Working on "Molecular & cell biology for dummies", being exactly at the chapter about glycolysis, Krebs cycle etc. Then this video came up. Good job, guys!
Great job! ... and that's how too much sugar leads to fatty liver (NAFLD) and excess TGs get exported to extrahepatic tissues leading to deposition of fat in skeletal muscle fibers (>> fatty muscles) leading to insulin resistance which get prossively worse and the patient enters the stages of pre-diabetes and then diabetes (T2DM). Insulin level rises progressively to overcome the worsening insulin resistance. Ultimately fat permeates the pancreas itself (>> fatty pancreas) leading to beta cell failure.
@@dana102083 this is bad advise. Cutting carbs does not resolve the issues. Cutting refined carbs and fruit juices does. Eating carbs from vegetables, fruits, legumes and whole grains shows consistent benefit, especially due to the fibers and antioxidants.
Yes that’s great for explain how bad refined fructose is to the body, especially in the form of HFCS (think sweetened cola drinks). But you left out the part of how the gut biome deals with the fibers, polyphenols, antioxidants of the whole apple-think of it as a timed, slow release of fructose and the role of gut bacteria to regulate and actually increase insulin sensitivity… from the whole apple. Having said that consider blueberries, blackberries and especially raspberries - more of that positive benefit but much less fructose than an apple. I’m just saying we need to see this holistically.
You cannot make fructose good for you in your mind’s eye by combining it with five and plant toxins - just saying 🤣 let’s not be gaslighting ourselves. Carbohydrates generally and fructose in particular are bad for us and there is no need for fibre in our diet. We are carnivore. Animal fat and animal protein preferably from ruminant source is our species appropriate diet.
One question: Can fructose, in a state of starvation or post exercise in depletion of glycogen, be converted through fructose-6-phosphate and then glucose-6-phosphate in to glycogen? Great vid, straight to the point!
A very small amount of fructose is stored as glycogen, the majority is stored as fat. If you exercise enough your body will switch from glycogen breakdown to fat break down for energy thus depleting the fat that was at one point fructose
@@BocusVeLucy No, fructose is primarily taken in by liver cells. It is then converted into citrate, and this excess citrate is used in fatty acid synthesis.
@@joohnnykuz5327 I think the question was in regards to when your body is in a state of starvation or post-workout glycogen depletion. In your opinion under those circumstances, would the fructose still go towards fatty acid synthesis instead of restoring blood glucose levels (which would be low in starvation) and restoring depleted glycogen? Intuitively I would guess that a greater than normal percentage of fructolysis would go toward glycolysis. Would that be correct?
@@claykurisaki9758 So in that event it can’t. Fructose CANT be used to synthesize FA because gluconeogenesis will be occurring and this process uptakes crucial elements needed for FA synthesis. Gluconeogenesis will occur when your blood sugar is low and your glycogen stores are depleted. Gluconeogensis needs oxaloacetate to proceed so it takes it up in the liver, and it’s shunted up the gluconeogenesis pathway. This is relevant because acetal coA, from fructose metabolism needs to react with oxaloacetate and cintrate synthase to create citrate to transport acetal coa out of the mitochondria of the hepatocytes(liver cells) and into the cytosol where fatty acid synthesis can occur. The fructose will undergo fructolysis, which ends at the creation of DHAP and GA3P, which is the step of glycosides after fructose 1,6BP. This part I’m not exactly sure but This fructose can either become pyruvate which can be used to synthesize glucose, via gluconeogenesis. Or DHAP and GA3P can be shunted into gluconeogenesis
Amazing. I love to learn about metabolism. I am a Marathoner and have noticed that some of the energy gels for Athletes contain a combinacion of Glucose and Fructose, my question is if once Fructose has reached Acetyl CoA this can enter the Krebs Cycle for ATP production, in other words how would Fructose provide energy for the body. Thank you in advance.
