Chemical Knots - Periodic Table of Videos
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- Опубликовано: 31 авг 2011
- How to make complicated molecules using a simple process - essentially tying knots in a string-like compound!
Rob Stockman's team's latest paper could contain important clues to the making of cheaper medicines.
The paper is at pubs.rsc.org/en/Content/Articl... (we think it is free but you'll have to log in, but you may need to open a free RSC account at pubs.rsc.org/en/account/register)
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The stuff these guys are doing is simply mind-bending to me. Individual molecules are so incredibly small and yet they can not only model their structure in three dimensions, but also manipulate them to achieve the desired shape. To me, this is pure magic. I can't even begin to imagine how this is done. Just... wow.
one pot synthesis: the king of organic chemistry
I love RUclips. It has allowed me to educate myself in those fields in which my previous teacher apparently failed to efficiëntly get his point across.
This is the sort of work that could revolutionise medicine as we know it! Keep up the good work Rob!
I have to say that this is my prefered part in chemistry, Organic Chemistry have been my favourite subject and everyday I read something somewhere about it.
Congratulations to Dr Rob Stockman for the discoveries, people not only research things to sell to pharmaceutical companies but also to research, as we've seen in the video, the behavior of these molecules or maybe trying to find and improvement in some organic reaction.
This is the most interesting/informative video I've seen on this channel until now, make more of these :)
Very interesting video. He doesn't just touch on the new process he developed, but also tells us a lot about how and why they try doing these things.
I love seeing how it's practical - it's not just cool, it's helping someone or something...
Absolutely Awesome!!! More efficiency is needed everywhere. Keep tying your chemical knots and GO GREEN!!!
I love watching these before I go to bed down here in Australia.
It depends when you upload them, but I generally watch them right before bed. A great way for me to relax.
Thank you! :)
This one of those ideas that seem so practical, you wonder why nobody was doing it already. And that's the genius of it! Very clever indeed.
People ask me if you can make a complicated structure through chemistry. This is a good example. I still remember the youtube video about olympacene molecule, that was sweet.
In pharma it's helpful to use x-ray crystallography to know the 3-D look of the enzyme so that people who have diseases where the disease is due to their body producing an enzyme that's doesn't work (loss of function, or functioning at an unwanted rate) can be treated by a chemical whose 3-D shape fit's into that defective protein and can reach it's active binding side ('active site') to either make the enzyme start functioning, or prevent it from functioning and catalyzing an unwanted reaction.
Heres another one from New Zealand! Love the videos and look forward to new uploads. Keep it going for us guys.
Enzymes (proteins) are 'activated' when a compound comes near i that has a 3-d structure such that 'fits into it', specifically so that a part of that compound comes in contact with a buried part of the enzyme 5:58 the 'cave' or better known as activation site.
Then the enzyme is changed in a number of different ways, either to deactivate it from catalyzing the reaction it's responsible for (or blocking active transport across the receptor) or to activate the enzymes function.
It's enjoyable to actually understand the mechanisms he is talking about.
stellar video. this is the best explained thing ive seen so far!
watching your videos give me inspiration for my school projects and work. XD thanks, Brady and all the lecturers.
This one in particular really blew me away and as these videos go that's saying a lot.
Chemistry is so fucking amazing.
Never mind Australian musicians, as Paul Dirac said, "In science you want to say something that nobody knew before, in words which everyone can understand. In poetry you always say something that everybody knows already in words that nobody can understand.”
@michalchik The proffessor is an intelligent man, used to using words even quite a competent person couldn't understand. He uses very simple expressions because thats how he thinks his point will get across to the most people.
And Brady is not a chemist, so he doesn't know alot about chemistry so he asks the questions he wants answered.
To be perfectly honest I love that these videos are so simple, yet so complex. It makes something interesting, that much more interesting.
very good work organic chemistry is the most fun i find. so much so that i have gone down this route in my college course =)
This is gonna make it simple?
I love you Brady.
The pull away at 0:47 had me on the floor laughing.
Well done Brady, well done sir.
