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PathologyCentral
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Добавлен 30 сен 2021
I'm a Professor of Pathology at Duke University School of Medicine and Course Director of our medical school pathology course. I am also a co-editor of Robbins Essential Pathology and the upcoming edition of Robbins & Kumar Basic Pathology. The Pathology Central channel is a resource for medical students and medical educators. I want to provide quality instruction on basic pathology in order to help you become the best physician you can be. I am very committed to patient care.
Deyrup Population Descriptors 2 16 24 edited
This video, from a Grand Rounds for the Duke Department of Pathology on 2/16/24, focuses on the National Academies of Sciences, Engineering and Medicine publication:
National Academies of Sciences, Engineering, and Medicine; Division of Behavioral and Social Sciences and Education; Health and Medicine Division; Committee on Population; Board on Health Sciences Policy; Committee on the Use of Race, Ethnicity, and Ancestry as Population Descriptors in Genomics Research. Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Field. Washington (DC): National Academies Press (US); 2023 Mar 14. PMID: 36989389.
National Academies of Sciences, Engineering, and Medicine; Division of Behavioral and Social Sciences and Education; Health and Medicine Division; Committee on Population; Board on Health Sciences Policy; Committee on the Use of Race, Ethnicity, and Ancestry as Population Descriptors in Genomics Research. Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Field. Washington (DC): National Academies Press (US); 2023 Mar 14. PMID: 36989389.
Просмотров: 143
Видео
Medical School Pathology: Pathophysiology of Neurodegenerative Disorders
Просмотров 1,3 тыс.Год назад
This video for medical students covers the complicated pathophysiology of neurodegenerative disorders by focusing on Alzheimer disease, Huntington disease and Parkinson disease. Material based on Robbins & Kumar Basic Pathology, 11th edition.
Medical School Pathology: Pathophysiology of Myelin Disorders
Просмотров 578Год назад
This video for medical students covers the pathophysiology, clinical features and morphologic findings of demyelinating (e.g., multiple sclerosis) and dysmyelinating (e.g., the leukodystrophies) disorders. Krabbe disease, metachromatic leukodystrophy and adrenoleukodystrophy are discussed.
Medical School Pathology: Pathophysiology of Inherited Metabolic Liver Diseases
Просмотров 726Год назад
This video for medical students focuses on three inherited metabolic liver diseases: hereditary hemochromatosis, Wilson disease and alpha 1 antitrypsin deficiency. There is a brief discussion of iron and copper metabolism, to provide a foundation for understanding the pathophysiology of these diseases. Morphologic findings and clinical features are discussed. This material is based on Robbins &...
Medical School Pathology: The Pathophysiology of Fatty Liver Disease
Просмотров 1,3 тыс.Год назад
This video for medical students focuses on the pathophysiology of the two pathways to fatty liver disease: 1) excess alcohol (alcohol-related fatty liver disease) and 2) insulin resistance/metabolic syndrome (nonalcoholic fatty liver disease, NAFLD). Morphologic findings (steatosis, steatohepatitis & steatofibrosis/cirrhosis) and clinical features are also discussed. Material is based on Robbin...
Medical School Pathology: Pathophysiology of the Prostate
Просмотров 3,4 тыс.Год назад
This video for medical students focuses on the two most important entities that involve the prostate: benign prostatic hyperplasia and adenocarcinoma of the prostate. The pathogenesis of these lesions, clinical features, morphology and treatment are discussed. This material is based on Robbins & Kumar Basic Pathology, 11th edition.
Medical School Pathology: Pathophysiology of Lung Tumors
Просмотров 940Год назад
This video for medical students covers the BIG THREE of lung carcinomas: small cell carcinoma, squamous cell carcinoma and adenocarcinoma. There is also a brief discussion of carcinoid tumors. In addition, the pathophysiology of the paraneoplastic syndromes associated with these malignancies is discussed. Based on Robbins & Kumar Basic Pathology, 11th edition.
Medical School Pathology: Pathophysiology of Respiratory Distress Syndrome
Просмотров 859Год назад
This video for medical students includes two entities: acute respiratory distress syndrome and neonatal respiratory distress syndrome. These are covered in two separate chapters in Robbins Pathology, but since they have some overlap in terms of pathophysiology and morphologic features, it can be useful to look at them together!