It gets used as energy if eaten while doing some sort of activity, the reason it turns into fatty acid is that, that's how it gets stored. Most people aren't running marathons and are getting their fructose from candy while not being active. So the best use for fructose (coming from a health/performance angle) would be to have it while doing some sort of workout/strenuous activity lasting an hour+ for its help in producing energy quickly. Since your using it theirs nothing to be converted into triglycerides. For everyone else snacking on the body cant regulate or stop its metabolism, so as soon as it goes inside your body, its either used for energy or stored as glycerides
I've read studies that shows it's better to have your post-workout drink be a combination of glucose and fructose. As mentioned in the video, absorption of glucose and fructose from the GI lumen is by different transporter systems (SGLT1 and GLUT5) and each of these transporter systems has a limit to how much they can absorb. By using a combination of 2 different transport systems, your body is able to absorb more total carbohydrates. I still think that under the body condition of blood glucose depletion (post workout), the fructose would be converted to glucose production rather than Acetyl CoA production, at least until your blood glucose is restored. Not an expert though, just my opinion.
Questions: 1) why wouldn't the large amounts of pyruvate formed from sucrose go through standard pyruvate metabolism the same way pyruvate from glucose does? 2) Even if sucrose is regulated upstream, why wouldn't fatty acid synthesis from fructose be regulated by the standard mechanisms of FA synthesis? (E.g. Acetyl-CoA carboxylase). Not all of the Acetyle-CoA has to turn into FA. 3) if excess FA are being synthesized in the cytosol, why wouldn't they just be secreted out into the blood stream? Fatty acids are fat soluble and can pass through the lipid membrane. Thanks
Great question. " Not all of the Acetyle-CoA has to turn into FA. How about consuming fructose while long endurance exercise ( Marathon ) I wonder if it will still be coverted into Tryglycerides or before that happends the body will use it as a source of energy.
I would love to use the fructolysis vs glycolysis as an figure in my bachelor degree. but i see a small mistake, its should be glukokinase not hexokinase as the enzyme in glykolysis in the liver, i know its an hexokinase, but the specific is glukokinase.
in the real facts, considering a western population for instance. The fructose that would lead to the synthesis of TAG would not come from fruits. It would come from sugar, from HFCS (high fructose corn syrup), which the "food" industry or rather the junk industry uses everywhere, right? I am a fruit eater, never eat industrial "junk", live on fruits, vegies, some tofu, a few things like that. Would I be at risk for NAFLD? obesity? diabetes? I hear too often that if you eat fruits, you get fat, you get diabetes, and so on and so on... I think it is very unfair
What's TAG? Also why wouldn't it? fructose from fruits and industrial sugar and HFCS is identical so then why would your body treat it differently? The only thing i can think of is certain polyphenols and flavonoids that fruits contain.
@@Takuma_Sakazaki Technically yeah hfcs has some glucose too, but really if we're talking about isolated fructose there's no health impact difference between the two.
It gets phosphorylated by hexokinase or glucokinase to produce glucose-6-phosphate. If energy levels are high, it will be converted to glucose-1-phosphate by a phosphoglucomutase enzyme and enter the glycogen synthesis pathway
Great ! Now please do one on maltose metabolism . The irony is that fructose has a GI or 19 and maltose has a GI of 105 yet fructose causes more fat . ---teh exception to teh rule that teh lower teh GI the less fattening and less likely to cause type 2 diabetes....
GI stands for Glycemic Index. It measures the amount of Glucose in the blood. Fructose is not Glucose so it won't show on the GI. This does not mean that Fructose isn't dangerous. In fact, the issue is exactly that Fructose metabolism is more uncontrolled than Glucose metabolism that makes it so comparatively dangerous.
@@bouncingbeebles Yes I understand now how refined Fructose causes "Fatty Liver" because it must be converted in the liver to a from of sugar our body can utilize .If , however, we eat whole fresh fruits like muscadine grapes or mangos our liver and pancreas can metabolize them without getting fatty liver or diabetes .For example I am 62 and have a home vineyard .For the last 13 years I have averaged 2 quarts of black muscadine grapes per day (I eat them frozen in the hot summer) but if you look at my videos you can see I am in superb physical condition . Recently a Book By a PHD with type 1 diabetes shows that eating fruit cures diabetes : "MASTERING DIABETES"
Good but this is not entirely accurate. The reason fructose (F) can be a rapid source of fat is not because of the conversion to acetyl-CoA. The real difference between F and glucose (G) is in the kinetics. It is important to recognize that both pathways wind up with the triose phosphates (Ga-3-P and DHAP). Fructokinase reaction is very fast and the glyceraldehyde kinase is irreversible. So if F is very high that will be converted to DHAP and then to glycerol-3-P. The FA comes mostly from re-cycled fat. We offered a perspective on where F really fits in. (Feinman & Fine, Nutrition & Metabolism). Important to remember that as much as 50 % of F can be converted to G so you have to be careful about details.
