Assuming you want to try it, here are three of my recommendations: Highest quality, liquid form*: amzn.to/3lvhN5W Cheaper, Good quality, Pill form*: amzn.to/3JXK7qX Vegan friendly*: amzn.to/408SXI9 *This product is independently lab tested to ensure the amount listed is correct (and is free of heavy metals); this is also an affiliate link, but I have no relationship with any of these brands.
Ginkgo Biloba was perfectly pronounced. Please also take into account that sunflower oil is extremely rich in Omega-6 acids - since Omega-3 and Omega-6 use the same converter, that sunflower oil will actually have a negative impact compared to someone not taking any sunflower oil. The ratio of Omega-6 to -3 in sunflower oil is 126:1, so the intake of sunflower oil literally floods the body with Onega-6 acids, so that the intake of an Omega-3 capsule hardly stands any chance against the massive amount of Omega-6 to get through that needle eye and be converted - the sheer amount of Omega-6 just blocks it. So it is sad to say, but the set up of that study was less than ideal.
This may worth further investigation: Some treatments only work in combination like piperine and cucurmine. Seems to be the same with Omega 3. I found this after a search on chatGPT as I forget where I first saw it: According to 1, alleviating cognitive decline with omega-3s may only occur with adequate B vitamin levels. Vitamins B 6, B 9, and B 12 break down the amino acid homocysteine, allowing for omega-3s to be incorporated into the membranes of brain cells. As we age, our brains progressively atrophy (deteriorate, shrink, degenerate), leading to cognitive decline. According to 2, researchers publishing in the European Journal of Nutrition have discovered that a combination of B vitamins and the omega-3 fatty acid DHA is linked to decreased cognitive decline in older individuals. A different post-hoc study showed that a combination of low homocysteine, an amino acid that is broken down by B vitamins, and omega-3 supplementation is associated with reduced cognitive decline.
Do you think men and women should get different ratios of EPA and DHA? There is a brand that supposedly flips the ratios for men from one to the other, a serving providing about 2.2 grams of DHA and .9 grams EPA. The brand you listed has about 1.5 EPA per 1 DHA.
Yes I’m no doctor or expert but I’ve watched many channels, read many books, articles, studies, listened to many podcasts and lectures and also have experimented on myself for the past 5 years and this by far is the best channel I’ve seen. Definitely much appreciated. I’m finding some of the best things in life being free cliche to be true in cases like this. All I have to pay is attention. 👀
A million viewers? That would be nice, however, the average person who would love to know the results of these experiments is missing the educational background that would make it very easy for them to listen to the complex information provided, not to mention the time needed. What I believe is really being presented here is a fine lay education in the methodology used in these kind of experiments, as well as how to read the data. The believable results are the reward for slogging thru the methodology and data. This old once-a-vegan will continue eating a can of sardines twice a week, yes, for the protein, but mostly for a natural source of B12 and the EPA/DHA omega 3s. BTW, that practice makes me a Flexitarian, which, statistically, is a group that lives the longest. I am betting that also includes the longest healthy life even as I have found no proof of such.
The red flag in Study 124 for me was seeing pre study Omega 3 index being a healthy nearly 7.5-8%. That’s surprisingly high and sure enough, the subjects are in Germany and I suspect have a significant amount of fatty fish in their regular diet. Typical in the US is 5% (Vegans can be as low as 3%). So my expectation is that going from a healthy about 8% to a healthy 10% for healthy adults in this age group would at best show only a small improvement. And that’s what you see. It would be more interesting if the group had started with a poorer diet like in the US and around 5%. The second study in the UK started with a lower percentage more typical of a omega-3 poor diet. As for study 125, supplementing with DHA-rich fish oil capsules, with what we know, it’s not surprising it didn’t help. My recollection is EPA can be converted to DHA but not the other way. So you are starting with an EPA poor diet and it remains an EPA poor diet during the study. Perhaps not surprising no cognitive benefits are seen. Still in general cognitive testing as a whole should be viewed with skepticism as well they really measure cognition. Didn’t look at the other papers, had already reviewed the literature before seeing this video. Interesting what grad students are doing to monetize science. All this is fun detail, but really just fatty fish twice a week and if not so in to eating fish just have a couple tsps a day of omega-3 enriched fish oil paying more attention to getting 2-3 g of EPA and call it a day.
I don't believe Craig's comment is accurate. The German does not consume much seafood, rather the traditional diet is meat-heavy; most of the country is inland. They do, like many other European countries, consume higher quality, less processed and less sugar-added food, compared to the Americans. They also consume quite a bit of sauerkraut, aka fermented cabbage which shows benefits to promote gut health. So is kimchi.
56:23 i think its pretty clear the response times all improved about 10%. That individually they don't test significant is no surprise given the small sample size, but the trend is clear
Most of these studies in the meta-analysis didn't last more than a few months I assume, would there be theoretical reasons to expect a cumulative effect over many years, like say 20 years? What do long term epistemiological studies show? For instance the Mediterranean diet, which is high in omega-3s, has been shown in some studies to delay mental decline.
I noticed that a problem with fish oil studies in that oils go rancid, sometimes rapidly and, I'm guessing here, perhaps simply by not storing in a fridge or freezer by the study participants. Thus long term studies would show, at best, an initial positive effect and no long term effect. As an omega fatty acid degrades over time, it's easily assumed that its potency declines as well. Did anybody control for this by: Duplicating the storage environment(s) and test the pill contents at least weekly. Supply fresh pills ~weekly. Otherwise, failure to control for oil degradation is what's actually being tested.
One of the potential causes of difference in outcomes can be the different antioxidants used to preserve Omega 3s (asthaxanthin, rosemary extract, vit E...). These are, for sure, not neutral.
What people tend to forget is that while omega 3 may be beneficial in principle, the fact that there are many supplements that come from ( farmed) fish full of heave metals, antibiotics and other medication and with capsules that don’t keep air out well so that the oil becomes oxidated. Makes you wonder if it’s even a good idea to take this supplement in the first place. I’m currently eating caught fish 2-3 times a week and I take a high quality algae based supplement on the other days.
Thanks, Dan. I appreciate the kind words. Funnily, I've received that comment many times, but 9 years later, the million subscriber mark evades me (by about 970,000, haha!). Still, I appreciate people like you speaking up - thank you.
Cool video, thank you for it! A few things from my point of view, the placebo is usually sunflower oil that has 2.4g of omega 6 in 4g, i think that could influence things a bit. Also maybe just like fasting has been shown to normalize some parameters in individuals but does nothing to healthy people, i think that omega 3 does the same with people that really need it. Bill Harris has a ton of information on this and, from my point of view, if you'd get a study for people with omega 3 index of 3% that is the average in USA, to the optimal 10% then you'd see a lot of improvement, but most people there probably have health issues. My main concern however with studies like this is that in nature, omega 3 doesnt come alone so we don't really know what effect the other nutrients have, maybe omega 3 needs something else to get in the brain and really affect cognition. I'd much rather see a study with 4-5 g of omega 3 from real food and see if it improves biomarkers and mental health. Granted it's hard to have a placebo group but i bet smart people could find a way. Also an underrated omega 3 source is beef/pork brain and it has tons of choline too.
