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This is so confusing is there some way we can make this very concise or is it just too nuanced for that

What if you have some of both the under and over mythelation symptoms

What if you have both under and over mythelation

No links that you thought were there.

Hi. Thank you for the video. I have had elevated B12 for a few years. Could never get answers from doctors. I was exposed to high levels of radiation for almost 10 years. Lived in the area of Chernobyl Nuclear Plant explosion. My Dad died from multiple myeloma. I tried to ignore it. However, now when I have symptoms I can’t ignore it any longer. I was hospitalized twice in the past 2 months. Unusual fatigue, very heavy legs, dizziness, nausea, itchy skin. Did all the tests possible. MRI’s do not show anything. Doctors say that I am a mystery for them and that they are not equipped to deal with it. What do I do now? I do not supplement with vitamins nor do I eat dairy and meat. No processed foods. Who can help?

I could use your help im at the end of my rope. Please help me

When a Lamborghini needs specific fuel rather than cheap garbage fuel do you call it weak? Or do you recognize it simply isn't a dump truck but rather a high performance vehicle. When a canary dies in a coal mine, do you call it genetically weak or do you thank it for its service and get out of the mine and stop letting people go into the mine until the mine is made more safe.

Why blame cheap synthetic vitamins and environmental toxins that are making high percentages of people with these variants sick and being used to "enrich" and "fortify" foods cheaply yet fuels billion dollar medical economy by keeping people ill. Why place the blame where it belongs when you can blame the humans and their dna as if the humans are the flaw rather than the system being the flaw by failing the humans with these gene SNPs. Lazy unethical mentally weak scientists. Greedy medical system. Psychotic world leaders that WANT people infertile and feel ENTITLED to do harm so long as it benefits themselves only.

What's everyone's name here?

I hope this can help at least someone. My elevated B12 levels were due to a B1 deficiency. I had both dry and wet Beriberi. If I understand it correctly B1 is crucial in the transportation chain of B12 and the other micro nutrients in to the cell. Elevated serum B12 is apparently common in a B1 deficiency. The entire chain breaks down without it.

I'm so glad I have found your channel. I am heterogeneous and thalassemia healthhy carrier. The hematologist told me to take folic acid every spring and autumn. Now I have B12 dificency. I take a B12 shot, folic acid and B6 ( owing to my attrofic gastric) I wonder whether my MTHFR will be able to methylate my Folic Acid. Do I have to take Folic Acid or do I have to take Folate instead. The problem is Folate is not available in Albania, where I am watching the video. I appreciate your channel.Thanks again.

Hubby knew something was wrong in 2015 and neuro didn’t test. Dropped him and he was lost out of neuro system for 2 1/2 yrs and getting worse. Had silent heart attacks and I insisted neuro testing. Was diagnosed with movement disorder and Parkinson’s and was put on carbo levo and built up to 8 a day with no help. Went to VA and no help until moving to NC and neuro tested b6 and was toxic. He now cannot feel feet on floor because of sensory nephrology

I would start with organic acids test and thyroid. Minerals and heavy metals. Check lithium levels required for transport. Organic acids will reveal inborn errors of metabolism and blocks. I would not start with genes. Good work up first before even thinking genes. Remember, bacterial organisms can make up to 15 types of cobalamins. How healthy is your gut microbiome? Organic acid test will reveal pathogenic species.

I’m 122 is that high? Seems 50-110 is normal idk. My feet started getting numb burn

My B-12 levels are slightly emevated, almost 1200. I am always tired, but do not sleep well I'm also diabetic and have blood pressure that spans high to very low(mostly high on the top and low bottom). I also have neurophy. Last March, i noticed my feet swelling. Went to see my doctor, who sent me immediately to emergency. My iron level was 7.2. the hospital kept me and started doing hourly blood test from. 7 pm. At 1 am, my iron dropped to 7 and i was goven a transfusion. They kept me for 3 days until my iron level was up to 9.7. iweighed myself the morning of my appointment, i was weighed again inmy drs office, then again at the hospital. I weighed 180. Within 30 days after my hospitalization, i weighed 144. Ive had a scope performed of my upper digestion, and a colonospy. Nothing found. Less than a yeat later, i weigh 124. All test results come back almost normal. Iron a little low, sefimentation high. Red blood cells large. And higher than normal B-12. Losing weight at about 1 1/2 pounds a month. Still tired and dont sleep for days. Any thoughts? Any further tests recommended?

