General Embryology - Detailed Animation On Embryonic Folding

Embryonic folding is the process of converting the embryo from a flat disc, into a cylinder.
This cylinder consists of three main layers, derived from the trilaminar embryonic disc: the endoderm in the center, the ectoderm on the outside, and the mesoderm, which is found between the two layers.
During the fourth week of development, folding of the embryo occurs as a result of the differential rates of growth of the embryonic structures. The embryonic disc and amnion grow rapidly, however, growth of the yolk sac is much slower.
Embryonic folding occurs in two planes: the horizontal plane, which results in the development of two lateral body folds, and the median sagittal plane, which causes the longitudinal cranial (head fold) and the caudal (tail fold) of the embryo to develop.
As folding continues simultaneously in both planes, the result is a very rapid development of the embryo.
The endoderm of the trilaminar disc is mainly responsible for the formation of the epithelial lining and glands of the gastrointestinal tract. As the lateral, cranial and caudal folds of the endoderm fold towards the midline, they fuse, incorporating the dorsal part of the yolk sac to create the primitive gut tube.
The gut tube is divided into three main parts: the foregut, midgut, and hindgut.
The foregut can be seen at the cranial end of the embryo and is temporarily closed by a membrane, called the oropharyngeal membrane. At the end of the fourth week of development, the oropharyngeal membrane ruptures to connect the future oral cavity with the pharynx.
Until the fifth week of development, the midgut is connected to the yolk sac, which narrows into a stalk known as the vitelline duct, as embryonic folding continues. Eventually, the yolk sac constricts and detaches from the midgut, and the midgut seals.
The caudal end of the hindgut is also temporarily closed by a membrane, called the cloacal membrane, which separates the upper and lower parts of the anal canal.
The cloacal membrane ruptures during the seventh week of development to form the urogenital and anal openings.
The ectoderm covers the entire outer surface of the developing embryo, except for the eventual umbilical region.
This germ layer, along with the dermatomes, lateral plate mesoderm, and neural crest cells formed during neurulation, eventually form the skin, as well as several other vital structures, including the central and peripheral nervous systems.
The mesoderm germ layers organize into somites, which eventually give rise to muscle tissue, cartilage, bone, and subcutaneous tissue of the skin.
As a result of embryonic folding, the major body plan becomes established, and the three germ layers continue to differentiate, giving rise to their own tissues and organ systems.
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[@muderakayleh]

this video is better than all the sophisticated talk in my embryology lectures ...

[@Canalistan]

You’re right

[@emrevarlk9958]

I agree with you the medicine science is so animationel for this reason this video is very helpful

[@priincpal5528]

I wonder now if u finished your medical school

[@TherealValBas]

I wish all my medical school classes was just like this: clear and concise. Thank you.

[@sakhilembokane9141]

Thank you so much. You are the people that give us degrees at the end of the day... much appreciated.

[@NeErNeYoYa]

Your videos about gastrulation, neurulation and embryonic folding are the best I found to understand it perfectly. Thanks for that. Now I can at long last study on, other topics to pass the test. :D

[@derMann901]

This is just too good. All the graphics of the different development stages are clear and easy to understand. After ours of researching books and the internet this is by far the best thing i found about embryology.

[@lstrawaya6403]

Thank you, you saved me during embryological classes and now you’re saving me for surgery classes, thank you for all efforts you do

[@fsdx416]

1:31 We were all mushrooms once

[@eintroll8792]

The endoderm IS NOT the yolk sac. Thats wrong. The Hypoblast never BECOMES the endoderm. PLEASE NOTE !

[@radwanabu-issa4350]

This is the best demonstration of the wrong "folding model"!

[@SyenPie]

INCREDIBLE video, you explained this topic much more clearly in under 3 min than my 50-minute lecture... bravo!

[@sophiepersch8740]

it's so educational to see this in moving pictures instead of stills. Much better understanding now. Thank you for that!

[@Johaaaaaanna]

I cannot Unterstand how this video only has approx. 600 thumbs up?! Perfect introduction into embryonic folding and even for me, as I speak German and my books are in German, too, I perfectly understand everything. Thanks for making this video.

