Innate immune signaling drives late cardiac toxicity following DNA damaging cancer therapies

Original paper: rupress.org/je...
Video Summary by Suchit H Patel (Memorial Sloan Kettering Cancer Center)
Description: Here, we describe a new animal model of cardiac toxicity following DNA damage that implicates cGAS/STING signaling in cardiac fibroblasts as a driver of late cardiac toxicity. We find delayed activation of a type I interferon response specific to cardiac fibroblasts following cardiac radiation or doxorubicin treatment, dependent on cGAS/STING signaling. Genetic or pharmacologic abrogation of this signaling eliminates the interferon response, rescues cardiac function, and improves cardiac specific mortality following DNA damaging treatments.
Keywords: cardiac toxicity, radiation, DNA damage, CGAS, STING
Original paper: rupress.org/je...