Medical School Pathology: Introduction to Myeloid Neoplasms
Просмотров 1,2 тыс.Год назад
This video for medical students focuses on the pathophysiology and morphologic features of the myeloid neoplasms: acute myeloid leukemias, myelodysplastic syndromes and myeloproliferative disorders (e.g., polycythemia vera)
Medical School Pathology: Hodgkin Lymphoma
Просмотров 916Год назад
This video for medical students focuses on the pathophysiology and morphologic features of the 5 types of Hodgkin lymphoma. Based on Robbins Pathology.
Medical School Pathology: Introduction to Lymphoid Neoplasms
Просмотров 2,1 тыс.Год назад
Hematopoietic neoplasms are HARD! This video will provide a framework for understanding lymphoid neoplasms and set you up for the Boards and the Wards.
Medical School Pathology: Pathophysiology of Peripheral Nerve Sheath Tumors & Tumor Syndromes
Просмотров 1,5 тыс.Год назад
This video for medical students covers the pathophysiology, clinical features and morphology of peripheral nerve sheath tumors (schwannoma, neurofibromas, malignant peripheral nerve sheath tumors) and their associated syndromes (neurofibromatosis 1 and 2).
Medical School Pathology: Pathophysiology of Muscular Dystrophy
Просмотров 1,1 тыс.Год назад
This video for medical students covers the pathophysiology of the muscular dystrophies: the dystrophinopathies (Duchenne and Becker muscular dystrophies, myotonic dystrophy, limb-girdle muscular dystrophies, Emery-Dreifuss muscular dystrophy, and facioscapulohumeral muscular dystrophy. Particular focus is paid to the clinical and morphologic features of Duchenne and Becker muscular dystrophy.
Medical School Pathology: Pathophysiology of Acute & Chronic Liver Failure
Просмотров 540Год назад
Many diseases can result in acute and/or chronic liver failure. This video for medical students explains the pathophysiology of these processes.
Medical School Pathology: Primary Biliary Cholangitis & Primary Sclerosing Cholangitis
Просмотров 766Год назад
Medical School Pathology: Primary Biliary Cholangitis & Primary Sclerosing Cholangitis
Medical School Pathology: Cerebral Edema, Hydrocephalus, Intracranial Pressure/Herniation
Просмотров 3,6 тыс.Год назад
Medical School Pathology: Cerebral Edema, Hydrocephalus, Intracranial Pressure/Herniation
Medical School Pathology: Pathophysiology of Carcinoma of the Cervix
Просмотров 2 тыс.Год назад
Medical School Pathology: Pathophysiology of Carcinoma of the Cervix
Medical School Pathology: Pathophysiology of Autoimmune Vasculitis
Просмотров 754Год назад
Medical School Pathology: Pathophysiology of Autoimmune Vasculitis
Medical School Pathology: Pathophysiology of Autoimmune Disease
Просмотров 3,8 тыс.Год назад
Medical School Pathology: Pathophysiology of Autoimmune Disease
Medical School Pathology: Clinical Aspects of Neoplasia
Просмотров 1 тыс.Год назад
Medical School Pathology: Clinical Aspects of Neoplasia
Medical School Pathology: Health Disparities
Просмотров 229Год назад
Medical School Pathology: Health Disparities
Medical School Pathology: Pathophysiology of Alcohol Consumption
Просмотров 678Год назад
Medical School Pathology: Pathophysiology of Alcohol Consumption
Medical School Pathology: Pathophysiology of Hypersensitivity
Просмотров 402Год назад
Medical School Pathology: Pathophysiology of Hypersensitivity
Medical School Pathology: Adenocarcinoma of the Pancreas
Просмотров 314Год назад
Medical School Pathology: Adenocarcinoma of the Pancreas
Medical School Pathology: The Pathology of Organ Transplant Rejection
Просмотров 827Год назад
Medical School Pathology: The Pathology of Organ Transplant Rejection
Medical School Pathology: Acute & Chronic Pancreatitis
Просмотров 326Год назад
Medical School Pathology: Acute & Chronic Pancreatitis
Medical School Pathology: Pathophysiology of Syphilis
Просмотров 481Год назад
Medical School Pathology: Pathophysiology of Syphilis
Medical School Pathology: Pathophysiology of Cardiac Valvular Disease
Просмотров 299Год назад
Medical School Pathology: Pathophysiology of Cardiac Valvular Disease
Medical School Pathology: Pathophysiology of Valvular Vegetations
Просмотров 486Год назад
Medical School Pathology: Pathophysiology of Valvular Vegetations
Phenomenal
Thank you!