Thanks, Sabin. I agree on your criticism of the placebo. It would have been better to look at something more inert. That said, we can control for changes by using a statistical analysis on the placebo measures. Additionally, not all the studies used sunflower - it was a minority, so if we group the studies together, that minority gets drowned out by the larger data set. I actually looked at omega-3 index, but left that in my Insider's version. You're right - it is possible there may be something else that could help omega-3's enter the brain - I'd be interested to learn some of those mechanisms. Although, it would be easy (although invasive) to test. The cerebrospinal fluid could be measured for serum omega-3 to determine if there is a brain absorption disparity.
@@Physionic I think i remember something about ApoE 4 that has big problems with omega 3s to get in the brain even though blood values are good, so might be something related to insulin i think. My theory is that ketosis is really important for omega 3s but i have no proof of that :)) ruclips.net/video/-f-CFQxaUY4/видео.html Pretty sure you know about this interview but in case you don't know, the guy seems to know what he talks about "Dr. Bill Harris is the author of more than 300 scientific papers on fatty acids and health. He is a professor in the Department of Medicine in the Samford School of Medicine at the University of South Dakota, the co-inventor of the Omega-3 Index, founder of OmegaQuant Analytics, and president and founder of the Fatty Acid Research Institute. " He has studies with 25g of omega 3s from salmon oil and it showed some benefit to healthy people but not that much, but when given to people with high triglycerides/ldl seems to have really big benefit. Also seems to benefit LPS induced inflammation , so who knows how it interacts with the microbiome too. So many questions, so little good studies 😄
Reverse engineering these studies and finding the people who were the most improved, then finding what they had in common would be a way to figure out what was going on. If most participants were lacking in multiple nutrients supplying just one shouldn't be expected to do much. Or if they were eating diets that were pro-dementia producing, which we might expect since they were in decline, would be a tug of war against anything positive. The way medical studies are designed is bizarre. Some people improved but let's just ignore them and move on to another study.
You do a great job! One thing I wondered was that I don’t remember them telling how much omega-3 people were given. What if omega 3 does help, but only at higher doses?
There is a fish oil paradox in cardiology where a small dose helps but a large dose increases risk. Omega-3s can reduce inflammation, but like Omega-6, they are easily oxidized and glycosylated meaning that they can transport oxidative and glycosylatative damage to cell membranes. There has never been demonstrated a health benefit with more than about 4 grams Omega-3 per day.
Here's a random thought as I rewatch this. I might be in the complete minority of one here, but firstly I see your analysis as everyone else likely does, quite incredibly detailed and objective. Invaluable. Top quality work. Now to my minority of one thought. I really really would like to get all my nutrition from actual food. So my current approach to omega-3 nutrients, is to eat wild caught frozen salmon that I cook obviously. Fish starts to rot the moment the fish dies, and out of water it's quite a rapid process. Frozen at the source is the only way to go in my opinion. I also eat canned sardines, and herring. Is this the best, most pragmatic approach for someone who wants to eat a truckload of omega-3 fatty acids? Is there a better way? Every time I see you come to a positive, high confidence, conclusion about one nutrient group or another, my first thought is, how do I eat this? Our seas are getting polluted. Our soil is stripped of it's minerals and diverse organic material. Farmers spray by the metric shit ton, NPK on the growables, leaving out the myriad dozens of other things that nature normally supplies. The NPK dominance leaves the crops weak, so they require massive amount herbicides and pesticides to allow them to come to fruition. Our livestock eats these products, the soy, the corn, the wheat, or the byproducts of these things more often, and all this stuff is deficient, so the animals are deficient, they get injections of all kinds, ammendments to their feed, and they're selectively bred to come to maturity in a fraction of the time nature intended. Grass fed is modestly better. But wild-land foraging animals are astoundingly better than the best commercial grass fed. This has been shown anecdotally by farmers who have open land, and allow their non-commercial cows to free roam. The meat that is harvested for the family, some of it has been tested, an the omega-3 to omega-6 ratio is marvelously superior to the best 100% organic grass fed and grass finished commercial beef. It's more on par and competitive with wild caught fatty fish in near pristine waters.... some day, these types of food sources will be more prized and valued then we can imagine....
There is a fish oil paradox in cardiology where a small dose helps but a large dose increases risk. Omega-3s can reduce inflammation, but like Omega-6, they are easily oxidized and glycosylated meaning that they can transport oxidative and glycosylatative damage to cell membranes. There has never been demonstrated a health benefit with more than about 4 grams Omega-3 per day.
@@kenadams5504 It would not be excessive. You could have 1 serving of salmon every day. If it's wild, it would be just over 2 grams of Omega-3. I knew some health and fitness experts promoting 15+ grams of omega-3 per day. One recently died of a heart attack.
Great in-depth analysis! Yah I would agree Omega-3 has some mild benefits especially on an anti-inflammatory front, though I wouldn't rely on it for large memory effects. I take it mainly to decrease triglcyerides and some anti-inflammatory effects, though not too much, because it can increase your LDL's especially in those who already have dyslipidemia.
@@firpofutbol The popular 2 hour podcasts are from my observation either informal and comedic and/or rely on quality guests or famous/semi famous host. Its not really a matter of being succinct or not IMO. Its really just that most people would watch a 10 minute video or shorter to understand something and for a channel to blow up on youtube, its typically around this time length. Podcast are a different story, sure many can blow up right from the start (but thats usually from exposure on bigger channels and what not) but most more academic or scientific focused are built over years of quality content. But IDK things just happen sometimes regardless of what I think or project - maybe this channel will blow up but I have my doubts do to a few factors - length being a major reason but lack of excitement and building interest probably being a part to - like selling why this or that is important or demonstrating more excitement, shock, emotion. It comes off as dry info for the most part and that doesnt typically sell/blow up especially at longer lengths.
@aaronlatif52 I feel the same way about the Andrew Huberman podcast, which are often 2+ hrs long. Way too long for me so Physionic's feels like it covers enough detail without the wasted conversation that comes in other formats. As a nurse, having taken anatomy and physiology, I find the content fascinating because I understand the context. Although I don't share your view of the content feeling dry in Physionic, I know what you mean because I find Huberman to be extremely dry and hard to listen to. It's all subjective. Personally I've been hooked on this channel since I discovered it.
Ginkgo Biloba was perfectly pronounced. Please also take into account that sunflower oil is extremely rich in Omega-6 acids - since Omega-3 and Omega-6 use the same converter, that sunflower oil will actually have a negative impact compared to someone not taking any sunflower oil. The ratio of Omega-6 to -3 in sunflower oil is 126:1, so the intake of sunflower oil literally floods the body with Onega-6 acids, so that the intake of an Omega-3 capsule hardly stands any chance against the massive amount of Omega-6 to get through that needle eye and be converted - the sheer amount of Omega-6 just blocks it. So it is sad to say, but the set up of that study was less than ideal.
Wasnt the sunflower oil given to the controll group and not the test group. The test group was only taking omega 3 capsules and no sunflower oil. So there is no worry to omega 3 intake in the test group.
Re: Liquid oil recommendation--Nordic Naturals also sells an identical product for less than half the price of the Ultimate Omega you recommend. The cheaper one is somewhat more than half the strength of the Ultimate bottle--so "Regular" at 1560mg/tsp for $22.06 versus Ultimate 2840mg/tsp for $61.16 --both in 8oz bottles. Thus you can spend $44.12 on two bottles and get more EPA/DHA from the same producer than if you spend $61.16. Have I missed something here?
