How Hypoxic Vasoconstriction Leads to Pulmonary Hypertension: A Deep Dive into Causes and Effects

In this video, we explore the physiological process of hypoxic vasoconstriction and how it can contribute to pulmonary hypertension. Learn about the short-term adaptive mechanisms and the long-term consequences of this process, including remodeling of vascular smooth muscle and increased pulmonary vascular resistance.
Timestamps:
0:01 Introduction to Hypoxic Vasoconstriction
0:15 Purpose of Hypoxic Vasoconstriction
0:51 Impact on Pulmonary Hypertension
1:24 Effects on Ion Flow and Membrane Potential
2:48 Voltage-Gated Potassium Channel Dysfunction
3:35 Calcium Channel Activation and Vasoconstriction
5:20 Consequences of Long-Term Vasoconstriction
7:45 Vascular Remodeling and Smooth Muscle Hypertrophy
10:50 Role of Growth Factors and Matrix Deposition
12:45 Endothelial Dysfunction and Reduced Vasodilation
14:02 Right Ventricular Impact and Pulmonary Resistance
17:18 Effects of Chronic Hypoxia and Viscosity
19:45 Cyclic Process of Pulmonary Hypertension Formation
20:35 Right Ventricular Remodeling and Heart Failure

[@krishvasa7644]

Great video! Love reviewing these topics you make.

[@MMH991]

Could you cover more ecg’s and videos regarding that? Thank you!

[@Stubborn214]

What books do u use?