[@goodman5836]

+Johanna Jhnk So ist es einfach auf RUclips. Zumindest ist die Zahl um ca.100 gestiegen...

[@andersmoberg867]

Great animation of embryonic folding; definitely helps to clarify the subject - thanks!

[@Sify3100]

An excellent animations and a beautiful description. Thank you!

[@samanthamartinez7089]

Omg thank you so much I have taken so many courses covering this process and was never truly able to understand what exactly is happening here but I just had that lightbulb experience watching this!!! So again, thank you very much!!! Lol and it only took less than three minutes!!! Haha, Wow!

[@aleksanna5828]

thank you, thank you, thank you! Your videos make approaching embriology sooooo much easier!

[@MedLund]

Love these videos. Gives a clear understanding before I go into more details which the med school requires. Thanks a lot :)

[@panayiotisantoniou5095]

amazing..in nearly 3 minutes you managed to enlighten us with such an amazing video! thank you sir

[@iffatsiddiqui1926]

Beautifully explained. Thanks a lot.

[@LayZeeBro]

This was amazing, thank you.

[@s.z8223]

So clear and concise! Wish my lecturer could be like this lol

[@r3dsh1ft3d]

Perfect! Thanks!

[@khooshipatel8552]

Brilliant animation. Thank you so much 👏

[@KJeansblue]

Thanks so much. this is very helpful I can't figure out how it look like till I found this hahaha thanks again 😄

[@lauhuili1090]

Wow,this video is so good,helps me to understand n clarify everything:)) Thank you!

[@_JOJO_8]

Thank you very much for these videos.

[@medicolife7360]

Perfect. Perfect. Perfect. On point. Thank you so much

[@amynabila1844]

thank you, thank you , thank youuuu, I don't get why profs have to make things so complicated when animations like these make it so easier to understand

[@wellermasong6765]

Really helped me understand it visually.

[@NhanNguyen-ip6gw]

Incredible!!! SO good :D

[@mezbahuddinkhanshakib1189]

Nice animation.

[@user-cz6jm8oe1v]

Thanks your video make the embryo so easy to understand 🤞🏼

[@mohammedalfaife]

Beautiful video 😍
Thanks

[@monyo8353]

Really really thank you this video is really great it helped me a lot :D

[@mariettevanjaarsveld4006]

So helpful, thank you!

[@aleidapinon]

Thank you so much, you really helped me understand the topic :)

[@no-handlleee]

so clear, thanks!

[@mohamedmogahed3323]

Amazing!!!
Thanx

[@KrittayoteSamranvetchaporn]

Thank you to save my day.

[@rehanarasheed2816]

Best videos on embryology

[@miro1mimi]

I CAN'T THANK YOU ENOUGH

[@aatifahkamboh]

Thank you so much.... This video is really amazing 👍

[@stellajaames9116]

Clarifies a lot,thank you

[@dooddle9585]

amazing

[@hamzayousif8750]

شكراً ي دكتور

[@sama_albairmani]

This is incredible
Unbelievable and indescribable ..

[@ZaidanyZ]

Very clear thank you

[@ZeeshanAli-br3sr]

thanks this is really helpful for me

[@benzzervival8035]

thank you, thank you so much

[@rere.s]

Thank you very much 💜

[@zainabalasadi6922]

You’re a Life saver 💙💙💙💙

[@hyeri-ssi6235]

thank you so much!

[@tatianatantrakumara4119]

bro, really, thank you so much!

[@samaymangueshkar5822]

Thank you

[@siap_too_kiann]

Thanks for your video : )

[@abdulahad8733]

very much helpful to understand..... pls keep it up for making us confident to beleif that embryology is easy😖😖 may god bless u

[@ikramasiddique1245]

Tysm..best explained with 3D.. Easy to memorize.👏

[@lalaaliyeva8304]

Thank you ❤

[@jeffkik9887]

THANK U SO MUCH; NOW I GOT IT .

[@ayamadaci1687]

amazing video! so helpfull ,made the comprehension of the lesson easier by making some imagination ... thank you very much!

[@a.a362]

Aya Madaci أيوه. ..

