BCR is an indispensable component of a potent adaptive immune system, which is fundamentally reliant upon its diverse repertoire. BCR is generally defined as a transmembrane receptor located on the B-cell surface or a kind of membrane-bound antibody form. BCRs are assembled during the B-cell development and went through somatic recombination of three gene segments of the heavy chain locus (V, D, J) and two gene segments of the light chain locus (V, J) to diversify variable region gene.
BCR is an indispensable component of a potent adaptive immune system, which is fundamentally reliant upon its diverse repertoire. BCR is generally defined as a transmembrane receptor located on the B-cell surface or a kind of membrane-bound antibody form. BCRs are assembled during the B-cell development and went through somatic recombination of three gene segments of the heavy chain locus (V, D, J) and two gene segments of the light chain locus (V, J) to diversify variable region gene.