I love RUclips. It has allowed me to educate myself in those fields in which my previous teacher apparently failed to efficiëntly get his point across.
The stuff these guys are doing is simply mind-bending to me. Individual molecules are so incredibly small and yet they can not only model their structure in three dimensions, but also manipulate them to achieve the desired shape. To me, this is pure magic. I can't even begin to imagine how this is done. Just... wow.
In pharma it's helpful to use x-ray crystallography to know the 3-D look of the enzyme so that people who have diseases where the disease is due to their body producing an enzyme that's doesn't work (loss of function, or functioning at an unwanted rate) can be treated by a chemical whose 3-D shape fit's into that defective protein and can reach it's active binding side ('active site') to either make the enzyme start functioning, or prevent it from functioning and catalyzing an unwanted reaction.
People ask me if you can make a complicated structure through chemistry. This is a good example. I still remember the youtube video about olympacene molecule, that was sweet.
@michalchik The proffessor is an intelligent man, used to using words even quite a competent person couldn't understand. He uses very simple expressions because thats how he thinks his point will get across to the most people. And Brady is not a chemist, so he doesn't know alot about chemistry so he asks the questions he wants answered. To be perfectly honest I love that these videos are so simple, yet so complex. It makes something interesting, that much more interesting.
Enzymes (proteins) are 'activated' when a compound comes near i that has a 3-d structure such that 'fits into it', specifically so that a part of that compound comes in contact with a buried part of the enzyme 5:58 the 'cave' or better known as activation site. Then the enzyme is changed in a number of different ways, either to deactivate it from catalyzing the reaction it's responsible for (or blocking active transport across the receptor) or to activate the enzymes function.
Never mind Australian musicians, as Paul Dirac said, "In science you want to say something that nobody knew before, in words which everyone can understand. In poetry you always say something that everybody knows already in words that nobody can understand.”
The molecular structure he holds up and calls an "antihypertensive" is a very close derivative of the potent hypnotic hallucinogen zolpidem where the ethylamide chain has been replaced with a methylamide chain. I wonder if the structure was incorrectly assembled or if this is a new drug that is yet unknown.
Very interesting video - a lot of it is over my head but it makes me want to learn more. I've wondered in the past while watching your videos how closely the models resemble what we would actually see if individual molecules were visible. It seems like all the bonds are the same length? The atoms vary in size more than the model shows maybe? Would like to hear more...
I have to say that this is my prefered part in chemistry, Organic Chemistry have been my favourite subject and everyday I read something somewhere about it. Congratulations to Dr Rob Stockman for the discoveries, people not only research things to sell to pharmaceutical companies but also to research, as we've seen in the video, the behavior of these molecules or maybe trying to find and improvement in some organic reaction.
Very interesting idea. Not sure if I understood it, but I didn't seem to get a clear answer to Brady's question of "well, what good are these? What do they do?" Do any of these molecules have any known or potential applications, or are these molecules more a 'proof of concept' demonstration, rather than 12 or so different designs each with it's own individual uses?
Awesome = ) As you might use some of the molecules as drugs, are enantiomers a problem (like D / L and alpha beta and so on)? Obviously they might be a problem if you have around 10 synthesis steps, but how big is the problem with your molecule (and less steps)?
@periodicvideos Yeah I did that as well, but strange that every UK institution is blocked when trying to log in through Shibboleth...think it must be a fault with the RSC site. I've been able to access any other paper through by Manchester Uni account so...
Feeling fantastic but very curious here . . . While those molecule models could be twisted, rearranged or otherwise manipulated (and most certainly visualised) almost at will, I wonder how these same things could be done on the molecular level. I mean, how would you twist the bonds of an actual molecule, and how would you verify which molecule actually corresponds to which structure with pin-point certainty?
@CosmicKitten89 Which is kind of what I am asking for here. There is a wealth of brilliant people interviewed in these videos and they are constantly told to dumb down what they have to say. I watch the videos of classes coming out of Stanford, MIT, Berkley, USC, IIT, Caltech which actually talk about the science but don't cover individual interesting topics like these videos do. The pace of those classes should be fine for you.