How does 1 tell if NAFLD or heading toward it, just high triglyceries? Mine have always been ok fasting. While looking thru 23andme snps on Snpedia noticed 1 is fructose intolerance (homoz) but looking up 3 others were all ok, guess it depends if that 1 snp is turned on and combined with all the others. Couldnt drink fruit juice as a kid or like cake (ice cream ok), but watermelon ok. Mom mostly fed us healthy foods ! See from your vid that we have many backup plans in our bodies !! Pretty nifty
i eat a lot of fruit, or at least i did before i got diagnosed with diabetes last month. i ate up to 6 bananas or mandarins or mangoes at least 3 days a week -- as i have done so for most of my 45 year life. The dietitian said to cut this down to 2 a day, and after watching videos like this, make me think that metformin wont do much for me. Any suggestions for medications or supplements to decrease the glucose? From what i have read about metformin it is targetted at the first 2 steps of glucose creation, and fructose does not come in the glucose process until a few steps later, correct?
I would try and decrease the grains and starches you eat ... cut out the breads, potatoes, and even the bananas. Keep eating fruits that are lower in carbs.
Glucose metabolism is regulated because glycolysis does not progress if the cell is in an energy surplus state (high ATP to AMP ratio and high citrate content) because citrate and ATP inhibit PFK-1. The result of this regulation is that the excess Glucose-6-Phosphate is directed towards glycogen synthesis.
@@Interestingworld4567 Also some of it goes into your fat cells (if they're insulin sensitive enough) and then into glycerol, and finally i believe some some turn into free fatty acids directly into the bloodstream and then these fatty acids enter the fat cells (i think these don't require insulin so yeah) and then combine with the glycerol (wich was previously glucose).
@@loganwolv3393 Yeah I also heard that if you eat too much glucose you can get fat but the sciences who said that said that Yu our will have to eat or consumed a ton of it.
Great video! Is the process for fructose the same from different sources? For example fructose from natural organic fruits and fructose from highly processed corn syrup? One only does good and the other harm..
thank you so much. Supposing that my source of fructose is exclusively from fruits, do I have a risk of obesity? I do eat a lot of fruits, tropical fruits in particular as I am very often in Asia (9 months a year).
Not really. the fiber in the fruits makes the absorption of fructose from fruits much slower allowing the body more time to do its job and not overloading the liver
There is absolutely no risk of obesity from consuming fruit. Quite the contrary. Please be your own scientist and consume only fruit and nothing else for 2 weeks and record how you feel on a daily basis. Please watch "Dr. Morse great lymphatic system". You are wonderful!!
@@KressRudra fruits do not over load the liver. You guys are probably eat meat dairy starch everyday (uric acid, lauric) and! Fructose by its self is the best things man can eat. Fruits contain h3o2 and many vitamins “vital minerals” the body needs.
So to be clear, from your drawings it looks as if fructose just gets turned into fat, and only then fat into ATP, but it's never from fructose to ATP directly, so essentially all of the fructose is an indirect source of ATP only through fat... intresting.
Your explanation is incorrect. When fructose is converted to G3P it meets up with the G3P from glucose metabolism. From there G3P either goes to for Lactic acid, Energy as ATP and production of fat (triglycerides). Therefore, fructose can turn into anything that glucose can. There's no evidence that a reasonable intake of fructose turns into fat. Excess calories from foods, particularly foods with added high-fructose corn syrup and other processed foods, will lead to fat deposition, particularly in the liver. This causes metabolic associated fatty liver disease (MAFLD).