You would not expect big strenght gains just from upping your protein intake alone (unless someone starts REALLY low), but it does not mean protein is of little value in strenght training.
Some treatments only work in combination like piperine and cucurmine. Seems to be the same with Omega 3. I found this after a search on chatGPT as I forget where I first saw it: According to 1, alleviating cognitive decline with omega-3s may only occur with adequate B vitamin levels. Vitamins B 6, B 9, and B 12 break down the amino acid homocysteine, allowing for omega-3s to be incorporated into the membranes of brain cells. As we age, our brains progressively atrophy (deteriorate, shrink, degenerate), leading to cognitive decline. According to 2, researchers publishing in the European Journal of Nutrition have discovered that a combination of B vitamins and the omega-3 fatty acid DHA is linked to decreased cognitive decline in older individuals. A different post-hoc study showed that a combination of low homocysteine, an amino acid that is broken down by B vitamins, and omega-3 supplementation is associated with reduced cognitive decline.
I seem to remember a lecture about some Omega 3 studies and an incidental finding was that the ppl that were found to be helped by Omega 3 all had lower cysteine levels. Anyone here remember something like that? Also saw phosphotidylcholine did better than phosphotidylserine. Any input appreciated.
As a neurologist, I must say there is no supplements recomendations in any medical guidelines regarding to mild cognitive impairment or dementia, neither by the european nor american societies. Phospholipids like Danone's "Souvenaid" have the same possible "mild" benefits but aren't in those guidelides too.
Also you don't see much experts defending the use of these supplements basing on their clinical experience/empirical results, for exemple in neurology congresses. It's like the community do not believe in any significant benefit, the focus being on monoclonal antibodies or more "agressive" approaches, let say
I have heard there is a 20 year between the research and the practical implementation. Some treatments only work in combination like piperine and cucurmine. Seems to be the same with Omega 3. I found this after a search on chatGPT as I forget where I first saw it: According to 1, alleviating cognitive decline with omega-3s may only occur with adequate B vitamin levels. Vitamins B 6, B 9, and B 12 break down the amino acid homocysteine, allowing for omega-3s to be incorporated into the membranes of brain cells. As we age, our brains progressively atrophy (deteriorate, shrink, degenerate), leading to cognitive decline. According to 2, researchers publishing in the European Journal of Nutrition have discovered that a combination of B vitamins and the omega-3 fatty acid DHA is linked to decreased cognitive decline in older individuals. A different post-hoc study showed that a combination of low homocysteine, an amino acid that is broken down by B vitamins, and omega-3 supplementation is associated with reduced cognitive decline.
I seem to remember a lecture about some Omega 3 studies and an incidental finding was that the ppl that were found to be helped by Omega 3 all had lower cysteine levels. Anyone here remember something like that? Also saw phosphotidylcholine did better than phosphotidylserine. Any input appreciated.
Can’t explain it, but omega-3’s seemingly cause brain fog in my case. Don’t know ! Perhaps I was taking too much. The ratios of EPA and DHA were correct with l negligible amounts of omega-6. Also don’t use any seed oils. I can’t remember exactly where, but have read that while this isn’t common, it isn’t exactly rare. Stoped all supplements of it and now just consume a tin of sardines. Seems to have helped and hopefully I’m getting a good amount of omegas. Have any of you experienced this as well ?
Thank you Nicholas for the effort you made for this content. Been taking Fish Oil / Krill Oil for quiet a while , yet I don’t really know if It benefits me. After watching this video I only have to finish the 2 bottles I purchased that’s it. Thanks again.
It seems like when other people reference this study and compared it to others there was a problem with the control using sunflower oil since it's so high in omega-6. And if I remember correctly there was a similar study that you something different and had a completely different result.
for some reason, I get headaches from omega 3 fish oil capsules, but not from vegetarian sources.. This even happens with Cod liver oil. My hypothesis was that my low anti-oxidant status due to my G6PD lowers my ability to process the reactive oxygen species from the digestion of these fats. I'd be interested in getting your opinion on this. as usual, keep up the good work.
I get these as well! It took me a while to pin point that the headaches were related to fish oil caps. I always wondered why this happened but never worked it out.
sometimes if the gallbladder is backed up you can get headaches. Maybe try taking Bile Salts, in particular TUDCA could help to breakdown the fats. I could be wrong but worth a try.
I am more interested to know if fish oil helps with reducing unhealthy fat storage and maintaining a leaner physique. That’s why I have been taking it. To “balance out” the omega 6s I get from the rest of my diet. It would be nice to know if that’s a real thing or just something people on RUclips say.
i tried taking fish oil pills (1000mg twice per day as per instructions) I did it without supervision though. I was also taking multivitamins/minerals as well. However after the first two days I started bleeding from my nose randomly or after sneezing this happened for three days straight which was obviously scary af so i just stopped it all together lol. i am however on the obese side (35 bmi) currently and im a heavy smoker, im sure somehow these things play in.
Thanks, that was a mouthfull. Sad to understand that the wffect was only midl, I think omega 3 has been praised a bit to highly in media for some time. Was hoping for more protection against dementia and such sinc it runs in my family. Thanks anyway.
Was wondering if all these studies used omega-3 capsules or did you just take those who used fish oil from Norway (say) coming from a top vendor? Are they same? Some believe the encapsulated omega oil is junk i.e. gone rancid.
Capsules. The capsules are measured for quality, so they're pristine condition. Plus, they measure blood omega-3 levels to determine absorption - all studies showed increased blood omega-3.
My children turned out gifted I attribute this to outside a lot……vit D. I would have added omega 3 especially in cheap sardines during pregnancy. Good idea to marry the smartest man you can find.
someone looked at whether oils in 'health' supplements were rancid or oxidized, and all of the samples were. I'll get my Omega-3s as real food. no need to add inflammation.
I would imagine it helps in the same way protein powder will help with muscle gain - you do not expect it to do the lifting for you, but it helps by providing building blocks. Maybe if you are really deficient, you can get some gains just from taking it, but nothing drastic - which doesn't mean it's all useless.
maybe a long vid like on resveratrol would be cool the science seems pretty mixed and also very much depending on the dosage 🤔 would probably be a hard endevour for 1 vid tho 😂make it 5 hours long and call it THE COMPLETE GUIDE TO RESVERATROL (or so) to get like 500k views in a year to make the effort worth it 😎
Thanks for the vid. It would be nice if population was shown not deficient in plant food and if the both group had few grams of omega 3(ALA) in the diet then test DHA/EPA pills. to really dissociate marine oil (algae/fish) from omega 3 in general. Overall allmost no study found significancy and idk how well how p-hacking was controlled for but given the industry bias it is not reassuring. The funnel plot show quite a publication bias. You were quite fast on that end part of your vid when it is precisely these few seconds that would deserve an hour for us to understand better your conclusion. Your conclusion was more or less what I already believed though the term "omega 3" need to further clarification (long chain and short chain etc).