Could you do a video explaining how they can design the molecules in a specific shape? For instance, how do you break off this atom, and replace it with that group of atoms? How do you manipulate the atoms? Is it all just mixing chemicals and hoping the right bonds form?
basically he's investigating a simpler, faster way of making complex molecules (represented here by all those plastic models) by folding up one to make many other different molecules, instead of the slow method that takes 20 steps to make one substance like he said these molecules could be useful drugs or materials or anything else so making them in one step = faster, easier and cheaper
I liked the comment "we always want to encourage luck." There's a lot to be said for plugging away at things just to make an opportunity for something nice to surprise you.
@periodicvideos If I try and log in through Athens (through any institution, not just my own) I get "Your selected institution has no access to this content. Please choose one of the options provided in the log in section to gain access to this content."
Wow, great video what an interesting concept. It's like once the first reaction is initiated the molecule pulled itself into a brand new shape. Is this going to be pushed into medical trials?
"Anyone can make the simple complicated. Creativity is making the complicated simple" Sometimes, you do, in fact, need to be creative to manage to make something complex. Though there is no reason to do that.
@CosmicKitten89 Well, Like I said, everyone has their own styles and needs. On a somewhat different subject, have you considered the possibility that you may have ADD? Its not really an inability to pay attention but an inability to adapt your attention to the demands of the environment. Many people with ADD have situations in which their focus is very good, they just can't transfer it at will.
@BruceNJeffAreMyFlies I do pick up books, but videos can communicate a lot of ideas more quickly and effectively. There is a dearth of science videos that even rise to the level of first year college science class while there are millions of youtube users interested in current science events in other fields that have advanced degrees in science. The people being interviewed here are professors doing great work but forced to explain it at an 8th grade level.
@culwin My basic point is, i simply see a way they are working to try to make these videos better and they are actually making things worse. If you think these videos are too hard or pitched just right you can say so. I like these videos, but I think they try too hard to make them for the lowest common denominator . I am not taking pot shots, I am offering advice on how I think they can be better. There is nothing wrong with trying to make a good thing better.
You're using a somewhat incorrect analogy here. The "scaffolding" he's referring to is more like the engine that the programs you modify use, not the program itself. In some cases it's a programming language, in others it's an actually program itself like Cryengine or Source. Try to think of it that way.
I was always wondering - how do you guys know that this is what the molecules look like? I'm pretty sure there isn't a microscope through which you can see these particular structures.
@CosmicKitten89 We are all different. I learn much more rapidly from an audiovisual format. I like references written, but new info explained. So why do you bother watching videos?
@michalchik If you want more scientific sceience then pick up a book. It's nice to be told something interesting without being bombarded by big words, whether you understand them or not.
@joewilder what do you mean "natural remedies"? most natural remedies that work have more side-effects and are more dangerous than the normal farmaceutical drugs. other "natural" remedies just don't work. to prevent serious side-effects drugs are first rigorously tested on animals, before human testing starts. hypertension, as you point out, if treated can prevent many lifethreatening conditions. prevention is more efficient than treating every single disease that results from hypertension.
I know scientific journals arent supposed to have snazzy names and are just supposed to be about what the work done was but just once i want someone to say "Fuck it" and name the paper something ridiculous and funny and catchy.
yes keep making the "scaffolding" so the drug companies, can add a bit here or there and keep those patents rolling in, while bussiness pushes to end the funding of research. Odd not matter how i mod a program of someone else’s i cannot resell it as my work, yet these drug companies do just that.
I love RUclips. It has allowed me to educate myself in those fields in which my previous teacher apparently failed to efficiëntly get his point across.
The stuff these guys are doing is simply mind-bending to me. Individual molecules are so incredibly small and yet they can not only model their structure in three dimensions, but also manipulate them to achieve the desired shape. To me, this is pure magic. I can't even begin to imagine how this is done. Just... wow.
one pot synthesis: the king of organic chemistry
This is the most interesting/informative video I've seen on this channel until now, make more of these :)
Very interesting video. He doesn't just touch on the new process he developed, but also tells us a lot about how and why they try doing these things.
