Glad to see you following this topic. For me, 2005 started Statins; beginning in about 1 to 2 Months acquired Diabeties; 6-9 months later, I was a "Raging" diabetic with several new Rxs including Insulin. I was fine before Statins. Low carb KETO helps me now but still fighting HbA1c. Oh by the way, I have been a Triathlete since 2001. Had to slow down training the 5 years I was on Statins.
Similar experience for me on athletic capability. I was an 800 meter runner a long time ago, switched to long-distance hiking. But while on statins could never go more than a few days, since getting off them, I basically can go as long as my wife will allow me to be away.
@dacisky....Totally agree with you! They only care about following the "Standard of Care" so they don't get sued if you die after taking statins and if you do die, then,they will blame it on your underlying health issues not the statins.
I’m T1D and have been for over 40 years…. Told my Dr (sorry, drug dealer) 4 months ago that I had stopped taking statins…. He flipped out… but then I explained the quality of life improvements I’ve had, including better blood sugar control… HbA1C is currently 5.4%…. So technically normal…. Kicking the stations to the kerb has helped LOWER my HbA1C…. That’s my N = 1 study…. So the choice is worse health by taking statins now or possibility of heart problems later…. Either way I am basically fucked… so I’ll take the quality of life benefits thanks very much much… its now how long you live… its how well you live…
Thanks for sharing. I never really think about T1D and statins, so I just looked it up for a quick idea. One site gave a risk reduction of 21% (without explaining that is a relatively risk reduction) and then went on to cite the incredibly misleading SAMSON trial to claim that 90% of adverse effects are nocebo. They claim that anti-statin info on the internet is misinformation. The very definition of irony.
I'm sad to hear of your loss. Unfortunately, they never point out that two thirds of the people who will have a heart attack without statins will still have them even with statins. We really need to find more effective treatments rather than just saying "take this pill. You're covered" which is what statin-pushing leads to.
An important test is a fasting insulin, it will indicate insulin resistance far earlier than any test mentioned here. The body can produce extra insulin to force more glucose into the cells and storage without raising A1c for as much as ten years. A fasting insulin of over ten will indicate that insulin is being overproduced and insulin resistance had begun. The test gives one a chance to deal with the problem while the damage is minimal.
Thanks for the insight. Yes, I didn't get into it here, but the tolerance test I took included fasting insulin and insulin at 1 and 2 hours. There's an ad for some T2D med where the announcer says something like "because your pancreas can still make insulin, it just needs a little help." That always struck me as the wrong approach. I suppose if the pancreas has reduced insulin output, that might be the correct thing to do. But I suspect that in many cases, the full blast of insulin is there but can't overcome the resistance, so putting out more insulin would bring down hba1c while subjecting the patient to hyperinsulinemia. I don't know this for sure, but I suspect it. In my case, fasting insulin measures are between 4 and 8 usually. The 8 is too high for my comfort.
@@mystatinfreelife Yes big Pharm's answers to diabetes are not only wrong, they are one hundred and eighty degrees out. I went on carnivore the last week of March at seventy two and by August my A1c was in the normal range and is the same as yours currently, still trending down. My fasting insulin was ten in May, five in August, and three last month. Dr Ken Berry says that under ten is fine, so I don't know that I would worry about eight, but lower is better of course.
There is another test called " C-Peptide" which measures the activity and amount of insulin produced by the" beta"cells in your pancreas which are found in the "islet of Langherhans" in the tail of the pancreas. It is also used to differentiate between T1D and T2D.
I appreciate your knowledge and expertise on this topic! I had a negative experience taking Atorvistatin!! Major muscle loss and this didn't sit well with me. My CHOLESTEROL is high.... I stopped taking Atorvistatin for over a year. I have had a heart attack and I have 3 heart Stents now. My Cardiologist wanted me to try ("Crestor")..... I was reluctant to do so... but I agreed to take a very low dose 5mg. of ("Crestor").... my PRIMARY Doctor has pushed me to increase dosage to 10mg. I still don't like the physical results I'm feeling from the ("Crestor")
Thanks for watching. I was on atorvastatin (Lipitor), rosuvastatin (Crestor), and pitavastatin (Livalo) at different times. All made me feel horrible. Since you're on secondary prevention, the doctors will push the statins even harder. There are alternatives like bempedoic acid, though I don't know if they are effective for secondary prevention.
