Receptor Tyrosine Kinases - RTK

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  • Опубликовано: 16 апр 2020
  • Hey Scientists,
    today Receptor Tyrosine Kinases are in the focus.
    Cheers,
    Henrik
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Комментарии • 34

  • @stefanugaz
    @stefanugaz 3 месяца назад +4

    This was beyond helpful. 10/10 quality information

  • @debigdogk9563
    @debigdogk9563 7 месяцев назад +5

    Woooow, !!!!! thank you for so much effort in putting this great videos together. 👏🏿👏🏿👏🏿👏🏿👏🏿

  • @neurosciencegirl
    @neurosciencegirl Год назад +2

    Great video - thank you so much for creating and sharing :)

  • @yasserelamin9340
    @yasserelamin9340 Год назад +1

    brilliant explanation -- thank you!

  • @darko1532
    @darko1532 Год назад +1

    thank you so much! incredibly good!

  • @nonaiq3649
    @nonaiq3649 5 месяцев назад +3

    Thank you so much 😊 ✨

  • @ikbaliremalkan4315
    @ikbaliremalkan4315 3 года назад +3

    it was really helpful, thank you

  • @doom_inik
    @doom_inik 3 года назад +3

    absolut hammer! you should make a video on nonreceptor t kinases now to complement this one, or are they so similar it wouldn't make sense to?

  • @may_mohammad
    @may_mohammad 2 года назад +2

    Thanks alot , this was very helpful !

  • @AmairaniRamirezRendon
    @AmairaniRamirezRendon Год назад +2

    wow super helpful!! thank you so much

  • @selin6552
    @selin6552 4 года назад +1

    Thank you

  • @douaa7901
    @douaa7901 5 месяцев назад +2

    thaaanks

  • @augustintoisoul6548
    @augustintoisoul6548 2 года назад +10

    Thank you !!!! I don't speak English but I understand this video well. The illustrations are really well done.

  • @saraelsayed5226
    @saraelsayed5226 Год назад +2

    ❤❤❤ thanks

  • @riyadmansour5237
    @riyadmansour5237 3 года назад +2

    It was, thanks a lot

  • @sirine6554
    @sirine6554 2 года назад +1

    Thanks

  • @salamabbb
    @salamabbb 6 месяцев назад +2

    Thaaaaaanks ❤❤❤❤❤❤❤

  • @ihtshamali9469
    @ihtshamali9469 3 года назад +2

    Plz make a video about ras raf pathway

  • @alinamoreno9235
    @alinamoreno9235 3 года назад +4

    Wonderfully explained!

    • @jessesteven3324
      @jessesteven3324 2 года назад

      i dont mean to be off topic but does someone know a tool to log back into an Instagram account..?
      I stupidly forgot my password. I would love any help you can offer me

    • @kyriedustin4619
      @kyriedustin4619 2 года назад

      @Jesse Steven instablaster =)

    • @jessesteven3324
      @jessesteven3324 2 года назад

      @Kyrie Dustin Thanks so much for your reply. I found the site on google and Im trying it out atm.
      Looks like it's gonna take quite some time so I will reply here later when my account password hopefully is recovered.

    • @jessesteven3324
      @jessesteven3324 2 года назад

      @Kyrie Dustin it worked and I now got access to my account again. Im so happy:D
      Thanks so much you really help me out :D

    • @kyriedustin4619
      @kyriedustin4619 2 года назад

      @Jesse Steven Happy to help :)

  • @rahafmajdi3609
    @rahafmajdi3609 3 года назад +3

    soo helpful
    i just want to ask a stupid question
    each tyrosine phosphorylate the other one that is in front of it right?
    why do we use 6ATP molecules, why not just 3?

    • @henrikslab
      @henrikslab  3 года назад +2

      So, RTKs are encoded by many genes in our DNA. That means we have different subfamilies (they contain different numbers of tyrosine residues in the cytosolic part -> in the video I drew just 6 but it can be even more). So depending on the subfamily of the RTK much more Phosphates can bind to the cytosolic part.
      To your question now: In theory 2 would be enough, right. But over the evolution, it one can speculate that it was advantageous for the genes to carry more tyrosine domains (it might be that cells and by that even animals with more domains had a selective advantage over cells with fewer phosphate binding RTKs (but since it is evolution, this is just speculation)

    • @anujagunasekera3120
      @anujagunasekera3120 2 года назад +1

      I think you can also add that cell reception typically amplifies the response, this is advantageous for stuff like hormones, at the end of the day if your pituitary gland releases lets say 1000 molecules of ADH (again the number is small for simplicity sake, your gland would release millions of these) there is no way to know how many of them would actually bind to the nephrons in your kidney, however we still need to produce an adequately large response therefore the ability of a single ligand to cause a lot of intracellular change is desired, this increases the efficiency as less ligand needs to be manufactured. Does that make sense?

  • @reinasleem3333
    @reinasleem3333 3 года назад +1

    Sooo helpful

  • @Futurescientist_
    @Futurescientist_ Год назад

    What is GRB2

  • @vybzhub1304
    @vybzhub1304 Месяц назад

    Why did you say trinucleotide?

  • @Med-student22
    @Med-student22 5 месяцев назад +6

    Big thank to Allah then then to you

  • @rakshitatambe8627
    @rakshitatambe8627 3 года назад +1

    Thank you