In pharma it's helpful to use x-ray crystallography to know the 3-D look of the enzyme so that people who have diseases where the disease is due to their body producing an enzyme that's doesn't work (loss of function, or functioning at an unwanted rate) can be treated by a chemical whose 3-D shape fit's into that defective protein and can reach it's active binding side ('active site') to either make the enzyme start functioning, or prevent it from functioning and catalyzing an unwanted reaction.
I love seeing how it's practical - it's not just cool, it's helping someone or something...
Absolutely Awesome!!! More efficiency is needed everywhere. Keep tying your chemical knots and GO GREEN!!!
People ask me if you can make a complicated structure through chemistry. This is a good example. I still remember the youtube video about olympacene molecule, that was sweet.
This one of those ideas that seem so practical, you wonder why nobody was doing it already. And that's the genius of it! Very clever indeed.
This is the sort of work that could revolutionise medicine as we know it! Keep up the good work Rob!
It's enjoyable to actually understand the mechanisms he is talking about.
Heres another one from New Zealand! Love the videos and look forward to new uploads. Keep it going for us guys.
@michalchik The proffessor is an intelligent man, used to using words even quite a competent person couldn't understand. He uses very simple expressions because thats how he thinks his point will get across to the most people.
And Brady is not a chemist, so he doesn't know alot about chemistry so he asks the questions he wants answered.
To be perfectly honest I love that these videos are so simple, yet so complex. It makes something interesting, that much more interesting.
watching your videos give me inspiration for my school projects and work. XD thanks, Brady and all the lecturers.
Enzymes (proteins) are 'activated' when a compound comes near i that has a 3-d structure such that 'fits into it', specifically so that a part of that compound comes in contact with a buried part of the enzyme 5:58 the 'cave' or better known as activation site.
Then the enzyme is changed in a number of different ways, either to deactivate it from catalyzing the reaction it's responsible for (or blocking active transport across the receptor) or to activate the enzymes function.
Never mind Australian musicians, as Paul Dirac said, "In science you want to say something that nobody knew before, in words which everyone can understand. In poetry you always say something that everybody knows already in words that nobody can understand.”
Excellent quote. I've heard a similar (Greek or Roman?) saying that "adding things can be done by anyone but to subtract things requires a genius."
The molecular structure he holds up and calls an "antihypertensive" is a very close derivative of the potent hypnotic hallucinogen zolpidem where the ethylamide chain has been replaced with a methylamide chain. I wonder if the structure was incorrectly assembled or if this is a new drug that is yet unknown.
Very interesting video - a lot of it is over my head but it makes me want to learn more. I've wondered in the past while watching your videos how closely the models resemble what we would actually see if individual molecules were visible. It seems like all the bonds are the same length? The atoms vary in size more than the model shows maybe? Would like to hear more...
stellar video. this is the best explained thing ive seen so far!
just read paper its amazing, i would recommend it to all people who have an education above year 12 to first year uni (chem)
This one in particular really blew me away and as these videos go that's saying a lot.
Nice work dude. It seems like this is how nature does it. :) I guess the easiest analogys do work in nature and life.
I have to say that this is my prefered part in chemistry, Organic Chemistry have been my favourite subject and everyday I read something somewhere about it.
Congratulations to Dr Rob Stockman for the discoveries, people not only research things to sell to pharmaceutical companies but also to research, as we've seen in the video, the behavior of these molecules or maybe trying to find and improvement in some organic reaction.
Chemistry is so fucking amazing.
and this is why I love organic chemistry
Very interesting idea. Not sure if I understood it, but I didn't seem to get a clear answer to Brady's question of "well, what good are these? What do they do?" Do any of these molecules have any known or potential applications, or are these molecules more a 'proof of concept' demonstration, rather than 12 or so different designs each with it's own individual uses?