I'll never forget a video I watched about statins presented by a very well known clinic that starts with a "M" and the speaker was asked about statins and becoming a T2D. I will never forget his reply. " Yes, it can push you into T2D, but you were heading that way anyway". What?????
another comment to this video is I stopped the statin at Pre diabetes and did Intermittent eating which is the way I always ate until they pushed me to eat more etc. 3 weeks before blood week I did this and at testing my blood sugar dropped 2 plus points down and weight down 11 pounds. Still living this way as I did first 50 years of my life thin and happy. Never told the doctor no statin and he loved my bloodwork and said I will outlive him! Trust me this cardio guy is 40 some super super thin and never gives out info. I am going back to who I have always been and my lifestyle has always been no fast food, alcohol ever in my life and whole foods home cooked. some eating out and good places only and a runner now walker as I am older now and they yell at me. Do try it. I will see where I am at at next blood draw which would be a year from this last one a few months ago. Still living the lifestyle and doing well.
Pretty much how I live now, including was a runner and now a walker (hiking when I can do it.) I was a competitive track athlete throughout High School and College, but I like to say "Training for competition and exercising for health are different things." Competitive training puts a lot of strain on the body. It does seem that doctors push the "eat constantly when you're older" idea, which in my humble opinion is the worst advice they can give, especially to diabetics.
@@mystatinfreelife My issue wasn’t diabetes it was Type A personality and taking care of mom for 10 years, building her a mother in law as the contractor, raising 3 granddaughters 7 days a week and usually all weekend and 80 hour a week business. I thought I could do it all cause I had to. Mom died, 4 years of sadness then a heart issue. Depression and anxiety will do this. Clean bill of health but eat now eat. Says I will outlive my 40 year old doctor but I just,want to live healthy and thin where I always was and or maybe a little more for aging. You cannot do it by stuffing food down 3 times a day and getting sleepy after lunch. Big dinners don’t work either. Mid meals work best. Not pre diabetic anymore and working on lowering it. Take care.
5 years ago I discovered that compared to the average person, I get an exaggerated rise in blood glucose after a high-carb meal (most likely caused by damage to my pancreas by 25 years on St. John's Wort, but that's another story). So I switched to a LCHF diet, typically 20 grams carbs per meal, which kept my BG under good control. I started a statin 4 months ago and yes, I believe I'm seeing some new insulin resistance. I wore a 14-day CGM 3 years ago, pre-statin, and again a month ago. My BG still seems well controlled on my normal low-carb diet (typically 20 grams carbs per meal), though rising a little more now that I'm on a statin. But I saw major changes when "stress testing" with a high-carb meal. 3 years ago my BG rose 62 points after a tasty meal of rice pudding and no exercise afterward. Now the same test raises my BG 98 points. Even more striking, 3 years ago when I ate the same rice pudding meal followed by a 7-mile fast walk, my BG actually DROPPED. Now the exact same test results in a 55 point rise. That's better then the 98 points with no post-meal exercise, so the exercise still has some effect, but not nearly as much. It certainly looks to me like my muscles, which 3 years ago used up the glucose as fast as it appeared in my blood, now aren't able to use the glucose nearly as well. Doesn't that sound like some insulin resistance? Why did I start on a statin, at 72? My LDL-C has always been around 190 but I always resisted a statin, partly because of my great TG/HDL ratio. But last year I had a calcium scan, with a score of 352 (higher than 65% of men my age, 71). This was the first hard evidence that my high LDL might actually be causing a problem. I first tried lowering saturated fat drastically and that lowered my LDL to 130. Still kind of high, so I reluctantly went on 5 mg rosuvastatin (Crestor) and 10 mg ezetimibe (Zetia). After 3 months my LDL was 50. My cardiologist was practically glowing, but my first reaction was to wonder if cholesterol that low is even healthy, and I still wonder about that. I can't feel any side effects, but I did a Cardio IQ test which showed that my small LDL, supposedly the most atherogenic, only dropped 18% compared to the 66% drop in my LDL-C, so the good "Pattern A" pre-statin now is reported as "Pattern B A" because the small LDL is now a larger percentage. I'll still stay on the statin for now, hoping that I've reduced my total risk, but I'll continue to search the evidence, including this channel.
