Drugs of Abuse: Ethanol, Methanol & Ethylene Glycol - Toxicology | Lecturio

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This video “Drugs of Abuse: Ethanol, Methanol & Ethylene Glyco” is part of the Lecturio course “Toxicology” ► WATCH the complete course on lectur.io/alcohols
► LEARN ABOUT:
Clinically important alcohols and their antagonists
Ethanol metabolism and metabolism inhibitors
Methanol "Wood Alcohol"
Ethylene glycol
Test question
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► READ TEXTBOOK ARTICLES related to this video:
How to Recognize and Treat the 5 Major Drug Intoxications
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Drugs of Abuse: Alcoholism, Opioids, Cocaine, Hallucinogens and More
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FROM THE VIDEO:
“Fomepizole is a drug that inhibits alcohol dehydrogenase. So, it allows methanol itself to be excreted unchanged in the urine so you don't build up toxic levels of formaldehyde. Ethanol is a competitive inhibitor of methanol intoxication and metabolism, so sometimes we will actually treat methanol toxicity with ethanol. Myself have treated a number of patients who had drink wood alcohol or methanol with intravenous ethanol to the point where we actually had to intubate them and put them on ventilators to compensate for the severe intoxication from the ethanol until they can clear the methanol and then they just were allowed to wear off the ethanol on their own…”

[@MimmiEkman-h2i]

Soothing voice, comprehensible lecture! thank you

[@mom_doc]

Thanks for a clear and simplified explanation. Great slides too!

[@kobeisgoated29]

Needed this for my forensic test

[@lecturiomedical]

We're very happy to see Lecturio has been helpful! If you'd like more videos like this, but also downloadable study materials, quizzes, learning path, access to 3D Model and much more, register and start your FREE trial today: lectur.io/freecontentyt

[@nyawirawaithaka4993]

Thank you!

[@ledfed1912]

I wonder what is the possible damage of ingesting a very small amount of ethylene glycol, lets say 0.5 ml. What is the threshold for damage?

[@alanzeblade928]

I don't understand why ingestion of ethanol would not cause metabolic acidosis, since the ratio NADH/NAD+ would be increased due to the conversion of ethanol to acetaldehyde, and subsequently to acetic acid.
The increased NADH/NAD+ ratio should, in turn, increase the depletion of pyruvate into lactate, which is basically acidic ? So why ?

[@KPDanni]

It should say that formic acid / formate is responsible for damage, not formaldehyde directly. Hmm..

[@GP-fj9qu]

How do you tackle the fact that doctors are not testing for poisoning cases on people with long history of chronic illness?
What type of doctors know about the after care of something like this?
All videos I find are about prevention and immediate treatment but not the long term treatment of recovery or even the survival rate.

[@tonymejia4251]

The alcohol and delirium psychiatry lecture from this same channel covers some of the topics listed in your comment. I am a nursing student but I am assuming doctors were also taught about the use of referals to AA or other support groups as they have the highest success rate to treat alchol abuse disorder. Most nursing/medical lectures focus on the inpatient setting (hospital) as a majority of the professionals work there. Referalls to outpatient therapy with a psychiatrist, Psych NP, and other psych professionals also help via using psychotherapy, CBT (reforming negative thoughts into positive ones to, for example, deter them from drinking) and the prescription of aversion therapy and narcan to make drinking alcohol have side effects and not be enjoyable. I hope this answers some of your questions.

[@lesliehilesgardener6959]

Keep seeking keep knocking pray He will Direct your steps if righteousness is the goal

[@IamBossolo]

Why do they put Methanol which is poision in red wine? and CBD OIL

[@alanzeblade928]

because its profitable

[@tupai62]

Hi, can ethanol mix with water?

[@safeyasaleh2462]

Can u told me how can I got fomepizole ?

[@-ahmedalqopaisi4281]

I need the ppt of this lecture as text

[@Remmmm9]

Idk what I'm doing here.. I was supposed to be drawing :D

[@hinkelstein69]

Ethylene glycol is not a drug of abuse. It has none of the effects of ethanol and methanol on the CNS. It can still be clinically important since ingestion of anti-freeze can occur, not so much for want of a "high", but because it tastes sweet.

[@GreenGameLol]

Ethylene Glycol (ethanediol) does cause intoxication, but it is just under half as potent as Ethanol at causing intoxication.
If you drank 5 shots of 40% Ethanol on an empty stomach, most people would feel a significant buzz, whereas with Ethylene Glycol, you'd probably have to drink 12 shots of a 60% solution to get an equivalent buzz

[@hinkelstein69]

@@GreenGameLol I get the point, and so this (CNS effects) must be corrected. However, I still contest that methanol and ethylene glycol are drugs of abuse [of any importance]. Ingestion is usually accidental, not deliberate (in contrast to ethanol), since the toxic effects are so dangerous (and unpleasant).

[@GreenGameLol]

@hinkelstein69 Yeah, which the reason why Methanol and Ethylene Glycol aren't manufactured as drinking alcohol like Ethanol is due to (like you said) the metabolites of MeOH and EG cause their horribly toxic effects.

[@kimienick6721]

I think someone put this shit at my rent room air cond 😹😹☺️... Later ask them clean it.... Have WAYANGMAN 😹😹

[@kimienick6721]

My mask also spray by this too😹😹😹

[@Afsarullingkonn]

😂😂😂😂

[@tasosath2031]

craaaaaaaaaaap

[@Sam-Samington]

When speaking about things like this it's best not to stumble over your words, or easier just do another take

[@Sam-Samington]

@@prateekmisra8251 "don't watch it then" after I've already watched it... Good one