish the best of luck to you and your mother!
Thank you.
You're welcome!
"Tired, lethargic, confused, comatosed"🤣🤣🤣
☺️😊😊😊
That was excellent! Very informative and entertaining at the same time.✌
Thank you 😊
Linking biochemistry to actual clinical practice makes.me so happy. I can't wait to inflict this new found knowledge on my med students during ward round 🤣
You sir, are a legend. Thank you so much for your videos
My pleasure 😇
You rock!. You are a good teacher and a good entertainer
I am honored!
You're so amazing, im watching all your videos and wish you make more.
Thank you so much!
One stop solution for laughter with medical knowledge ;-) Be the way you are Sir!
Thank you 🙏
🌼🌼 great job thank you
when I want to learn anything I hope you made a video about it
thank you for making us laugh while still trying to teach us, it makes it less torturing :)
3:56 “ This is the famous triad of wernicke’s aphasia “ :p
Oops 🙊
I am so sorry!
I meant “Wernicke’s encephalopathy”
You’re so sharp!
Medicosis Perfectionalis I take notes from your videos . You’re great mashalah 👍🏻🤍
Medicosis# Netflix for medicos!!!! Wow.....
U are a great teacher u deserve it.... Doc...
awesome video, TY, needed to find out about this
Thanks 😊
@@MedicosisPerfectionalis yes very precise, things i never heard before :)
LOOOOOL!!! great video by the way
Thank you ☺️
now i know why some of my patient gone to neuroglycopenic coma and death, after given dextrose, without knowing they might have malnutrition prior to presentation to emergency department, but i cant stop my ED colleague as they are the initial treating doctor
Thank you so much prof for this lecture
You’re very welcome!
Are you happy now ?? Yeahhh.
😂😂
How much thiamine and how much glucose? And how much time between????
What did he say??
no hablo inglés muy bien pero la explicación la entendí, muchas gracias
OK, but what if all your doctors have their heads up their anatomical sphincters and they just think you're "depressed, stressed, or anxious"? What if you have been becoming increasingly paralyzed for several years, have been diagnosed with POTS, start having seizures, ptosis and have tingling extremities, but doctors want to say you just have "functional neurological disorder," instead of assessing you for possible metabolic deficiency/ dysfunction. What if you have been having 4 glasses of wine a night for a decade, but have downplayed this to doctors because it's human nature to do so? For these reasons, if you are unable to get a doctor to help, can you reverse thiamine deficiency using supplements before it's too late, to save your own life? Or can it only be IV?
I think I love you! Subscribed! Nursing school thanks you.
Serenity Freedom My pleasure 😇
i watch your videos. i am happy and passing med school lool
I like that he's answering to every single comment
hehe
I clicked on this video just to see why you give thiamine first or with dextrose (since it was not mentioned in the last Korsakoff Syndrome video) and oops but I get it now thanks so much. I am currently using Uworld to prepare for my NCLEX exam. Aside from your videos I also use SimpleNursing. Do you have courses that specifically prepare for test questions that would be asked on the NCLEX? I believe your content is underrated and hope you get the views you deserve. "Are you happy now?" - if you are referring to a song when you say this, which song because I can't recall artist's name. Also the picmonics link hookup is only for medical but the nursing page is much cheaper...you don't happen to have a link hookup for nursing right?
First time here and already loving it
Thank you 😊
please upload fat soluble vitamins too ..you teach awesome ,love ya
Sure
Can we give thiamine with narmal saline then dextrose...
Great lesson, thank you :)
My pleasure 😇
OMG , I can't stop laughing 🤣😅 thank you 🙏❤️
My pleasure 😇
Thank you ..you are really amazing
This video is a bomb! Thank you sir!
My pleasure 😇
What's the time interval between thiamine and glucose?
What do you mean?
@@MedicosisPerfectionalis how long do we wait after giving thiamine to give glucose next?
@@kathmandunepal9547 good question
normally you give 3x500mg over 30min for 2d, so my guess would be after 30min
i need questions for this playlist of biochemistry ...... where can i find it please ??
Magistral
Thanks so much and 😂😂❤
I appreciate you!
at some point, is it genetic?
What is “it” referring to?
thank you so much
My pleasure 😇
Wow I love u make it so fun and entertaining 👌🏼
Thank you 🙏
Would you please tell me what nmda is?
A glutamate receptor in the brain 🧠.
@@MedicosisPerfectionalis Dose B1 need a thiamine transporter or a glutamine receptor?
just wow
In love with you from India
Thank you 😊
Accidentally said Aphasia at 3:55
Shut up the patient is dying 😂
I am confused!! Repeat
OK ok. But iv been putting my thiamine in a glucose bag forever. Soooo first dose in a Nacl bag?
Edit: also had to agree iv never laughed at a biochem lesson prior to now
who names these things😂😂
Amaaaaazzzzzzing
Thankkkk you
My pleasure 😇
Of course I’m happy now😂😂😂😂
Amazing 🤩
goooooooooodddd haha thanks!!!
My pleasure 😇
You're a legend! 😂 Jokes on point!
English please
Amblyopia.
" Yoooouuu fooool" 😂😂😂😂😂
Haha 😂
LOL, edit every video, anyway, thx a lot
haha.. too good man
Thank you for watching!
You got a super Humor 🤣
Get your head Off Honey 😜
Love it haha
Micah Perry Thank you 😊
B1 and stuff
??
Woooow who are you😂😂😂😂👌🏿
I am a secret agent 🕵️♂️ . LOL 😂
Cross-eyed drunk, it's been called
Lol i am happy now 🤣🤣🤣🤣
Haha 😂
Awesome 😎
Thank you moaning man!
what kind of presentation is this? are you talking on the phone????😂😂😂👎👊
:D
😊😊
Lack of order, a story with too many boredom from speaker, abundant redundancy.
Ok