So the very end of this video highlights the mechanism by which all that unneeded fructose is shunted into fat around your liver and all over, ultimately interfering with other metabolic activities and resulting in obesity and diabetes. The fructose is largely coming from sugar. Your body manages the glucose but not the fructose. Cut out the sugar, go keto / IF for three or four months. You will be amazed but it is not easy to get started. Make yourself go two weeks and the rest of the three months will be a snap. Then check in with yourself and see how you feel.
The attack against Fructose is misguided. Yes, high fructose corn syrup laced with mercury is horrible for you, but pure fructose from a clean source can be a very medicinal carbohydrate. It's big advantage is that, unlike glucose, it's use is not inhibited by elevated free fatty acids aka the randle cycle.
@@muchasalud2011 …BIG STRONG (healthy!😉) gorillas are (naturally) fruitarian… and I’m sure that if they could speak (to you)- “they’d” beg to differ- telling “you” to wipe the “dribble” from your mouth- if they didn’t choose to backhand such blasphemy- from it👍🏻…
Wow u r a genius. Do you do tutoring for small groups via Skype? If you charge a small fee per person you can probably make about $150/hr Do you have skype and a website- can u tell us if you can do this for small groups maybe each participant can pay $10/hr. If you hold it at 30 people and keep it at 2hr segments (30 min Lect then 20 min Questions back and forth... then last hour a special topic hour on current research) I think this would be amazing 😃
![Seungmin "그렇게, 천천히, 우리(As we are)" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/kAzmhLHePqU/mqdefault.jpg)
![Felix "Unfair" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/Oswujxm2Ag0/mqdefault.jpg)
Very lucidly explained how fructose generates Triglycerides without any checks and balances. Hence much more dangerous than glucose.
Great video, explained very well
Hello
Well hello there
You only eat meat... lol you got 2 years left mate all your cancer markers are up uppp😂
Wow I didn't know you would be here
Great
as a person who is diagnosed with Fructose malabsorption - I find this quite educating. Thank you!
Working on "Molecular & cell biology for dummies", being exactly at the chapter about glycolysis, Krebs cycle etc.
Then this video came up.
Good job, guys!
Brilliant! As a non-chemist, you made it really easy to understand. Thank you for posting!
I had to look up a couple definitions, that's great. Finally I can really learn something. I'm passed the Metabolism 101 videos. This is awesome
great video it explains the core of the matter differently from many video tutorial that are very long but very confusing THANK YOU
Great job!
... and that's how too much sugar leads to fatty liver (NAFLD) and excess TGs get exported to extrahepatic tissues leading to deposition of fat in skeletal muscle fibers (>> fatty muscles) leading to insulin resistance which get prossively worse and the patient enters the stages of pre-diabetes and then diabetes (T2DM). Insulin level rises progressively to overcome the worsening insulin resistance. Ultimately fat permeates the pancreas itself (>> fatty pancreas) leading to beta cell failure.
Great
Where are the studies
@@hermanmcleod5182
You ask for studies. Please show studies provided or done by you .
great video . i have fatty liver disease. and understanding this will make me adhere to a better healtht habit.
Hope you cut the carbs!
@@dana102083 this is bad advise. Cutting carbs does not resolve the issues. Cutting refined carbs and fruit juices does. Eating carbs from vegetables, fruits, legumes and whole grains shows consistent benefit, especially due to the fibers and antioxidants.
@@dana102083 Not yet 😔
Thank you for this helpful informative presentation on fructose. Now I understand why fat is build up quicker with fructose consumption
excellent!!! now if i had known this 20 years ago my liver could have been saved
No time like the present!
Where y'all at?
Yes that’s great for explain how bad refined fructose is to the body, especially in the form of HFCS (think sweetened cola drinks). But you left out the part of how the gut biome deals with the fibers, polyphenols, antioxidants of the whole apple-think of it as a timed, slow release of fructose and the role of gut bacteria to regulate and actually increase insulin sensitivity… from the whole apple. Having said that consider blueberries, blackberries and especially raspberries - more of that positive benefit but much less fructose than an apple. I’m just saying we need to see this holistically.