Nice work dude. It seems like this is how nature does it. :) I guess the easiest analogys do work in nature and life.
and this is why I love organic chemistry
Very interesting video - a lot of it is over my head but it makes me want to learn more. I've wondered in the past while watching your videos how closely the models resemble what we would actually see if individual molecules were visible. It seems like all the bonds are the same length? The atoms vary in size more than the model shows maybe? Would like to hear more...
Superb...!! Really interesting!!
just read paper its amazing, i would recommend it to all people who have an education above year 12 to first year uni (chem)
The molecular structure he holds up and calls an "antihypertensive" is a very close derivative of the potent hypnotic hallucinogen zolpidem where the ethylamide chain has been replaced with a methylamide chain. I wonder if the structure was incorrectly assembled or if this is a new drug that is yet unknown.
This was really cool, thanks.
Excellent quote. I've heard a similar (Greek or Roman?) saying that "adding things can be done by anyone but to subtract things requires a genius."
Could you do a video explaining how they can design the molecules in a specific shape? For instance, how do you break off this atom, and replace it with that group of atoms?
How do you manipulate the atoms? Is it all just mixing chemicals and hoping the right bonds form?
I loved my Organic chem class, thats some pretty spiffy use of ring forming reactions.
has this been known before in other examples or is this the first time something like this has been done? (the multiple knot tying method)
Who would have thought Organic could be so interesting!
I was hoping for a Trefoil knot!
What exactly do those created molecules attach to? I didn't get that part.
Very interesting idea. Not sure if I understood it, but I didn't seem to get a clear answer to Brady's question of "well, what good are these? What do they do?" Do any of these molecules have any known or potential applications, or are these molecules more a 'proof of concept' demonstration, rather than 12 or so different designs each with it's own individual uses?
I look forward to seeing those films.
Awesome = ) As you might use some of the molecules as drugs, are enantiomers a problem (like D / L and alpha beta and so on)? Obviously they might be a problem if you have around 10 synthesis steps, but how big is the problem with your molecule (and less steps)?
I like the organic chem model set you're using here. Do you remember the name of it?
@CosmicKitten89 Which is kind of what I am asking for here. There is a wealth of brilliant people interviewed in these videos and they are constantly told to dumb down what they have to say. I watch the videos of classes coming out of Stanford, MIT, Berkley, USC, IIT, Caltech which actually talk about the science but don't cover individual interesting topics like these videos do. The pace of those classes should be fine for you.
@periodicvideos thanks!
@periodicvideos Yeah I did that as well, but strange that every UK institution is blocked when trying to log in through Shibboleth...think it must be a fault with the RSC site. I've been able to access any other paper through by Manchester Uni account so...
Organic chemistry's so beautiful... :3
basically he's investigating a simpler, faster way of making complex molecules (represented here by all those plastic models) by folding up one to make many other different molecules, instead of the slow method that takes 20 steps to make one substance like he said
these molecules could be useful drugs or materials or anything else so making them in one step = faster, easier and cheaper
When I saw the title of the video I thought you were gonna talk about knotanes...
Still, that was a very nice video :)
I enjoyed the paper. A little technical, but very interesting.
kewl ! i want more videos like this plz plz plz plz :)
Very, very cool! It's reminiscent of protein formation...
Feeling fantastic but very curious here . . .
While those molecule models could be twisted, rearranged or otherwise manipulated (and most certainly visualised) almost at will, I wonder how these same things could be done on the molecular level.
I mean, how would you twist the bonds of an actual molecule, and how would you verify which molecule actually corresponds to which structure with pin-point certainty?
Brady should just make a whole orgchem channel and call it White Powder. :p
so, is this bending and changing the shape of molocules literal? like what is the process?
I liked the comment "we always want to encourage luck." There's a lot to be said for plugging away at things just to make an opportunity for something nice to surprise you.
@periodicvideos If I try and log in through Athens (through any institution, not just my own) I get "Your selected institution has no access to this content. Please choose one of the options provided in the log in section to gain access to this content."