Awesome = ) As you might use some of the molecules as drugs, are enantiomers a problem (like D / L and alpha beta and so on)? Obviously they might be a problem if you have around 10 synthesis steps, but how big is the problem with your molecule (and less steps)?
@periodicvideos Yeah I did that as well, but strange that every UK institution is blocked when trying to log in through Shibboleth...think it must be a fault with the RSC site. I've been able to access any other paper through by Manchester Uni account so...
Feeling fantastic but very curious here . . .
While those molecule models could be twisted, rearranged or otherwise manipulated (and most certainly visualised) almost at will, I wonder how these same things could be done on the molecular level.
I mean, how would you twist the bonds of an actual molecule, and how would you verify which molecule actually corresponds to which structure with pin-point certainty?
This is gonna make it simple?
I love you Brady.
@CosmicKitten89 Which is kind of what I am asking for here. There is a wealth of brilliant people interviewed in these videos and they are constantly told to dumb down what they have to say. I watch the videos of classes coming out of Stanford, MIT, Berkley, USC, IIT, Caltech which actually talk about the science but don't cover individual interesting topics like these videos do. The pace of those classes should be fine for you.
has this been known before in other examples or is this the first time something like this has been done? (the multiple knot tying method)
very good work organic chemistry is the most fun i find. so much so that i have gone down this route in my college course =)
Could you do a video explaining how they can design the molecules in a specific shape? For instance, how do you break off this atom, and replace it with that group of atoms?
How do you manipulate the atoms? Is it all just mixing chemicals and hoping the right bonds form?
basically he's investigating a simpler, faster way of making complex molecules (represented here by all those plastic models) by folding up one to make many other different molecules, instead of the slow method that takes 20 steps to make one substance like he said
these molecules could be useful drugs or materials or anything else so making them in one step = faster, easier and cheaper
The pull away at 0:47 had me on the floor laughing.
Well done Brady, well done sir.
I loved my Organic chem class, thats some pretty spiffy use of ring forming reactions.
I liked the comment "we always want to encourage luck." There's a lot to be said for plugging away at things just to make an opportunity for something nice to surprise you.
I like the organic chem model set you're using here. Do you remember the name of it?
@periodicvideos If I try and log in through Athens (through any institution, not just my own) I get "Your selected institution has no access to this content. Please choose one of the options provided in the log in section to gain access to this content."
Who would have thought Organic could be so interesting!
Organic chemistry's so beautiful... :3
Brady should just make a whole orgchem channel and call it White Powder. :p
When I saw the title of the video I thought you were gonna talk about knotanes...
Still, that was a very nice video :)
Can you tell me where you get those models? I am a chemist and we could use those at work!
This is the best channel on youtube. PErIODs
(Phosphorus, Erbium, iodine, Oxygen, Darmstadtium)
I was hoping for a Trefoil knot!
What exactly do those created molecules attach to? I didn't get that part.
Wow, great video what an interesting concept. It's like once the first reaction is initiated the molecule pulled itself into a brand new shape. Is this going to be pushed into medical trials?
I enjoyed the paper. A little technical, but very interesting.
so, is this bending and changing the shape of molocules literal? like what is the process?
"Anyone can make the simple complicated. Creativity is making the complicated simple" Sometimes, you do, in fact, need to be creative to manage to make something complex. Though there is no reason to do that.
@CosmicKitten89 Well, Like I said, everyone has their own styles and needs. On a somewhat different subject, have you considered the possibility that you may have ADD? Its not really an inability to pay attention but an inability to adapt your attention to the demands of the environment. Many people with ADD have situations in which their focus is very good, they just can't transfer it at will.
i was surprised, he actually did make it sound simple.
Amazing, combining computing power with chemistry and biology... Its like applied string theory of all the other sciences.
Just out of my nerdy med student curiosity, what antihypertensive is that first molecule?
Superb...!! Really interesting!!
Would this be considered biological or pharmaceutical synthetic chemistry?
Man, I love organic chemistry.