I would really push back on your publication bias point. There's literally nothing else to say on the topic. Additionally, only 3 or so studies were identified as having potential bias - I'm not sure what else I could have said on that front. Plus, keep in mind, even if I had an hour's worth to say on publication bias (which I absolutely didn't - it's pretty cut and dry) - I doubt 99.9% of people want to hear me drone on about a topic they have zero interest in. I covered all the major points and moved on.
@@Physionic as you said 1:31:45 there is most likely some publication bias. 3 studies were eliminated because thought to have potential bias but that are only the most obvious ones the funnel plot indicate that probably other studies has been eliminated (showing negatives) even before the meta-analysis, that probably skewed the data. the things to say was not so much in those 3 studies but maybe a bit, there is the somewhat counter-intuitive fact that once removal of some publication bias the hedges'g increase for memory, the thing you said about p-value, maybe p-hacking etc. overall I agree with you I was a bit greedy indeed, my statement of an hour was hyperbolic as I felt the most interesting things to me started here so it was totally not a critic just my greed talking. I obviously totally get you not having the time for that and I'm alrealy thankfull for the point you have covered.
algae EPA/DHA is best (cost cents too, many brands or real seaweed food). Bivalves are vegans friendly but not as healthy( it is still animal food so same habitual deadly flaws) . I personnaly found EPA/DHA useless though. Long chain omega 3 might has its risk too so some choose to avoid it and that's okay (a useless hassle if seaweed are part of your previous habits), everyone is able to elongate ALA enough to get the long chain (which is in the order of mg unlike ALA in grams) in different degree. ALA as other benefit too.
I would disagree. All the independent lab testing results I've seen have shown algae fish oil to be extremely under dosed. Those that were more highly dosed had other issues, like not containing the amount marketed. So, that may be why you haven't experienced benefits, but that's speculation on my part.
@@Physionic thank you for your answer. you disagree with what? it is a bit fuzzy but as it seems like you are just disagreeing with my personal/anecdotal habit of me founding useless to take these pills (not with higher claims like the existence of algae pills etc) and that is fine but I am not sure of what to say. though when you said that fish oil were extremely underdosed in lab test you kind of goes my way... I do not take fish oil as it is not ethical. Not just because of problems regarding the business of fish oil on health (like dosage or rancification hiding with flavor, pollutant control etc). But, to be clear, the same fatty acid in algae pills are ethical and I still do not take them either. Also benefits is not something one person "experiment" that is anecdotal fallacy. am I supposed to do a pool of memory test and just to witness some benefit and then attribut it to this new pill (and also artbitrarly attribute any downside to it). whether or not long chain omega 3 as some degree of possible health benefit it can still be deem useless for someone to integrate this new habit into his life (many little things are healthy to do to in various degree).
Gotcha - I was disagreeing with algae EPA/DHA being the best. To your second point, I agree - it's tough to test on yourself, but considering you mentioned you were able to tell if made no difference, I figured you'd be able to test it again in a similar fashion to the first time.
@@Physionic I guess you found algae equal to fish oil then But Algae being the best has more to do with other science than your subfield of biology obviously, though even when it come to fitness there is some argument to be made for algae but if quality (pollutant control etc) is there, it is indeed mostly same despite the sources of fish oil being objectively disgustingly dirty/shady and unethical. One is able to tell if a thing made a difference or not with the litterature as anecdotaly there is many bias (though it can have its wheight indeed if one has specific scientifically related problems and his followed by a physician etc but I am fine) and looking at how a new habit fit into his lifestyle etc and calculating cost/benefit overall. So your suggestion if people feel that marine oil does not have any effect, is too increase the dosage, that can be dangerous at some point but I can see your point indeed despite the litterature showing that healthy people will be unlikely be able to see the benefit if/when there would be one.
Learn how to make points . Long talk is boring. Human attention at best is 20 minutes. Good topics but who is your listeners? The observer in Quantum physics , listeners in physionic.
Then it would have been a different kind of channel. People read books and we see an increasing popularity of long form content (podcasts)? I love this channel because I get to follow the train of thought. If shorter is better you might consider TikTok.
Your attention span maybe 20 minutes and this is commonly the case based on lifestyle and diet and personal mindfulness practices. The healthier I am, the longer my attention span. I absolutely love the depth of this guy's work. If you want to takeaways, join his Insider community and support the guy financially to get the synthesized bullet point information from his massive amount of content on Research publication analysis
![Experts are wrong about Calories. [Science Explained]](http://i.ytimg.com/vi/wKEP_Z6u-L0/mqdefault.jpg)
![Experts are wrong about Calories. [Science Explained]](/img/tr.png)
Assuming you want to try it, here are three of my recommendations:
Highest quality, liquid form*: amzn.to/3lvhN5W
Cheaper, Good quality, Pill form*: amzn.to/3JXK7qX
Vegan friendly*: amzn.to/408SXI9
*This product is independently lab tested to ensure the amount listed is correct (and is free of heavy metals); this is also an affiliate link, but I have no relationship with any of these brands.
do you know of this brand? is it any good?
Higher quality and fresh enough, only in Norway. You won't get it here.
Ginkgo Biloba was perfectly pronounced. Please also take into account that sunflower oil is extremely rich in Omega-6 acids - since Omega-3 and Omega-6 use the same converter, that sunflower oil will actually have a negative impact compared to someone not taking any sunflower oil. The ratio of Omega-6 to -3 in sunflower oil is 126:1, so the intake of sunflower oil literally floods the body with Onega-6 acids, so that the intake of an Omega-3 capsule hardly stands any chance against the massive amount of Omega-6 to get through that needle eye and be converted - the sheer amount of Omega-6 just blocks it. So it is sad to say, but the set up of that study was less than ideal.
This may worth further investigation: Some treatments only work in combination like piperine and cucurmine. Seems to be the same with Omega 3. I found this after a search on chatGPT as I forget where I first saw it: According to 1, alleviating cognitive decline with omega-3s may only occur with adequate B vitamin levels. Vitamins B 6, B 9, and B 12 break down the amino acid homocysteine, allowing for omega-3s to be incorporated into the membranes of brain cells. As we age, our brains progressively atrophy (deteriorate, shrink, degenerate), leading to cognitive decline.
According to 2, researchers publishing in the European Journal of Nutrition have discovered that a combination of B vitamins and the omega-3 fatty acid DHA is linked to decreased cognitive decline in older individuals. A different post-hoc study showed that a combination of low homocysteine, an amino acid that is broken down by B vitamins, and omega-3 supplementation is associated with reduced cognitive decline.
Do you think men and women should get different ratios of EPA and DHA? There is a brand that supposedly flips the ratios for men from one to the other, a serving providing about 2.2 grams of DHA and .9 grams EPA. The brand you listed has about 1.5 EPA per 1 DHA.
This has more value than a paid course . Thank you nic
Thanks!!
Yes I’m no doctor or expert but I’ve watched many channels, read many books, articles, studies, listened to many podcasts and lectures and also have experimented on myself for the past 5 years and this by far is the best channel I’ve seen. Definitely much appreciated. I’m finding some of the best things in life being free cliche to be true in cases like this. All I have to pay is attention. 👀
I can't believe this channel doesn't reach a bigger viewership. Amazing content as usual. Thanks Nicholas.
It will grow
I know--right! However, people are generally lazy... unfortunately.