No
Why not? Too many cooks in the kitchen and everyone contradicts themselves.@@matthewcordeiro2073
You cannot make fructose good for you in your mind’s eye by combining it with five and plant toxins - just saying 🤣 let’s not be gaslighting ourselves. Carbohydrates generally and fructose in particular are bad for us and there is no need for fibre in our diet. We are carnivore. Animal fat and animal protein preferably from ruminant source is our species appropriate diet.
Hi. Why "especially raspberries"?
this is super helpful , thank you so much
you have the model for NAFLD. Now CAn you present studies showing NAFLD being caused by whole fruit consumption?
Love it... Thanks for doing this.
So should type 1 diabetics become fruitarians to help avoid the glucose pathways as much as possible?
One question: Can fructose, in a state of starvation or post exercise in depletion of glycogen, be converted through fructose-6-phosphate and then glucose-6-phosphate in to glycogen? Great vid, straight to the point!
A very small amount of fructose is stored as glycogen, the majority is stored as fat. If you exercise enough your body will switch from glycogen breakdown to fat break down for energy thus depleting the fat that was at one point fructose
@@joohnnykuz5327 thanks for the answer!
@@BocusVeLucy No, fructose is primarily taken in by liver cells. It is then converted into citrate, and this excess citrate is used in fatty acid synthesis.
@@joohnnykuz5327 I think the question was in regards to when your body is in a state of starvation or post-workout glycogen depletion. In your opinion under those circumstances, would the fructose still go towards fatty acid synthesis instead of restoring blood glucose levels (which would be low in starvation) and restoring depleted glycogen? Intuitively I would guess that a greater than normal percentage of fructolysis would go toward glycolysis. Would that be correct?
@@claykurisaki9758 So in that event it can’t.
Fructose CANT be used to synthesize FA because gluconeogenesis will be occurring and this process uptakes crucial elements needed for FA synthesis.
Gluconeogenesis will occur when your blood sugar is low and your glycogen stores are depleted.
Gluconeogensis needs oxaloacetate to proceed so it takes it up in the liver, and it’s shunted up the gluconeogenesis pathway.
This is relevant because acetal coA, from fructose metabolism needs to react with oxaloacetate and cintrate synthase to create citrate to transport acetal coa out of the mitochondria of the hepatocytes(liver cells) and into the cytosol where fatty acid synthesis can occur.
The fructose will undergo fructolysis, which ends at the creation of DHAP and GA3P, which is the step of glycosides after fructose 1,6BP.
This part I’m not exactly sure but
This fructose can either become pyruvate which can be used to synthesize glucose, via gluconeogenesis.
Or DHAP and GA3P can be shunted into gluconeogenesis
super clear, many thanks !!
Brilliant clear explanation
Amazing. I love to learn about metabolism. I am a Marathoner and have noticed that some of the energy gels for Athletes contain a combinacion of Glucose and Fructose, my question is if once Fructose has reached Acetyl CoA this can enter the Krebs Cycle for ATP production, in other words how would Fructose provide energy for the body. Thank you in advance.
It gets used as energy if eaten while doing some sort of activity, the reason it turns into fatty acid is that, that's how it gets stored. Most people aren't running marathons and are getting their fructose from candy while not being active.
So the best use for fructose (coming from a health/performance angle) would be to have it while doing some sort of workout/strenuous activity lasting an hour+ for its help in producing energy quickly. Since your using it theirs nothing to be converted into triglycerides.
For everyone else snacking on the body cant regulate or stop its metabolism, so as soon as it goes inside your body, its either used for energy or stored as glycerides
*For everyone else snacking, the body ^
I've read studies that shows it's better to have your post-workout drink be a combination of glucose and fructose. As mentioned in the video, absorption of glucose and fructose from the GI lumen is by different transporter systems (SGLT1 and GLUT5) and each of these transporter systems has a limit to how much they can absorb. By using a combination of 2 different transport systems, your body is able to absorb more total carbohydrates. I still think that under the body condition of blood glucose depletion (post workout), the fructose would be converted to glucose production rather than Acetyl CoA production, at least until your blood glucose is restored. Not an expert though, just my opinion.
@@claykurisaki9758 Great input, it makes so much sense, Thank you
@@claykurisaki9758
Hi. Why would you want "to absorb more total carbohydrates" AFTER workout ?