[@kylehan6246]

well done

[@ahmadaliazimjonov6572]

Very good

[@meriembensouna7252]

Merci beaucoup beaucoup, c'est grâce à vous que j'ai compris l'embryologie humaine 😊😊😊

[@samiyafakir9501]

love it

[@swan6959]

Hats off Sir❤️

[@boredtodeath741]

this is so sad i finally am able to visualize this after all those classes of bio/physio/embyrology lol been just memorizing definitions and relationships but never had the picture in my head. thank you, makes it so much easier

[@sobialaghari225]

This video explained me in less than 3 minutes what cost me days of studying.

[@sreoshysaha2359]

Thanks a ton😍😍😍

[@ruqayahakhtar5067]

Crystal clear❤👍👍

[@aim1627]

you're the best

[@lindanonyukela7447]

Thank you!!!You have just condensed my 3 pages notes into a clear, easy-to-understand video. Do you perchance have notes on these sections? I'm assuming it would be easier to study from your notes, judging from how clear and concise your explanations are.

[@Innocence934]

Nice

[@DhanaLakshmi-ub4ff]

good information

[@medicallifewithjohn]

Thanks

[@rosarioruiz6146]

Por fin entiendo ese dibujo que parece un hongo. 🍄 😭 Einfach wunderbar! Amazing!

[@abdullahjatt5911]

V informative sir

[@BH-zz7tb]

Thanx

[@mmukhti1729]

permission to download ^^ thanks

Perfecto

[@siphenathimanyaba1910]

This makes me wonder why this can take one hour in class when it is this simple!

[@user-er3yd2sn2d]

thanks from iraq 💜🥺

[@Lulema_]

راااااائع

[@sadiyehatalko4290]

Great video but as I know oropharingeal membrane do not consist intraembrionic mesoderm layer. It consist only ectoderm and the endoderm.

[@ayafares3447]

Thanks for this great video
I want to ask you a question , what is the correct order from dorsal to ventral for these concepts ?
-Notochord-Nural plate-foregut-wall of body

[@321admin123]

Wooooooh who r u? This video is crazy amazing - u made a ridiculous med school embryo class digestible

[@bluebyrne7864]

I love youuuu

[@Ricky97HD]

Wish I'd studied biology further now, but I'm assuming that from this, based upon the proportion of ectoderm, mesoderm and endoderm tissue, the body's 'somatotype' or distinct category that most associate as being, skinny, average, or naturally fatty, are deprived from the initial embryonic folding that occurs during fetal development. Which in turn means that some people are more naturally skinny or fatty, or somewhere in between. Love to know the biology behind body composition etc.

[@bushraalhafez171]

Where do i get the full series of this videos production of embryology ?

[@cesararteagab.9077]

Unbelievable.

[@drgcrystal18]

Could someone help me understand where/how the PGCs are involved during this process of gut invagination?

[@binshinaahussein1726]

Pest channel of embryology
Thanks

[@weshasawi]

What happens after that?!

[@ajithkumarselvan6258]

Still the best one #2024 ❤

[@dunyaabubakir1059]

👏👏👏

[@vadimushakov5883]

There is a major error in this video: 2:31 showing that all the picture we had previously becomes an embrion. In fact only two layers of the ectoderm that are straightly above the mesoderm layers on that pic are forming the embrion. The rest is an amniotic cavity. And the cavity that is right above the mesoderm is the neural tube.

[@kamalkumarkhatri531]

❤️

[@user-em6km9dj5w]

can anyone answer me...?
now two videos ago, we have mentioned the orientation or the axis of the embryo.. cranial, caudal, left and right..
but I see here in 2:31 the orientaion is reversed!! right?
I do not know even what my exact question is... but I think there is something wrong here.. any help? 🤔

[@BIGDADDY-hb1zf]

اتفرج يا سيد يا انور

[@user-qd6ei9is6p]

ايش مسوي فيك انور

[@user-vm3so2nn4v]

0:07 - 0:14 ; 1:20 - 1:23 for slow motion

[@aprilshower7799]

Psalm 139:13-14
For you created my inmost being;
You knit me together in my mother’s womb. I praise you because I am fearfully and wonderfully made; Your works are wonderful, I know that full well.