Yep. Poor methylator and detoxer with sensory neuropathy triggered by b6. Deficient and toxic. Histamine triggers flares as well. Lots of heavy metals so epigenetically triggered genes. Finally found someone to help but I’m complicated. This is my full time focus.

Which vitamin is best for a person who has a afib. And problems with kidney failure?

❤ I'm watching from South Texas .

My B12 is 2000. I can sleep 30 hrs straight. No supplements

It wasn't until I went to the third neurologist who finally checked my b6 level and it was 4 times what I needed. Now I deal with peripheral neuropathy every day.

I was diagnosed in 1999 with idiopathic peripheral neuropathy. Again in 2013. I was also diagnosed with diabetes Type 2 in 2014 (provoked through Spiricort given to suppress symptoms of Polymyalgia Rheumatica) and had a heart attack in 2019. For neuropathic pain relief I was started on Gabapentin and Cymbalta arund in 2012. Because of horrid cognitive side effects, Cymbalta was switched out for Effexor. Unfortunately, these cognitive side effects didn't stop, so I stopped using them. So, I ended up stopping these. 2015 - started taking the following instead: R-Lipoic Acid 300 (240) mg - 1-1-1-1 Acetyl-L-Carnitine 750 mg - 1-1-0-1 N-Acetyl Cysteine (NAC) 1000 mg - 1-0-1-0 Omega 3 (fish oil) 1000 mg - 1-0-1-0 Borage Oil 1000 mg (GLA = Gamma Linolenic Acid) - 1-1-1-0 (stopped 1. nov. 2023) Magnesium 100 mg - 1-1-1-1 These above have helped some. I came to use these through exclusionary processes. IOW, I'd take a substance for a while, noting sensations. Then I'd stop and see what happens. These above “passed” this exclusionary process. If I noticed an increase in severity of symptoms when stopping a substance, I could conclude, that it was actually helpful when I was taking it. I then added Benfotiamine starting on 15.08.2023. Helped greatly, most overt pain gone, but numbness still prevalent (time of writing 22.12.2023). Some stomach ache if dosage is over 150mg, so I take 100/150mg 1-1-0-0 / 150mg 0-0-1-0 and 250mg before going to bed (0-0-0-1) - I don't get stomach ache before going to sleep or during the night. I then added on September 5, 2023 (as it stands 25. Nov. 2023): Folic acid 1.7 mg 1-1-1-0 Biotin 5 mg 1-0-0-0 Methylcobalamin 1500 mcg 1-1-1-0 Vitamin B6 P5P 27mg 1-1-0-0 The 4 above plus Benfotiamine & R-Lipoic acid, according to this study, which has been cited many times in meta studies concerning use of supplements to treat neuropathy pain: Maladkar, M., Tekchandani, C. and Dave, U. (2014) Post-Marketing Surveillance of Fixed Dose Combination of Methylcobalamin, Alpha Lipoic Acid, Folic Acid, Biotin, Benfotiamine & Vitamin B6-Nutripathy for the Management of Peripheral Neuropathy. Journal of Diabetes Mellitus, 4, 124-132. dx.doi.org/10.4236/jdm.2014.42019 www.scirp.org/journal/paperinformation.aspx?paperid=46105 “Results: Treatment led to significant reduction from baseline score in various neuropathy symptoms from the 4th week itself. After 12 weeks of treatment, the mean pain score declined by 78.0%, numbness by 92.1% and muscle weakness by 96.9%. Also, there was 96.0% & 99.2% reduction in tingling & burning sensation respectively. No serious adverse events were reported. Conclusion: The current study confirms that fixed dose combination of Methylcobalamin, ALA, Folic Acid, Biotin, Benfotiamine & Vitamin B6 is effective & well tolerated in the management of peripheral neuropathy.” “This PMS included 497 patients with peripheral neuropathy and was conducted at 5 different centers by qualified investigators. The efficacy of the treatment was assessed based on improvement in parameters like neuropathic pain, numbness, muscle weakness, tingling and burning. Investigation of parameters was performed throughout the treatment period on: visit I (baseline), visit II (week 4), visit III (week 8) and visit IV (week 12).” “Patients with peripheral neuropathy were orally administered fixed dose combination of Methylcobalamin 1500 mcg, ALA 200 mg, folic acid 5 mg, biotin 5 mg, Benfotiamine 50 mg & vitamin B6 5 mg once daily for 12 weeks.” Hakim, M., Kurniani, N., Pinzon, R. T., Tugasworo, D., Basuki, M., Haddani, H., Pambudi, P., Fithrie, A., & Wuysang, A. D. (2018). Management of peripheral neuropathy symptoms with a fixed dose combination of high-dose vitamin B1, B6 and B12: A 12-week prospective non-interventional study in Indonesia. Asian Journal of Medical Sciences, 9(1), 32-40. doi.org/10.3126/ajms.v9i1.18510 nepjol.info/index.php/AJMS/article/view/18510 Baltrusch, Simone (2021) The role of Neurotropic B Vitamins in Nerve Regeneration, Biomed Res Int. 2021; 2021: 9968228. Published online 2021 Jul 13. doi: 10.1155/2021/9968228 www.hindawi.com/journals/bmri/2021/9968228/ Pinzon RT, Schellack N, Matawaran BJ, et al. (2023) Clinical Recommendations for the use of Neurotropic B vitamins (B1, B6, and B12) for the Management of Peripheral Neuropathy: Consensus from a Multidisciplinary Expert Panel. J Assoc Physicians India 2023;71(7):93-98. www.japi.org/y26464c4/clinical-recommendations-for-the-use-of-neurotropic-b-vitamins-b1-b6-and-b12-for-the-management-of-peripheral-neuropathy-consensus-from-a-multidisciplinary-expert-panel Silviana, Meyvita, Tugasworo, Dodik, Belladonna,Maria (2020) The Efficacy of Vitamin B1, B6, and B12 Forte Therapy in Peripheral Neuropathy Patients, DOI: doi.org/10.14710/dimj.v2i1.9549 Geller M, Oliveira L, Nigri R, Mezitis SG, Ribeiro MG, et al. (2017) B Vitamins for Neuropathy and Neuropathic Pain. Vitam Miner 6: 161. www.hilarispublisher.com/open-access/b-vitamins-for-neuropathy-and-neuropathic-pain-2376-1318-1000161.pdf Amorin Remus Popa, Simona Bungau, Cosmin MihaiI Vesa, Andrei Cristian Bondar, Carmen Pantis, Octavian Machiar, Ioana Alina DimulescuI, Delia Carmen Nistor Cseppento, Marius Rus, (2019) Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy, Revista de Chimie, Buchares, Original Edition- 70(9) DOI:10.37358/RC.19.9.7498, www.researchgate.net/publication/336529734_Evaluating_the_Efficacy_of_the_Treatment_with_Benfotiamine_and_Alpha-lipoic_Acid_in_Distal_Symmetric_Painful_Diabetic_Polyneuropathy H. Stracke, W. Gaus, U. Achenbach, K. Federlin, R.G. Bretzel, (2008) Benfotiamine in Diabetic Polyneuropathy (BENDIP): Results of a Randomised, Double Blind, Placebo- controlled Clinical Study, 2008 Nov;116(10):600-5. doi: 10.1055/s-2008-1065351. Epub 2008 May 13. pubmed.ncbi.nlm.nih.gov/18473286/ Carlos-Alberto Calderon-Ospina, Mauricio Orlando Nava-Mesa & Ana María Paez-Hurtado (2020) Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review, Therapeutics and Clinical Risk Management, 16:, 1275-1288, DOI: 10.2147/TCRM.S274122 www.tandfonline.com/doi/full/10.2147/TCRM.S274122

