Burkitt’s Lymphoma - Diagnosis and Treatment - Non-Hodgkin's Lymphoma - Aggressive Neoplasm
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- Опубликовано: 7 сен 2024
- Burkitt’s Lymphoma - Diagnosis and Treatment - Non-Hodgkin's Lymphoma - Aggressive Neoplasm
Lymphoma can be Hodgkin or Non-Hodgin's (such as Burkitt's lymphoma).
Hematological malignancies can be divided into leukemias, lymphomas, and multiple myeloma.
Lymphomas can be divided into Hodgkin's lymphoma and non-Hodgkin's lymphoma.
Non-Hodgkin's lymphoma can be subdivided into aggressive lymphoma and indolent lymphoma.
Aggressive non-Hodgkin's lymphoma includes:
*Diffuse large B-cell lymphoma (DLBCL)
*Burkitt's lymphoma.
*Mantle cell lymphoma.
*Precursor T-cell lymphoblastic lymphoma.
*B-lymphoblastic lymphoma.
Indolent non-Hodgkin's lymphomas include:
*Follicular lymphoma
*Marginal zone B-cell lymphoma (MALToma)
*Hairy cell leukemia/ lymphoma.
*Waldenstrom macroglobulinemia.
*Mycosis fungoides/ Sezary syndrome.
Burkitt's is associated with HIV/ AIDS as well as EBV virus.
It has an African subtype (jaw mass) and an American subtype (GI symptoms)...Burkitt's is the most rapidly progressive human tumor.
To diagnose, you need a core needle biopsy or an excisional biopsy of the lymph node (Starry-Sky appearance). Immunohistochemistry for CD19 + , CD20+, CD22+
Uric acid levels can be high---Give allopurinol (Xanthine oxidase inhibitor).
Staging of cancer is important (Ann-Arbor classification).
Treatment: Combination Chemotherapy (R-CHOP) regimen.
Tumor lysis syndrome can ensue.
PET scan is helpful.
The lymph node is a bean-shaped body (not a gland) that interrupts the flow of lymph through the lymphatic vessels.
Afferent lymphatics go towards the lymph node, while efferent exits the node. The lymph node has cortex (which contains the follicle, germinal center, mantle, and margin).
Lymphocyte activation and differentiation occur in the lymph node.
Lymph is a colorless fluid that floats in the lymphatic vessels (lymphatics) of your lymphatic systems.
Formed from the interstitial fluid (extracellular fluid) and returns back to the big veins (Superior vena cava) through the thoracic duct and Right lymphatic duct.
Lymph slows down when it passes in lymph nodes.
Lacteals are a special type of lymph, they are milky because they contain chylomicrons.
Lymph node enlargement can happen in cases of lymphoma (painless lymphadenopathy) or infection (painful).
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End of september 2018 i found out i have this problem. April 2019 after 7 months of chemotherapy i.m ok. No visible side effects. December 2019 back to work after recovery.
I am a survivor sporadic burkitts lymphoma i was fourteen years old year 1992when diagnosed at stage three did one year chemo in remission but relased at one year from being diagnosed.relapsed in the central nervous system my eyes when crossed and my right side of my face went paralyzed.i was told i was mist likely going to die. I had an autologist stem cell transplant with full body radiation first adolecent to have it done . And first adolecent to have one in boise idaho. The cancer is gone after a long hard battle but suffer the side effects from my intense therapy. But over all my doctors say i am in good shape for what i have been through i am 44 years old jesus gets most of the credit for making it ❤ jennifer beasley
So glad to hear that, Im treating this lymphoma. Second session (2 out of 6) and Im feeling great already, Im sure this lymphoma is gone already!
Im doing R-DA-EPOCH. You did this same protocol?
Man why did I not find your channel like 6 months ago. Man these videos are just awesome. I am telling you. They are better than any path videos out there. You combined Pathoma, Goljan, Robins and so much more. Hats off man. I did the leukemia videos today and now I can say I actually know what the hell is going on! lol. Awesome work. Keep it up
Awesome 👏
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@@MedicosisPerfectionalis Of course man. But after my path final exam. Which is divided in 2 parts. I will share this on 18th November to all my friends. And my IG status too. Not before that. I dont want all of them to ace the exams. Let me get some good grades then I will open the TREASURE CHEST to them. I am broke af. So no patron for me. But I will do whatever it takes to make this channel popular. Thats a promise. Its the least I can do.
@@MedicosisPerfectionalis How much is the patreon sub, the cost I mean? I want the notes.
I have different tiers for different things....$25 on Patreon to get all of my notes that I wrote until this day. If you just want the hematology, it’s less than $12 on my website www.medicosisperfectionalis.com/ If you have questions, email me at medicosisperfectionalis@gmail.com , I would love to send you my notes.
Thanks a ton!
You did it great , i dont know how i give you thank, but allah will reward you jannah❤🎉
Thank you!
I raise my hat to you! well explained. Inspiring!
Thanks 🙏
Thank you so much.
Sir, plz explain,, if there is hypocalcemia due to tumour lysis syndrome,, then how hypercalcemia can be a feature
Very good
Thanks 🙏
Many thanks
very nice explanation
Thank you, dear!
THANK BRO
My pleasure 😇
I know a white woman from the California/ New Mexico area that had the African subtype of Burkitt's lymphoma.
Do you mean with "median survival rate: 1-2 years" without treatment or with treatment. I thought that with treatment chances are a lot better than that. Once cured a long remission is ahead, certainly in younger patients.
Untreated. Otherwise what's the point of going through the hell of chemo.
Thank you for your nice tutorials, I have the question, is it advisable to initiate the treatment to the patients before staging?? Since some areas in Africa you may find it very difficult to get a CT scan.
Honestly, I don’t know...Only a specialist can help with that.
It is not advisable to do so
Kindly refer to next facility for staging
Clinical Oncologist in africa
Sir it was really amazing 🙏🙏🙏🙏🙏🙏👍👍🎊
Thank you 🙏
Thanks for the video! Rituximab is not used here in contrast to diffuse large B-cell right?
what you think about tumor lysis syndrome video making
Any medical advice to a guy who's brother died from this?
I am so sorry to hear about your brother.
It’s sad.
I don’t know if there’s anything you can do.
Please talk to your doctor!
great
Thanks a lot!
When you say 1-2 years survival rate you mean without treatment, right?
I bloody hope so, its been a year since....
What are some examples of B symptoms?
Constitutional symptoms: fever, weight loss, night sweats.
@@MedicosisPerfectionalis ohh thanks 🙌
why is FNAC not recommended in most of the lymphomas?
Sample is very small.
@@MedicosisPerfectionalis thankyou :)
I'm laughing at this flashbacking to 2006 and there was no time so the Doc guessed and chemo, it was a good guess and the TLS was a bitch though with organ failure
I am so sorry to hear that!
How is your health today?