Thanks for watching and sharing. It sounds like you have a good handle on what you need to watch for. Be aware that statins may also increase your CAC score by stabilizing soft plaque into hard plaque. That's not necessarily bad if after that the score stays steady because it could mean that soft plaque has been successfully stabilized and other lifestyle changes are preventing new soft plaque from accumulating.
Hello, I was put on statins recently and now suffering all manner of problems, especially muscle and joint aches. However I was put on them to address high cholesterol and triglycerides, what’s the alternative. You may have mentioned this in other videos but why was you put on statins in the first place and have you overcome those issues and how? Appreciate the videos and content, thank you…
I was put on statins for high cholesterol, but without an actual risk assessment. My doctor was fixated on anything over 200 as needing treatment. In retrospect, I did a risk assessment using an on-line calculator and my 10 year risk was only 4%, so by today's standards I should never have been put on them. An alternative that may have fewer adverse effects, assuming your cholesterol really indicates a problem, is bempedoic acid. High triglycerides generally seem to indicate higher risk, and if you are able to use diet and exercise to control trigs that may be better. These are good options to discuss with your doctor. You may want to use the 2018 PCE risk calculator to determine your estimated risk. It's available at www.merckmanuals.com/professional/multimedia/clinical-calculator/cardiovascular-risk-assessment-10-year-revised-pooled-cohort-equations-2018
5:24 - exactly what I though. All the statins studies are showing relative risk but now if it comes to T2D they use the absolute risk? That's ridiculous. Also you have to know that diabetes develops for several decades (see the research of Dr. Joseph Kraft in the 1960s) - so the risk of a progression TOWARDS diabetes will be much much much larger - because many people will not cross that boundary yet but that is not relevant because same mechanisms will apply to them as - it will just shorten significantly the time when they will be diagnosed with T2D in the future...
Thanks. In fact, the first test I took, about a year and a half ago, was a more comprehensive Kraft Insulin survey. My PCP shrugged at it. Clearly didn't understand the result and didn't care since she didn't order it. Thought I was okay because the final measures were BG 85 mg/dL and insulin 4.5. Completely ignored the 1 hr reading, which was over 300! I'm sure this was from decades of my thinking rice krispy squares were healthy because they were fat-free and "just" sugar.
One brief foray into the wonderful world of statins several years ago, and I've been fighting my HBA1C ever since (It was 5.3 before). Now low-carb; I'm down to 6.2. Wouldn't you know it? The doc prescribes another statin! (Won't be taking it)
Wow as usual very thought provoking. You mentioned your lawyer; many are alchohol abusers, and they seem to prefer insulin pumps :; my gut is telling me B3 `may` help reverse NAFLD where as statins ? nah... [just say no !] The value of HBA1c is that is an integrator. Triglycerides for example have a huge variance as do spot glucose measures. It correlates (spookily high) to albumin levels hence kidney damage correlates to Hb1ac integrated over 20 yrs.... the eye disease and amputations are NOT 1st order correlations. AMD might well be referred to as micro vascular disease. Treating so called pre-diabetes is not usually addressed in western medicine.. i wish i had at least tried harder when i was 50 as now i feel like i am pissing in the wind (so trying MounJaro [too little sadly too late]), Insulin was never meant to treat type IIs and personally i believe in those sub geno types you called type 1.5 and type 3 and you might want to explore that sub catagorization... topic some more, I run a lot by a retired pharmacist i know, and he agrees with your unstated premise the whole movement was $$$$$ driven so when they went off patent suddenly we have lost interest. Ctep in hibitors and Pcsk9 inhibitors not withstanding. The most prescribed diabetes medicine of all time address's ampK which has gotten new life from the longevity folks... check out these 2: Can Niacin (Vitamin B3) reduce Heart Disease? [Study 198 - 201 Analysis] Metformin's Mechanism of Action (also physionic)
metformin "addresses AMPK" by being a mitochondrial poison. not very clever. the best way is NOT to overwhelm your mitochondrias and give them chance to regenerate (by lowering insulin which will then allow/boost mitophagy...)