Thanks, get to the practical points from these studies to improve health. Too long , it is for students not for hard working people wants to learn
A million viewers? That would be nice, however, the average person who would love to know the results of these experiments is missing the educational background that would make it very easy for them to listen to the complex information provided, not to mention the time needed. What I believe is really being presented here is a fine lay education in the methodology used in these kind of experiments, as well as how to read the data. The believable results are the reward for slogging thru the methodology and data. This old once-a-vegan will continue eating a can of sardines twice a week, yes, for the protein, but mostly for a natural source of B12 and the EPA/DHA omega 3s. BTW, that practice makes me a Flexitarian, which, statistically, is a group that lives the longest. I am betting that also includes the longest healthy life even as I have found no proof of such.
It if far too nuance for most people.
The red flag in Study 124 for me was seeing pre study Omega 3 index being a healthy nearly 7.5-8%. That’s surprisingly high and sure enough, the subjects are in Germany and I suspect have a significant amount of fatty fish in their regular diet. Typical in the US is 5% (Vegans can be as low as 3%). So my expectation is that going from a healthy about 8% to a healthy 10% for healthy adults in this age group would at best show only a small improvement. And that’s what you see. It would be more interesting if the group had started with a poorer diet like in the US and around 5%. The second study in the UK started with a lower percentage more typical of a omega-3 poor diet. As for study 125, supplementing with DHA-rich fish oil capsules, with what we know, it’s not surprising it didn’t help. My recollection is EPA can be converted to DHA but not the other way. So you are starting with an EPA poor diet and it remains an EPA poor diet during the study. Perhaps not surprising no cognitive benefits are seen. Still in general cognitive testing as a whole should be viewed with skepticism as well they really measure cognition. Didn’t look at the other papers, had already reviewed the literature before seeing this video. Interesting what grad students are doing to monetize science. All this is fun detail, but really just fatty fish twice a week and if not so in to eating fish just have a couple tsps a day of omega-3 enriched fish oil paying more attention to getting 2-3 g of EPA and call it a day.
Great point about Study 124, Craig. I do think the DHA supplementation is appropriate, however, for the reason I mentioned in the mechanism section.
I don't think Germans eat a lot of fatty fish in general. I would even say most Germans eat fish less than 1 time per week.
I don't believe Craig's comment is accurate. The German does not consume much seafood, rather the traditional diet is meat-heavy; most of the country is inland. They do, like many other European countries, consume higher quality, less processed and less sugar-added food, compared to the Americans. They also consume quite a bit of sauerkraut, aka fermented cabbage which shows benefits to promote gut health. So is kimchi.
56:23 i think its pretty clear the response times all improved about 10%. That individually they don't test significant is no surprise given the small sample size, but the trend is clear
Most of these studies in the meta-analysis didn't last more than a few months I assume, would there be theoretical reasons to expect a cumulative effect over many years, like say 20 years? What do long term epistemiological studies show? For instance the Mediterranean diet, which is high in omega-3s, has been shown in some studies to delay mental decline.
I noticed that a problem with fish oil studies in that oils go rancid, sometimes rapidly and, I'm guessing here, perhaps simply by not storing in a fridge or freezer by the study participants.
Thus long term studies would show, at best, an initial positive effect and no long term effect.
As an omega fatty acid degrades over time, it's easily assumed that its potency declines as well.
Did anybody control for this by:
Duplicating the storage environment(s) and test the pill contents at least weekly.
Supply fresh pills ~weekly.
Otherwise, failure to control for oil degradation is what's actually being tested.
Someone should setup an industry standard when using omega 3 oils in studies.
For example, all oils to be refrigerated.
You should do a deep dive on cerebrolysin, it a bunch of growth factors from pig brain that is used for strokes and TBIs in many countries
Never heard of it, sounds really interesting, Calcium - thanks.
Thank you for sharing so much knowledge!
Thanks!
Thank you, slack!
One of the potential causes of difference in outcomes can be the different antioxidants used to preserve Omega 3s (asthaxanthin, rosemary extract, vit E...). These are, for sure, not neutral.
What people tend to forget is that while omega 3 may be beneficial in principle, the fact that there are many supplements that come from ( farmed) fish full of heave metals, antibiotics and other medication and with capsules that don’t keep air out well so that the oil becomes oxidated. Makes you wonder if it’s even a good idea to take this supplement in the first place. I’m currently eating caught fish 2-3 times a week and I take a high quality algae based supplement on the other days.
Your videos are awesome. I love this type of content, man. Your channel is going to get huge, a million subscribers easy.
Thanks, Dan. I appreciate the kind words. Funnily, I've received that comment many times, but 9 years later, the million subscriber mark evades me (by about 970,000, haha!). Still, I appreciate people like you speaking up - thank you.
@@PhysionicIf you were to share your wisdom on podcasts, like mine, it would speed up the process :)
@@Physionic It will happen, Nick.
Cool video, thank you for it!
A few things from my point of view, the placebo is usually sunflower oil that has 2.4g of omega 6 in 4g, i think that could influence things a bit.
Also maybe just like fasting has been shown to normalize some parameters in individuals but does nothing to healthy people, i think that omega 3 does the same with people that really need it. Bill Harris has a ton of information on this and, from my point of view, if you'd get a study for people with omega 3 index of 3% that is the average in USA, to the optimal 10% then you'd see a lot of improvement, but most people there probably have health issues.
My main concern however with studies like this is that in nature, omega 3 doesnt come alone so we don't really know what effect the other nutrients have, maybe omega 3 needs something else to get in the brain and really affect cognition. I'd much rather see a study with 4-5 g of omega 3 from real food and see if it improves biomarkers and mental health. Granted it's hard to have a placebo group but i bet smart people could find a way.
Also an underrated omega 3 source is beef/pork brain and it has tons of choline too.
Thanks, Sabin. I agree on your criticism of the placebo. It would have been better to look at something more inert. That said, we can control for changes by using a statistical analysis on the placebo measures. Additionally, not all the studies used sunflower - it was a minority, so if we group the studies together, that minority gets drowned out by the larger data set. I actually looked at omega-3 index, but left that in my Insider's version. You're right - it is possible there may be something else that could help omega-3's enter the brain - I'd be interested to learn some of those mechanisms. Although, it would be easy (although invasive) to test. The cerebrospinal fluid could be measured for serum omega-3 to determine if there is a brain absorption disparity.
@@Physionic I think i remember something about ApoE 4 that has big problems with omega 3s to get in the brain even though blood values are good, so might be something related to insulin i think. My theory is that ketosis is really important for omega 3s but i have no proof of that :))
ruclips.net/video/-f-CFQxaUY4/видео.html
Pretty sure you know about this interview but in case you don't know, the guy seems to know what he talks about
"Dr. Bill Harris is the author of more than 300 scientific papers on fatty acids and health. He is a professor in the Department of Medicine in the Samford School of Medicine at the University of South Dakota, the co-inventor of the Omega-3 Index, founder of OmegaQuant Analytics, and president and founder of the Fatty Acid Research Institute. "
He has studies with 25g of omega 3s from salmon oil and it showed some benefit to healthy people but not that much, but when given to people with high triglycerides/ldl seems to have really big benefit.
Also seems to benefit LPS induced inflammation , so who knows how it interacts with the microbiome too. So many questions, so little good studies 😄
APOE was looked at in several of the studies - no effects found, but that may be underpowered.
