This Is The Optimal Erythrocyte Sedimentation Rate
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- Опубликовано: 18 ноя 2023
- Are you looking at your blood tests and reviewing your erythrocyte sedimentation rate (ESR), wondering what the optimal ESR is?
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In this video, we're going to look at the optimal erythrocyte sedimentation rate (ESR). As we discussed in a previous video, the ESR is the rate at which red blood cells fall or settle into a hematocrit tube. This rate can tell us about certain immune activity and also inflammation.
Specifically, the standard reference range for ESR is age- and gender-specific. For instance, at LabCorp, for a male aged 0 to 50 years, the range is 0 to 15 millimeters per hour. As you get older, above 50 years, the range goes up to 0 to 30 millimeters per hour. For females aged 0 to 50 years, the range starts closer to 0 to 30 millimeters per hour. And above 50 years, the LabCorp reference range is 0 to 40 millimeters per hour.
Just as a comparison, I also looked at the NIH reference values for ESR. If you're less than 50 years old, the range there for males is 0 to 15 millimeters per hour. And above 50 years old for males, the range is less than 15 millimeters per hour. For females less than 50 years old, the range is 20 millimeters per hour. And as you get above 50 years old for females, the range is less than 30 millimeters per hour. As you can see, there is a bit of a difference between those two reference ranges, but the general idea is yes, it will go up as you get older, and for males and females, there will be a bit of a difference, with the range being slightly higher for females.
These are the stated or standard reference ranges that you'll see for this test. Of course, we know that the ESR level will go up when you have more inflammation going on in your body, and that this is a good test to use to track the amount of inflammation going on in your body and track the immune activity going on in your body. We also know that many common health issues increase with aging, and that inflammation is a key driver or variable in most, but not all, chronic disease processes.
So the question then is, is there something inherent in the aging process, independent of inflammation, that's causing us to want to have a higher reference range for someone who's older? And if not, would we then want to change the reference range or reference interval that we're going to shoot for as we get older?
Studies looking at this question or looking to answer this question find that when they correct for things like elevated fibrinogen, elevated glucose, and elevated triglycerides, there's really not a lot of difference in the ESR as you get older. So if you have normal triglycerides, normal glucose, and normal fibrinogen, you actually have the same sedimentation rate that you would if you're 20 years old versus 70 years old.
When things like blood sugar and triglycerides are elevated, they do create micro-inflammation in the blood vessels. With this kind of micro-inflammation, you're not going to get diagnosed with an autoimmune disease, and many times it's just going to be overlooked entirely because it's not going to increase the numbers, the sedimentation rate, or other inflammatory markers by a whole lot. However, if you're interested in optimal health, then you want your ESR to be in the optimal range and possibly in a lower range than what your age-defined reference range would suggest. 
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Any ideas on why my son’s CRP level would be 11.2 but the ESR is only a 6? He is only 23 years old, but is experiencing high ALT and some issues with his liver and is currently overweight. I am guessing that the inflammation is being caused by the liver and the fat cells. Correct? I am just surprised that the ESR was not high, as well.
Check out my newer video on Sedimentation rate there are several non inflammatory things that can influence ESR creating a false negative. For instance having larger red blood cell size or MCV could do this. There are also other things in the serum blood like protein levels that can affect the esr. That video will help break it down but has to do with the electromagnetic field of the blood and red blood cells. Good luck 👍
Hello,
I would like to ask, even if this is off topic. You had a videos about Homocysteine. I will keep this as short as a I can 🙂
55 days ago, my Homocysteine was 13.7 umol/l today it is 26.9umol/l, same lab. Approx same fasting period after last meal (over 12 hrs)
I am 55 days on strict lion diet (carnivore), mostly doing OMAD. Before that, S.A.D diet, altho not junk diet, but also not low carb diet.
HbA1c went also up, but only by 3% still around 5.3%
Glucose went from 87 to 92 so it is the same too.
C-peptide a bit decreased from 400pmol to 371pmol (from 1.2 ng/mL to 1.12 ng/mL)
But I do not get that Homocysteine.. My average daily protein intake from red meat only was 134g/day so 2g/kg of my bodyweight. fat intake was 165g/day
Blood pressure went down from 115/85 to like 95/60 give or take, pulse used to be 60, now 55-60 so the same.
Cholesterol was TOTAL 340, HDL 68 LDL 288 and Trig 88
55 days ago: Total 260, HDL 57 , LDL 206 and Trig 57
CRP was
Female aged 82 , previously on Prednisone for PMR and I don't want to go back there, so 15 is normal?
yes
I am 40 female with esr 22 and the doctor didn't say anything about it. Hope I am safe?. Thank you for all you do doctor
Im a 38 y/o female with esr of 38 and my PC didnt say anything either!