How can insulin resistance, something that raises your heart disease risk 6 times (500% increase), or full blown type 2 diabetes, 10.8 times (980% increase) be LESS dangerous than a raised ldl, which increases your risk 1.4 times (40% increase)? These are the risks from the Women’s health initiative. It makes no sense to continue a statin if you develop insulin resistance or type 2 diabetes.
T2D. Your cholesterol is a little high. That puts you at risk for heart disease. T2D put you at risk for heart disease. Let's put you on a statin. Statins will increase your blood sugar and hamper your blood sugar control. Which will make your diabetes worse. Which will affect your heart and cholesterol. Lets put you on something that will make you worse. And that will increase your liver enzymes.. which will affect your diabetes. What if you get the muscle problems and find you have to decrease or can't exercise at all... That will affect your cholesterol, diabetis, heart.. they didn't say that but I know it. Went off within my first 4 months forget it. As soon as I had dequerveins tendonitis and my ankles felt sprained all the time. In my liver enzymes went way up. And I ended up on 8 weeks of physical hand therapy
Glad to see you following this topic. For me, 2005 started Statins; beginning in about 1 to 2 Months acquired Diabeties; 6-9 months later, I was a "Raging" diabetic with several new Rxs including Insulin. I was fine before Statins. Low carb KETO helps me now but still fighting HbA1c. Oh by the way, I have been a Triathlete since 2001. Had to slow down training the 5 years I was on Statins.
Similar experience for me on athletic capability. I was an 800 meter runner a long time ago, switched to long-distance hiking. But while on statins could never go more than a few days, since getting off them, I basically can go as long as my wife will allow me to be away.
@@mystatinfreelife eife?
Wife
@@btudrus fixed it
@@mystatinfreelife yeah, i was not sure if it was an error as i'm not a native english speaker.... too many new words and constructs these days...😁
My observations is Dr.'s don't care about the patient's qualityvof life as long as those numbers are pretty,that's all that matters.
Good reason why we have to make our own quality of life decisions. 🙂
@dacisky....Totally agree with you! They only care about following the "Standard of Care" so they don't get sued if you die after taking statins and if you do die, then,they will blame it on your underlying health issues not the statins.
I’m T1D and have been for over 40 years…. Told my Dr (sorry, drug dealer) 4 months ago that I had stopped taking statins…. He flipped out… but then I explained the quality of life improvements I’ve had, including better blood sugar control… HbA1C is currently 5.4%…. So technically normal…. Kicking the stations to the kerb has helped LOWER my HbA1C…. That’s my N = 1 study….
So the choice is worse health by taking statins now or possibility of heart problems later…. Either way I am basically fucked… so I’ll take the quality of life benefits thanks very much much… its now how long you live… its how well you live…
Thanks for sharing. I never really think about T1D and statins, so I just looked it up for a quick idea. One site gave a risk reduction of 21% (without explaining that is a relatively risk reduction) and then went on to cite the incredibly misleading SAMSON trial to claim that 90% of adverse effects are nocebo. They claim that anti-statin info on the internet is misinformation. The very definition of irony.
What a great video - it organizes a lot of my recent thoughts and concerns. And thank you for the links! I just subscribed 🙂
My husband was diabetic and on statins. Statins did not stop him from having 2 heart attacks and premature death. So it goes for statins.
I'm sad to hear of your loss. Unfortunately, they never point out that two thirds of the people who will have a heart attack without statins will still have them even with statins. We really need to find more effective treatments rather than just saying "take this pill. You're covered" which is what statin-pushing leads to.