Good Day I'm currently in a critical state and have been following research programs from the hospital. I was born with a genetic condition called Neurofibromatosis, which Ideally causes lumps of tumours to grow in areas with nerves I also present with brownish spots called coffee au lait spots Anyway, this is just a background. So late last year and this year, I presented a few symptoms on my right hand, pins and needle , numbness across my ulnar nerves ( pinky and ring finger). So Dr thought, ohh Cubital tunnel syndrome So they gave me meds Symptoms got worse and paralyzed my right hand, I couldn't sleep I was in pain. So they request for an MRI, chest and they found the lump in the Right axilla/armpit. I had surgery and the lump wasn't completely removed. The lab results came back positive for a malignant peripheral nerve sheath tumour (MPNST) with rhabdomyoblastic differentiation (Triton tumour), aris. The worst part is I'm still in pain and the lump is growing back. I don't know what to do anymore. I need medical assistance in understanding why the pain is quite persistent. There's a lot more, I just need help because I'm drowning and I'm not getting straight answers. Any response will highly be appreciated.
thank u
You're welcome!
Thank you Dr. ❤
Most welcome!
What is the implication of IDC without DCIS? Does this imply a lack of local, clonal cellular evolution and suggest breast reseeding from a distant metastatic locus? Thanks so much for this excellent channel!
Great presentation, particularly on how the social conditions lead to differences in diseases supposedly based on biological race.
Thank you for such great presentation on a very important topic. As an oncology pharmacist, your presentation makes me rethink how useful (or NOT) it is to look at the pharmacokinetics or drug metabolism data that supposedly vary in different races. Medline MeSH still have white people, Asian, etc. as well.
Thank you for the feedback! This is so important!
Thank you
You're welcome
Thank you Dr. Deyrup I know that pathologists often describe the gross pathology in food terms, but this description of the histology is so helpful that I will never forget it the difference again. I am an oncology pharmacist and I am systematically going through your videos, including the non-oncology subjects because I found that so educational and engaging.
Thank you so much for the feedback!!
thanks this was amazing
Thank you for these videos. I was looking for detailed videos to follow along with my Robin's book (I am using the 10th edition of Basis of Disease). I am interested in the Path A direction, and I want to learn as much as I can about pathology before I apply. Your videos have helped a lot.
Glad to hear it!
Greetings from Germany! I love your lectures. I am a medical student and I use your lectures to prepare one of my exams. In German medical schools also we are thought only caucasion do get MS for example even though there are so many cases contradicting it. There is even a German study showing that if immigration was before the age of 15 the risk of having MS is similar to the national average. The average time needed to diagnose MS in Germany is over 2 years and when one belongs to the "wrong" community it takes even longer to get a diagnostic.
Danke schön!
You are so good
Thank you!
Thank u for this amazing class. Simple and precise ❤
Thank you sir great explanation
Excellent presentation
Awesome lecture. To the point, concise, and deeply understandable.
Many thanks!
It’s super useful mam ❤ Thanks 🤩
That was so interesting, thank you so much !
Was just diagnosed with Clear Renal Cell Carcinoma...thanks for the interesting explanation. I have worked in a hematology lab for 41 years but have always been interested in pathology.
You are most welcome. Wishing you the best of luck!
@@PathologyCentral Robotic partial nephrectomy was a complete success...cancer free!!
I assume most cells in human body are dormant (permanently differentiated, senescent, quiescent) and therefore not taking up labelled glucose in PET scan?
Gate keeping this channel! You r the best!!
Thank you Dr. Deyrup for such an engaging and clear presentation, particularly in pointing the relevance of various new information. As an oncology pharmacist, I find it challenging to remember the genes and proteins involved in carcinogenesis, many of which have become targets for drug therapy. Knowing what the do in normal cells give me a better framework to learn about them.
Thanks
I’m being %100 honest, your explanations are just a masterpiece This need more attention fr
Please spread the word!
you are the best thank you doc :)
Thanks 🤩 It is so understandable 👏🏻
Fantastic Content !!!!! I've just discovered your channel and I loved it !!!! Thank you for this high standard lesson❤
You are welcome! Please spread the word!
