How to Treat Estrogen Receptor-Low Breast Cancer: All You Need to Know
HTML-код
- Опубликовано: 28 июл 2024
- What are the treatment options for estrogen receptor-low breast cancer? What does ER-low mean? In this video, Dr. Jennifer Griggs explains everything you need to know about estrogen receptor-low breast cancer and its treatment.
Sign up to get your personalized Yerbba Report at: app.yerbba.com/signup
Connect With Yerbba!
WEBSITE: www.yerbba.com
INSTAGRAM: yerbba
FACEBOOK: yerbba.breast.cancer
TWITTER: yerbba_bc
BLOG: blog.yerbba.com/
Disclaimer: Yerbba RUclips videos are for informational purposes only, do not constitute medical advice, and are not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your medical team, mental health professional, or other qualified health provider with any questions you may have regarding your medical condition.
Thank you, for your continuous educational material.
Thanks for watching!
Thank you!
Thank you for watching!
Thank you so much. I am a Ph.D student and be interested about breast cancer.
Thanks for watching!
This video mostly refers to tumors. What about ER Positive DCiS? Would endocrine therapy help to reduce the risk of breast cancer in the future prior to it developing into a tumor?
Thanks for the clarification. The video is intended to refer to both invasive and non-invasive (DCIS) tumors. Endocrine therapy decreases the risk of DCIS and invasive cancer in people who have a breast conserving procedure such as a lumpectomy.
Please advise what kind of cancers are ER low breast cancers? Thank you!
The pathology report for a "low estrogen receptor positive" tumor will indicate that estrogen receptor presence is 1 to 10%.
@@yerbba Thank you!
Hello! As per biopsy report of my mother it shown as tumor T3N0M0. Estrogen level-3% , progesterone- 5% her2 negative. Our oncologist telling it can be considered as triple negative. How far it can be correct mam.
Treatment plan is weekly chemo with 12 cycles carboplatin&paclitaxel. What are the chance of re ocuurence mam??
In general, the receptors are considered negative if the percentage is under 1%. In a tumor with ER and PR between 1 and 9%, the tumor would be considered "low ER and low PR." People with tumors that are low ER and PR tend and HER2-negative tend to benefit from chemotherapy. If the other tumor characteristics warrant chemotherapy, the regimen your mother is being offered is an effective regimen.
In terms of likelihood of cure, it is difficult to say specifically without more information, such as tumor size, lymph node status, and other characteristics.
Trying to wrap my head around whether I will need chemo or not. Clinical pathology from biopsy says er low, pr negative her2 negative, grade 3. Seeing low er+ and grade 3 has me thinking chemo is probably in my future??? Surgery is in one week.
Those two features are ones that often do prompt a recommendation for chemotherapy, you are right. It is possible that a tumor such as this could be sent for a genomic assay (for example, the 21-gene assay, to see if there is benefit from chemotherapy. The results of those tests do usually indicate that chemotherapy is helpful in an ER-low, grade 3 tumor. Other features that contribute to decisions about chemotherapy are tumor size and lymph node status. Come back and let us know how you're doing.
@yerbba surgery was one week ago. 6mm tumor, clear margins, 4 lymph nodes removed, all negative. Was excited at the good news and they are/were sending out for oncotype dx. Now two days ago there was an addendum to the pathology. They retested for hormones and her2. Came back zero percent estrogen instead of the weak positive that the original biopsy showed. Of course, now i am kind of freaking out as this now says tumor is TNBC. I saw this addendum on mychart but haven't spoken to oncologist yet. I don't know if they will bother sending out for oncotype since now it says no er+. I guess there will be no aromatase inhibitor either, and I am guessing a longer, tougher chemo?? I am just shocked and concerned about this turn of events. Oncology appointment isn't until Friday 9/8
@@judybee6698hi! I hope you are well and coping well with the situation. I wish you a quick recovery.
Hello Dr thank you for all the information. My pathology report says ER 5% PR 95% HER 2 . Could this be an error? My oncologist appointment is on sep 27.
It is worth asking your medical team their thoughts about this report, but having such a report is not implausible. Thank you for watching.
Is estrogen low positive more likely to be HER2 positive?
Not necessarily, no.
Hi Mam if allred score is er 4 and pr 3, focal weak positive. Then is it considered low in hormone receptor in this case is letrozole useful
People with an ER score of 4 are likely to be offered endocrine therapy because there is very likely to be some benefit.
Dear Doc, I am 36 years old and ER 3/8, PR - and hr2+. Considering the outcomes of endocrine therapy, can I opt out in the first place itself? Thank you.
It's common to be hesitant about starting any new treatment, and there is a lot of discouraging information about endocrine therapy. Many people find it helpful to the medication for 3 months to see how they tolerate it.
@@yerbba Thank you, this makes sense. Different people react differently and there is never a same size which fits all. I really want to thank you for the tremendous job you are doing.
Er negative pr(11 20%)her2 neu negative...stage 2a....mam patients complete curable?🙏🙏
The goal of treatment most definitely is cure. Wishing you the best.
I was told I have a low ER positive breast cancer 5% pr- her2- so far no lymph nodes involved.possibly stagd 2-3. Surgery in 10 days. It will go back to pathology after surgery. What are the chances the pathology can change to regular pr+ or could this possibly be a tnbc? Hoping chemo isn't in my future.
Really good questions. This is a low level of both the estrogen and progesterone receptor but not technically PR-negative. It is likely, however, that a genomic assay would show a reasonable benefit of chemotherapy (just speaking in terms of probabilities). If this is stage III (3) disease, chemotherapy is typically offered. Wishing you the best. Keep coming back.