My regular one a day multi-vitamin for 50+ women has over 1000% of the DV of B12!! It also has 353% of the DV of B6. Why are they putting outrageous amounts in a multi-vitamin? No wonder I’ve tested so high with B12!

Looks like your website went out of business

Treat mold 1st or metals. And how do u safely treat metals

U can’t get toxicity from b 12

Good luck finding a doctor to do all these tests. It’s like calling a Cop when you need a Detective.

THANK YOU, for so much good information!! It is so great to hear doctors interested in preventive/functional medicine vs just prescribing medicines. You are actually looking into the root causes so that the condition can hope to be corrected vs just treating symptoms. Love that!! My Family Med doctor tested my ferritin (iron) level a year and a half ago because I have been chronically anemic and she was considering iron supplementation. Well, it was a surprise to find my ferritin level was at least 4X more than normal (897)! So I had the genetic test for hemochromatosis and indeed, I've got that genetic mutation. After that she tested my folate and vitamin B12 levels. Folate was normal (>24). Vitamin B12 was high (">2000"). I was taking a B12 supplement every day (5,000 mcg as methylcobalamin). I stopped taking that on my own when I got the results, with my md's knowledge. NOW I am wondering if my iron overload could have hindered transport of Vitamin B12 across my cell membranes, (you kind of alluded to that potential?) thus leaving an excess of B12 in my bloodstream... Because I also have a LOT of the symptoms of B12 deficiency! AND I am wondering if an intracellular deficiency of B12 could be responsible for my anemia! Crazy, huh? My bone marrow biopsy indicated that I don't produce enough RBC's. I have been going for phlebotomy frequently to decrease my ferritin levels and it is now down to normal (80). =) They only take 400mls at a time because of my anemia. (My Hgb is usually just over 11, hct low 30's.) So now that I understand more, I will be asking my Hemotologist (actually an NP) to re-check another B12 level now that my ferritin level is normal, and if it's still high, to pursue further testing to determine WHY, as you have so clearly indicated its importance!! I will be checking your website, and referring my Hematology NP to it!

This is good information and I thank you for sharing. But it's sad to go to the links for YGT and the Facebook page only to find they no longer exist. WHO does one go to for this kind of testing? I just looked up "geneticists" in my area and there are none. :-( If I understood the info correctly, if I have neuropathy symptoms.... and my B6 shows up as high, I may still benefit from taking a medical form of B6 to get the needed vitamin INSIDE the cells?

My b12 levels are high 1,400, I feel pins and needles all over my body, the doctor ask me to stop taking b12, but has investigated the cause of the problem, I am in so much pain.😢😢😢😢

My wife had the levels at out of scale 2000 and medics says that are nothing to worry about. What's ur opinion

So ive been dealing with idiopathic neuropathy in both feet for a few years now and my doctor just shrugs his shoulders and im not diabetic and i have finally found out about this and i got to thinking you know ive consumed energy drinks for probably the past 15 years pretty much everyday and probably more than one a day and i see those things are loaded with the synthetic version of B6 and not the active version....i personally feel im very B6 toxic...any advice on how to detox for this....ive stopped drinking the energy drinks and now pay attention to everything i consume.

Thanks John Thomas for the great information!

I am so glad I came across this information! I was told to take B6 , B2 and a few other things. From early March until June 30th I was not able to walk and the pain was excruciating! I had seen doctor after after doctor and no one knew what was happening. As a mom of two boys, it killed me to not be able to walk at all! I was TERRIFIED and the pain never went away. I got my blood tested and the B6 was flagged HIGH. I stopped taking it for over two weeks now and feel less pain and can walk a little more every day. I’m praying I fully heal one day soon! Now I need to look further into this! Thank you!!

Excellent info thank y’all so much 🙏

I know 2 people with MTHFR mutation and double dose of B6 in the blood. Does it mean that it can’t be turned into active form and the body is in deficit? Do they have to supplement with the activated form? How to get rid of this blood excess? They don’t supplement.

This explains what has been happening to me for the last twenty + years, what type of doctor should I see to help with with this?

Is there a full version of this vid?

You said you were gonna link tests in video description but there are no links. Where do I begin to investigate these things for myself and get tested by a professional who can help?

Everybody needs to look into alpha lipoic acid especially diabetics with peripheral neuropathy. It's fat and water soluble and removes oxidative stress

I have not touched a B12 supplement but mine just came back and it was 1415

Thanks for your video, I have high b12 around 1350 and have never taken b12 supplement, my doctor have no idea why this is the case but the main issue for me is that I now have severe chronic insomnia and could go 4 days in a row with absolute zero sleep for 18 months now which has ruined my life. I have had three mri scan of my brain, two sleep studies and other blood tests but have found no cause gor this terrible insomnia, what specific blood tests should I have? Could the insomnia be caused by high b12? I had to stop buying any cereal or food that listed b12 on the ingredients list, pls reply

Could it be caused by Fatty liver? If it’s cancer, how do they find out? What tests should they do? Thanks:)

Interesting that this vid is not full of comments. It seems like those who are into Anthony William are not interesting in other science informations.

He's very well informed .. unbelievable

Can copper toxicity cause elevated b12 but deficient at the same time, I pretty sure that’s what’s going on with me I have low b12 symptoms pins and needles hands and feet and body parts as well even though my levels are high but I am copper toxic.

My b12 is over 2000 always high taking b12 but not that much have mtrr and mthr wondering why this is happening

To long getting to the information!

What’s the supplement I need to transport b12 into cell?

I have high B12 for years without supplementation. Terrible insomnia and histamine intolerance. No doctor addresses it for me. I don't have a high homocysteine level. I do have a high MCV anyone with any input?