An important test is a fasting insulin, it will indicate insulin resistance far earlier than any test mentioned here. The body can produce extra insulin to force more glucose into the cells and storage without raising A1c for as much as ten years. A fasting insulin of over ten will indicate that insulin is being overproduced and insulin resistance had begun. The test gives one a chance to deal with the problem while the damage is minimal.
Thanks for the insight. Yes, I didn't get into it here, but the tolerance test I took included fasting insulin and insulin at 1 and 2 hours. There's an ad for some T2D med where the announcer says something like "because your pancreas can still make insulin, it just needs a little help." That always struck me as the wrong approach. I suppose if the pancreas has reduced insulin output, that might be the correct thing to do. But I suspect that in many cases, the full blast of insulin is there but can't overcome the resistance, so putting out more insulin would bring down hba1c while subjecting the patient to hyperinsulinemia. I don't know this for sure, but I suspect it. In my case, fasting insulin measures are between 4 and 8 usually. The 8 is too high for my comfort.
@@mystatinfreelife Yes big Pharm's answers to diabetes are not only wrong, they are one hundred and eighty degrees out. I went on carnivore the last week of March at seventy two and by August my A1c was in the normal range and is the same as yours currently, still trending down. My fasting insulin was ten in May, five in August, and three last month. Dr Ken Berry says that under ten is fine, so I don't know that I would worry about eight, but lower is better of course.
There is another test called " C-Peptide" which measures the activity and amount of insulin produced by the" beta"cells in your pancreas which are found in the "islet of Langherhans" in the tail of the pancreas. It is also used to differentiate between T1D and T2D.
@@karimaogden3875 That is a useful one too, insulin levels are very important health markers.
I appreciate your knowledge and expertise on this topic! I had a negative experience taking Atorvistatin!! Major muscle loss and this didn't sit well with me. My CHOLESTEROL is high.... I stopped taking Atorvistatin for over a year. I have had a heart attack and I have 3 heart Stents now. My Cardiologist wanted me to try ("Crestor")..... I was reluctant to do so... but I agreed to take a very low dose 5mg. of ("Crestor").... my PRIMARY Doctor has pushed me to increase dosage to 10mg. I still don't like the physical results I'm feeling from the ("Crestor")
Thanks for watching. I was on atorvastatin (Lipitor), rosuvastatin (Crestor), and pitavastatin (Livalo) at different times. All made me feel horrible. Since you're on secondary prevention, the doctors will push the statins even harder. There are alternatives like bempedoic acid, though I don't know if they are effective for secondary prevention.
I'll never forget a video I watched about statins presented by a very well known clinic that starts with a "M" and the speaker was asked about statins and becoming a T2D. I will never forget his reply. " Yes, it can push you into T2D, but you were heading that way anyway". What?????
Yikes, yeah I know the "M" place. They'll also tell that T2D is "chronic and progressive." So no hope of recovery or remission. Just take more drugs.
another comment to this video is I stopped the statin at Pre diabetes and did Intermittent eating which is the way I always ate until they pushed me to eat more etc. 3 weeks before blood week I did this and at testing my blood sugar dropped 2 plus points down and weight down 11 pounds. Still living this way as I did first 50 years of my life thin and happy. Never told the doctor no statin and he loved my bloodwork and said I will outlive him!
Trust me this cardio guy is 40 some super super thin and never gives out info. I am going back to who I have always been and my lifestyle has always been no fast food, alcohol ever in my life and whole foods home cooked. some eating out and good places only and a runner now walker as I am older now and they yell at me. Do try it. I will see where I am at at next blood draw which would be a year from this last one a few months ago. Still living the lifestyle and doing well.
Pretty much how I live now, including was a runner and now a walker (hiking when I can do it.) I was a competitive track athlete throughout High School and College, but I like to say "Training for competition and exercising for health are different things." Competitive training puts a lot of strain on the body. It does seem that doctors push the "eat constantly when you're older" idea, which in my humble opinion is the worst advice they can give, especially to diabetics.
