Thank you for this very interesting input - it would be very helpful to have such a marker for objective evidence to avoid being missdiagnosed with Cushing. I was being diagnosed having an iatrogen cushing due to weight gain, resulting from being too exhausted for sport activity, and that also includes the face and abdomen, but mainly legs and arms. Needing to discuss that the weight gain is not the only indicator for Cushing, and that its common to see weight gain in the face of a person and also at the belly, as its uncommon to gain weight only in the arms and legs., is very frustrating. Esp. when most of the other criteria for Cushing, that are esp. more objective (Weight gain can also be objectified by measuring circumference, if one is interested in making a correct diagnosis and to avoid the risk of a misdiagnosis) are not fullfilled and rather indicate cortisol deficiency. It would be thus amazing to have objective parameter for diagnosis, that are respected by doctors. People are not machines, where everyone needs the same dose, but are very individual in their metabolism - metabolism always sounds very simple, but it is a highly complex matter, with genes being switched on and off, as you have shown very nicely, and which then in turn can influence themselves directly or indirectly and are also influenced by other hormones. A very complex thing, but which makes medicin that fascinating. But It should therefore be clear that each patient must be considered individually - that should actually be self-evident, but unfortunately it is not. But such data as presented will help to make this complex situation clear and will be very helpful, if an objective parameter will be found. Thank you for the very interesting details 🙂
Thank you for this very interesting input - it would be very helpful to have such a marker for objective evidence to avoid being missdiagnosed with Cushing. I was being diagnosed having an iatrogen cushing due to weight gain, resulting from being too exhausted for sport activity, and that also includes the face and abdomen, but mainly legs and arms. Needing to discuss that the weight gain is not the only indicator for Cushing, and that its common to see weight gain in the face of a person and also at the belly, as its uncommon to gain weight only in the arms and legs., is very frustrating. Esp. when most of the other criteria for Cushing, that are esp. more objective (Weight gain can also be objectified by measuring circumference, if one is interested in making a correct diagnosis and to avoid the risk of a misdiagnosis) are not fullfilled and rather indicate cortisol deficiency. It would be thus amazing to have objective parameter for diagnosis, that are respected by doctors.
People are not machines, where everyone needs the same dose, but are very individual in their metabolism - metabolism always sounds very simple, but it is a highly complex matter, with genes being switched on and off, as you have shown very nicely, and which then in turn can influence themselves directly or indirectly and are also influenced by other hormones. A very complex thing, but which makes medicin that fascinating. But It should therefore be clear that each patient must be considered individually - that should actually be self-evident, but unfortunately it is not. But such data as presented will help to make this complex situation clear and will be very helpful, if an objective parameter will be found. Thank you for the very interesting details 🙂