Questions:
1) why wouldn't the large amounts of pyruvate formed from sucrose go through standard pyruvate metabolism the same way pyruvate from glucose does?
2) Even if sucrose is regulated upstream, why wouldn't fatty acid synthesis from fructose be regulated by the standard mechanisms of FA synthesis? (E.g. Acetyl-CoA carboxylase). Not all of the Acetyle-CoA has to turn into FA.
3) if excess FA are being synthesized in the cytosol, why wouldn't they just be secreted out into the blood stream? Fatty acids are fat soluble and can pass through the lipid membrane.
Thanks
Great question. " Not all of the Acetyle-CoA has to turn into FA. How about consuming fructose while long endurance exercise ( Marathon ) I wonder if it will still be coverted into Tryglycerides or before that happends the body will use it as a source of energy.
Probably because your body wants to store fat, even though you don't want it to ...
VERY helpful, thank you!!
very good explanation
Спасибі, я хоть і англійської не знаю але мені допомогло, я серйозно і без сарказму🤝
Nice Resume, Congrats..
Just brilliant.
Thank u,it helps me a lot
Thank you so much! Amazing work
Excellent Video... Good job!
I would love to use the fructolysis vs glycolysis as an figure in my bachelor degree. but i see a small mistake, its should be glukokinase not hexokinase as the enzyme in glykolysis in the liver, i know its an hexokinase, but the specific is glukokinase.
Yes you're right
This video was great!
great video!!
Great video? Images are excellent/clear, are they from a textbook?
💜💜💜💜i enjoy so much ..and i think it,s very helpfull and simple 🍃💜💜..keep on ..💜💜💜
Isn't it glyceraldehyde hydrogenase at 10:13 rather than dehydrogenase? -CH=O -> CH2-OH?
Great video, thanks 💜
in the real facts, considering a western population for instance. The fructose that would lead to the synthesis of TAG would not come from fruits. It would come from sugar, from HFCS (high fructose corn syrup), which the "food" industry or rather the junk industry uses everywhere, right? I am a fruit eater, never eat industrial "junk", live on fruits, vegies, some tofu, a few things like that. Would I be at risk for NAFLD? obesity? diabetes?
I hear too often that if you eat fruits, you get fat, you get diabetes, and so on and so on... I think it is very unfair
You're right. Really the fructose we should be worried about is in the form of high-fructose corn syrup.
What's TAG? Also why wouldn't it? fructose from fruits and industrial sugar and HFCS is identical so then why would your body treat it differently? The only thing i can think of is certain polyphenols and flavonoids that fruits contain.
@@loganwolv3393 TAG, triAcylGlycerides
@@loganwolv3393Whole fruit fructose and isolated hcfs are not the same.
@@Takuma_Sakazaki Technically yeah hfcs has some glucose too, but really if we're talking about isolated fructose there's no health impact difference between the two.
thank you! great video
What happens to glucose during glycolysis when stopped by high energy states?
It gets phosphorylated by hexokinase or glucokinase to produce glucose-6-phosphate. If energy levels are high, it will be converted to glucose-1-phosphate by a phosphoglucomutase enzyme and enter the glycogen synthesis pathway
Great ! Now please do one on maltose metabolism . The irony is that fructose has a GI or 19 and maltose has a GI of 105 yet fructose causes more fat . ---teh exception to teh rule that teh lower teh GI the less fattening and less likely to cause type 2 diabetes....
GI stands for Glycemic Index. It measures the amount of Glucose in the blood. Fructose is not Glucose so it won't show on the GI. This does not mean that Fructose isn't dangerous. In fact, the issue is exactly that Fructose metabolism is more uncontrolled than Glucose metabolism that makes it so comparatively dangerous.
