How to Treat Triple Positive Breast Cancer: All You Need to Know
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- Опубликовано: 17 апр 2023
- What is triple positive breast cancer? What are possible treatment options? What should you expect? In this video, Dr. Jennifer Griggs explains everything you need to know about triple positive breast cancer.
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Thank you for the helpful medical advice.
Thank you for watching
Very informative. Thank you.
Thank you for watching. We are so glad you found this video helpful.
You are realy blessed🙏🙏🙏🙏
Thank you for watching.
Thank you for really taking the time to explain it. I’m currently doing adjuvant treatment after stage 3 her2 positive. Had my surgery and reconstruction. Went straight into adjuvant.
Anyone facing it, it’s so much easier than chemo before hand. I got diagnosed at 40, so definitely the younger end. But life is slowly getting back to normal, back doing all the things I could before, just with extra drs visits.
It's great to hear that you're progressing well through your treatment and getting back to normal activities. Your positive attitude and sharing your experience can be encouraging for others facing similar challenges. Thank you for sharing your experience with the Yerbba community!
Glad to hear life is getting back to normal for you. My journey is just starting. I look forward to being where you are in the process. Thank you for sharing.
@@JeanninesCornerOfTheInternet I’m sorry to hear that. You’ve got this. If I can give any advice it would be we all have a different story, We’ve all felt different effects from chemo. So take it day by day, also be kind to yourself. There will be days where you’re too tired to do things and that’s okay.
@@sueb9692 I will definitely keep this in mind. :)
Hi there! My mom has been diagnosed with breast cancer (hormone-positive). However, her HER2 status is inconclusive, that is, two immunohistochemistry (IHC) tests showed that it is HER-negative. While, another fluorescence in situ hybridization (FISH) showed that it was borderline which later confirmed that it is HER2-positive. In this case, what can be done? What if she starts treatment for HER2-positive breast cancer (Trastuzumab) and chemotherapy (epirubicin) when in fact she has HER2-negative breast cancer? What would happen? Thank you
These tests used breast tissue samples from 2 different biopsies.
This is always a difficult situation. In general, we try not to withhold anti-HER2 therapy even if there is some doubt about the status. It is so effective in treating cells that have excess amounts of HER2.
Plz make a video on upcoming treatment option goal under trial and available
There are a lot of clinical trials in breast cancer. Is there a particular trial you're interested in?
@@yerbba i just want to know what is the upcoming therapy will come her2 positive
I would like to add that there is a small set of people that are triple positive that do need more than one chemotherapy because their levels of ER/PR are particularly high and the standard treatment does not work as well. I was diagnosed in 2020 with it (Stage 1a, grade 2) and given Taxol/Herceptin (12 weekly rounds) then finished with Herceptin only in November 2021. In October 2022, I found a lump near one of my mastectomy scars that turned out to be a recurrence (triple positive, stage 1c, grade 3). This recurrence was even more strongly positive in ER/PR receptors than the first occurrence. It is thought that in some people (about 10%) , the HER2 receptors are not as sensitive to Herceptin and work with the hormone receptors to resist treatment. This time I'm getting Perjeta along with Herceptin for HER2 and also taxotere and carboplatin (TCHP). I'll also get radiation. Hopefully, this will take care of it as I don't know what would be tried if it returns a third time.
Sorry about the recurrence, wish you quick and full recovery, wanted to ask how long will you be taking taxol/carboplatin for? Is it 12 weeks or 16 weeks, my daughter is triple positive with tumor size 5cm, she is on TCHP regimen. Thanks
Im triple positive idc stage 1 grade 3. Ive received 4 round of ec.and now on weekly taxol and 3 weekly herceptin.
Thanks for taking the time to write and share your experience. Wishing you the best.
Have you did surgery also..... How many rounds of chemo
Hi There! I was initially diagnosed with ER/PR+ HER- Stage 1 grade 3 bc. After surgery, I was put on Letrozole and more recently after 3 months of surgery, I learned that I am HER2 based on a FISH analysis. I can very concerned about it. I had IHCs, oncotype testing and mammaprint that all said that I was HERS-. The doctor wants to put me on chemo/target therapy. Please give me your thoughts. I read about chemotherapy crosswalks and don’t know if this is wise. Please advise.
This is a rare and difficult situation. Without being directly involved in your care, it is challenging to weigh in.
For stage 1 bc triple positive, you said less chemo (only 1) and dual for her2. Do you mean THP protocol?
The T should be a weekly Taxol or Taxotere every 3 weeks? What do you recommend?
For low risk HER2-positive breast cancer, single-agent paclitaxel (the only chemotherapy, that is) and trastuzumab (Herceptin) can be given instead of a three-drug regimen.
@@yerbba Thank you for your reply. A family member yesterday started neoadjuvant chemotherapy, paclitaxel (T) weekly and HP every 3 weeks.
Your videos were very helpful to us.
