Epithelial alarmin TL1A is a co-factor of IL-33

TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation.
Original paper: rupress.org/je...
Authors:
Pauline Schmitt, Anais Duval, Mylène Camus, Emma Lefrançais, Stéphane Roga, Cécile Dedieu, Nathalie Ortega, Elisabeth Bellard, Emilie Mirey, Emmanuelle Mouton-Barbosa, Odile Burlet-Schiltz, Anne Gonzalez-de-Peredo, Corinne Cayrol and Jean-Philippe Girard
Lead author Jean-Philippe Girard provides an overview of their article published in JEM about the molecular mechanisms involved in the initiation of allergic airway inflammation. The study reveals that TL1A is an epithelial alarmin which cooperates with IL-33 for rapid induction of IL-9high ILC2s a few minutes after allergen exposure.
Keywords
Innate immunity, Allergy, Lung inflammation, Asthma, IL-33, TL1A, Epithelial cells, Cytokine, Alarmin, Fungal allergen