@@bouncingbeebles Yes I understand now how refined Fructose causes "Fatty Liver" because it must be converted in the liver to a from of sugar our body can utilize .If , however, we eat whole fresh fruits like muscadine grapes or mangos our liver and pancreas can metabolize them without getting fatty liver or diabetes .For example I am 62 and have a home vineyard .For the last 13 years I have averaged 2 quarts of black muscadine grapes per day (I eat them frozen in the hot summer) but if you look at my videos you can see I am in superb physical condition . Recently a Book By a PHD with type 1 diabetes shows that eating fruit cures diabetes : "MASTERING DIABETES"
Good but this is not entirely accurate. The reason fructose (F) can be a rapid source of fat is not because of the conversion to acetyl-CoA. The real difference between F and glucose (G) is in the kinetics. It is important to recognize that both pathways wind up with the triose phosphates (Ga-3-P and DHAP). Fructokinase reaction is very fast and the glyceraldehyde kinase is irreversible. So if F is very high that will be converted to DHAP and then to glycerol-3-P. The FA comes mostly from re-cycled fat. We offered a perspective on where F really fits in. (Feinman & Fine, Nutrition & Metabolism). Important to remember that as much as 50 % of F can be converted to G so you have to be careful about details.
Thank you soooo much!!!
How does 1 tell if NAFLD or heading toward it, just high triglyceries? Mine have always been ok fasting. While looking thru 23andme snps on Snpedia noticed 1 is fructose intolerance (homoz) but looking up 3 others were all ok, guess it depends if that 1 snp is turned on and combined with all the others. Couldnt drink fruit juice as a kid or like cake (ice cream ok), but watermelon ok. Mom mostly fed us healthy foods ! See from your vid that we have many backup plans in our bodies !! Pretty nifty
Nice video.
is fructose malabsorption explained by missing any of these or damaged Glut5 or Glut2
This is so good
Thanks v much for this
Thank you!
Iwe uli wa last🙏🙏
Very helpful 👍
Glad it helped :)
Is fructose more harm than glucose?
is fructose creat fatty liver? Pls guide
Thanks a lot
i eat a lot of fruit, or at least i did before i got diagnosed with diabetes last month. i ate up to 6 bananas or mandarins or mangoes at least 3 days a week -- as i have done so for most of my 45 year life. The dietitian said to cut this down to 2 a day, and after watching videos like this, make me think that metformin wont do much for me. Any suggestions for medications or supplements to decrease the glucose? From what i have read about metformin it is targetted at the first 2 steps of glucose creation, and fructose does not come in the glucose process until a few steps later, correct?
I would try and decrease the grains and starches you eat ... cut out the breads, potatoes, and even the bananas. Keep eating fruits that are lower in carbs.
Investigate carnivore diet. Eliminate fruit altogether. Try it for a month and see how it affects you
Thank you...
Oxidative anda non-oxidative??
i loved the video so much i was gonna unlike my already put like trying to put another like xD
Because of your last comments, I ask myself : Is it also possible to produce Triglycerides only out of GLUCOSE?
Yes it's possible. watch ninja nerd metabolic metabolism
Why is glucose metabolism regulated by the body? And what is the result of its regulation?
Thanks!
Glucose metabolism is regulated because glycolysis does not progress if the cell is in an energy surplus state (high ATP to AMP ratio and high citrate content) because citrate and ATP inhibit PFK-1. The result of this regulation is that the excess Glucose-6-Phosphate is directed towards glycogen synthesis.
Great!
Since there are limiting factors on glucose metabolism, what happens to excess glucose in diet?
It gets converted into Glycogen, Glycogen gets store in the mustles and liver.
For example RICE is just pure GLUCOSE eat a ton of it and you are going to stored the one that you don't need in Glycogen.
I think people who get obese and deceases it goes all down to eating desorters.
@@Interestingworld4567 Also some of it goes into your fat cells (if they're insulin sensitive enough) and then into glycerol, and finally i believe some some turn into free fatty acids directly into the bloodstream and then these fatty acids enter the fat cells (i think these don't require insulin so yeah) and then combine with the glycerol (wich was previously glucose).
@@loganwolv3393 Yeah I also heard that if you eat too much glucose you can get fat but the sciences who said that said that Yu our will have to eat or consumed a ton of it.
Almost all alcoholics who didn't make it on our ward were also sugar junkies.
Converting fructose to fatty acids is an endothermic reaction
superb! =D
So theres no down regulation of the enzymes.
yes ..that why it cause obesity by time ..