Hi there! My mom has been diagnosed with breast cancer (hormone-positive). However, her HER2 status is inconclusive; that is, two immunohistochemistry (IHC) tests showed that it is HER-negative. While, another fluorescence in situ hybridization (FISH) showed that it was borderline which later confirmed that it is HER2-positive. In this case, what can be done? What if she starts treatment for HER2-positive breast cancer (Trastuzumab) and chemotherapy (epirubicin) when in fact she has HER2-negative breast cancer? What would happen? Thank you
These tests used breast tissue samples from 2 different biopsies.
hello maam i was a tripple possitive and i already finished 8session for chemotheraphy and i was on going radio theraphy but i still not undergo surgery because i am scared is that ok.
It's totally understandable to be scared. Studies that have skipped surgery have found that the breast cancer is more likely to come back. People are therefore encouraged to have surgery. It's important that your fears are addressed fully by a compassionate medical team. Wishing you all the best.
@@yerbba thank u maam for the helpful advice.
hello maam i already finished my radiation therapy last may 2 and i am now and the healing process hoping my recovery and hoping also that my cancer well no longer camback eventhough i scape for sugery. thats i always prayed to God.
I posted a comment about some triple positive tumors being resistant to treatment, but now I don't see it.
Hi Lisa, we aren't able to see your comment either. Would you like to send it again?
@@yerbba My comment was simply that I had read research that suggested that there is a subset of triple positive tumors that appear to be treatment resistant; in particular resistant to herceptin. The point was made that triple positive tumors don't always respond in the way that hormone negative HER2 positive tumors did to herceptin. I'm suspicious that I might be a part of that subset because my triple positive tumor recurred less than a year after completing treatment the first time. My oncologist hopes that herceptin and perjeta along with chemotherapy will keep it away.
Thanks for writing. You're correct in that there are a subset of people who seems to have less of a response to Herceptin. We hope the new regimen is effective. Dual HER2 blockage has been a game-changer for many people.
My mom is 82, weak, depressed triple postive her2+. It was suggested she do chemo, TDM1 5 hours a week for one year, lumpectomy and radiation!! Seriously . being there for 4 hours like a tour created massive fear and ptsd not comfort. Now she wants none of it. Another Dr has suggested Tamoxifen. She just want to live a QUALITY life and if we dont follow their protocol they said "we cannot help you". What is the analysis or trials of diet, exercise, supplements, alternative treatments at this age in comparision to the toxins at this point in life? A few more years but pain and suffering from sickness and side effects? I can say it has not been a comforting experience so far. And not asking what the patients wants and how to support this journey has been the most disappointing.
This sounds so hard. Nothing is more important that understanding a patient's goals of care. It is likely that you will find another medical team that can help her achieve her goals of comfort and quality. A palliative care specialist is also very likely to help.
I'm hearing more women that are having only 5 sessions of radiation these days. Can you please elaborate on this? Thank you.
I just had five sessions and I was thrilled !
@@sueu6263 Was this because your tumor was small? I'm wondering about the reasons for this as I only want 5 as well.
Hypofractionated radiation therapy has been studied in several trials and, if your treatment center is delivering radiation therapy this way, is a safe and highly effective option with less inconvenience.
Is it true they’re working on a vaccine for triple negative breast cancer?
Yes, there is a lot being done in the area of vaccines for all types of breast cancer, including triple-negative breast cancer. Stay tuned.
@@yerbba Thank you! That’s exciting! I don’t ever want this tnbc again! Blessings🌷
Triple positive breast cancer is good or bad....
It's hard not to want to compare one type of cancer to another. So many other factors play a role in prognosis, including stage and the health of the patient. When patients ask, "Is it better or worse to have such-and-such?", we find the best answer is that the cancer you have is the one that you have. We treat each person only for the cancer that they have
Thank you so much for this video! You actually helped calm me quite a bit with your easy-to-understand explanation. My ears really perked up when you mentioned "de-escalating therapy". I would love your opinion on 2 questions:
1. Based on my info, how do you see triple positive cancer recurring in my future?
2. Based on my info, do you see the regimen, I am soon to start, as very sound or possible overkill?
I am post-menopausal
Initially diagnosed with stage 1 grade 3 INVASIVE LOBULAR CARCINOMA via biopsy
ER/PR Positive HER2 2+ ... after FSH HER2 low
Ki-67 = 50-60%
Tumor removed with clean margins and with 3 lymph nodes removed which all came back clear
After surgery biopsy moved me from stage 1 to stage 2 with final result being HER2 positive
Now that the tumor is removed my treatment will be:
Taxotere and Carboplatin every 21 days for 6 cycles along with Herceptin and Perjeta
Once I complete chemo I will continue with the Herceptin and Perjeta for a year
I was so overwhelmed with everything I couldn't even begin to think about/talk about/question/process, the radiation and pill therapy just yet, but I believe there will be radiation following chemo along with hormone suppressants for at least 5 years.
Thank you for your time :)
That is a "thorough" regimen for certain. The relatively high Ki67 and the HER2 positivity are most likely prompting this recommendation. If you are uncertain about this regimen for you, talk with your team about another option.