@@mystatinfreelife My issue wasn’t diabetes it was Type A personality and taking care of mom for 10 years, building her a mother in law as the contractor, raising 3 granddaughters 7 days a week and usually all weekend and 80 hour a week business. I thought I could do it all cause I had to. Mom died, 4 years of sadness then a heart issue. Depression and anxiety will do this. Clean bill of health but eat now eat. Says I will outlive my 40 year old doctor but I just,want to live healthy and thin where I always was and or maybe a little more for aging. You cannot do it by stuffing food down 3 times a day and getting sleepy after lunch. Big dinners don’t work either. Mid meals work best. Not pre diabetic anymore and working on lowering it. Take care.
@@mystatinfreelife Gotta tell ya I answered your post cause that picture looked soooo sad! I felt bad.
5 years ago I discovered that compared to the average person, I get an exaggerated rise in blood glucose after a high-carb meal (most likely caused by damage to my pancreas by 25 years on St. John's Wort, but that's another story). So I switched to a LCHF diet, typically 20 grams carbs per meal, which kept my BG under good control.
I started a statin 4 months ago and yes, I believe I'm seeing some new insulin resistance. I wore a 14-day CGM 3 years ago, pre-statin, and again a month ago. My BG still seems well controlled on my normal low-carb diet (typically 20 grams carbs per meal), though rising a little more now that I'm on a statin. But I saw major changes when "stress testing" with a high-carb meal. 3 years ago my BG rose 62 points after a tasty meal of rice pudding and no exercise afterward. Now the same test raises my BG 98 points. Even more striking, 3 years ago when I ate the same rice pudding meal followed by a 7-mile fast walk, my BG actually DROPPED. Now the exact same test results in a 55 point rise. That's better then the 98 points with no post-meal exercise, so the exercise still has some effect, but not nearly as much. It certainly looks to me like my muscles, which 3 years ago used up the glucose as fast as it appeared in my blood, now aren't able to use the glucose nearly as well. Doesn't that sound like some insulin resistance?
Why did I start on a statin, at 72? My LDL-C has always been around 190 but I always resisted a statin, partly because of my great TG/HDL ratio. But last year I had a calcium scan, with a score of 352 (higher than 65% of men my age, 71). This was the first hard evidence that my high LDL might actually be causing a problem. I first tried lowering saturated fat drastically and that lowered my LDL to 130. Still kind of high, so I reluctantly went on 5 mg rosuvastatin (Crestor) and 10 mg ezetimibe (Zetia). After 3 months my LDL was 50. My cardiologist was practically glowing, but my first reaction was to wonder if cholesterol that low is even healthy, and I still wonder about that. I can't feel any side effects, but I did a Cardio IQ test which showed that my small LDL, supposedly the most atherogenic, only dropped 18% compared to the 66% drop in my LDL-C, so the good "Pattern A" pre-statin now is reported as "Pattern B A" because the small LDL is now a larger percentage. I'll still stay on the statin for now, hoping that I've reduced my total risk, but I'll continue to search the evidence, including this channel.
Thanks for watching and sharing. It sounds like you have a good handle on what you need to watch for. Be aware that statins may also increase your CAC score by stabilizing soft plaque into hard plaque. That's not necessarily bad if after that the score stays steady because it could mean that soft plaque has been successfully stabilized and other lifestyle changes are preventing new soft plaque from accumulating.
Hello, I was put on statins recently and now suffering all manner of problems, especially muscle and joint aches. However I was put on them to address high cholesterol and triglycerides, what’s the alternative. You may have mentioned this in other videos but why was you put on statins in the first place and have you overcome those issues and how? Appreciate the videos and content, thank you…
I was put on statins for high cholesterol, but without an actual risk assessment. My doctor was fixated on anything over 200 as needing treatment. In retrospect, I did a risk assessment using an on-line calculator and my 10 year risk was only 4%, so by today's standards I should never have been put on them.
An alternative that may have fewer adverse effects, assuming your cholesterol really indicates a problem, is bempedoic acid. High triglycerides generally seem to indicate higher risk, and if you are able to use diet and exercise to control trigs that may be better. These are good options to discuss with your doctor. You may want to use the 2018 PCE risk calculator to determine your estimated risk. It's available at www.merckmanuals.com/professional/multimedia/clinical-calculator/cardiovascular-risk-assessment-10-year-revised-pooled-cohort-equations-2018
Thank you
Thank you!