I've seen some of it. I'd need to go through it again.
Reverse engineering these studies and finding the people who were the most improved, then finding what they had in common would be a way to figure out what was going on.
If most participants were lacking in multiple nutrients supplying just one shouldn't be expected to do much.
Or if they were eating diets that were pro-dementia producing, which we might expect since they were in decline, would be a tug of war against anything positive.
The way medical studies are designed is bizarre.
Some people improved but let's just ignore them and move on to another study.
It would be most interesting to follow patients over a few years and see if there is a change in rate of decline.
Most important health information - excellent presentation. Much thanks, I cannot express more gratitude.
Thank you!
You do a great job! One thing I wondered was that I don’t remember them telling how much omega-3 people were given. What if omega 3 does help, but only at higher doses?
There is a fish oil paradox in cardiology where a small dose helps but a large dose increases risk. Omega-3s can reduce inflammation, but like Omega-6, they are easily oxidized and glycosylated meaning that they can transport oxidative and glycosylatative damage to cell membranes. There has never been demonstrated a health benefit with more than about 4 grams Omega-3 per day.
@@mertonhirsch4734 The large dose increases risks in those with pre-existing issues
Here's a random thought as I rewatch this. I might be in the complete minority of one here, but firstly I see your analysis as everyone else likely does, quite incredibly detailed and objective. Invaluable. Top quality work. Now to my minority of one thought. I really really would like to get all my nutrition from actual food. So my current approach to omega-3 nutrients, is to eat wild caught frozen salmon that I cook obviously. Fish starts to rot the moment the fish dies, and out of water it's quite a rapid process. Frozen at the source is the only way to go in my opinion. I also eat canned sardines, and herring. Is this the best, most pragmatic approach for someone who wants to eat a truckload of omega-3 fatty acids? Is there a better way? Every time I see you come to a positive, high confidence, conclusion about one nutrient group or another, my first thought is, how do I eat this? Our seas are getting polluted. Our soil is stripped of it's minerals and diverse organic material. Farmers spray by the metric shit ton, NPK on the growables, leaving out the myriad dozens of other things that nature normally supplies. The NPK dominance leaves the crops weak, so they require massive amount herbicides and pesticides to allow them to come to fruition. Our livestock eats these products, the soy, the corn, the wheat, or the byproducts of these things more often, and all this stuff is deficient, so the animals are deficient, they get injections of all kinds, ammendments to their feed, and they're selectively bred to come to maturity in a fraction of the time nature intended. Grass fed is modestly better. But wild-land foraging animals are astoundingly better than the best commercial grass fed. This has been shown anecdotally by farmers who have open land, and allow their non-commercial cows to free roam. The meat that is harvested for the family, some of it has been tested, an the omega-3 to omega-6 ratio is marvelously superior to the best 100% organic grass fed and grass finished commercial beef. It's more on par and competitive with wild caught fatty fish in near pristine waters.... some day, these types of food sources will be more prized and valued then we can imagine....
I just found this channel and it is gold! Thanks!
There is a fish oil paradox in cardiology where a small dose helps but a large dose increases risk. Omega-3s can reduce inflammation, but like Omega-6, they are easily oxidized and glycosylated meaning that they can transport oxidative and glycosylatative damage to cell membranes. There has never been demonstrated a health benefit with more than about 4 grams Omega-3 per day.
Would 200 grms of fatty fish , every 5 days, be a healthy omega 3 amount.?
@@kenadams5504 It would not be excessive. You could have 1 serving of salmon every day. If it's wild, it would be just over 2 grams of Omega-3. I knew some health and fitness experts promoting 15+ grams of omega-3 per day. One recently died of a heart attack.
@@kenadams5504 It wouldn't be too much. It would likely be enough to prevent deficiencies. You could eat that much Salmon 3-4 times a week.
Brave Study - Completed on 9/27/23 - using Vascepa (EPA) - following a AD high risk patient population for at leat 4.5 years.
Great in-depth analysis! Yah I would agree Omega-3 has some mild benefits especially on an anti-inflammatory front, though I wouldn't rely on it for large memory effects. I take it mainly to decrease triglcyerides and some anti-inflammatory effects, though not too much, because it can increase your LDL's especially in those who already have dyslipidemia.
I thought ldl is associated with better longevity .....as long as the ldl particles are not the damaged type, ( from oxidation and glycation).
Omega 3 is a composition of many different Acids. Essentially, DHA has been shown to raise LDL, EPA does not.
This channel is going to blow up within a year. WATCH.
Maybe but to blow up I think he will need to distill or cut up the video in about 10 minute chunks.
@@aaronlatif52 I think he's pretty succinct given the amount of material covered compared to other popular podcasts that last 2+ hours per podcast.
@@firpofutbol The popular 2 hour podcasts are from my observation either informal and comedic and/or rely on quality guests or famous/semi famous host.
Its not really a matter of being succinct or not IMO. Its really just that most people would watch a 10 minute video or shorter to understand something and for a channel to blow up on youtube, its typically around this time length. Podcast are a different story, sure many can blow up right from the start (but thats usually from exposure on bigger channels and what not) but most more academic or scientific focused are built over years of quality content.
But IDK things just happen sometimes regardless of what I think or project - maybe this channel will blow up but I have my doubts do to a few factors - length being a major reason but lack of excitement and building interest probably being a part to - like selling why this or that is important or demonstrating more excitement, shock, emotion. It comes off as dry info for the most part and that doesnt typically sell/blow up especially at longer lengths.
@aaronlatif52 I feel the same way about the Andrew Huberman podcast, which are often 2+ hrs long. Way too long for me so Physionic's feels like it covers enough detail without the wasted conversation that comes in other formats. As a nurse, having taken anatomy and physiology, I find the content fascinating because I understand the context. Although I don't share your view of the content feeling dry in Physionic, I know what you mean because I find Huberman to be extremely dry and hard to listen to. It's all subjective. Personally I've been hooked on this channel since I discovered it.
Ginkgo Biloba was perfectly pronounced. Please also take into account that sunflower oil is extremely rich in Omega-6 acids - since Omega-3 and Omega-6 use the same converter, that sunflower oil will actually have a negative impact compared to someone not taking any sunflower oil. The ratio of Omega-6 to -3 in sunflower oil is 126:1, so the intake of sunflower oil literally floods the body with Onega-6 acids, so that the intake of an Omega-3 capsule hardly stands any chance against the massive amount of Omega-6 to get through that needle eye and be converted - the sheer amount of Omega-6 just blocks it. So it is sad to say, but the set up of that study was less than ideal.
Yep☝️
Wasnt the sunflower oil given to the controll group and not the test group. The test group was only taking omega 3 capsules and no sunflower oil. So there is no worry to omega 3 intake in the test group.
Re: Liquid oil recommendation--Nordic Naturals also sells an identical product for less than half the price of the Ultimate Omega you recommend. The cheaper one is somewhat more than half the strength of the Ultimate bottle--so "Regular" at 1560mg/tsp for $22.06 versus Ultimate 2840mg/tsp for $61.16 --both in 8oz bottles. Thus you can spend $44.12 on two bottles and get more EPA/DHA from the same producer than if you spend $61.16. Have I missed something here?