@BruceNJeffAreMyFlies I do pick up books, but videos can communicate a lot of ideas more quickly and effectively. There is a dearth of science videos that even rise to the level of first year college science class while there are millions of youtube users interested in current science events in other fields that have advanced degrees in science. The people being interviewed here are professors doing great work but forced to explain it at an 8th grade level.
@culwin My basic point is, i simply see a way they are working to try to make these videos better and they are actually making things worse. If you think these videos are too hard or pitched just right you can say so. I like these videos, but I think they try too hard to make them for the lowest common denominator . I am not taking pot shots, I am offering advice on how I think they can be better. There is nothing wrong with trying to make a good thing better.
Would i be completely wrong if i said this is sort of like an extremely simplified version of how proteins fold?
This was really cool, thanks.
@periodicvideos You should come to new zealand and do a video on sodium fluoroacetate/1080 we'd love to have more clear info on it
Could you please tell us the Chemistry of flame?
You're using a somewhat incorrect analogy here. The "scaffolding" he's referring to is more like the engine that the programs you modify use, not the program itself. In some cases it's a programming language, in others it's an actually program itself like Cryengine or Source. Try to think of it that way.
awesome! serendipity = a happy accident :D
If u guys do come to Aussie, be sure to jump the ditch and do NZ too.... Roto-vegas still awaits you... :)
would you do a video on the chemistry of a combustion engine vs a vapor engine in a car and jim ogle?
I was always wondering - how do you guys know that this is what the molecules look like? I'm pretty sure there isn't a microscope through which you can see these particular structures.
@masluxx Sometimes they can't, because certain compounds are patented.
@roidroid
Sorry, I don't see any of that, just the other Nottingham Science productions. If you have watched similar content, it changes the filter.
@periodicvideos Got it now, but had to go through my VPN. :)
thumbs up for intelligent drug design.
@periodicvideos thanks!
It reminds me a bit of Knot theory in Mathematics, only applied.
@CosmicKitten89 We are all different. I learn much more rapidly from an audiovisual format. I like references written, but new info explained. So why do you bother watching videos?
kewl ! i want more videos like this plz plz plz plz :)
I want to be a synthetic organic chemist so badly. Damn my Chemical Engineering track.
@michalchik If you want more scientific sceience then pick up a book. It's nice to be told something interesting without being bombarded by big words, whether you understand them or not.
@joewilder what do you mean "natural remedies"? most natural remedies that work have more side-effects and are more dangerous than the normal farmaceutical drugs. other "natural" remedies just don't work. to prevent serious side-effects drugs are first rigorously tested on animals, before human testing starts. hypertension, as you point out, if treated can prevent many lifethreatening conditions. prevention is more efficient than treating every single disease that results from hypertension.
Calling an antihypertensive medication a "sedative" is not even an oversimplification, it's just incorrect.
@QwoPhasaArius I like his work and understand its interest, I just wanted a deeper explanation.,
I know scientific journals arent supposed to have snazzy names and are just supposed to be about what the work done was but just once i want someone to say "Fuck it" and name the paper something ridiculous and funny and catchy.
yes keep making the "scaffolding" so the drug companies, can add a bit here or there and keep those patents rolling in, while bussiness pushes to end the funding of research. Odd not matter how i mod a program of someone else’s i cannot resell it as my work, yet these drug companies do just that.
I wanted see a "molecular" trefoil knot for example. I was disapointed.
I love the Texas clock on the shelf behind him. Im from Texas. I always imagined people in Europe would say, "Texas? Whats that?"
receptor sites in the body or brain
That's a great question.
@periodicvideos Don't worry about it, Australians think in reverse, being upside down all the time sends a lot of blood to the head.
@periodicvideos Alright, thanks! :)
You should have titled the paper "Knot your typical diester"
i dont understand this but i got it at school :D
so basically just fool around with different molecules and see what you can get
get paid well to do that, where do i sign up?????????????
This is fakin genius.
Love your awesome white shirt ;)
very nice
I have a shirt just like that one! =D
gj btw ^^
Wonderful =)