Brilliant, thank you. I've started working in ENT as a Physio and this is a terrific resource
this really helped me thank you
Thank you Dr. Deyrup for the excellent lecture that helps me appreciate the RB more clearly than how I learned it and the two-hit hypothesis through Cancer Biology lecture
Nursing student here and I found this helpful. I’m trying to wrap my head around DIC and HELLP syndrome because my instructors are burnt out lol
Thank you Dr Deyrup for a great short lecture. I am an oncology pharmacist with some basic general basic pathology and oncology pathology training as part of my postgraduate studies. Your opening slides of why we need to histopathology are similar to what I have been telling my pharmacy colleagues of why oncology pharmacists need to know about pathology. More than other therapeutic areas, pathology report is the central part of oncology, and not knowing it well deprives me from communicating not only with the physicians and other healthcare disciplines, but also with the patients who usually know a lot about their pathology. Over the past decade, more and more drugs are more targeted with specific histology so it's no longer enough to know NSCLC vs. SCLC, I also have to know NSCLC other than squamous cells, etc. Now we have to know about ER-low positive, HER2-low positive, and how that fits into triple negative breast cancer. Having an appreciation of the challenges in differentiating different intensity of ICH staining for ER is so important, when trying to understand the therapeutic decision. I hope you can do more oncology pathology and if possible molecular pathology related to cellular targets due to gene mutations or overexpressions, and PD-1 staining for the checkpoint inhibitor immunotherapy.
Can we mention that p53 gene is located at chromosome 17 p arm, so deletion of 17p is associated similar problems as p53 mutations
Thank you Dr. Deyrup for the excellent lecture, both in contents and presentation. I feel such a privilege to have discovered to access to your lectures, which further increased my interest in cancer pathology. I am a clinical pharmacist practising in oncology for the past 25 years. I have always been interested in pathology, initially because no retake exam was allowed for the basic medical pathology course during my postgraduate PharmD program, and then because pathology plays such an essential part of cancer care, that cancer pathology was mandatory for my MSc in Oncology program. For the past 15 years I have been trying to understand more in-depth because more and more new oncology drugs are targeting the molecular pathology of the tumours.
Great to meet you! Thank you for all your comments!
Thank you for being a proper scientist.
Thank u madam very clear information
Thank you so much for this very important discussion. I have two reasons, one professional and one personal, that makes this information incredibly relevant to me. Professionally, I work in the biotech industry and am trying to help our company prepare to comply with the draft guidance from the FDA regarding diversity action planning for all of our pivotal and phase 3 trials. It has been a very interesting process to listen to people's responses when I talk about the need to have more solid, scientific data regarding efficacy and safety in under-represented populations and people struggle to understand the why. This is an example of why, it is so important. We need to be sure that people preparing to become medical providers have science and fact-based information about any condition that is accurate and peer reviewed. The personal reason this is compelling to me is that I am a female with severe hemophilia A due to extreme x-inactivation of my mother's non-mutated X chromosome leaving me with the activated X of my father who also had hemophilia. I clearly have 0-1% clotting factor VIII in circulation, yet doctors keep telling me that I don't have classical hemophilia because women don't get hemophilia. They have said this while looking at a lifetime of factor VIII assays. I am always shocked and angry that these physicians anchor so strongly to what they have been "taught" in medical school they cannot set that aside and actually look at data and listen to me describe my medical history and clinical manifestation of the condition. Luckily, one cannot keep arguing with a person with 0-1% factor viii levels and i do get treatment. It is the huge group of women who have a partial x-inactivation who suffer. These women have factor levels, that in men would be classified as mild or moderate hemophilia yet, because they are women, they will not be prescribed treatment for potential internal bleeding. It is 2024 and the story has not changed much from when I was told as a little girl that my mother was wrong, that I did not have hemophilia and that I should only listen to him. Ugh! Thank you so much for your excellent work and making it available on you-tube.
Appreciate🙏
Dear Dr. Deyrup, I thoroughly enjoy your lectures. Just wanted to point out at 13.00 minutes - there is a minor error - the slide says immune complex mediated vasculitis (Goodpastures), I note that Goodpastures is a type 2 antibody mediated hypersensitivity. Keep up the great work! Jay
Thank you for this informative video. 4th year med student here and this gave me a concise and well round idea of the concept. Grateful ❤
With the polyol pathway, I think glucose to sorbitol is the NADPH consumption step. Sorbitol to fructose would be an oxidation reaction by polyol dehydrogenase coupled to a reduction of NAD to NADH. Great content, thank you,
Thanks, great presentation!
Very useful information on Myeloid neoplasm
Thank you so much for uploading these video's. Its really helpful to use as a supplemental notes for pathology
If fasL is expressed on self reactive T cells is it part of autoimmunity?
does MS involve cranial nerve nuclei and cranial nerves. i think they are part of PNS, so, MS wont involve cranial nerve nuclei and cranial nerves
Thanks for this. Very explicit and didactic 😊
🔥🔥
Thank you!
Hello doc I always watch your videos, your videos are very helpful aside from reading the Robin patho. Thank you so much
Thank you for the feedback!! It means a lot to me!