Can you tell me where you get those models? I am a chemist and we could use those at work!
i was surprised, he actually did make it sound simple.
Wow, great video what an interesting concept. It's like once the first reaction is initiated the molecule pulled itself into a brand new shape. Is this going to be pushed into medical trials?
awesome! serendipity = a happy accident :D
If u guys do come to Aussie, be sure to jump the ditch and do NZ too.... Roto-vegas still awaits you... :)
very nice
That's a great question.
Amazing, combining computing power with chemistry and biology... Its like applied string theory of all the other sciences.
Wonderful =)
Man, I love organic chemistry.
@periodicvideos You should come to new zealand and do a video on sodium fluoroacetate/1080 we'd love to have more clear info on it
Very clever :)
@CosmicKitten89 Well, Like I said, everyone has their own styles and needs. On a somewhat different subject, have you considered the possibility that you may have ADD? Its not really an inability to pay attention but an inability to adapt your attention to the demands of the environment. Many people with ADD have situations in which their focus is very good, they just can't transfer it at will.
Would this be considered biological or pharmaceutical synthetic chemistry?
Could you please tell us the Chemistry of flame?
@periodicvideos Got it now, but had to go through my VPN. :)
Just out of my nerdy med student curiosity, what antihypertensive is that first molecule?
@BruceNJeffAreMyFlies I do pick up books, but videos can communicate a lot of ideas more quickly and effectively. There is a dearth of science videos that even rise to the level of first year college science class while there are millions of youtube users interested in current science events in other fields that have advanced degrees in science. The people being interviewed here are professors doing great work but forced to explain it at an 8th grade level.
would you do a video on the chemistry of a combustion engine vs a vapor engine in a car and jim ogle?
@culwin My basic point is, i simply see a way they are working to try to make these videos better and they are actually making things worse. If you think these videos are too hard or pitched just right you can say so. I like these videos, but I think they try too hard to make them for the lowest common denominator . I am not taking pot shots, I am offering advice on how I think they can be better. There is nothing wrong with trying to make a good thing better.
It reminds me a bit of Knot theory in Mathematics, only applied.
@QwoPhasaArius I like his work and understand its interest, I just wanted a deeper explanation.,
@masluxx Sometimes they can't, because certain compounds are patented.
Would i be completely wrong if i said this is sort of like an extremely simplified version of how proteins fold?
I was always wondering - how do you guys know that this is what the molecules look like? I'm pretty sure there isn't a microscope through which you can see these particular structures.
I have a shirt just like that one! =D
gj btw ^^
@periodicvideos Alright, thanks! :)
@roidroid
Sorry, I don't see any of that, just the other Nottingham Science productions. If you have watched similar content, it changes the filter.
I want to be a synthetic organic chemist so badly. Damn my Chemical Engineering track.
@michalchik If you want more scientific sceience then pick up a book. It's nice to be told something interesting without being bombarded by big words, whether you understand them or not.
This is fakin genius.
This is the best channel on youtube. PErIODs
(Phosphorus, Erbium, iodine, Oxygen, Darmstadtium)
thumbs up for intelligent drug design.
i dont understand this but i got it at school :D
Cool.
"Anyone can make the simple complicated. Creativity is making the complicated simple" Sometimes, you do, in fact, need to be creative to manage to make something complex. Though there is no reason to do that.
Love your awesome white shirt ;)
receptor sites in the body or brain
You're using a somewhat incorrect analogy here. The "scaffolding" he's referring to is more like the engine that the programs you modify use, not the program itself. In some cases it's a programming language, in others it's an actually program itself like Cryengine or Source. Try to think of it that way.
@CosmicKitten89 We are all different. I learn much more rapidly from an audiovisual format. I like references written, but new info explained. So why do you bother watching videos?
@yardy66 And another.
Go the A.B.'s!
receptors: you can think of them as little buttons or switches on a cell. There are thousands of different types on cells, and most drugs exploit these receptors.
@axelasdf scroll down the list
I wanted see a "molecular" trefoil knot for example. I was disapointed.