You would not expect big strenght gains just from upping your protein intake alone (unless someone starts REALLY low), but it does not mean protein is of little value in strenght training.
Some treatments only work in combination like piperine and cucurmine. Seems to be the same with Omega 3. I found this after a search on chatGPT as I forget where I first saw it: According to 1, alleviating cognitive decline with omega-3s may only occur with adequate B vitamin levels. Vitamins B 6, B 9, and B 12 break down the amino acid homocysteine, allowing for omega-3s to be incorporated into the membranes of brain cells. As we age, our brains progressively atrophy (deteriorate, shrink, degenerate), leading to cognitive decline.
According to 2, researchers publishing in the European Journal of Nutrition have discovered that a combination of B vitamins and the omega-3 fatty acid DHA is linked to decreased cognitive decline in older individuals. A different post-hoc study showed that a combination of low homocysteine, an amino acid that is broken down by B vitamins, and omega-3 supplementation is associated with reduced cognitive decline.
I seem to remember a lecture about some Omega 3 studies and an incidental finding was that the ppl that were found to be helped by Omega 3 all had lower cysteine levels. Anyone here remember something like that? Also saw phosphotidylcholine did better than phosphotidylserine. Any input appreciated.
Thanks. One beauty of your spiels is that by teaching one learns far more as you are under the gun.
Thx Nic for the insightful videos.
Wrt Omega 3, did any study measure the effect on cholesterol?
Thx in advance
As a neurologist, I must say there is no supplements recomendations in any medical guidelines regarding to mild cognitive impairment or dementia, neither by the european nor american societies. Phospholipids like Danone's "Souvenaid" have the same possible "mild" benefits but aren't in those guidelides too.
Also you don't see much experts defending the use of these supplements basing on their clinical experience/empirical results, for exemple in neurology congresses. It's like the community do not believe in any significant benefit, the focus being on monoclonal antibodies or more "agressive" approaches, let say
Glad you're speaking up, Rodrigo - thanks for chiming in!
A 2014 study in the journal JAMA found that high amounts of vitamin E can help people with mild to moderate Alzheimer’s disease.
I have heard there is a 20 year between the research and the practical implementation.
Some treatments only work in combination like piperine and cucurmine. Seems to be the same with Omega 3. I found this after a search on chatGPT as I forget where I first saw it: According to 1, alleviating cognitive decline with omega-3s may only occur with adequate B vitamin levels. Vitamins B 6, B 9, and B 12 break down the amino acid homocysteine, allowing for omega-3s to be incorporated into the membranes of brain cells. As we age, our brains progressively atrophy (deteriorate, shrink, degenerate), leading to cognitive decline.
According to 2, researchers publishing in the European Journal of Nutrition have discovered that a combination of B vitamins and the omega-3 fatty acid DHA is linked to decreased cognitive decline in older individuals. A different post-hoc study showed that a combination of low homocysteine, an amino acid that is broken down by B vitamins, and omega-3 supplementation is associated with reduced cognitive decline.
I seem to remember a lecture about some Omega 3 studies and an incidental finding was that the ppl that were found to be helped by Omega 3 all had lower cysteine levels. Anyone here remember something like that? Also saw phosphotidylcholine did better than phosphotidylserine. Any input appreciated.
Great Job breaking all this down
Thanks
Thanks, Joseph!
Can’t explain it, but omega-3’s seemingly cause brain fog in my case. Don’t know !
Perhaps I was taking too much. The ratios of EPA and DHA were correct with l
negligible amounts of omega-6. Also don’t use any seed oils.
I can’t remember exactly where, but have read that while this isn’t common, it isn’t exactly rare.
Stoped all supplements of it and now just consume a tin of sardines. Seems to have helped and hopefully I’m getting a good amount of omegas.
Have any of you experienced this as well ?
You're correct in serial 3s and 7's.
Thank you Nicholas for the effort you made for this content. Been taking Fish Oil / Krill Oil for quiet a while , yet I don’t really know if It benefits me. After watching this video I only have to finish the 2 bottles I purchased that’s it. Thanks again.
It seems like when other people reference this study and compared it to others there was a problem with the control using sunflower oil since it's so high in omega-6. And if I remember correctly there was a similar study that you something different and had a completely different result.
You should release another video on Omega-3s !
for some reason, I get headaches from omega 3 fish oil capsules, but not from vegetarian sources.. This even happens with Cod liver oil. My hypothesis was that my low anti-oxidant status due to my G6PD lowers my ability to process the reactive oxygen species from the digestion of these fats. I'd be interested in getting your opinion on this.
as usual, keep up the good work.
Interesting. I'd need to look into the G6PD. I'm curious - there must be some chemical difference between the two.
I get these as well! It took me a while to pin point that the headaches were related to fish oil caps. I always wondered why this happened but never worked it out.
sometimes if the gallbladder is backed up you can get headaches. Maybe try taking Bile Salts, in particular TUDCA could help to breakdown the fats.
I could be wrong but worth a try.
37:14 aparentemente o organismo absorve melhor dha (fish omega 3) do que epa (plant omega 3).
Studies should not be ignored because of their funding source(s), *BUT*
Studies designed to obtain pre-determined results should be discounted.
What is your opinion on Omega 3s being the most unstable due to multiple double bonds ?
It's true, they are highly unstable compared to saturated fats. However, if that is the basis for an argument against them, that is 100% nonsensical.
yeah, they break apart and scavenge the bloodstream
Great overview.
Thanks, Kris!
excellent analysis
What's your opinion on Supplementation vs eating Sardines for example
I am more interested to know if fish oil helps with reducing unhealthy fat storage and maintaining a leaner physique. That’s why I have been taking it. To “balance out” the omega 6s I get from the rest of my diet. It would be nice to know if that’s a real thing or just something people on RUclips say.
Please have a study on spirulina and retinopathy
But why from a point of view of ecology omega 3 can interact so profoundly with neurons?
i tried taking fish oil pills (1000mg twice per day as per instructions) I did it without supervision though. I was also taking multivitamins/minerals as well. However after the first two days I started bleeding from my nose randomly or after sneezing this happened for three days straight which was obviously scary af so i just stopped it all together lol. i am however on the obese side (35 bmi) currently and im a heavy smoker, im sure somehow these things play in.
Thanks, that was a mouthfull. Sad to understand that the wffect was only midl, I think omega 3 has been praised a bit to highly in media for some time. Was hoping for more protection against dementia and such sinc it runs in my family. Thanks anyway.
that is really pure knowledge
Something to consider in these studies is dose, studies are using low doses skewered the results
I'll be one of those comments now. What about lions mane mushrooms, also in relation to cognitive effects.
Should we be worried about the propencity of omega 3 supplements to oxidise ?
Yes, but not for your health (based on the preliminary research I've read), for your wallet.
Would you recommend the ester form over the traditional one?
Was wondering if all these studies used omega-3 capsules or did you just take those who used fish oil from Norway (say) coming from a top vendor? Are they same? Some believe the encapsulated omega oil is junk i.e. gone rancid.
Capsules. The capsules are measured for quality, so they're pristine condition. Plus, they measure blood omega-3 levels to determine absorption - all studies showed increased blood omega-3.
