NATALIE trial - Ribociclib - Tiny IDFS and imbalanced censoring | Why the trial is flawed
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- Опубликовано: 30 июн 2024
- Vinay Prasad, MD MPH; Physician & Professor
Hematologist/ Oncologist
Professor of Epidemiology, Biostatistics and Medicine
Author of 450+ Peer Reviewed papers, 2 Books, 2 Podcasts, 100+ op-eds.
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Thank you Timothée and Vinay for an excellent review of NATALEE, again digging deep into the data!
This was a very instructive video. Really informative for daily clinical practice. Good job.
I think your characters really fit together. The one person is easy and calm, the other has a little bit more temperament.
I am wondering if you could comment on the MONARCH-E study of adjuvant abemaciclib? The benefit there seems much more clinical significant probably because of the inclusion of higher risk population, but also possible due to the fact that is is slightly a different molecule and given continuously instead of intead of 3weeks on and 1week off like ribociclib?
I declined the cdk 4/6 after studying Monarch-E, and feel even more confident this was the right decision after your break down of this study, thank you!
Very interesting. I'm on Abemaciclib, Tamoxifen and Zoladex since being diagnosed 5 months ago. I achieved NED status last month. I insisted on taking the CDK 4/6 inhibitor at the lowest dose (50mg) and have had no side effects but after achieving NED my doctor really pushed me to increase to 100mg to "keep you NED", I struggle with figuring out what's too much. This was really interesting.
If the top brass at Novartis says that the Giants are crumbling you'll know it's a blockbuster!
His video is being censored
Fantastic analysis guys, sharing with my oncology colleagues.
Excellent analysis, thanks for your work guys
for COVID death, the difference could be one use preferred term "COVID-19" , and the other use grouped term which includes preferred terms "COVID-19" and "COVID-19 Pneumonia"
Excellent analysis 🎉😮
Do you have any insight into exemestane (aromasin)?
tx
We never had so much cancer of all these types in my mothers and earlier in my generation.
It's the jabs.
@@sl4983 CNBC "Phizer is betting big on cancer drugs to turn business around after Covid decline - Here's what to know."
Article March 10, 2024
😢
I did not comply.
life expectancy has been dropping for the last decade.
@@carlosgaspar8447 ALL their. Own. regularly advertised...d r u g you commercials end with causes c a n c er and even d e a t h.
It’s the food, the lifestyle… the chemicals. It’s damaging us badly
Did they talk about vitamin d levels?
Would they like to put everyone on this drug just in case?
Idiocy.
His video is being censored
I can watch other channels fine, this one's buffering
Your video and comments are being censored
No they are not
@@carolinereidartist It was on my end. No other video or channel was.