5:24 - exactly what I though. All the statins studies are showing relative risk but now if it comes to T2D they use the absolute risk? That's ridiculous.
Also you have to know that diabetes develops for several decades (see the research of Dr. Joseph Kraft in the 1960s) - so the risk of a progression TOWARDS diabetes will be much much much larger - because many people will not cross that boundary yet but that is not relevant because same mechanisms will apply to them as - it will just shorten significantly the time when they will be diagnosed with T2D in the future...
Thanks. In fact, the first test I took, about a year and a half ago, was a more comprehensive Kraft Insulin survey. My PCP shrugged at it. Clearly didn't understand the result and didn't care since she didn't order it. Thought I was okay because the final measures were BG 85 mg/dL and insulin 4.5. Completely ignored the 1 hr reading, which was over 300! I'm sure this was from decades of my thinking rice krispy squares were healthy because they were fat-free and "just" sugar.
One brief foray into the wonderful world of statins several years ago, and I've been fighting my HBA1C ever since (It was 5.3 before). Now low-carb; I'm down to 6.2. Wouldn't you know it? The doc prescribes another statin! (Won't be taking it)
mayo clinic only diagnosis after 3 checks not 2. Told my doctor got ignored,
Wow as usual very thought provoking. You mentioned your lawyer; many are alchohol abusers, and they seem to prefer insulin pumps :; my gut is telling me B3 `may` help reverse NAFLD where as statins ? nah... [just say no !]
The value of HBA1c is that is an integrator. Triglycerides for example have a huge variance as do spot glucose measures. It correlates (spookily high) to albumin levels hence kidney damage correlates to Hb1ac integrated over 20 yrs.... the eye disease and amputations are NOT 1st order correlations. AMD might well be referred to as micro vascular disease.
Treating so called pre-diabetes is not usually addressed in western medicine.. i wish i had at least tried harder when i was 50 as now i feel like i am pissing in the wind (so trying MounJaro [too little sadly too late]), Insulin was never meant to treat type IIs and personally i believe in those sub geno types you called type 1.5 and type 3 and you might want to explore that sub catagorization... topic some more, I run a lot by a retired pharmacist i know, and he agrees with your unstated premise the whole movement was $$$$$ driven so when they went off patent suddenly we have lost interest. Ctep in hibitors and Pcsk9 inhibitors not withstanding.
The most prescribed diabetes medicine of all time address's ampK which has gotten new life from the longevity folks...
check out these 2:
Can Niacin (Vitamin B3) reduce Heart Disease? [Study 198 - 201 Analysis]
Metformin's Mechanism of Action (also physionic)
metformin "addresses AMPK" by being a mitochondrial poison.
not very clever.
the best way is NOT to overwhelm your mitochondrias and give them chance to regenerate (by lowering insulin which will then allow/boost mitophagy...)
How can insulin resistance, something that raises your heart disease risk 6 times (500% increase), or full blown type 2 diabetes, 10.8 times (980% increase) be LESS dangerous than a raised ldl, which increases your risk 1.4 times (40% increase)? These are the risks from the Women’s health initiative. It makes no sense to continue a statin if you develop insulin resistance or type 2 diabetes.
T2D. Your cholesterol is a little high. That puts you at risk for heart disease. T2D put you at risk for heart disease. Let's put you on a statin. Statins will increase your blood sugar and hamper your blood sugar control. Which will make your diabetes worse. Which will affect your heart and cholesterol. Lets put you on something that will make you worse. And that will increase your liver enzymes.. which will affect your diabetes. What if you get the muscle problems and find you have to decrease or can't exercise at all... That will affect your cholesterol, diabetis, heart.. they didn't say that but I know it. Went off within my first 4 months forget it. As soon as I had dequerveins tendonitis and my ankles felt sprained all the time. In my liver enzymes went way up. And I ended up on 8 weeks of physical hand therapy
Tanks for sharing your story!
Russ, thank you for the video. Another reason not to take a Statin.