My children turned out gifted I attribute this to outside a lot……vit D. I would have added omega 3 especially in cheap sardines during pregnancy. Good idea to marry the smartest man you can find.
someone looked at whether oils in 'health' supplements were rancid or oxidized, and all of the samples were.
I'll get my Omega-3s as real food.
no need to add inflammation.
what about caprylic acid hmmmmm
Hold up, so you are saying they used a supplement of Sunflower Oil as placebo?
Is N-acetyl cyteine supplement creatine?
No
Essential fatty acids, essential for disease. Bad PUFAs are not just seed oils.
I'm not sure what you mean.
I take it every day, but can't remember why
Do you happen to know if there is any effect on intelligence from omega 3 intake?
Unfortunately, that wasn't one of the measures - maybe something for the future, Noah!
I would imagine it helps in the same way protein powder will help with muscle gain - you do not expect it to do the lifting for you, but it helps by providing building blocks. Maybe if you are really deficient, you can get some gains just from taking it, but nothing drastic - which doesn't mean it's all useless.
Can fish oil supplements help with memory retention and focus? I have short term memory loss sometimes anyone feedback?
I never heard of global cognition before. Maybe I should try it.
:)
I wish I had your knowledge
maybe a long vid like on resveratrol would be cool
the science seems pretty mixed and also very much depending on the dosage 🤔
would probably be a hard endevour for 1 vid tho 😂make it 5 hours long and call it THE COMPLETE GUIDE TO RESVERATROL (or so) to get like 500k views in a year to make the effort worth it 😎
😂I think that would work. Like the one minute cure video on hydrogen Peroxide
Sunflower oil is highly inflammatory!
Well, at least we can say it didn’t have negative effects on cognition.
fish oils in tabs and gels are about as fresh and rancid as vege seed oils when you buy them in clear plastic bottles on store shelves. dont touch em.
Thanks for the vid.
It would be nice if population was shown not deficient in plant food and if the both group had few grams of omega 3(ALA) in the diet then test DHA/EPA pills. to really dissociate marine oil (algae/fish) from omega 3 in general.
Overall allmost no study found significancy and idk how well how p-hacking was controlled for but given the industry bias it is not reassuring. The funnel plot show quite a publication bias. You were quite fast on that end part of your vid when it is precisely these few seconds that would deserve an hour for us to understand better your conclusion. Your conclusion was more or less what I already believed though the term "omega 3" need to further clarification (long chain and short chain etc).
I would really push back on your publication bias point. There's literally nothing else to say on the topic. Additionally, only 3 or so studies were identified as having potential bias - I'm not sure what else I could have said on that front. Plus, keep in mind, even if I had an hour's worth to say on publication bias (which I absolutely didn't - it's pretty cut and dry) - I doubt 99.9% of people want to hear me drone on about a topic they have zero interest in. I covered all the major points and moved on.
@@Physionic as you said 1:31:45 there is most likely some publication bias. 3 studies were eliminated because thought to have potential bias but that are only the most obvious ones the funnel plot indicate that probably other studies has been eliminated (showing negatives) even before the meta-analysis, that probably skewed the data.
the things to say was not so much in those 3 studies but maybe a bit, there is the somewhat counter-intuitive fact that once removal of some publication bias the hedges'g increase for memory, the thing you said about p-value, maybe p-hacking etc.
overall I agree with you I was a bit greedy indeed, my statement of an hour was hyperbolic as I felt the most interesting things to me started here so it was totally not a critic just my greed talking. I obviously totally get you not having the time for that and I'm alrealy thankfull for the point you have covered.
Wait... no Person Man Woman Camera TV testing???
I think low carb no carb omega 3 would have been a group.
Try sardines yourself n of one. Add me to yours amazing . The supplement faulty degradation occurs quickly.
algae EPA/DHA is best (cost cents too, many brands or real seaweed food). Bivalves are vegans friendly but not as healthy( it is still animal food so same habitual deadly flaws) . I personnaly found EPA/DHA useless though.
Long chain omega 3 might has its risk too so some choose to avoid it and that's okay (a useless hassle if seaweed are part of your previous habits), everyone is able to elongate ALA enough to get the long chain (which is in the order of mg unlike ALA in grams) in different degree. ALA as other benefit too.
I would disagree. All the independent lab testing results I've seen have shown algae fish oil to be extremely under dosed. Those that were more highly dosed had other issues, like not containing the amount marketed. So, that may be why you haven't experienced benefits, but that's speculation on my part.
@@Physionic thank you for your answer.
you disagree with what? it is a bit fuzzy but as it seems like you are just disagreeing with my personal/anecdotal habit of me founding useless to take these pills (not with higher claims like the existence of algae pills etc) and that is fine but I am not sure of what to say.
though when you said that fish oil were extremely underdosed in lab test you kind of goes my way... I do not take fish oil as it is not ethical. Not just because of problems regarding the business of fish oil on health (like dosage or rancification hiding with flavor, pollutant control etc). But, to be clear, the same fatty acid in algae pills are ethical and I still do not take them either.
Also benefits is not something one person "experiment" that is anecdotal fallacy. am I supposed to do a pool of memory test and just to witness some benefit and then attribut it to this new pill (and also artbitrarly attribute any downside to it). whether or not long chain omega 3 as some degree of possible health benefit it can still be deem useless for someone to integrate this new habit into his life (many little things are healthy to do to in various degree).
Gotcha - I was disagreeing with algae EPA/DHA being the best.
To your second point, I agree - it's tough to test on yourself, but considering you mentioned you were able to tell if made no difference, I figured you'd be able to test it again in a similar fashion to the first time.
@@Physionic I guess you found algae equal to fish oil then
But Algae being the best has more to do with other science than your subfield of biology obviously, though even when it come to fitness there is some argument to be made for algae but if quality (pollutant control etc) is there, it is indeed mostly same despite the sources of fish oil being objectively disgustingly dirty/shady and unethical.
One is able to tell if a thing made a difference or not with the litterature as anecdotaly there is many bias (though it can have its wheight indeed if one has specific scientifically related problems and his followed by a physician etc but I am fine) and looking at how a new habit fit into his lifestyle etc and calculating cost/benefit overall. So your suggestion if people feel that marine oil does not have any effect, is too increase the dosage, that can be dangerous at some point but I can see your point indeed despite the litterature showing that healthy people will be unlikely be able to see the benefit if/when there would be one.
Why this obsession with fish oil when algae oil has been available now for over a decade?
interesting
Sunflower oil 😂, no thanks ✌
Smith Susan Harris Karen Lopez William
Learn how to make points . Long talk is boring. Human attention at best is 20 minutes. Good topics but who is your listeners? The observer in Quantum physics , listeners in physionic.
Then it would have been a different kind of channel. People read books and we see an increasing popularity of long form content (podcasts)? I love this channel because I get to follow the train of thought. If shorter is better you might consider TikTok.
There are already plenty of short videos on this topic, it's nice to have a deep dive.
Your attention span maybe 20 minutes and this is commonly the case based on lifestyle and diet and personal mindfulness practices. The healthier I am, the longer my attention span. I absolutely love the depth of this guy's work. If you want to takeaways, join his Insider community and support the guy financially to get the synthesized bullet point information from his massive amount of content on Research publication analysis
*****
Your video is tooooo long.
That’s the whole intent.