Great video! Is the process for fructose the same from different sources? For example fructose from natural organic fruits and fructose from highly processed corn syrup? One only does good and the other harm..
Once you isolate any chemical from source, then it becomes a drug and is extremely dangerous to you and that means all 150 trillion cells of you
thank you so much. Supposing that my source of fructose is exclusively from fruits, do I have a risk of obesity? I do eat a lot of fruits, tropical fruits in particular as I am very often in Asia (9 months a year).
Not really. the fiber in the fruits makes the absorption of fructose from fruits much slower allowing the body more time to do its job and not overloading the liver
@@KressRudra yes, I know, that's why i never drink fruit juices
There is absolutely no risk of obesity from consuming fruit. Quite the contrary. Please be your own scientist and consume only fruit and nothing else for 2 weeks and record how you feel on a daily basis. Please watch "Dr. Morse great lymphatic system". You are wonderful!!
@@susanbrankie1204 i feel great eating icing sugar out of a bowl too. Dopamine is awesome!
@@KressRudra fruits do not over load the liver. You guys are probably eat meat dairy starch everyday (uric acid, lauric) and! Fructose by its self is the best things man can eat. Fruits contain h3o2 and many vitamins “vital minerals” the body needs.
Dang, another video told me that the liver simply turns fructose into glucose
спасибо большое
i love your funny words magic man
So to be clear, from your drawings it looks as if fructose just gets turned into fat, and only then fat into ATP, but it's never from fructose to ATP directly, so essentially all of the fructose is an indirect source of ATP only through fat... intresting.
Your explanation is incorrect. When fructose is converted to G3P it meets up with the G3P from glucose metabolism. From there G3P either goes to for Lactic acid, Energy as ATP and production of fat (triglycerides). Therefore, fructose can turn into anything that glucose can. There's no evidence that a reasonable intake of fructose turns into fat. Excess calories from foods, particularly foods with added high-fructose corn syrup and other processed foods, will lead to fat deposition, particularly in the liver. This causes metabolic associated fatty liver disease (MAFLD).
Thank you sir i from Pakistan
So the very end of this video highlights the mechanism by which all that unneeded fructose is shunted into fat around your liver and all over, ultimately interfering with other metabolic activities and resulting in obesity and diabetes. The fructose is largely coming from sugar. Your body manages the glucose but not the fructose. Cut out the sugar, go keto / IF for three or four months. You will be amazed but it is not easy to get started. Make yourself go two weeks and the rest of the three months will be a snap. Then check in with yourself and see how you feel.
Using bad microphone causes echoes
The attack against Fructose is misguided. Yes, high fructose corn syrup laced with mercury is horrible for you, but pure fructose from a clean source can be a very medicinal carbohydrate. It's big advantage is that, unlike glucose, it's use is not inhibited by elevated free fatty acids aka the randle cycle.
@@muchasalud2011 …BIG STRONG (healthy!😉) gorillas are (naturally) fruitarian… and I’m sure that if they could speak (to you)- “they’d” beg to differ- telling “you” to wipe the “dribble” from your mouth- if they didn’t choose to backhand such blasphemy- from it👍🏻…
Wow u r a genius. Do you do tutoring for small groups via Skype? If you charge a small fee per person you can probably make about $150/hr
Do you have skype and a website- can u tell us if you can do this for small groups maybe each participant can pay $10/hr. If you hold it at 30 people and keep it at 2hr segments (30 min Lect then 20 min Questions back and forth... then last hour a special topic hour on current research)
I think this would be amazing 😃
How many apples (or bananas) to eat per day to get a fatty liver?
@Brandon Aitken That's good to hear because I frequently have ~20 bananas a day before other fruits.
Can someone simplify this please:/
I only got that fructose -> triglycerides
Well that's the essential part.
30 seconds in... it's a pentose not a hexose.....
Fructose is a hexose
Count the number of carbons, it’s 6.
SHOW ME A FAT FRUTARIAN. THAT HAS NOT JUST STARTED
Improve your audio quality
frig off
You must have wax in your ears 😉
100% fruit juice is not a health food.
low-fat yogurt is a joke.
Thanks!
In English please 🤣
Great video!
Thank you!
Thanks very much 👏🏽